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7 results on '"Malinverni, Claire"'

1. Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors

Author

Velcicky, Juraj, primary, Janser, Philipp, additional, Gommermann, Nina, additional, Brenneisen, Silke, additional, Ilic, Slavica, additional, Vangrevelinghe, Eric, additional, Stiefl, Nikolaus, additional, Boettcher, Andreas, additional, Arnold, Christelle, additional, Malinverni, Claire, additional, Dawson, Janet, additional, Murgasova, Renata, additional, Desrayaud, Sandrine, additional, Beltz, Karen, additional, Hinniger, Alexandra, additional, Dekker, Carien, additional, Farady, Christopher J., additional, and Mackay, Angela, additional

Published
2024
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3. The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition

Author

Bardet, Maureen, primary, Unterreiner, Adeline, additional, Malinverni, Claire, additional, Lafossas, Frédérique, additional, Vedrine, Corinne, additional, Boesch, Danielle, additional, Kolb, Yeter, additional, Kaiser, Daniel, additional, Glück, Anton, additional, Schneider, Martin A, additional, Katopodis, Andreas, additional, Renatus, Martin, additional, Simic, Oliver, additional, Schlapbach, Achim, additional, Quancard, Jean, additional, Régnier, Catherine H, additional, Bold, Guido, additional, Pissot-Soldermann, Carole, additional, Carballido, José M, additional, Kovarik, Jiri, additional, Calzascia, Thomas, additional, and Bornancin, Frédéric, additional

Published
2017
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5. Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

Author

Ginster, Stefanie, primary, Bardet, Maureen, additional, Unterreiner, Adeline, additional, Malinverni, Claire, additional, Renner, Florian, additional, Lam, Stephen, additional, Freuler, Felix, additional, Gerrits, Bertran, additional, Voshol, Johannes, additional, Calzascia, Thomas, additional, Régnier, Catherine H., additional, Renatus, Martin, additional, Nikolay, Rainer, additional, Israël, Laura, additional, and Bornancin, Frédéric, additional

Published
2017
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6. The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

Author

Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A., Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H., Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M., and Kovarik, Jiri

Abstract

Abstract: Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity is not fully understood. Here, we studied how MALT1 proteolytic function regulates T‐cell activation and fate after engagement of the T‐cell receptor pathway. We show that MLT‐827, a potent and selective MALT1 paracaspase inhibitor, does not prevent the initial phase of T‐cell activation, in contrast to the pan‐protein kinase C inhibitor AEB071. However, MLT‐827 strongly impacted cell expansion after activation. We demonstrate this is the consequence of profound inhibition of IL‐2 production as well as reduced expression of the IL‐2 receptor alpha subunit (CD25), resulting from defective canonical NF‐κB activation and accelerated mRNA turnover mechanisms. Accordingly, MLT‐827 revealed a unique transcriptional fingerprint of MALT1 protease activity, providing evidence for broad control of T‐cell signaling pathways. Altogether, this first report with a potent and selective inhibitor elucidates how MALT1 paracaspase activity integrates several T‐cell activation pathways and indirectly controls gamma‐chain receptor dependent survival, to impact on T‐cell expansion. [ABSTRACT FROM AUTHOR]

Published
2018
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7. Cleavage by MALT1 induces cytosolic release of A20

Author

Malinverni, Claire, primary, Unterreiner, Adeline, additional, Staal, Jens, additional, Demeyer, Annelies, additional, Galaup, Marion, additional, Luyten, Marcel, additional, Beyaert, Rudi, additional, and Bornancin, Frédéric, additional

Published
2010
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