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1. A cell-adapted SARS-CoV-2 mutant, showing a deletion in the spike protein spanning the furin cleavage site, has reduced virulence at the lung level in K18-hACE2 mice.

Author

Valleriani, Fabrizia, Di Pancrazio, Chiara, Spedicato, Massimo, Di Teodoro, Giovanni, Malatesta, Daniela, Petrova, Tetyana, Profeta, Francesca, Colaianni, Maria Loredana, Berjaoui, Shadia, Puglia, Ilaria, Caporale, Marialuigia, Rossi, Emanuela, Marcacci, Maurilia, Luciani, Mirella, Sacchini, Flavio, Portanti, Ottavio, Bencivenga, Francesco, Decaro, Nicola, Bonfante, Francesco, and Lorusso, Alessio

Published
2024
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8. Immunization with Usutu virus and with a chimeric West Nile virus (WNV) harboring Usutu-E protein protects immunocompetent adult mice against lethal challenges with different WNV lineage 1 and 2 strains

Author

Jurisic, Lucija, primary, Malatesta, Daniela, additional, Zaccaria, Guendalina, additional, Di Teodoro, Giovanni, additional, Bonfini, Barbara, additional, Valleriani, Fabrizia, additional, Teodori, Liana, additional, Bencivenga, Francesco, additional, Leone, Alessandra, additional, Ripà, Paola, additional, D’Innocenzo, Vincenzo, additional, Rossi, Emanuela, additional, and Lorusso, Alessio, additional

Published
2023
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11. Co-Infection of L. monocytogenes and Toxoplasma gondii in a Sheep Flock Causing Abortion and Lamb Deaths

Author

De Angelis, Maria Elisabetta, primary, Martino, Camillo, additional, Chiaverini, Alexandra, additional, Di Pancrazio, Chiara, additional, Di Marzio, Violeta, additional, Bosica, Serena, additional, Malatesta, Daniela, additional, Salucci, Stefania, additional, Sulli, Nadia, additional, Acciari, Vicdalia Aniela, additional, and Pomilio, Francesco, additional

Published
2022
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14. Heat shock protein expression in canine osteosarcoma

Author

Romanucci, Mariarita, D'Amato, Giuliana, Malatesta, Daniela, Bongiovanni, Laura, Palmieri, Chiara, Ciccarelli, Andrea, Buracco, Paolo, Morello, Emanuela, Maniscalco, Lorella, De Maria, Raffaella, Martano, Marina, and Salda, Leonardo Della

Published
2012

15. Validation of AmpliSeq NGS Panel for BRCA1 and BRCA2 Variant Detection in Canine Formalin-Fixed Paraffin-Embedded Mammary Tumors

Author

Di Giacomo, Daniela, primary, Di Domenico, Marco, additional, Defourny, Sabrina Vanessa Patrizia, additional, Malatesta, Daniela, additional, Di Teodoro, Giovanni, additional, Martino, Michele, additional, Viola, Antonello, additional, D’Alterio, Nicola, additional, Cammà, Cesare, additional, Modesto, Paola, additional, and Petrini, Antonio, additional

Published
2022
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17. The envelope protein of Usutu virus attenuates West Nile virus virulence in immunocompetent mice

Author

Zaccaria, Guendalina, primary, Malatesta, Daniela, additional, Jurisic, Lucija, additional, Marcacci, Maurilia, additional, Di Teodoro, Giovanni, additional, Conte, Annamaria, additional, Teodori, Liana, additional, Monaco, Federica, additional, Marini, Valeria, additional, Casaccia, Claudia, additional, Savini, Giovanni, additional, Di Gennaro, Annapia, additional, Rossi, Emanuela, additional, D’Innocenzo, Vincenzo, additional, D’Alterio, Nicola, additional, and Lorusso, Alessio, additional

Published
2021
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20. Whole-Genome Sequences of SARS-CoV-2 Lineage B.1.525 Strains (Variant η) Detected from Patients in the Abruzzo Region (Central Italy) during Spring 2021

Author

Delli Compagni, Emiliano, primary, Mangone, Iolanda, additional, Bonfini, Barbara, additional, Di Gennaro, Annapia, additional, Teodori, Liana, additional, Leone, Alessandra, additional, Casaccia, Claudia, additional, Portanti, Ottavio, additional, Averaimo, Daniela, additional, Zilli, Katiuscia, additional, Malatesta, Daniela, additional, Ancora, Massimo, additional, Scialabba, Silvia, additional, Di Domenico, Marco, additional, and Lorusso, Alessio, additional

Published
2021
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24. Detection of Astrovirus in a Cow with Neurological Signs by Nanopore Technology, Italy

Author

Zaccaria, Guendalina, primary, Lorusso, Alessio, additional, Hierweger, Melanie M., additional, Malatesta, Daniela, additional, Defourny, Sabrina VP, additional, Ruggeri, Franco, additional, Cammà, Cesare, additional, Ricci, Pasquale, additional, Di Domenico, Marco, additional, Rinaldi, Antonio, additional, Decaro, Nicola, additional, D’Alterio, Nicola, additional, Petrini, Antonio, additional, Seuberlich, Torsten, additional, and Marcacci, Maurilia, additional

Published
2020
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25. Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection

Author

Crisi, Paolo Emidio, primary, Dondi, Francesco, additional, De Luca, Eliana, additional, Di Tommaso, Morena, additional, Vasylyeva, Kateryna, additional, Ferlizza, Enea, additional, Savini, Giovanni, additional, Luciani, Alessia, additional, Malatesta, Daniela, additional, Lorusso, Alessio, additional, and Boari, Andrea, additional

Published
2020
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26. Survivin and Sox9: Potential Stem Cell Markers in Canine Normal, Hyperplastic, and Neoplastic Canine Prostate

Author

Bongiovanni, Laura, Caposano, Francesca, Romanucci, Mariarita, Grieco, Valeria, Malatesta, Daniela, Brachelente, Chiara, Massimini, Marcella, Benazzi, Cinzia, Thomas, Rachel E., Salda, Leonardo Della, LS Pathobiologie, dPB RMSC, LS Pathobiologie, dPB RMSC, Bongiovanni, L, Caposano, F, Romanucci, M, Grieco, V, Malatesta, D, Brachelente, C, Massimini, M, Benazzi, C, Thomas, RE, and Salda, LD.

Subjects
Male, 040301 veterinary sciences, Fluorescent Antibody Technique, Biology, survivin, Immunofluorescence, Stem cell marker, 0403 veterinary science, dog, immunohistochemistry, prostate carcinoma, Sox9, stem cells, survivin, 03 medical and health sciences, Dogs, Prostate, stem cells, Survivin, Biomarkers, Tumor, medicine, Carcinoma, Animals, Dog Diseases, 030304 developmental biology, 0303 health sciences, General Veterinary, medicine.diagnostic_test, Prostatic Neoplasms, Cancer, SOX9 Transcription Factor, 04 agricultural and veterinary sciences, Hyperplasia, medicine.disease, veterinary(all), dog, immunohistochemistry, prostate carcinoma, Sox9, Veterinary (all), medicine.anatomical_structure, Cancer research, Stem cell
Abstract

Canine prostatic carcinoma is a relevant model for human prostatic carcinoma. Survivin is proposed as a biomarker of malignancy in human prostatic cancer. Sox9 is a stem cell marker required for prostate development and expressed in several adult tissues. The aims of the present study were to evaluate the patterns and expression levels of 2 putative stem cell markers, survivin and Sox9, in canine benign prostatic hyperplasia (BPH) and prostatic carcinoma to investigate their potential as stem cell markers. Immunohistochemistry with specific antibodies was performed on 3 samples of normal prostate gland, 18 samples of canine BPH, and 16 samples of prostatic carcinoma. The basal cell layer of normal and hyperplastic prostatic lobules had nuclear Sox9 immunolabeling and nuclear and rarely cytoplasmic survivin immunostaining, identifying them as potential stem cell markers. Significantly more frequent survivin and Sox9 expression (≥10% of nuclei) was observed in prostatic carcinoma as compared with BPH. The potential coexpression of survivin with Sox9, androgen receptor, and p63 was also investigated in selected BPH and prostatic carcinoma cases with immunofluorescence, and a partial colocalization was observed. Results indicate that Sox9 and survivin could be considered markers of stemness in canine prostate cells. Given its role in proliferation, cells in the basal cell layer with nuclear survivin expression are likely to be transit-amplifying cells that maintain some stem cell proprieties. © The Author(s) 2018.

Published
2019

27. Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy

Author

De Luca, Eliana, primary, Crisi, Paolo Emidio, additional, Marcacci, Maurilia, additional, Malatesta, Daniela, additional, Di Sabatino, Daria, additional, Cito, Francesca, additional, D’Alterio, Nicola, additional, Puglia, Ilaria, additional, Berjaoui, Shadia, additional, Colaianni, Maria Loredana, additional, Tinelli, Antonella, additional, Ripà, Paola, additional, Vincifori, Giacomo, additional, Di Teodoro, Giovanni, additional, Dondi, Francesco, additional, Savini, Giovanni, additional, Boari, Andrea, additional, and Lorusso, Alessio, additional

Published
2020
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28. Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, β-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma

Author

Bongiovanni Laura, Mazzocchetti Francesca, Malatesta Daniela, Romanucci Mariarita, Ciccarelli Andrea, Buracco Paolo, De Maria Raffaella, Palmieri Chiara, Martano Marina, Morello Emanuela, Maniscalco Lorella, and Salda Leonardo

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Background Osteosarcoma (OSA) represents the most common canine primary bone tumour. Despite several pathways have been investigated so far, few molecules have been identified as prognostic tools or potential therapeutic targets, and there is still the need to find out molecular pathways with specific influence over OSA progression to facilitate earlier prognosis and treatment. Aims of the present study were to evaluate the immunohistochemical pattern and levels of expression of a panel of molecules (survivin, β-catenin, caspase 3 -inactive and active forms- and p53) involved in cell cycle and apoptosis regulation in canine OSA samples, known to be of interest in the study also of human OSA, and to detect specific relations among them and with histological tumour grade, disease free interval (DFI) and overall survival (OS). Results Nuclear β-catenin immunostaining was detected in normal osteoblasts adjacent to the tumour, and in 47% of the cases. Cytoplasmic and/or membranous immunostaining were also observed. Nuclear survivin and p53 positive cells were found in all cases. Moderate/high cytoplasmic β-catenin expression (≥10% positive cells) was significantly associated with the development of metastasis (P = 0.014); moderate/high nuclear p53 expression (≥10% positive cells) was significantly associated with moderate/high histological grade (P = 0.017) and shorter OS (P = 0.049). Moderate/high nuclear survivin expression (≥15% positive cells) showed a tendency toward a longer OS (P = 0,088). Conclusions The present results confirmed p53 as negative prognostic marker, while suggested survivin as a potential positive prognostic indicator, rather than indicative of a poor prognosis. The detection of nuclear β-catenin immunostaining in normal osteoblasts and the absent/low expression in most of the OSAs, suggested that this pathway could not play a major role in oncogenic transformation of canine osteoblasts. Further studies are needed to confirm these hypotheses.

Published
2012
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29. Replication kinetics and cellular tropism of emerging reoviruses in sheep and swine respiratory ex vivo organ cultures

Author

Di Teodoro, Giovanni, primary, Bortolami, Alessio, additional, Teodori, Liana, additional, Leone, Alessandra, additional, D’Alterio, Nicola, additional, Malatesta, Daniela, additional, Rosamilia, Alfonso, additional, Colaianni, Maria Loredana, additional, Petrini, Antonio, additional, Terregino, Calogero, additional, Savini, Giovanni, additional, Bonfante, Francesco, additional, and Lorusso, Alessio, additional

Published
2019
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32. Left atrial appendage rupture due to blunt chest trauma in an Eurasian otter (Lutra lutra): Rottura dell’appendice atriale sinistra per trauma toracico in una lontra (Lutra lutra)

Author

Romanucci, Mariarita, Fusillo, Romina, Marcelli, Manlio, Massimini, Marcella, Malatesta, Daniela, Bongiovanni, Laura, Salda, Leonardo Della, Romanucci, Mariarita, Fusillo, Romina, Marcelli, Manlio, Massimini, Marcella, Malatesta, Daniela, Bongiovanni, Laura, and Salda, Leonardo Della

Abstract

An adult male Eurasian otter, found dead on the roadside, was submitted for post-mortem examination in April 2014 at the Veterinary Pathology Unit of the Faculty of Veterinary Medicine of Teramo, as part of the RECAL [RECovery and post mortem Analysis of Eurasian otters (Lutra lutra) in the National Park of Cilento, Vallo di Diano and Alburni (Salerno, Italy), and surrounding areas] project. Necropsy revealed an abundant hemothorax associated with multifocal, bilateral pulmonary contusions and lacerations, and a severe hemopericardium characterised by the presence of a wide blood clot in the intact pericardial sac. Two small laceration wounds of the left auricle were found at the base, along the atrioventricular groove, and on the outer free wall. Since myocardial and endocardial tissues showed no other gross and histopathological abnormalities, a left atrial appendage rupture resulting from a blunt chest trauma was diagnosed. Blunt traumatic cardiac rupture is a rarely reported, life-threatening condition in humans. To the best of our knowledge, this is the first report on a left atrial appendage rupture due to blunt chest trauma in veterinary literature. The possible occurrence of a cardiac rupture following a blunt thoracic injury should be taken into consideration in veterinary emergency care.

Published
2019

33. Survivin and Sox9: Potential Stem Cell Markers in Canine Normal, Hyperplastic, and Neoplastic Canine Prostate

Author

LS Pathobiologie, dPB RMSC, Bongiovanni, Laura, Caposano, Francesca, Romanucci, Mariarita, Grieco, Valeria, Malatesta, Daniela, Brachelente, Chiara, Massimini, Marcella, Benazzi, Cinzia, Thomas, Rachel E., Salda, Leonardo Della, LS Pathobiologie, dPB RMSC, Bongiovanni, Laura, Caposano, Francesca, Romanucci, Mariarita, Grieco, Valeria, Malatesta, Daniela, Brachelente, Chiara, Massimini, Marcella, Benazzi, Cinzia, Thomas, Rachel E., and Salda, Leonardo Della

Published
2019

34. Left atrial appendage rupture due to blunt chest trauma in an Eurasian otter (Lutra lutra): Rottura dell’appendice atriale sinistra per trauma toracico in una lontra (Lutra lutra)

Author

LS Pathobiologie, dPB RMSC, Romanucci, Mariarita, Fusillo, Romina, Marcelli, Manlio, Massimini, Marcella, Malatesta, Daniela, Bongiovanni, Laura, Salda, Leonardo Della, LS Pathobiologie, dPB RMSC, Romanucci, Mariarita, Fusillo, Romina, Marcelli, Manlio, Massimini, Marcella, Malatesta, Daniela, Bongiovanni, Laura, and Salda, Leonardo Della

Published
2019

35. Supplemental Material, DS1_VET_10.1177_0300985818794161 - Survivin and Sox9: Potential Stem Cell Markers in Canine Normal, Hyperplastic, and Neoplastic Canine Prostate

Author

Bongiovanni, Laura, Caposano, Francesca, Mariarita Romanucci, Grieco, Valeria, Malatesta, Daniela, Brachelente, Chiara, Massimini, Marcella, Benazzi, Cinzia, Thomas, Rachel E., and Salda, Leonardo Della

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, DS1_VET_10.1177_0300985818794161 for Survivin and Sox9: Potential Stem Cell Markers in Canine Normal, Hyperplastic, and Neoplastic Canine Prostate by Laura Bongiovanni, Francesca Caposano, Mariarita Romanucci, Valeria Grieco, Daniela Malatesta, Chiara Brachelente, Marcella Massimini, Cinzia Benazzi, Rachel E. Thomas, and Leonardo Della Salda in Veterinary Pathology

Published
2018
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38. Pathology in practice

Author

Romanucci, Mariarita, Massimini, Marcella, Valerii, Valeria, Malatesta, Daniela, Bongiovanni, Laura, and DELLA SALDA, Leonardo

Published
2017

40. Left atrial appendage rupture due to blunt chest trauma in an Eurasian otter (Lutra lutra)

Author

Romanucci, Mariarita, Fusillo, Romina, Marcelli, Manlio, Massimini, Marcella, Malatesta, Daniela, Bongiovanni, Laura, and DELLA SALDA, Leonardo

Subjects
Rupture, Male, lcsh:Veterinary medicine, Thoracic Injuries, Heart, Wounds, Nonpenetrating, Fatal Outcome, Heart Injuries, Italy, Blunt trauma, lcsh:SF600-1100, Animals, Atrial Appendage, lcsh:Animal culture, Eurasian otter, lcsh:SF1-1100, Otters
Abstract

An adult male Eurasian otter, found dead on the roadside, was submitted for post-mortem examination in April 2014 at the Veterinary Pathology Unit of the Faculty of Veterinary Medicine of Teramo, as part of the RECAL [RECovery and post mortem Analysis of Eurasian otters (Lutra lutra) in the National Park of Cilento, Vallo di Diano and Alburni (Salerno, Italy), and surrounding areas] project. Necropsy revealed an abundant hemothorax associated with multifocal, bilateral pulmonary contusions and lacerations, and a severe hemopericardium characterised by the presence of a wide blood clot in the intact pericardial sac. Two small laceration wounds of the left auricle were found at the base, along the atrioventricular groove, and on the outer free wall. Since myocardial and endocardial tissues showed no other gross and histopathological abnormalities, a left atrial appendage rupture resulting from a blunt chest trauma was diagnosed. Blunt traumatic cardiac rupture is a rarely reported, life-threatening condition in humans. To the best of our knowledge, this is the first report on a left atrial appendage rupture due to blunt chest trauma in veterinary literature. The possible occurrence of a cardiac rupture following a blunt thoracic injury should be taken into consideration in veterinary emergency care.

Published
2015

43. Role of nectin-4 in canine prostate cancer

Author

DELLA SALDA, Leonardo, Massimini, Marcella, Benazzi, Cinzia, Palmieri, Chiara, Malatesta, Daniela, Romanucci, Mariarita, Bongiovanni, Laura, Dondi, F., Passantino, G., and Perillo, A.

Published
2015

49. Role of betha catenin in canine osteosarcoma

Author

Bongiovanni, Laura, Mazzocchetti, Francesca, Malatesta, Daniela, Romanucci, Mariarita, Buracco, Paolo, DE MARIA, Raffaella, Palmieri, Chiara, and Della Salda Leonardo

Published
2012

50. Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours

Author

Bongiovanni, Laura, D'Andrea, Alessandra, Romanucci, Mariarita, Malatesta, Daniela, Candolini, M, DELLA SALDA, Leonardo, Mechelli, L, Sforna, M, Brachelente, C., LS Pathobiologie, and dPB RMSC

Subjects
skin tumor, dog, epithelial-mesenchymal transition, veterinary(all)
Abstract

Background - Epithelial-to-mesenchymal transition (EMT) is a multistep process, important in tumour invasion and metastasis, characterized by loss of epithelial markers, redistribution of β-catenin and gain of mesenchymal markers. Hyposthesis/Objectives - Our aim was to investigate the immunohistochemical aberrant expression of cytokeratin, vimentin, survivin and heat shock protein72 (Hsp72) in canine cutaneous epithelial tumours, to understand the association of expression of these molecules with features of malignancy and their role in the EMT phenotype. Methods - Ten canine squamous cell carcinomas (SCCs; one with lymph node metastasis), 30 canine hair follicle tumours (six pilomatricomas, eight infundibular keratinizing acanthomas, six trichoepitheliomas and 10 trichoblastomas) and five normal skin samples were investigated by immunohistochemistry using specific anti-vimentin, -cytokeratin, -survivin and -Hsp72 antibodies. A semi-quantitative method was used to analyse the results, as follows: 0 to

Published
2012

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