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In article questions of influence of ethnocultural traditions for moral formation of youth are considered. Necessity of use of the ethnocultural approach for education for formation of the harmonious person, influence of traditional values on formation of outlook of children and youth is shown. Questions of is standard-legal regulation of questions of a state policy in the field of education and socialisation of children and youth within the limits of Strategy of development of education in the Russian Federation for the period till 2025 are studied. Considered main activities of the state, federal, regional and noncommercial organisations on realisation of a state policy in the field of Strategy on the basis of traditional Russian spiritual and moral values, traditions of the people of the Russian Federation are considered. Are revealed the actions directed on maintenance international (interethnic) and interfaith of the consent in the youth environment, preventive maintenance and the prevention of displays of extremism in activity of youth associations. Traditional and new forms of ethnocultural actions which can be interesting to youth with a view of attraction their attention to national cultures are presented. On an example of the South of Russia a variety of the spent ethnocultural actions.

The article examines in detail the concept of separation from the point of view of various psychological theories. We can conclude that separation is a complex and complex process that occurs individually, depending on the personal characteristics of family members, the characteristics of the family system, the age and gender of the child, and is based on long-term deep trusting relationships. Let us dwell on the study of the types and types of separation. Separation is a natural process that is necessary for the development of a healthy personality. However, it is important to remember that this does not mean cutting yourself off from your parents for life. Some connection with parents may remain important to a person throughout his life. It is important to find a balance between independence and connection with family. In general, psychological separation is a necessary stage in the development of a teenager, but its influence on the value-semantic sphere can be ambiguous. It is important that parents help their children through this process and try to maintain open and understanding communication with them. The separation process begins in adolescence and can continue throughout adulthood. Its main goal is to form a personality capable of independent decision-making and responsibility for their actions.

In this paper, the author’s approach to the definition of the concept of an ecosystem of sectoral management is proposed, the possibility of introducing this concept into the system of state regulation of oil companies and the industry as a whole is considered. The article describes the main indicators included in the process-project model of sectoral management, which is the center of the concept of the sectoral management ecosystem, provides a methodology for calculating and monitoring these indicators, and analyzes the benefits of implementing this concept in the state regulation system.

In modern conditions, issues related to the effectiveness of the regulation of the oil industry by the state are becoming increasingly important. In January 2018, the World Economic Forum was held in Davos, at which, in particular, the impact of the growth of protectionist trends in the global trade in hydrocarbons and the impact of climate change on the planet on the export of hydrocarbons was noted. As a result of the forum, the key ways of adjusting the policy of states in the relevant area were identified. At the same time, a significant number of states are already seeing the process of changing state regulation of the industry. Given the current crisis situation associated with the coronavirus pandemic, an increasing number of private enterprises are coming under state control, which gives rise to new discussions about the renaissance of the so-called state capitalism.. In this article, the authors examined country specific features, as well as various concepts of the formation and development of state capitalism in the oil industry.

In modern conditions, issues related to the effectiveness of the regulation of the oil industry by the state are becoming increasingly important. In January 2018, the World Economic Forum was held in Davos, which, in particular, noted the impact of the growth of protectionist trends in the global trade in hydrocarbons, and the impact of climate change on the planet on the export of hydrocarbons. As a result of the forum, the key ways of adjusting the policy of states in the relevant area were identified. At the same time, a significant number of states are already seeing the process of changing state regulation of the industry. In this article, the authors analyzed the systems of state regulation of the oil industry in different countries, and also gave assessments of the possibility of integrating new mechanisms into the system of sectoral management in Russia in the conditions of post-covid reality

The article discusses the directions, problems and results of using digital solutions in enterprises in the service sector. It is shown that digitalization in the service sector is due to the emergence of a new type of resource - a large amount of specific information about stakeholders. Digitalization has a direct effect on enterprises in the service sector in the form of the development of the institutional environment and the technical infrastructure of digitalization, as well as an indirect action related to the transformation of the enterprises of this industry themselves, their missions and goals. The areas of digitalization in the service sector are indicated. It is shown that the use of digital technologies affects cost reduction and sales growth, and also has a significant impact on the formation and use of the intellectual capital of service enterprises. The features of the formation of the intellectual capital of the enterprise at the stages of the life cycle are considered. The elements of intellectual capital are clarified, which have received an impetus for development due to digitalization. Possible positive directions of the impact of digitalization on the elements of intellectual capital are presented, and the dynamics of the impact of digitalization decisions on the elements of intellectual capital at the stages of the enterprise life cycle is considered.

The article focuses on the spatial conditions of sustainable urban development. They cannot develop without taking into account its inherent tendencies. Using the example of the Russian Federation, the authors performed an analysis of the spatial factor of urban development. The directions of its influence are established; the zoning in the spatial development of the country is highlighted; the laws and tendencies of the transformation of cities under the influence of changes in the economic space were established. The authors substantiated the need to coordinate the development strategies of Russian cities with the measures of the state regional policy. This will allow taking into account the peculiarities of the regions and territories in which the cities are located. It also shows the need for faster development of transport infrastructure in Russia, which increases the coherence of the economic space of the country, stimulates interregional and intercity (inter-settlement) communications. Concerning the zone of the Russian European Core, recommendations were given on prioritizing measures and tools for sustainable urban development. It has been proposed to take into account in the state and municipal policy the main vectors of spatial development (West - East; North - South; Center -Periphery).

Object of study - the impact of the transport system on economic security. Applied research and calculations are performed on the example of the Lipetsk region (Russia). The study used methods of system analysis, performance evaluation, statistical method, calculation of Engel and Uspensky coefficients, etc. Analysis of data on the provision of transport infrastructure in the regions of Russia and other countries showed that insufficient development of transport is a “weak spot” in Russian regions. To solve it, the following measures were proposed: development of public urban transport, modernization of the integrated transport system of urban agglomerations, introduction of a strategic approach to managing transport development, construction of toll roads and highways, more active use of electronic control systems for urban transport systems. To assess the effectiveness of the development strategy of urban transport systems, the authors suggested using a number of criteria. This is a criterion of fiscal efficiency; environmental performance criterion; criterion of strategic coherence. Their use allows optimizing the development of transport in Russian cities. As a result, the economic security of their development will be reliably ensured.

In the modern economy, there are problems associated with investing in infrastructure development. Its facilities are public goods. Therefore, private business is not interested in their creation and development. And the state does not have sufficient resources to solve the problems of infrastructure development. Therefore, the mechanism of interaction between the state and business on the basis of public-private partnership (PPP) has spread in this sphere. The analysis shows that the forms of PPP depend on the country (region) and industry. Therefore, increasing the effectiveness of PPP, as the authors have shown, should be based on the specificity of projects. The article analyzes the experience and perspectives of PPP development in the Russian transport industry. The authors concluded that the interaction of power and private capital is the most effective mechanism in modern conditions for the creation and development of transport infrastructure in Russia. At the same time, the article focuses on the financial component of PPP in transport.

Littoral cell angioma is a very rare benign splenic neoplasm with typical morphological features. It is difficult to differentiate this angioma from other benign or malignant splenic tumors. It is a unique vascular tumor followed by abdominal pain or detected incidentally during examination. Incidence of this tumor is small, as only few appropriate cases were described in the literature. We present successful surgical treatment of littoral cell angioma of the spleen. The issues of clinical course, diagnosis, therapeutic tactics, morphologic and histochemical features are discussed.

We present successful surgical treatment of a patient with chronic kidney disease (CKD) and hyperparathyroidism undergoing renal replacement therapy. At baseline, parathyroidectomy via cervical access was performed for parathyroid adenomas. After 6 years, clinical and laboratory relapse of disease required thoracoscopic resection of atypically located anterior mediastinal adenoma. This case demonstrates that this disease is one of the most difficult in modern medicine requiring a special approach in diagnosis and treatment. Patients with CKD and hyperparathyroidism need for follow-up, control of total and ionized serum calcium, inorganic phosphorus and parathormone, osteodensitometry, ultrasound and scintigraphy of thyroid and parathyroid glands, and, if necessary, CT or MRI of the neck and chest organs.

The authors describe thyroidectomy in a patient with multinodular toxic goiter stage V, severe thyrotoxicosis complicated by thyro-cardiac disease, strangulation syndrome and severe comorbidities. Nodular euthyroid goiter was first diagnosed in 1992, and resection of the right thyroid lobe was performed. Progressive enlargement of thyroid gland and thyrotoxicosis occurred after coronavirus infection in February, 2020. Along with progression of thyrotoxicosis and strangulation of cervical organs, the patient suffered from portal vein thrombosis, pulmonary embolism. Myeloproliferative disease with essential thrombocythemia was also diagnosed. Volume of the right and left thyroid lobes was 69 and 101.3 cm 3 , respectively. X-ray examination of the esophagus revealed narrowing at C6 level up to 5-8 mm. Surgery time was 2 hours, dimension of removed right thyroid lobe - 10.0×7.5×6.5 cm, left thyroid lobe - 11.0×6.5×5.5 cm, total weight - 348 g. The patient was discharged in 6 days after surgery.

The relevance of the study of behavioral disorders in children and adolescents with intellectual disability is determined by the fact that the problem is at the intersection of different disciplines (psychiatry, psychology, pedagogics, sociology, criminology). Also, there are difficulties in analyzing the interaction between biological and social factors in etiology of such disorders. The review article discusses various aspects of behavioral disorders in children and adolescents with intellectual disability - the historical background, prevalence, etiology and pathogenesis, clinical picture. The authors point to the need for a new approach to the classification of behavioral disorders in intellectual disability.

Objective: To evaluate effectiveness and safety of umbilical cord blood cells (UCBC) in children with ASD., Material and Methods: The study comprised 13 boys and 2 girls, mean age 7.0±0.5 years (test group), and 9 boys and 1 girl, mean age 6.0±1.3 years (control group) diagnosed with autism or autistic syndrome. UCBC were infused intravenously in a single dose of 250±20 million cells, four times at 14±3-day intervals. Dynamics of cognitive functions were assessed with WISC subscales, questionnaire Skvortsov Developmental Profile Survey and brainstem auditory evoked potentials (BAEPs) conducted before therapy and six months after the first injection. The dynamic of autistic symptoms was explored with CASD and ATEC questionnaires, fulfilled at the start of the study, 3 and 6 months later (test group) or at the start of the study, and 6 months later (control group)., Results: UCBC was well tolerated and caused no appreciable adverse effects. Observation revealed improvement in cognitive functioning and alleviation of autistic symptoms in patients of the test group six months after the first UCBC injection. Positive dynamics were more noticeable in the test group than in the control group receiving standard therapy., Conclusion: The use of UCBC is safe and might be effective in the complex therapy of autism.

Sleep disturbances are frequently observed in patients with substance use disorders during active use as well as in withdrawal period and in remission. However, there is limited information about the association between sleep disturbances and substance use disorders. This review summarizes results of the studies on specific characteristics of sleep disturbances related to alcohol, opioids and psychostimulants (cocaine) use. Data on objective and subjective measurements of sleep characteristics at different stages of the course of an addiction disorder (active use, withdrawal, remission) are presented.

The review presents current data on the nature of cognitive deficit in children with hyperkinetic disorder, and possible pathophysiological mechanisms of the disease. Considering possible neurobiological components of hyperkinetic disorder, attention is given to pathological functional connections underlying specific clinical manifestations of the disease.

In this review, the authors analyze the causes of the high prevalence of autism spectrum disorders (ASD) in recent decades. It is shown that the expansion of the boundaries of the 'autistic spectrum' concept led to a significant spread of data on its prevalence, depending on the time, diagnostic criteria, country and region. Stability of the diagnosis of ASD is not high and depends on the age of the child. Diagnostic practice in comorbid psychiatric disorders unfairly shifted toward ASD. At the same time, the hypothesis on the uniqueness of autistic manifestations in infancy is not convincingly confirmed. The practical aspect of the problem of the epidemiology of autism does not exclude, but on the contrary, presupposes early detection of nonspecific mental disorders followed by medical-psychological-pedagogical correction.

The paper considers the phenomenon of «mental atony» in children with developmental delay, intellectual disability and autism. The condition of mental atony is a congenital or early acquired even decrease in mental tone, manifested by the reduced ability to concentrate attention, a decline of the targeted activity, difficulties in contacting, weakening of unconditioned reflexes, lack of instinctive manifestations, «mobilization» of mental functions by persistent verbal and tactile stimulation. The article provides the history of the «mental atony» theory, as well as clinical features, epidemiology, etiology, pathogenesis and nosological specificity of the condition. Moreover, the criteria for the differential diagnosis between the atonic form of intellectual disability and autism are discussed in detail. Based on the analysis of literature and the results of own clinical observations, the authors conclude that a thorough differential analysis between childhood autism and atonic form of intellectual disability in children is necessary, otherwise, there is a risk of overdiagnosis of autistic disorders. The authors also point to the role of the brain lesion, particularly in the area of reticular formation, in the occurrence of phenomena of mental atony.

In this review article, the authors consider a role of interaction between noradrenergic and dopaminergic systems in children with hyperkinetic disorder without impairment of the operational system of intelligence. The uneven development of higher mental functions observed in these cases is determined by the specificity of the formation of functional systems and the inclusion of compensatory mechanisms as well.

The article presents the remote results of treatment of an obliterating atherosclerosis of arteries of the lower extremities of the II stage at patients of advanced and senile age after the combined use of ozone therapy and gravitational therapy. We performed a prospective randomized study in three parallel groups (139 patients). The 1st group (n=57) received standard medical therapy in combination with ozone therapy; the group was divided into two subgroups: for patients of subgroup 1a (n=28) - intravenous ozonized physiological solution was performed, for patients of subgroup 1b (n=29) - major ozonized autohemotherapy. For patients of the 2nd group (n=62) - a comprehensive treatment, including gravitational therapy in addition to medical ozone, was carried out. In this group were also identified two subgroups: subgroup 2a (n=31) - patients received standard medical therapy in combination with ozonized physiological solution and gravitational therapy, subgroup 2b (n=31) - standard medical therapy in conjunction with major ozonized autohemotherapy and gravitational therapy. The 3rd control group (n=20) included patients, who received only standard medical therapy. Dynamics of changes of a stage of a disease and the number of surgeries in the remote period was estimated (up to 7 years). After 6 months of follow-on stages of the distribution of the disease patients significantly (p>0,05) did not differ from the initial amount. Analysis of survival and probable risk at 7 years of follow-Cox regression method revealed a maximum efficiency in the subgroup 2a where the risk of probability of surgeries and also increases in a stage of a disease effectively decreased.

Aim: To study the features of the dynamics of different clinical variants of developmental delay (DD) in preschoolers with residual brain damage and analyze the relationship of these types with disease course and prognosis., Material and Methods: Eighty-six children (76 boys and 10 girls), aged 3-6 years, were examined., Results and Conclusion: The following clinical variants have been described: DD with speech impairments (motor and sensory-motor alalia); DD with hyperdynamic syndrome; DD with autistic syndrome; DD with affective instability syndrome; DD with neurotic syndromes (cerebroasthenic syndrome and other neurotic-like conditions). It is assumed that a poor prognosis in preschool children with developmental delay is associated with manifestations of the autisticand alalia syndromes.

Analysed herein are the results of treating a total of 139 patients presenting with stage II chronic lower limb ischaemia. The patients were subdivided into three groups, depending on the variant of treatment performed. Group One patients (n=57) received standard conservative therapy combined with ozone therapy, with the Group being further subdivided into two subgroups: patients of subgroup 1a (n=28) were subjected to intravenous administration of ozonated physiological solution (OPS), subgroup 1b patients (n=29) were given big autohemoozonetherapy (BAT). Group Two patients (n=62) underwent complex treatment including beside medical ozone gravitation therapy (GT). Group Two patients were also subdivided into two subgroups: subgroup 2a patients (n=31) received standard conservative therapy combined with OPS and GT, subgroup 2b patients (n=31) received standard conservative therapy in combination with BAT and GT. Group Three (Control Group) was composed of 20 patients receiving standard conservative therapy alone. The highest efficacy was observed in the subgroup of patients receiving OPS and GT, with the patients of this subgroup showing a statistically significant increase in the pain-free walking distance by 116.5% and in the ankle-brachial index by 49.2%, also demonstrating the most pronounced positive dynamics of lipid metabolism parameters: a decrease in total cholesterol by 21.3%, low density lipoproteins by 25.4%, very low density lipoproteins by 24.2% and triglycerides by 18.5%. Besides, a tendency was observed towards normalization of the haemostasis system indices: fibrinogen decreased by 21.8%, prothrombin index by 13%, fibrin monomer complexes retraction by 18.2%, and the clotting time increased by 20.7%. Hence, combined use of ozonated physiological solution and gravitation therapy in treatment of patients with stage II chronic lower limb ischaemia promotes a considerable increase in the pain-free walking distance and ankle-brachial index, as well as contributes to correction of lipid metabolic disorders and haemocoagulation.

Aim: To develop a clinical classification of pathological fantasies (fantasy syndrome) in children and adolescents regardless of nosological attribution., Material and Methods: We examined 109 patients, aged 3-16 years, using psychopathological and instrumental (EEG and MRI) methods., Results and Conclusion: Authors developed the clinical typology of pathological fantasies in children with different mental diseases and disorders. The following variants of fantasy syndromes were singled out: 1. fantasizing with sensorealization of mental images; 2. fantastic stories (subdivided into 5 different variants): 2.1 easily provoked fantasies with situation-conditioned content; 2.2. fantasizing with increased falsehood; 2.3. sexual allegations and self-accusations; 2.4. fantasizing about imaginary worlds; 2.5. fantasies about a fictional friend); 3. playing transformation; 4. fantasies with a predominance of specific hobbies.

The authors carried out a comparative analysis of the results of management of patients presenting with stage II lower-limb atherosclerosis obliterans according to the classification of A.V. Pokrovsky (1973) in three clinical groups. Group One patients (n=118) were subjected to conventional conservative therapy combined with gravitational therapy, Group Two patients (n=28) underwent plasmapheresis on the background of standard conservative therapy, and Group Three patients (n=40) in the composition of the combined therapy received gravity therapy and plasmapheresis. Prior to treatment, the patients were found to have alterations in the lipid spectrum mainly at the expense of an increase in the level of triglycerides, elevated concentration of C-reactive protein, and pronounced circulatory impairments in the lower extremities on ultrasound Doppler examination. After treatment, the most effective correction of the levels of C-reactive protein, fibrinogen and triglycerides appeared to be in those groups where patients received plasmapheresis. The use of gravitational therapy ensured a considerable increase in the regional blood flow. A combination of plasmapheresis and gravitational therapy in the composition of comprehensive therapy made it possible to act upon various links of pathogenesis of atherosclerosis obliterans and to substantially improve the treatment outcomes in this cohort of patients.

The article discusses the clinical variants of psychosis in children with mental retardation. A particular group of psychotic disorders - oligophrenia psychosis, is described. A total of 28 children (19 boys) who were hospitalized in a psychiatric hospital or treated as outpatients from 1992 to 2012 were examined. The average age of the patients was 12±1.3 years. The duration of follow-up (analysis of medical records or direct clinical observation) was up to 18 years. Almost all children had mild mental retardation (only one patient had moderate mental retardation). Diagnosis corresponded to ICD-10 codes F06.07, F06.27, F06.29, F06.817 or F06.819. Mental retardation corresponded to the second code section F70 (F71 in one case). Clinical and psychopathological methods, follow-up study, statistical analysis of the data were used. Four clinical variants of oligophrenia psychoses in children were identified: 1) psychosis with amentive confusion, 2) schizophreniform psychosis, 3) verbal hallucinosis, 4) psychosis with a predominance of psychomotor agitation.

Observation of a group of children and adolescents, aged 8-17 years, with organic psychosis are reviewed. Four main variants, including organic schizoid psychoses; organic affective psychoses; periodic organic psychoses and organic hallucinosis, are described.

Ultrasound duplex scanning was used to compare the results of the treatment of 162 patients suffering from atherosclerosis obliterans of the lower extremities. It is to be noted that 50 patients were administered only gravitation therapy, 72 patients underwent a complex of treatment measures including, in addition to gravitation therapy, physiotherapy and drug treatment, and 40 patients received conservative treatment alone. The assessment criteria were the maximal systolic velocity of blood flow (V(max)), end diastolic mean, velocity (V(min)), mean maximal velocity (V(mean)), volume velocity of blood flow (V(vol)), ankle/brachial index (ABI), and index of regional perfusion (IRP), proposed by us and representing the percent ratio of the volume velocity of blood flow to the minute heart volume (MHV). It has been revealed in the course of the treatment that the best clinical outcome was recorded in patients who received a complex of treatment measures. The use of gravitation therapy alone provided better treatment results as compared to those obtained in patients administered standard conservative therapy. Of all the indicators used, only V(mean), V(vol), ABI and IRP are of the clinical significance. However, the most significant information on the segmental blood flow was obtained on the assessment of the IRP whose values did not depend on the changes in central hemodynamics. In contrast to the ABI, the advantage of the IRP lies in the possibility of blood flow assessment in different segments and arteries of the extremities. So, the use of the quantitative indicators of ultrasound duplex scanning and, first of all, of the IRP, allows an objective evaluation of the segmental blood flow and may serve one of the significant criteria of the treatment effectiveness.

The paper analyses the effect of mild gravitational overload (MGO) produced by patient's centrifugation in short-radius centrifuge in cranio-sacral orientation (+Gz) as a part of combined therapy for lower limb arteriosclerosis obliterans. Total 211 patients with I-II grade disease were divided into 3 groups: the first group (59 patients) was treated only by MGO, the second (100 patients) received both MGO and conventional conservative therapy, the third control group (52 patients) underwent conventional therapy only. The best clinical outcome was achieved in the 1st and 2nd groups. Pain-free walking distance increased 2-5-fold (vs 1.5 in control), mean volume blood flow velocity in different arterial beds increased 21-33% (vs 7.5% in control), index of regional perfusion - 25-29% (vs 10% in control), ankle-brachial index - 0.09-0.17 (vs 0.03 in control). Computer termography revealed recovery of leg and foot termographic picture in 86.67%, 92.59%, and 42.86% of cases in the 1st, 2nd and 3rd groups, respectively. Similarly, exercise tolerance measured by bicycle ergometry increased in the 1st and 2nd groups 1.5-1.9-fold (mean 60-85 s) and 1.3-fold (mean 37 s) in control. Thus mild gravitational overload has demonstrated clinical effectiveness in complex therapy of lower limb arteriosclerosis obliterans.

The article sums up results of treatment of 152 patients with obliterating atherosclerosis of the lower extremity arteries which were exposed to 2-3 G gravitation overloading made in a centrifuge of a short radius in direction head--pelvis. The gravitation overloading in the regimen followed were not found to have negative effects of central hemodynamics. Peripheral circulation was noted to considerably improve which is confirmed: 1) by clinical data showing 2-5 times longer distance of painless walking; 2) by the data of ultrasound dopplerography manifested as larger volume rate of blood flow and regional perfusion index; 3) by thermographic explorations evidencing the recovery of the thermoprophile of the legs and feet. Thus, the application of gravitation overloading is a new effective method of conservative treatment of patients with the pathology in question.

The authors made a statistical analysis of 1491 case histories in children aged 4-14 years treated for various psychotic disorders at a mental hospital in 1992-2001. The proportion of these children remained to be relatively stable and averaged 14.2% of the total number of inpatients. Throughout the 10-year follow-up, among children with psychoses, boys were prevalent: an average ratio of boys to girls being 3.4:1. In Saint Petersburg, there has been recently a steady reduction in the number of children with psychosis admitted to hospitals, the number patients treated in the outpatient setting being on the increase. At the same time the rates of rehospitalizations are also on the rise of patients mainly with severest psychoses. In the past 10 years, Saint Petersburg has been a town of a steady rise in the number of disabled individuals due to mental diseases among children with schizophrenia and dementia admitted to the hospital.

Possibilities of thermography for diagnosis of lower limbs arterial diseases and evaluation of treatment results were analyzed. Quantitative evaluation of infra-red imaging with detection of mean temperature, area of thermo-profile and thermographic index is proposed. Possibility of this method for detection of microcirculatory disorders in the limbs before clinical manifestation is demonstrated. Therefore thermography is a reliable method of early diagnosis. Thermography permits to perform qualitative and quantitative analysis of regional blood flow and microcirculation and consequently to use this method for evaluation of treatment efficacy.

Advantages of the formation of gastroduodenal anastomosis using the microsurgical precision technique as compared to the two-row interrupted Albert-Lembert suture and the one-row suture of Pirogov-Mateshuk were established in an experimental investigation in 63 dogs. The article describes the precision suture technique proposed by the authors which was used in Billroth-I resection of the stomach in 15 patients. It was shown that the use of the precision suture resulted in healing by the first intention type, without motor evacuatory disorders and with shorter time of hospital treatment.