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1. Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible

Author

Olthof, Pim B., Erdmann, Joris I., Alikhanov, Ruslan, Charco, Ramón, Guglielmi, Alfredo, Hagendoorn, Jeroen, Hakeem, Abdul, Hoogwater, Frederik J. H., Jarnagin, William R., Kazemier, Geert, Lang, Hauke, Maithel, Shishir K., Malago, Massimo, Malik, Hassan Z., Nadalin, Silvio, Neumann, Ulf, Olde Damink, Steven W. M., Pratschke, Johann, Ratti, Francesca, Ravaioli, Matteo, Roberts, Keith J., Schadde, Erik, Schnitzbauer, Andreas A., Sparrelid, Ernesto, Topal, Baki, Troisi, Roberto I., and Groot Koerkamp, Bas

Published
2024
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3. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Hauke Lang, Smith, Martin, deOliveira, Michelle L., Adair, Anya, Gilg, Stefan, Swijnenburg, Rutger-Jan, Jaekers, Joris, Jegatheeswaran, Santhalingam, Buis, Carlijn, Parks, Rowan, Bockhorn, Maximilian, Conroy, Thierry, Petras, Panagiotis, Primavesi, Florian, Chan, Anthony K.C., Cipriani, Federica, Rubbia-Brandt, Laura, Foster, Lucy, Abdelaal, Amr, Yaqub, Sheraz, Rahbari, Nuh, Fondevila, Constantino, Abradelo, Manuel, Kok, Niels FM., Tejedor, Luis, Martinez-Baena, Dario, Azoulay, Daniel, Maglione, Manuel, Serradilla-Martín, Mario, Azevedo, José, Romano, Fabrizio, Line, Pål-Dag, Forcén, Teresa Abadía, Panis, Yves, Stylianides, Nicolas, Bale, Reto, Quaia, Emilio, Yassin, Nuha, Duque, Victoria, Espin-Basany, Eloy, Mellenhorst, Jarno, Rees, Adam, Adeyeye, Ademola, Tuynman, Jurriaan B., Simillis, Constantinos, Duff, Sarah, Wilson, Richard, De Nardi, Paola, Palmer, Gabriella Jansson, Zakaria, Andee Dzulkarnaen, Perra, Teresa, Porcu, Alberto, Tamini, Nicolò, Kelly, Michael E., Metwally, Islam, Morarasu, Stefan, Carbone, Fabio, Estaire-Gómez, Mercedes, Perez, Elena Martin, Seligmann, Jennifer, Gollins, Simon, Braun, Michael, Hessheimer, Amelia, Alonso, Vincente, Radhakrishna, Ganesh, Alam, Noreen, Camposorias, Constantinos, Barriuoso, Jorge, Ross, Paul, Ba-Ssalamah, Ahmed, Muthu, Sivakumar, Filobbos, Rafik, Nadarajah, Vinotha, Hattab, Annas, Newton, Claire, Barker, Sharon, Sibbald, Jill, Hancock, Jodie, de Liguori Carino, Nicola, Deshpande, Rahul, Lancellotti, Francesco, Paterna, Sandra, Gutierrez-Diez, Marta, Artigas, Consuelo, Siriwardena, Ajith K., Serrablo, Alejandro, Fretland, Åsmund A., Wigmore, Stephen J., Ramia-Angel, Jose M., Malik, Hassan Z., Stättner, Stefan, Søreide, Kjetil, Zmora, Oded, Meijerink, Martijn, Kartalis, Nikolaos, Lesurtel, Mickaël, Verhoef, Cornelis, Balakrishnan, Anita, Gruenberger, Thomas, Jonas, Eduard, Devar, John, Jamdar, Saurabh, Jones, Robert, Hilal, Mohammad A., Andersson, Bodil, Boudjema, Karim, Mullamitha, Saifee, Stassen, Laurents, Dasari, Bobby V.M., Frampton, Adam E., Aldrighetti, Luca, Pellino, Gianluca, Buchwald, Pamela, Gürses, Bengi, Wasserberg, Nir, Gruenberger, Birgit, Spiers, Harry V.M., Jarnagin, William, Vauthey, Jean-Nicholas, Kokudo, Norihiro, Tejpar, Sabine, Valdivieso, Andres, and Adam, René

Published
2023
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5. Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible

Author

MS CGO, Cancer, Olthof, Pim B, Erdmann, Joris I, Alikhanov, Ruslan, Charco, Ramón, Guglielmi, Alfredo, Hagendoorn, Jeroen, Hakeem, Abdul, Hoogwater, Frederik, Jarnagin, William R, Kazemier, Geert, Lang, Hauke, Maithel, Shishir K, Malago, Massimo, Malik, Hassan Z, Nadalin, Silvio, Neumann, Ulf, Olde Damink, Steven W M, Pratschke, Johann, Ratti, Francesca, Ravaioli, Matteo, Roberts, Keith J, Schadde, Erik, Schnitzbauer, Andreas A, Sparrelid, Ernesto, Topal, Baki, Troisi, Roberto I, Groot Koerkamp, Bas, Perihilar Cholangiocarcinoma Collaboration Group, MS CGO, Cancer, Olthof, Pim B, Erdmann, Joris I, Alikhanov, Ruslan, Charco, Ramón, Guglielmi, Alfredo, Hagendoorn, Jeroen, Hakeem, Abdul, Hoogwater, Frederik, Jarnagin, William R, Kazemier, Geert, Lang, Hauke, Maithel, Shishir K, Malago, Massimo, Malik, Hassan Z, Nadalin, Silvio, Neumann, Ulf, Olde Damink, Steven W M, Pratschke, Johann, Ratti, Francesca, Ravaioli, Matteo, Roberts, Keith J, Schadde, Erik, Schnitzbauer, Andreas A, Sparrelid, Ernesto, Topal, Baki, Troisi, Roberto I, Groot Koerkamp, Bas, and Perihilar Cholangiocarcinoma Collaboration Group

Published
2024

6. Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma:Left-Sided Resection is Preferred When Possible

Author

Olthof, Pim B, Erdmann, Joris I, Alikhanov, Ruslan, Charco, Ramón, Guglielmi, Alfredo, Hagendoorn, Jeroen, Hakeem, Abdul, Hoogwater, Frederik J H, Jarnagin, William R, Kazemier, Geert, Lang, Hauke, Maithel, Shishir K, Malago, Massimo, Malik, Hassan Z, Nadalin, Silvio, Neumann, Ulf, Olde Damink, Steven W M, Pratschke, Johann, Ratti, Francesca, Ravaioli, Matteo, Roberts, Keith J, Schadde, Erik, Schnitzbauer, Andreas A, Sparrelid, Ernesto, Topal, Baki, Troisi, Roberto I, Groot Koerkamp, Bas, Olthof, Pim B, Erdmann, Joris I, Alikhanov, Ruslan, Charco, Ramón, Guglielmi, Alfredo, Hagendoorn, Jeroen, Hakeem, Abdul, Hoogwater, Frederik J H, Jarnagin, William R, Kazemier, Geert, Lang, Hauke, Maithel, Shishir K, Malago, Massimo, Malik, Hassan Z, Nadalin, Silvio, Neumann, Ulf, Olde Damink, Steven W M, Pratschke, Johann, Ratti, Francesca, Ravaioli, Matteo, Roberts, Keith J, Schadde, Erik, Schnitzbauer, Andreas A, Sparrelid, Ernesto, Topal, Baki, Troisi, Roberto I, and Groot Koerkamp, Bas

Abstract

BACKGROUND: A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality and long-term survival of right- versus left-sided liver resections for pCCA.METHODS: Patients who underwent major liver resection for pCCA at 25 Western centers were stratified according to the type of hepatectomy-left, extended left, right, and extended right. The primary outcomes were 90-day mortality and overall survival (OS).RESULTS: Between 2000 and 2022, 1701 patients underwent major liver resection for pCCA. The 90-day mortality was 9% after left-sided and 18% after right-sided liver resection (p < 0.001). The 90-day mortality rates were 8% (44/540) after left, 11% (29/276) after extended left, 17% (51/309) after right, and 19% (108/576) after extended right hepatectomy (p < 0.001). Median OS was 30 months (95% confidence interval [CI] 27-34) after left and 23 months (95% CI 20-25) after right liver resection (p < 0.001), and 33 months (95% CI 28-38), 27 months (95% CI 23-32), 25 months (95% CI 21-30), and 21 months (95% CI 18-24) after left, extended left, right, and extended right hepatectomy, respectively (p < 0.001). A left-sided resection was an independent favorable prognostic factor for both 90-day mortality and OS compared with right-sided resection, with similar results after excluding 90-day fatalities.CONCLUSIONS: A left or extended left hepatectomy is associated with a lower 90-day mortality and superior OS compared with an (extended) right hepatectomy for pCCA. When both a left and right liver resection are feasible, a left-sided liver resection is preferred.

Published
2024

9. Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study

Author

Primrose, JN, Fox, RP, Morement, H, Chan, O, Rees, C, Ma, YT, Hickish, T, Falk, S, Finch-Jones, M, Pope, I, Corrie, P, Crosby, T, Sothi, S, Sharkland, K, Adamson, D, Wall, L, Evans, J, Dent, J, Hombaiah, U, Iwuji, C, Anthoney, A, Bridgewater, J, Cunningham, D, Gillmore, R, Ross, P, Slater, S, Wasan, H, Waters, J, Valle, JW, Palmer, D, Malik, H, Neoptolemos, J, Faluyi, O, Sumpter, K, Dernedde, U, Maduhusudan, S, Cogill, G, Archer, C, Iveson, T, Wadsley, J, Darby, S, Peterson, M, Mukhtar, AA, Thorpe, JG, Bateman, A, Tsang, D, Cummins, S, Nolan, L, Beaumont, E, Prasad, R, Mirza, D, Stocken, D, Praseedom, R, Davidson, B, Raftery, J, Zhu, S, Garden, J, Stubbs, C, Coxon, F, Primrose, John N, Fox, Richard P, Palmer, Daniel H, Malik, Hassan Z, Prasad, Raj, Mirza, Darius, Anthony, Alan, Corrie, Pippa, Falk, Stephen, Finch-Jones, Meg, Wasan, Harpreet, Ross, Paul, Wall, Lucy, Wadsley, Jonathan, Evans, Jeff T R, Stocken, Deborah, Praseedom, Raaj, Ma, Yuk Ting, Davidson, Brian, Neoptolemos, John P, Iveson, Tim, Raftery, James, Zhu, Shihua, Cunningham, David, Garden, O James, Stubbs, Clive, Valle, Juan W, and Bridgewater, John

Published
2019
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11. British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma

Author

Rushbrook, Simon M, primary, Kendall, Timothy James, additional, Zen, Yoh, additional, Albazaz, Raneem, additional, Manoharan, Prakash, additional, Pereira, Stephen P, additional, Sturgess, Richard, additional, Davidson, Brian R, additional, Malik, Hassan Z, additional, Manas, Derek, additional, Heaton, Nigel, additional, Prasad, K Raj, additional, Bridgewater, John, additional, Valle, Juan W, additional, Goody, Rebecca, additional, Hawkins, Maria, additional, Prentice, Wendy, additional, Morement, Helen, additional, Walmsley, Martine, additional, and Khan, Shahid A, additional

Published
2023
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12. Multisocietal European consensus on the terminology, diagnosis, and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, Ajith K, primary, Serrablo, Alejandro, additional, Fretland, Åsmund Avdem, additional, Wigmore, Stephen J, additional, Ramia-Angel, Jose Manuel, additional, Malik, Hassan Z, additional, Stättner, Stefan, additional, Søreide, Kjetil, additional, Zmora, Oded, additional, Meijerink, Martijn, additional, Kartalis, Nikolaos, additional, Lesurtel, Mickaёl, additional, Verhoef, Kees, additional, Balakrishnan, Anita, additional, Gruenberger, Thomas, additional, Jonas, Eduard, additional, Devar, John, additional, Jamdar, Saurabh, additional, Jones, Robert, additional, Hilal, Mohammad Abu, additional, Andersson, Bodil, additional, Boudjema, Karim, additional, Mullamitha, Saifee, additional, Stassen, Laurents, additional, Dasari, Bobby V M, additional, Frampton, Adam E, additional, Aldrighetti, Luca, additional, Pellino, Gianluca, additional, Buchwald, Pamela, additional, Gürses, Bengi, additional, Wasserberg, Nir, additional, Gruenberger, Birgit, additional, Spiers, Harry V M, additional, Jarnagin, William, additional, Vauthey, Jean-Nicholas, additional, Kokudo, Norihiro, additional, Tejpar, Sabine, additional, Valdivieso, Andres, additional, and Adam, René, additional

Published
2023
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13. British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma.

Author

Rushbrook, Simon M., Kendall, Timothy James, Yoh Zen, Albazaz, Raneem, Manoharan, Prakash, Pereira, Stephen P., Sturgess, Richard, Davidson, Brian R., Malik, Hassan Z., Manas, Derek, Heaton, Nigel, Prasad, K. Raj, Bridgewater, John, Valle, Juan W., Goody, Rebecca, Hawkins, Maria, Prentice, Wendy, Morement, Helen, Walmsley, Martine, and Khan, Shahid A.

Subjects
CHOLANGITIS, GALLBLADDER cancer, CHOLANGIOCARCINOMA, MEDICAL personnel, BILIARY tract cancer, GREENHOUSE gas mitigation, DIAGNOSIS
Published
2024
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16. PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research

Author

Jones, Robert P, primary, Mielgo, Ainhoa, additional, Schmid, Michael, additional, Bury, Danielle, additional, Andrews, Timothy, additional, Burdak-Rothkamm, Susanne, additional, Shackcloth, Michael, additional, J. S. Cross, Timothy, additional, Fenwick, Stephen, additional, Malik, Hassan Z, additional, Diaz-Nieto, Rafa, additional, Ottensmeier, Christian, additional, Palmer, Daniel H, additional, and Vimalachandran, Dale, additional

Published
2023
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17. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases:an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, Ajith K., Serrablo, Alejandro, Fretland, Åsmund A., Wigmore, Stephen J., Ramia-Angel, Jose M., Malik, Hassan Z., Stättner, Stefan, Søreide, Kjetil, Zmora, Oded, Meijerink, Martijn, Kartalis, Nikolaos, Lesurtel, Mickaël, Verhoef, Cornelis, Balakrishnan, Anita, Gruenberger, Thomas, Jonas, Eduard, Devar, John, Jamdar, Saurabh, Jones, Robert, Hilal, Mohammad A., Andersson, Bodil, Boudjema, Karim, Mullamitha, Saifee, Stassen, Laurents, Dasari, Bobby V.M., Frampton, Adam E., Aldrighetti, Luca, Pellino, Gianluca, Buchwald, Pamela, Gürses, Bengi, Wasserberg, Nir, Gruenberger, Birgit, Spiers, Harry V.M., Jarnagin, William, Vauthey, Jean Nicholas, Kokudo, Norihiro, Tejpar, Sabine, Valdivieso, Andres, Adam, René, Hauke Lang, Lang, Smith, Martin, deOliveira, Michelle L., Adair, Anya, Gilg, Stefan, Swijnenburg, Rutger Jan, Jaekers, Joris, Jegatheeswaran, Santhalingam, Buis, Carlijn, Parks, Rowan, Kok, Niels FM, Siriwardena, Ajith K., Serrablo, Alejandro, Fretland, Åsmund A., Wigmore, Stephen J., Ramia-Angel, Jose M., Malik, Hassan Z., Stättner, Stefan, Søreide, Kjetil, Zmora, Oded, Meijerink, Martijn, Kartalis, Nikolaos, Lesurtel, Mickaël, Verhoef, Cornelis, Balakrishnan, Anita, Gruenberger, Thomas, Jonas, Eduard, Devar, John, Jamdar, Saurabh, Jones, Robert, Hilal, Mohammad A., Andersson, Bodil, Boudjema, Karim, Mullamitha, Saifee, Stassen, Laurents, Dasari, Bobby V.M., Frampton, Adam E., Aldrighetti, Luca, Pellino, Gianluca, Buchwald, Pamela, Gürses, Bengi, Wasserberg, Nir, Gruenberger, Birgit, Spiers, Harry V.M., Jarnagin, William, Vauthey, Jean Nicholas, Kokudo, Norihiro, Tejpar, Sabine, Valdivieso, Andres, Adam, René, Hauke Lang, Lang, Smith, Martin, deOliveira, Michelle L., Adair, Anya, Gilg, Stefan, Swijnenburg, Rutger Jan, Jaekers, Joris, Jegatheeswaran, Santhalingam, Buis, Carlijn, Parks, Rowan, and Kok, Niels FM

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management. Methods: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term “early metachronous metastases” applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with “late metachronous metastases” applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusions: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

19. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

Author

Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., and Park, B. Kevin

Published
2015
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29. Long-Term Outcomes and Exploratory Analyses of the Randomized Phase III BILCAP Study

Author

Bridgewater, John, Fletcher, Peter, Palmer, Daniel H., Malik, Hassan Z., Prasad, Raj, Mirza, Darius, Anthony, Alan, Corrie, Pippa, Falk, Stephen, Finch-Jones, Meg, Wasan, Harpreet, Ross, Paul, Wall, Lucy, Wadsley, Jonathan, Evans, Thomas R., Stocken, Deborah, Stubbs, Clive, Praseedom, Raaj, Ma, Yuk Ting, Davidson, Brian, Neoptolemos, John, Iveson, Tim, Cunningham, David, Garden, O. James, Valle, Juan W., and Primrose, John

Subjects
Biliary Tract Neoplasms/drug therapy, Cancer Research, Adolescent, Manchester Cancer Research Centre, Oncology, Chemotherapy, Adjuvant, ResearchInstitutes_Networks_Beacons/mcrc, Humans, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Prognosis, Capecitabine
Abstract

PURPOSE The BILCAP study described a modest benefit for capecitabine as adjuvant therapy for curatively resected biliary tract cancer (BTC), and capecitabine has become the standard of care. We present the long-term data and novel exploratory subgroup analyses. METHODS This randomized, controlled, multicenter, phase III study recruited patients age 18 years or older with histologically confirmed cholangiocarcinoma or muscle-invasive gallbladder cancer after resection with curative intent and an Eastern Cooperative Oncology Group performance status of < 2. Patients were randomly assigned 1:1 to receive oral capecitabine (1,250 mg/m2 twice daily on days 1-14 of a 21-day cycle, for eight cycles) or observation. The primary outcome was overall survival (OS). This study is registered with EudraCT 2005-003318-13. RESULTS Between March 15, 2006, and December 4, 2014, 447 patients were enrolled; 223 patients with BTC resected with curative intent were randomly assigned to the capecitabine group and 224 to the observation group. At the data cutoff of January 21, 2021, the median follow-up for all patients was 106 months (95% CI, 98 to 108). In the intention-to-treat analysis, the median OS was 49.6 months (95% CI, 35.1 to 59.1) in the capecitabine group compared with 36.1 months (95% CI, 29.7 to 44.2) in the observation group (adjusted hazard ratio 0.84; 95% CI, 0.67 to 1.06). In a protocol-specified sensitivity analysis, adjusting for minimization factors, nodal status, grade, and sex, the OS hazard ratio was 0.74 (95% CI, 0.59 to 0.94). We further describe the prognostic impact of R status, grade, nodal status, and sex. CONCLUSION This long-term analysis supports the previous analysis, suggesting that capecitabine can improve OS in patients with resected BTC when used as adjuvant chemotherapy after surgery and should be considered as the standard of care.

Published
2022
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32. Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration

Author

Chan, Benjamin K.Y., primary, Elmasry, Mohamed, additional, Forootan, Shiva S., additional, Russomanno, Giusy, additional, Bunday, Tobias M., additional, Zhang, Fang, additional, Brillant, Nathalie, additional, Starkey Lewis, Philip J., additional, Aird, Rhona, additional, Ricci, Emanuele, additional, Andrews, Timothy D., additional, Sison‐Young, Rowena L., additional, Schofield, Amy L., additional, Fang, Yongxiang, additional, Lister, Adam, additional, Sharkey, Jack W., additional, Poptani, Harish, additional, Kitteringham, Neil R., additional, Forbes, Stuart J., additional, Malik, Hassan Z., additional, Fenwick, Stephen W., additional, Park, B. Kevin, additional, Goldring, Christopher E., additional, and Copple, Ian M., additional

Published
2021
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