1. Antidiabetic Properties of Caffeoylmalic Acid, a Bioactive Natural Compound Isolated from Urtica dioica.
- Author
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Rehman G, Khan I, Rauf A, Rashid U, Siddique A, Shah SMM, Akram Z, AlMasoud N, Alomar TS, Shah ZA, and Ribaudo G
- Subjects
- Animals, Mice, Male, Molecular Structure, Diabetes Mellitus, Experimental drug therapy, Malates pharmacology, Phytochemicals pharmacology, Phytochemicals isolation & purification, Insulin blood, Caffeic Acids pharmacology, Caffeic Acids isolation & purification, Hypoglycemic Agents pharmacology, Hypoglycemic Agents isolation & purification, Urtica dioica chemistry, Molecular Docking Simulation, Blood Glucose drug effects
- Abstract
The uncontrolled hyperglycemia that characterizes diabetes mellitus (DM) causes several complications in the organism. DM is among the major causes of deaths, and the limited efficacy of current treatments push the search for novel drug candidates, also among natural compounds. We focused our attention on caffeoylmalic acid, a phenolic derivative extracted from Urtica dioica, a plant investigated for its potential against type 2 DM. This compound was tested for its antidiabetic activity in vitro through a glucose uptake assay, in vivo in a mouse DM model and through molecular docking towards α-amylase and α-glucosidase. The effects on glucose blood level, liver enzymes, insulin and creatinine levels as well as on lipid and blood parameters, considered biochemical markers of diabetes, were also evaluated. The results showed an antidiabetic activity in vitro and in vivo, as the compound stimulates glucose absorbtion and reduces blood glucose levels. Moreover, it ameliorates lipid profile, liver and blood parameters, with moderate effect on insulin secretion. Taken together, these findings pave the way for the compounds from this class of caffeoylmalic acid as potential antidiabetic compounds., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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