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463 results on '"Malhi G"'

1. Combining predominant polarity and affective spectrum concepts in bipolar disorder: towards a novel theoretical and clinical perspective

Author

Bartoli, F, Malhi, G, Carrà, G, Bartoli F., Malhi G. S., Carrà G., Bartoli, F, Malhi, G, Carrà, G, Bartoli F., Malhi G. S., and Carrà G.

Abstract

This is an overview of recent advances on predominant polarity conceptualization in bipolar disorder (BD). Current evidence on its operationalized definitions, possible contextualization within the affective spectrum, along with its epidemiological impact, and treatment implications, are summarized. Predominant polarity identifies three subgroups of patients with BD according to their mood recurrencies: (i) those with depressive or (ii) manic predominance as well as (iii) patients without any preponderance ('nuclear' type). A predominant polarity can be identified in approximately half of patients, with similar rates for depressive and manic predominance. Different factors may influence the predominant polarity, including affective temperaments. More generally, affective disorders should be considered as existing on a spectrum ranging from depressive to manic features, also accounting for disorders with 'ultrapredominant' polarity, i.e., unipolar depression and mania. While mixed findings emerge on its utility in clinical practice, it is likely that the construct of predominant polarity, in place of conventional differentiation between BD-I and BD-II, may be useful to clarify the natural history of the disorder and select the most appropriate interventions. The conceptualization of predominant polarity seems to reconcile previous theoretical views of both BD and affective spectrum into a novel perspective. It may provide useful information to clinicians for the early identification of possible trajectories of BD and thus guide them when selecting interventions for maintenance treatment. However, further research is needed to clarify the specific role of predominant polarity as a key determinant of BD course, outcome, and treatment response.

Published
2024

7. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis

Author

Wise, T, Radua, J, Via, E, Cardoner, N, Abe, O, Adams, T M, Amico, F, Cheng, Y, Cole, J H, de Azevedo Marques Périco, C, Dickstein, D P, Farrow, T FD, Frodl, T, Wagner, G, Gotlib, I H, Gruber, O, Ham, B J, Job, D E, Kempton, M J, Kim, M J, Koolschijn, P CMP, Malhi, G S, Mataix-Cols, D, McIntosh, A M, Nugent, A C, OʼBrien, J T, Pezzoli, S, Phillips, M L, Sachdev, P S, Salvadore, G, Selvaraj, S, Stanfield, A C, Thomas, A J, van Tol, M J, van der Wee, N JA, Veltman, D J, Young, A H, Fu, C H, Cleare, A J, and Arnone, D

Published
2017
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14. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations

Author

Yatham, LN, Chakrabarty, T, Bond, DJ, Schaffer, A, Beaulieu, S, Parikh, SV, McIntyre, RS, Milev, RV, Alda, M, Vazquez, G, Ravindran, AV, Frey, BN, Sharma, V, Goldstein, BI, Rej, S, O’Donovan, C, Tourjman, V, Kozicky, JM, Kauer-Sant’Anna, M, Malhi, G, Suppes, T, Vieta, E, Kapczinski, F, Kanba, S, Lam, RW, Kennedy, SH, Calabrese, J, Berk, Michael, Post, R, Yatham, LN, Chakrabarty, T, Bond, DJ, Schaffer, A, Beaulieu, S, Parikh, SV, McIntyre, RS, Milev, RV, Alda, M, Vazquez, G, Ravindran, AV, Frey, BN, Sharma, V, Goldstein, BI, Rej, S, O’Donovan, C, Tourjman, V, Kozicky, JM, Kauer-Sant’Anna, M, Malhi, G, Suppes, T, Vieta, E, Kapczinski, F, Kanba, S, Lam, RW, Kennedy, SH, Calabrese, J, Berk, Michael, and Post, R

Published
2021

15. Neural activity during response inhibition associated with improvement of dysphoric symptoms of PTSD after trauma-focused psychotherapy-an EEG-fMRI study

Author

Bryant, RA, Williamson, T, Erlinger, M, Felmingham, KL, Malhi, G, Hinton, M, Williams, L, Korgaonkar, MS, Bryant, RA, Williamson, T, Erlinger, M, Felmingham, KL, Malhi, G, Hinton, M, Williams, L, and Korgaonkar, MS

Abstract

Although trauma-focused cognitive behavioural therapy (TF-CBT) is the frontline treatment for posttraumatic stress disorder (PTSD), up to one half of patients do not respond optimally to this treatment. Inhibitory functions are important for successful management of PTSD, yet there is a dearth of knowledge regarding the extent to which neural mechanisms unpinning response inhibition are associated with TF-CBT response. Treatment-seeking PTSD patients (n = 40) were assessed during a response inhibition task (the Go/No-Go task) while undergoing functional magnetic imaging (fMRI) and event-related potentials (ERP) in separate sessions. PTSD symptom severity was assessed with the Clinician-Administered PTSD Scale, before undergoing nine sessions of TF-CBT. They were then reassessed post-treatment to estimate reduction in fear and dysphoric symptoms of PTSD. Although neural responses during the inhibitory task did not predict overall symptom change, reduced activation in the left precuneus and the right superior parietal cortex predicted greater improvement in dysphoric symptoms. ERP responses during response inhibition indicated that lower P3 peak latency predicted greater reduction of dysphoric symptoms. There were no significant predictors of changes of fear symptoms. These findings indicate that neural activity associated with response inhibition can act as a predictive biomarker of TF-CBT response for PTSD symptoms. This pattern of findings underscores the importance of delineating the role of biomarkers to predict remission of subtypes of PTSD.

Published
2021

20. P660 The impact of COVID-19 on the provision of care for patients with Inflammatory Bowel Disease: A cross sectional survey

Author

Malhi, G, Mikail, M0, Chambers, J, Khanna, R, and Wilson, A

Subjects
Poster Presentations, Epidemiology, AcademicSubjects/MED00260
Abstract

Background COVID-19 was declared a worldwide pandemic in March of 2020. Since its onset, the focus of many healthcare systems shifted toward limiting non-essential visits to hospitals in order to prioritize and allocate resources toward treating those affected by COVID-19. Those with Inflammatory Bowel Disease (IBD) have been particularly impacted. We aimed to survey IBD patients to determine how they have been affected by changes to the provision of care due to the COVID-19 pandemic. Methods A mixed methods survey was conducted with patients with an IBD diagnosis who received care for their IBD since March 17, 2019 in Canada. The primary aims of the survey were to evaluate any differences in access to or usage of IBD-related care including medications, clinic visits in addition to patient experience with virtual care. Results A total of 135 complete or partial responses were received, of which 90 responses were included for having answered >50% of questions. The majority of respondents were from Ontario, with a mean age of 42 years, and over 75% being female. 67% had Crohn’s Disease, and 69% were on a biologic. Three percent of respondents stopped taking all IBD-related medications without the advice of their gastroenterologist due to pandemic-related concerns while 8% reported difficulty obtaining their medications. Thirty-eight percent reported a delay in being able to see their gastroenterologist, with a majority reporting a delay >4 weeks (n=21). Twenty-three percent required a visit to the emergency department due to IBD-related concerns, and 13% of participants were admitted to hospital. 33% reported a delay in endoscopy, with a majority reporting a delay greater than 3 months (n=17). Thirty-eight percent reported receiving poorer care since the pandemic began, while 36% reported no change. 76% of respondents used Telehealth for their appointments. 66% reported they were able to speak with their gastroenterologist within 15 minutes of their appointment time. Thirty percent preferred telehealth appointments to in-person visits. Half reported no change with their quality of interaction with their gastroenterologists. Conclusion Preliminary data highlight that patients have experienced significant delays in IBD care during the COVID-19 pandemic, with more than one third reporting a reduction in the quality of that care. Interestingly, only a minority of patients stopped medication or had reduced access during the pandemic. Further studies will help define whether there were a significant change in the number of hospitalizations due to this delay. Virtual care is a useful tool during the pandemic, but its mixed feedback raises questions about how it can be effectively utilized in the future.

Published
2021

46. A growth in bipolar disorder?

Author

Xu, J., Rasmussen, I.-A., Berntsen, E. M., Moss, K., Shnier, R., Lagopoulos, J., and Malhi, G. S.

Published
2007

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