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BACKGROUND Cognition generally declines gradually over time due to progressive degeneration of the brain, leading to dementia and eventual loss of independent functions. Cognition in the six domains (perceptual motor, executive function, complex attention, learning and memory, social cognition and language) varies in their rate of regression. Current modality of cognitive assessment using neuropsychological, questionnaire-based such as the Montreal Cognitive Assessment (MoCA) has its limitations and is influenced by age. Virtual reality (VR) has been introduced as a potential alternative tool to assess cognition. A novel fully immersive automated VR system (CAVIRE) has been developed to assess the six cognitive domains. As cognition is associated with age, VR performance is postulated to vary with age using this system. OBJECTIVE This study aimed to evaluate the VR performance of cognitively healthy adults using the CAVIRE system based on its automated scoring matrix and completion time. METHODS Conducted in a public primary care clinic in Singapore, the study recruited 25 multi-ethnic Asian adults in each of the age groups in years: 1. 35-44; 2. 45-54; 3. 55-64 and 4. 65-74. Their eligibility included a MoCA score of 26 or higher to reflect normal cognition and understanding the automated English instructions in the CAVIRE system. They completed common daily activities from brushing teething to shopping across 13 virtual segments. Their performances were automatically evaluated and computed using cognitive domain score matrix and completion time of the VR tasks. These VR performance indices were compared across the age groups using a one-way ANOVA, F-test of the hypothesis, followed by pair-wise comparisons in the event of a significant F-test (p RESULTS One participant dropped out from Group 1. The demographic characteristics of 99 participants were similar across the 4 age groups. Overall, younger participants in Groups 1 and 2 attained higher VR performance scores and shorter completion time using the CAVIRE system, compared to those in Groups 3 and 4 in every cognitive domain (all p CONCLUSIONS The CAVIRE VR performance scores and completion time significantly differ between the younger and older Asian participants with normal cognition. Enhancements to the system are needed to establish the age-group specific normal performance indices. CLINICALTRIAL INTERNATIONAL REGISTERED REPORT RR2-10.3389/fnagi.2020.604670