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2. Racial/ethnic differences in eligibility for asthma biologics among pediatric populations

Author

Wohlford, Eric M., Huang, Peter F., Elhawary, Jennifer R., Millette, Lauren A., Contreras, Maria G., Witonsky, Jonathan, Holweg, Cécile T.J., Oh, Sam S., Lee, Christine, Merenda, Christine, Rabin, Ronald L., Araojo, Richardae, Mak, Angel C.Y., Eng, Celeste S., Hu, Donglei, Huntsman, Scott, LeNoir, Michael A., Rodríguez-Santana, Jose R., Borrell, Luisa N., and Burchard, Esteban G.

Published
2021
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3. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Author

Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Chen, Yii-Der Ida, Cho, Michael H., Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, Das, Sayantan, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Do, Ron, Duan, Qing, Duggirala, Ravi, Durda, Peter, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Ellinor, Patrick, Emery, Leslie, Farber, Charles, Farnam, Leanna, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi (Priscilla), Germer, Soren, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola, He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hokanson, John, Holly, Kramer, Hong, Elliott, Hoth, Karin, (Agnes) Hsiung, Chao, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A., Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kachroo, Priyadarshini, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kathiresan, Sekar, Kaufman, Laura, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Krauter, Stephanie, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Seunggeun Shawn, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Yun, Lin, Honghuang, Lin, Keng Han, Liu, Simin, Liu, Yongmei, Loos, Ruth, Lubitz, Steven, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manson, JoAnn, Margolin, Lauren, Martin, Lisa, Mathai, Susan, Mathias, Rasika, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, Mei, Hao, Meyers, Deborah A., Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L., Mitchell, Braxton, Montasser, May E., Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C., Nadkarni, Girish, Naik, Rakhi, Natarajan, Pradeep, Nekhai, Sergei, Nickerson, Deborah, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Pankow, James, Papanicolaou, George, Parker, Margaret, Parsa, Afshin, Penchev, Sara, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S., Phillips, Sam, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Prokopenko, Dmitry, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Ramachandran, Vasan, Rao, D.C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Regan, Elizabeth, Reiner, Alex, Rice, Ken, Rich, Stephen, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sakornsakolpat, Phuwanat, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sheehan, Vivien, Shetty, Amol, Shetty, Aniket, Sheu, Wayne Hui-Heng, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne, Streeten, Elizabeth, Sung, Yun Ju, Su-Lasky, Jessica, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Tinker, Lesley, Tirschwell, David, Tiwari, Hemant, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wan, Emily, Wang, Fei Fei, Watson, Karol, Weeks, Daniel E., Weir, Bruce, Weiss, Scott, Weng, Lu-Chen, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Wong, Quenna, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yang, Rongze, Zaghloul, Norann, Zekavat, Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zheng, Xiuwen, Zhi, Degui, Zhou, Xiang, Zody, Michael, Zoellner, Sebastian, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Levin, Albert M., Gui, Hongsheng, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Weiss, Scott T., and Lasky-Su, Jessica A.

Published
2019
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5. Ambient air pollution, asthma drug response, and telomere length in African American youth

Author

Lee, Eunice Y., Oh, Sam S., White, Marquitta J., Eng, Celeste S., Elhawary, Jennifer R., Borrell, Luisa N., Nuckton, Thomas J., Zeiger, Andrew M., Keys, Kevin L., Mak, Angel C.Y., Hu, Donglei, Huntsman, Scott, Contreras, Maria G., Samedy, Lesly-Anne, Goddard, Pagé C., Salazar, Sandra L., Brigino-Buenaventura, Emerita N., Davis, Adam, Meade, Kelley E., LeNoir, Michael A., Lurmann, Fred W., Burchard, Esteban G., Eisen, Ellen A., and Balmes, John R.

Published
2019
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6. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Author

Taub, Margaret A., Conomos, Matthew P., Keener, Rebecca, Iyer, Kruthika R., Weinstock, Joshua S., Yanek, Lisa R., Lane, John, Miller-Fleming, Tyne W., Brody, Jennifer A., Raffield, Laura M., McHugh, Caitlin P., Jain, Deepti, Gogarten, Stephanie M., Laurie, Cecelia A., Keramati, Ali, Arvanitis, Marios, Smith, Albert V., Heavner, Benjamin, Barwick, Lucas, Becker, Lewis C., Bis, Joshua C., Blangero, John, Bleecker, Eugene R., Burchard, Esteban G., Celedón, Juan C., Chang, Yen Pei C., Custer, Brian, Darbar, Dawood, de las Fuentes, Lisa, DeMeo, Dawn L., Freedman, Barry I., Garrett, Melanie E., Gladwin, Mark T., Heckbert, Susan R., Hidalgo, Bertha A., Irvin, Marguerite R., Islam, Talat, Johnson, W. Craig, Kaab, Stefan, Launer, Lenore, Lee, Jiwon, Liu, Simin, Moscati, Arden, North, Kari E., Peyser, Patricia A., Rafaels, Nicholas, Seidman, Christine, Weeks, Daniel E., Wen, Fayun, Wheeler, Marsha M., Williams, L. Keoki, Yang, Ivana V., Zhao, Wei, Aslibekyan, Stella, Auer, Paul L., Bowden, Donald W., Cade, Brian E., Chen, Zhanghua, Cho, Michael H., Cupples, L. Adrienne, Curran, Joanne E., Daya, Michelle, Deka, Ranjan, Eng, Celeste, Fingerlin, Tasha E., Guo, Xiuqing, Hou, Lifang, Hwang, Shih-Jen, Johnsen, Jill M., Kenny, Eimear E., Levin, Albert M., Liu, Chunyu, Minster, Ryan L., Naseri, Take, Nouraie, Mehdi, Reupena, Muagututi‘a Sefuiva, Sabino, Ester C., Smith, Jennifer A., Smith, Nicholas L., Lasky-Su, Jessica, Taylor, James G., VI, Telen, Marilyn J., Tiwari, Hemant K., Tracy, Russell P., White, Marquitta J., Zhang, Yingze, Wiggins, Kerri L., Weiss, Scott T., Vasan, Ramachandran S., Taylor, Kent D., Sinner, Moritz F., Silverman, Edwin K., Shoemaker, M. Benjamin, Sheu, Wayne H.-H., Sciurba, Frank, Schwartz, David A., Rotter, Jerome I., Roden, Daniel, Redline, Susan, Raby, Benjamin A., Psaty, Bruce M., Peralta, Juan M., Palmer, Nicholette D., Nekhai, Sergei, Montgomery, Courtney G., Mitchell, Braxton D., Meyers, Deborah A., McGarvey, Stephen T., Mak, Angel C.Y., Loos, Ruth J.F., Kumar, Rajesh, Kooperberg, Charles, Konkle, Barbara A., Kelly, Shannon, Kardia, Sharon L.R., Kaplan, Robert, He, Jiang, Gui, Hongsheng, Gilliland, Frank D., Gelb, Bruce D., Fornage, Myriam, Ellinor, Patrick T., de Andrade, Mariza, Correa, Adolfo, Chen, Yii-Der Ida, Boerwinkle, Eric, Barnes, Kathleen C., Ashley-Koch, Allison E., Arnett, Donna K., Albert, Christine, Laurie, Cathy C., Abecasis, Goncalo, Nickerson, Deborah A., Wilson, James G., Rich, Stephen S., Levy, Daniel, Ruczinski, Ingo, Aviv, Abraham, Blackwell, Thomas W., Thornton, Timothy, O’Connell, Jeff, Cox, Nancy J., Perry, James A., Armanios, Mary, Battle, Alexis, Pankratz, Nathan, Reiner, Alexander P., and Mathias, Rasika A.

Published
2022
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7. Lymph node–resident dendritic cells drive T H 2 cell development involving MARCH1

Author

Castellanos, Carlos A., primary, Ren, Xin, additional, Gonzalez, Steven Lomeli, additional, Li, Hong Kun, additional, Schroeder, Andrew W., additional, Liang, Hong-Erh, additional, Laidlaw, Brian J., additional, Hu, Donglei, additional, Mak, Angel C.Y., additional, Eng, Celeste, additional, Rodríguez-Santana, José R., additional, LeNoir, Michael, additional, Yan, Qi, additional, Celedón, Juan C., additional, Burchard, Esteban G., additional, Zamvil, Scott S., additional, Ishido, Satoshi, additional, Locksley, Richard M., additional, Cyster, Jason G., additional, Huang, Xiaozhu, additional, and Shin, Jeoung-Sook, additional

Published
2021
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8. Epigenome-wide association study of bronchodilator response in African Americans

Author

Perez-Garcia, Javier, primary, Li, Annie, additional, Herrera-Luis, Esther, additional, Mak, Angel C.Y., additional, Borrel, Luisa N., additional, Hu, Donglei, additional, Eng, Celeste, additional, Beckman, Kenneth B., additional, Keys, Kevin L., additional, Huntsman, Scott, additional, Lorenzo-Diaz, Fabian, additional, Pino-Yanes, Maria, additional, and Burchard, Esteban G., additional

Published
2021
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9. Gene expression in African Americans and Latinos reveals ancestry-specific patterns of genetic architecture

Author

Kachuri, Linda, primary, Mak, Angel C.Y., additional, Hu, Donglei, additional, Eng, Celeste, additional, Huntsman, Scott, additional, Elhawary, Jennifer R., additional, Gupta, Namrata, additional, Gabriel, Stacey, additional, Xiao, Shujie, additional, Keys, Kevin L., additional, Oni-Orisan, Akinyemi, additional, Rodríguez-Santana, José R., additional, LeNoir, Michael, additional, Borrell, Luisa N., additional, Zaitlen, Noah A., additional, Williams, L. Keoki, additional, Gignoux, Christopher R., additional, Burchard, Esteban González, additional, and Ziv, Elad, additional

Published
2021
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10. Native American Ancestry and Air Pollution Interact to Impact Bronchodilator Response in Puerto Rican Children with Asthma

Author

Contreras, Maria, primary, Keys, Kevin, additional, Magana, Joaquin, additional, Goddard, Page, additional, Risse-Adams, Oona, additional, Zeiger, Andrew M., additional, Mak, Angel C.Y., additional, Samedy-Bates, Lesly-Anne, additional, Neophytou, Andreas, additional, Lee, Eunice, additional, Thakur, Neeta, additional, Elhawary, Jennifer R., additional, Hu, Donglei, additional, Huntsman, Scott, additional, Eng, Celeste, additional, Hu, Ting, additional, Burchard, Esteban G., additional, and White, Marquitta J., additional

Published
2021
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11. Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function

Author

Goddard, Pagé C., primary, Keys, Kevin L., additional, Mak, Angel C.Y., additional, Lee, Eunice Yujung, additional, Liu, Amy K., additional, Samedy-Bates, Lesly-Anne, additional, Risse-Adams, Oona, additional, Contreras, María G., additional, Elhawary, Jennifer R., additional, Hu, Donglei, additional, Huntsman, Scott, additional, Oh, Sam S., additional, Salazar, Sandra, additional, Eng, Celeste, additional, Himes, Blanca E., additional, White, Marquitta J., additional, and Burchard, Esteban G., additional

Published
2020
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12. Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1.

Author

Castellanos, Carlos A., Ren, Xin, Gonzalez, Steven Lomeli, Li, Hong Kun, Schroeder, Andrew W., Liang, Hong-Erh, Laidlaw, Brian J., Hu, Donglei, Mak, Angel C.Y., Eng, Celeste, Rodríguez-Santana, José R., LeNoir, Michael, Yan, Qi, Celedón, Juan C., Burchard, Esteban G., Zamvil, Scott S., Ishido, Satoshi, Locksley, Richard M., Cyster, Jason G., and Huang, Xiaozhu

Abstract

Type 2 T helper (TH2) cells are protective against parasitic worm infections but also aggravate allergic inflammation. Although the role of dendritic cells (DCs) in TH2 cell differentiation is well established, the underlying mechanisms are largely unknown. Here, we show that DC induction of TH2 cells depends on membrane-associated RING-CH-1 (MARCH1) ubiquitin ligase. The pro-TH2 effect of MARCH1 relied on lymph node (LN)–resident DCs, which triggered T cell receptor (TCR) signaling and induced GATA-3 expression from naïve CD4+ T cells independent of tissue-driven migratory DCs. Mice with mutations in the ubiquitin acceptor sites of MHCII and CD86, the two substrates of MARCH1, failed to develop TH2 cells. These findings suggest that TH2 cell development depends on ubiquitin-mediated clearance of antigen-presenting and costimulatory molecules by LN-resident DCs and consequent control of TCR signaling. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Author

Kachroo, Priyadarshini, primary, Hecker, Julian, additional, Chawes, Bo L., additional, Ahluwalia, Tarunveer S., additional, Cho, Michael H., additional, Qiao, Dandi, additional, Kelly, Rachel S., additional, Chu, Su H., additional, Virkud, Yamini V., additional, Huang, Mengna, additional, Barnes, Kathleen C., additional, Burchard, Esteban G., additional, Eng, Celeste, additional, Hu, Donglei, additional, Celedón, Juan C., additional, Daya, Michelle, additional, Levin, Albert M., additional, Gui, Hongsheng, additional, Williams, L. Keoki, additional, Forno, Erick, additional, Mak, Angel C.Y., additional, Avila, Lydiana, additional, Soto-Quiros, Manuel E., additional, Cloutier, Michelle M., additional, Acosta-Pérez, Edna, additional, Canino, Glorisa, additional, Bønnelykke, Klaus, additional, Bisgaard, Hans, additional, Raby, Benjamin A., additional, Lange, Christoph, additional, Weiss, Scott T., additional, Lasky-Su, Jessica A., additional, Abe, Namiko, additional, Abecasis, Goncalo, additional, Albert, Christine, additional, Palmer Allred, Nicholette (Nichole), additional, Almasy, Laura, additional, Alonso, Alvaro, additional, Ament, Seth, additional, Anderson, Peter, additional, Anugu, Pramod, additional, Applebaum-Bowden, Deborah, additional, Arking, Dan, additional, Arnett, Donna K., additional, Ashley-Koch, Allison, additional, Aslibekyan, Stella, additional, Assimes, Tim, additional, Auer, Paul, additional, Avramopoulos, Dimitrios, additional, Barnard, John, additional, Barnes, Kathleen, additional, Barr, R. Graham, additional, Barron-Casella, Emily, additional, Beaty, Terri, additional, Becker, Diane, additional, Becker, Lewis, additional, Beer, Rebecca, additional, Begum, Ferdouse, additional, Beitelshees, Amber, additional, Benjamin, Emelia, additional, Bezerra, Marcos, additional, Bielak, Larry, additional, Bis, Joshua, additional, Blackwell, Thomas, additional, Blangero, John, additional, Boerwinkle, Eric, additional, Borecki, Ingrid, additional, Bowler, Russell, additional, Brody, Jennifer, additional, Broeckel, Ulrich, additional, Broome, Jai, additional, Bunting, Karen, additional, Burchard, Esteban, additional, Cardwell, Jonathan, additional, Carty, Cara, additional, Casaburi, Richard, additional, Casella, James, additional, Chaffin, Mark, additional, Chang, Christy, additional, Chasman, Daniel, additional, Chavan, Sameer, additional, Chen, Bo-Juen, additional, Chen, Wei-Min, additional, Chen, Yii-Der Ida, additional, Choi, Seung Hoan, additional, Chuang, Lee-Ming, additional, Chung, Mina, additional, Cornell, Elaine, additional, Correa, Adolfo, additional, Crandall, Carolyn, additional, Crapo, James, additional, Cupples, L. Adrienne, additional, Curran, Joanne, additional, Curtis, Jeffrey, additional, Custer, Brian, additional, Damcott, Coleen, additional, Darbar, Dawood, additional, Das, Sayantan, additional, David, Sean, additional, Davis, Colleen, additional, de Andrade, Mariza, additional, DeBaun, Michael, additional, Deka, Ranjan, additional, DeMeo, Dawn, additional, Devine, Scott, additional, Do, Ron, additional, Duan, Qing, additional, Duggirala, Ravi, additional, Durda, Peter, additional, Dutcher, Susan, additional, Eaton, Charles, additional, Ekunwe, Lynette, additional, Ellinor, Patrick, additional, Emery, Leslie, additional, Farber, Charles, additional, Farnam, Leanna, additional, Fingerlin, Tasha, additional, Flickinger, Matthew, additional, Fornage, Myriam, additional, Franceschini, Nora, additional, Fu, Mao, additional, Fullerton, Stephanie M., additional, Fulton, Lucinda, additional, Gabriel, Stacey, additional, Gan, Weiniu, additional, Gao, Yan, additional, Gass, Margery, additional, Gelb, Bruce, additional, Geng, Xiaoqi (Priscilla), additional, Germer, Soren, additional, Gignoux, Chris, additional, Gladwin, Mark, additional, Glahn, David, additional, Gogarten, Stephanie, additional, Gong, Da-Wei, additional, Goring, Harald, additional, Gu, C. Charles, additional, Guan, Yue, additional, Guo, Xiuqing, additional, Haessler, Jeff, additional, Hall, Michael, additional, Harris, Daniel, additional, Hawley, Nicola, additional, He, Jiang, additional, Heavner, Ben, additional, Heckbert, Susan, additional, Hernandez, Ryan, additional, Herrington, David, additional, Hersh, Craig, additional, Hidalgo, Bertha, additional, Hixson, James, additional, Hokanson, John, additional, Holly, Kramer, additional, Hong, Elliott, additional, Hoth, Karin, additional, (Agnes) Hsiung, Chao, additional, Huston, Haley, additional, Hwu, Chii Min, additional, Irvin, Marguerite Ryan, additional, Jackson, Rebecca, additional, Jain, Deepti, additional, Jaquish, Cashell, additional, Jhun, Min A., additional, Johnsen, Jill, additional, Johnson, Andrew, additional, Johnson, Craig, additional, Johnston, Rich, additional, Jones, Kimberly, additional, Kachroo, Priyadarshini, additional, Kang, Hyun Min, additional, Kaplan, Robert, additional, Kardia, Sharon, additional, Kathiresan, Sekar, additional, Kaufman, Laura, additional, Kelly, Shannon, additional, Kenny, Eimear, additional, Kessler, Michael, additional, Khan, Alyna, additional, Kinney, Greg, additional, Konkle, Barbara, additional, Kooperberg, Charles, additional, Krauter, Stephanie, additional, Lange, Ethan, additional, Lange, Leslie, additional, Laurie, Cathy, additional, Laurie, Cecelia, additional, LeBoff, Meryl, additional, Lee, Seunggeun Shawn, additional, Lee, Wen-Jane, additional, LeFaive, Jonathon, additional, Levine, David, additional, Levy, Dan, additional, Lewis, Joshua, additional, Li, Yun, additional, Lin, Honghuang, additional, Lin, Keng Han, additional, Liu, Simin, additional, Liu, Yongmei, additional, Loos, Ruth, additional, Lubitz, Steven, additional, Lunetta, Kathryn, additional, Luo, James, additional, Mahaney, Michael, additional, Make, Barry, additional, Manichaikul, Ani, additional, Manson, JoAnn, additional, Margolin, Lauren, additional, Martin, Lisa, additional, Mathai, Susan, additional, Mathias, Rasika, additional, McArdle, Patrick, additional, McDonald, Merry-Lynn, additional, McFarland, Sean, additional, McGarvey, Stephen, additional, Mei, Hao, additional, Meyers, Deborah A., additional, Mikulla, Julie, additional, Min, Nancy, additional, Minear, Mollie, additional, Minster, Ryan L., additional, Mitchell, Braxton, additional, Montasser, May E., additional, Musani, Solomon, additional, Mwasongwe, Stanford, additional, Mychaleckyj, Josyf C., additional, Nadkarni, Girish, additional, Naik, Rakhi, additional, Natarajan, Pradeep, additional, Nekhai, Sergei, additional, Nickerson, Deborah, additional, North, Kari, additional, O'Connell, Jeff, additional, O'Connor, Tim, additional, Ochs-Balcom, Heather, additional, Pankow, James, additional, Papanicolaou, George, additional, Parker, Margaret, additional, Parsa, Afshin, additional, Penchev, Sara, additional, Peralta, Juan Manuel, additional, Perez, Marco, additional, Perry, James, additional, Peters, Ulrike, additional, Peyser, Patricia, additional, Phillips, Lawrence S., additional, Phillips, Sam, additional, Pollin, Toni, additional, Post, Wendy, additional, Becker, Julia Powers, additional, Boorgula, Meher Preethi, additional, Preuss, Michael, additional, Prokopenko, Dmitry, additional, Psaty, Bruce, additional, Qasba, Pankaj, additional, Qin, Zhaohui, additional, Rafaels, Nicholas, additional, Raffield, Laura, additional, Ramachandran, Vasan, additional, Rao, D.C., additional, Rasmussen-Torvik, Laura, additional, Ratan, Aakrosh, additional, Redline, Susan, additional, Reed, Robert, additional, Regan, Elizabeth, additional, Reiner, Alex, additional, Rice, Ken, additional, Rich, Stephen, additional, Roden, Dan, additional, Roselli, Carolina, additional, Rotter, Jerome, additional, Ruczinski, Ingo, additional, Russell, Pamela, additional, Ruuska, Sarah, additional, Ryan, Kathleen, additional, Sakornsakolpat, Phuwanat, additional, Salimi, Shabnam, additional, Salzberg, Steven, additional, Sandow, Kevin, additional, Sankaran, Vijay, additional, Scheller, Christopher, additional, Schmidt, Ellen, additional, Schwander, Karen, additional, Schwartz, David, additional, Sciurba, Frank, additional, Seidman, Christine, additional, Seidman, Jonathan, additional, Sheehan, Vivien, additional, Shetty, Amol, additional, Shetty, Aniket, additional, Sheu, Wayne Hui-Heng, additional, Shoemaker, M. Benjamin, additional, Silver, Brian, additional, Silverman, Edwin, additional, Smith, Jennifer, additional, Smith, Josh, additional, Smith, Nicholas, additional, Smith, Tanja, additional, Smoller, Sylvia, additional, Snively, Beverly, additional, Sofer, Tamar, additional, Sotoodehnia, Nona, additional, Stilp, Adrienne, additional, Streeten, Elizabeth, additional, Sung, Yun Ju, additional, Su-Lasky, Jessica, additional, Sylvia, Jody, additional, Szpiro, Adam, additional, Sztalryd, Carole, additional, Taliun, Daniel, additional, Tang, Hua, additional, Taub, Margaret, additional, Taylor, Kent, additional, Taylor, Simeon, additional, Telen, Marilyn, additional, Thornton, Timothy A., additional, Tinker, Lesley, additional, Tirschwell, David, additional, Tiwari, Hemant, additional, Tracy, Russell, additional, Tsai, Michael, additional, Vaidya, Dhananjay, additional, VandeHaar, Peter, additional, Vrieze, Scott, additional, Walker, Tarik, additional, Wallace, Robert, additional, Walts, Avram, additional, Wan, Emily, additional, Wang, Fei Fei, additional, Watson, Karol, additional, Weeks, Daniel E., additional, Weir, Bruce, additional, Weiss, Scott, additional, Weng, Lu-Chen, additional, Willer, Cristen, additional, Williams, Kayleen, additional, Wilson, Carla, additional, Wilson, James, additional, Wong, Quenna, additional, Xu, Huichun, additional, Yanek, Lisa, additional, Yang, Ivana, additional, Yang, Rongze, additional, Zaghloul, Norann, additional, Zekavat, Maryam, additional, Zhang, Yingze, additional, Zhao, Snow Xueyan, additional, Zhao, Wei, additional, Zheng, Xiuwen, additional, Zhi, Degui, additional, Zhou, Xiang, additional, Zody, Michael, additional, and Zoellner, Sebastian, additional

Published
2019
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14. Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis

Author

Wong, Karen H.Y., primary, Levy‐Sakin, Michal, additional, Ma, Walfred, additional, Gonzaludo, Nina, additional, Mak, Angel C.Y., additional, Vaka, Dedeepya, additional, Poon, Annie, additional, Chu, Catherine, additional, Lao, Richard, additional, Balamir, Melek, additional, Grenville, Zoe, additional, Wong, Nicolas, additional, Kane, John P., additional, Kwok, Pui‐Yan, additional, Malloy, Mary J., additional, and Pullinger, Clive R., additional

Published
2019
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15. On the cross-population generalizability of gene expression prediction models

Author

Keys, Kevin L., primary, Mak, Angel C.Y., additional, White, Marquitta J., additional, Eckalbar, Walter L., additional, Dahl, Andrew W., additional, Mefford, Joel, additional, Mikhaylova, Anna V., additional, Contreras, María G., additional, Elhawary, Jennifer R., additional, Eng, Celeste, additional, Hu, Donglei, additional, Huntsman, Scott, additional, Oh, Sam S., additional, Salazar, Sandra, additional, Lenoir, Michael A., additional, Ye, Jimmie C., additional, Thornton, Timothy A., additional, Zaitlen, Noah, additional, Burchard, Esteban G., additional, and Gignoux, Christopher R., additional

Published
2019
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16. A high-resolution, chromosome-assigned Komodo dragon genome reveals adaptations in the cardiovascular, muscular, and chemosensory systems of monitor lizards

Author

Lind, Abigail L., primary, Lai, Yvonne Y.Y., additional, Mostovoy, Yulia, additional, Holloway, Alisha K., additional, Iannucci, Alessio, additional, Mak, Angel C.Y., additional, Fondi, Marco, additional, Orlandini, Valerio, additional, Eckalbar, Walter L., additional, Milan, Massimo, additional, Rovatsos, Michail, additional, Kichigin, Ilya G., additional, Makunin, Alex I., additional, Pokorná, Martina J., additional, Altmanová, Marie, additional, A. Trifonov, Vladimir, additional, Schijlen, Elio, additional, Kratochvíl, Lukáš, additional, Fani, Renato, additional, Jessop, Tim S., additional, Patarnello, Tomaso, additional, Hicks, James W., additional, Ryder, Oliver A., additional, Mendelson, Joseph R., additional, Ciofi, Claudio, additional, Kwok, Pui-Yan, additional, Pollard, Katherine S., additional, and Bruneau, Benoit G., additional

Published
2019
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17. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Author

Kachroo, Priyadarshini, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Cho, Michael H., Qiao, Dandi, Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Daya, Michelle, Levin, Albert M., Gui, Hongsheng, Williams, L. Keoki, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Lange, Christoph, Weiss, Scott T., Lasky-Su, Jessica A., Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Loos, Ruth, Kachroo, Priyadarshini, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Cho, Michael H., Qiao, Dandi, Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Daya, Michelle, Levin, Albert M., Gui, Hongsheng, Williams, L. Keoki, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Lange, Christoph, Weiss, Scott T., Lasky-Su, Jessica A., Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, and Loos, Ruth

Abstract

Background: Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma. Methods: WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based Genetic Epidemiology of Asthma in Costa Rica study. Asthma affection status was defined through a physician's diagnosis of asthma, and most participants with asthma also had airway hyperresponsiveness (AHR) to methacholine. Family-based association tests for single variants were performed to assess the associations with lung function phenotypes. Results: A genome-wide significant association was identified between baseline FEV1/FVC ratio and a single-nucleotide polymorphism in the top hit cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) (rs12051168; P = 3.6 × 10−8 in the unadjusted model) that retained suggestive significance in the covariate-adjusted model (P = 5.6 × 10−6). Rs12051168 was also nominally associated with other related phenotypes: baseline FEV1 (P = 3.3 × 10−3), postbronchodilator (PB) FEV1 (7.3 × 10−3), and PB FEV1/FVC ratio (P = 2.7 × 10−3). The identified baseline FEV1/FVC ratio and rs12051168 association was meta-analyzed and replicated in three independent cohorts in which most participants with asthma also had confirmed AHR (combined weighted z-score P =.015) but not in cohorts without information about AHR. Conclusions: These findings suggest that using specific asthma characteristics, such as AHR, can help identify more genetically homogeneous asthma subgroups with genotype-phenotype associations that may not be observed in all children with asthma. CRISPLD2 also may be important for baseline lung f

Published
2019

18. Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

Author

Lind, Abigail L., Lai, Yvonne Y.Y., Mostovoy, Yulia, Holloway, Alisha K., Iannucci, Alessio, Mak, Angel C.Y., Fondi, Marco, Orlandini, Valerio, Eckalbar, Walter L., Milan, Massimo, Rovatsos, Michail, Kichigin, Ilya G., Makunin, Alex I., Johnson Pokorná, Martina, Altmanová, Marie, Trifonov, Vladimir A., Schijlen, Elio, Kratochvíl, Lukáš, Fani, Renato, Velenský, Petr, Rehák, Ivan, Patarnello, Tomaso, Jessop, Tim S., Hicks, James W., Ryder, Oliver A., Mendelson, Joseph R., Ciofi, Claudio, Kwok, Pui Yan, Pollard, Katherine S., Bruneau, Benoit G., Lind, Abigail L., Lai, Yvonne Y.Y., Mostovoy, Yulia, Holloway, Alisha K., Iannucci, Alessio, Mak, Angel C.Y., Fondi, Marco, Orlandini, Valerio, Eckalbar, Walter L., Milan, Massimo, Rovatsos, Michail, Kichigin, Ilya G., Makunin, Alex I., Johnson Pokorná, Martina, Altmanová, Marie, Trifonov, Vladimir A., Schijlen, Elio, Kratochvíl, Lukáš, Fani, Renato, Velenský, Petr, Rehák, Ivan, Patarnello, Tomaso, Jessop, Tim S., Hicks, James W., Ryder, Oliver A., Mendelson, Joseph R., Ciofi, Claudio, Kwok, Pui Yan, Pollard, Katherine S., and Bruneau, Benoit G.

Abstract

Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.

Published
2019

20. Genetic Determinants of Telomere Length in African American Youth

Author

Zeiger, Andrew M., primary, White, Marquitta J., additional, Oh, Sam S., additional, Witonsky, Jonathan, additional, Contreras, Maria G., additional, Goddard, Pagé C., additional, Lee, Eunice Y., additional, Keys, Kevin L., additional, Samedy, Lesly-Anne, additional, Liberto, Jennifer R., additional, Mak, Angel C.Y., additional, Magaña, Joaquín, additional, Risse-Adams, Oona, additional, Eng, Celeste, additional, Hu, Donglei, additional, Huntsman, Scott, additional, Salazar, Sandra, additional, Davis, Adam, additional, Meade, Kelley, additional, Brigino-Buenaventura, Emerita, additional, LeNoir, Michael A., additional, Farber, Harold J., additional, Bibbins-Domingo, Kirsten, additional, Borrell, Luisa N., additional, and Burchard, Esteban G., additional

Published
2018
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21. Whole genome sequencing of pharmacogenetic drug response in racially and ethnically diverse children with asthma

Author

Mak, Angel C.Y., primary, White, Marquitta J., additional, Szpiech, Zachary A., additional, Eckalbar, Walter L., additional, Oh, Sam S., additional, Pino-Yanes, Maria, additional, Hu, Donglei, additional, Goddard, Pagé, additional, Huntsman, Scott, additional, Galanter, Joshua, additional, Torgerson, Dara G., additional, Wu, Ann Chen, additional, Himes, Blanca E., additional, Germer, Soren, additional, Vogel, Julia M., additional, Bunting, Karen L., additional, Eng, Celeste, additional, Salazar, Sandra, additional, Keys, Kevin L., additional, Liberto, Jennifer, additional, Nuckton, Thomas J., additional, Nguyen, Thomas A., additional, Kwok, Pui-Yan, additional, Levin, Albert M., additional, Celedón, Juan C., additional, Forno, Erick, additional, Hakonarson, Hakon, additional, Sleiman, Patrick M., additional, Dahlin, Amber, additional, Tantisira, Kelan G., additional, Weiss, Scott T., additional, Serebrisky, Denise, additional, Brigino-Buenaventura, Emerita, additional, Farber, Harold J., additional, Meade, Kelley, additional, Lenoir, Michael A., additional, Avila, Pedro C., additional, Sen, Saunak, additional, Thyne, Shannon M., additional, Rodriguez-Cintron, William, additional, Winkler, Cheryl A., additional, Moreno-Estrada, Andrés, additional, Sandoval, Karla, additional, Rodriguez-Santana, Jose R., additional, Kumar, Rajesh, additional, Williams, L. Keoki, additional, Ahituv, Nadav, additional, Ziv, Elad, additional, Seibold, Max A., additional, Darnell, Robert B., additional, Zaitlen, Noah, additional, Hernandez, Ryan D., additional, and Burchard, Esteban G., additional

Published
2017
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23. Whole Genome Sequencing Identifies CRISPLD2as a Lung Function Gene in Children With Asthma

Author

Kachroo, Priyadarshini, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Cho, Michael H., Qiao, Dandi, Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Daya, Michelle, Levin, Albert M., Gui, Hongsheng, Williams, L. Keoki, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Lange, Christoph, Weiss, Scott T., Lasky-Su, Jessica A., Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Chen, Yii-Der Ida, Cho, Michael H., Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, Das, Sayantan, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Do, Ron, Duan, Qing, Duggirala, Ravi, Durda, Peter, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Ellinor, Patrick, Emery, Leslie, Farber, Charles, Farnam, Leanna, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi (Priscilla), Germer, Soren, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola, He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hokanson, John, Holly, Kramer, Hong, Elliott, Hoth, Karin, (Agnes) Hsiung, Chao, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A., Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kachroo, Priyadarshini, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kathiresan, Sekar, Kaufman, Laura, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Krauter, Stephanie, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Seunggeun Shawn, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Yun, Lin, Honghuang, Lin, Keng Han, Liu, Simin, Liu, Yongmei, Loos, Ruth, Lubitz, Steven, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manson, JoAnn, Margolin, Lauren, Martin, Lisa, Mathai, Susan, Mathias, Rasika, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, Mei, Hao, Meyers, Deborah A., Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L., Mitchell, Braxton, Montasser, May E., Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C., Nadkarni, Girish, Naik, Rakhi, Natarajan, Pradeep, Nekhai, Sergei, Nickerson, Deborah, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Pankow, James, Papanicolaou, George, Parker, Margaret, Parsa, Afshin, Penchev, Sara, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S., Phillips, Sam, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Prokopenko, Dmitry, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Ramachandran, Vasan, Rao, D.C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Regan, Elizabeth, Reiner, Alex, Rice, Ken, Rich, Stephen, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sakornsakolpat, Phuwanat, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sheehan, Vivien, Shetty, Amol, Shetty, Aniket, Sheu, Wayne Hui-Heng, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne, Streeten, Elizabeth, Sung, Yun Ju, Su-Lasky, Jessica, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Tinker, Lesley, Tirschwell, David, Tiwari, Hemant, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wan, Emily, Wang, Fei Fei, Watson, Karol, Weeks, Daniel E., Weir, Bruce, Weiss, Scott, Weng, Lu-Chen, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Wong, Quenna, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yang, Rongze, Zaghloul, Norann, Zekavat, Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zheng, Xiuwen, Zhi, Degui, Zhou, Xiang, Zody, Michael, and Zoellner, Sebastian

Abstract

Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma.

Published
2019
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