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1. Report on the Family Support Act of 1988 Job Opportunities and Basic Skills (JOBS) Training Program.

Author

NETWORK: America's Two-Year Coll. Employment, Training, and Literacy Consortium, Cleveland, OH., Visdos, Robert J., and Malley, Mary R.

Abstract

Intended to assist two-year colleges in understanding the educational aspects of the Job Opportunities and Basic Skills (JOBS) Training Program, this five-part report provides a brief summary of the intent of the program, as well as suggestions regarding ways two-year colleges can become involved. The sections of the report offer information on the following: (1) the legislative origins of JOBS as Title II of the 1988 Family Support Act, state requirements for receipt of federal funding for JOBS, and procedures for two-year college participation as a JOBS service provider; (2) mandated and optional educational activities provided for by JOBS, including such mandated activities as basic and remedial education to achieve a basic literacy level, and education for individuals with limited English proficiency; and such optional activities as secondary and postsecondary education related to an individual's employment goals, and support for educational activities or training initiated by an individual prior to their participation in JOBS in which satisfactory progress is being made; (3) a directory of JOBS program directors by state (including the Virgin Islands, Guam, and Puerto Rico); (4) fiscal year (FY) 1990 JOBS funding allocations by state; and (5) projections regarding the impact of the Gramm-Rudman-Hollings cutbacks on each state's JOBS funding. (JMC)

Published
1990

2. Report on U.S. Department of Labor Programs and Funding through the Job Training Partnership Act (JTPA), 1990.

Author

NETWORK: America's Two-Year Coll. Employment, Training, and Literacy Consortium, Cleveland, OH., Visdos, Robert J., and Malley, Mary R.

Abstract

Designed to assist two-year colleges in increasing their level of involvement in the delivery of services under the Job Training Partnership Act (JTPA), this report describes the JTPA, reviews the role of two-year colleges in JTPA service delivery, and provides information on fiscal year (FY) 1991 JTPA funding availability and levels. Following a letter directed to potential community college service providers, section I describes JTPA legislation, reviewing the specific title authorizations and FY91 funding available for summer youth employment and training programs; employment and training assistance for dislocated workers; programs for Native Americans, and Alaskan and Hawaiian natives; training programs for migrant farm workers; and employment programs for veterans. Section II presents two United States Department of Labor fact sheets reviewing program highlights for the JTPA and the Economic Dislocation and Worker Adjustment Assistance Act (EDWAA). Section III contains a copy of a training and employment guidance letter from the Assistant Secretary of Labor which reviews the purposes of, background to, and guidelines for participation in the JTPA and the Job Opportunities and Basic Skills (JOBS) programs. Included in this section are reference materials and information on the JOBS program, including features that affect activities and responsibilities under the JTPA. In addition, this section provides policy guidance regarding the role that JTPA providers, the State Job Training Coordinating Councils, and private industry councils should play in JOBS. (JMC)

Published
1990

5. Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2

Author

Yang, Michael G., primary, Xiao, Zili, additional, Zhao, Rulin, additional, Tebben, Andrew J., additional, Wang, Bei, additional, Cherney, Robert J., additional, Batt, Douglas G., additional, Brown, Gregory D., additional, Cvijic, Mary Ellen, additional, Duncia, John V., additional, Gallela, Michael A., additional, Gardner, Daniel S., additional, Khandelwal, Purnima, additional, Malley, Mary F., additional, Pang, Jian, additional, Rose, Anne V., additional, Santella, Joseph B., additional, Sarjeant, Amy A., additional, Xu, Songmei, additional, Mathur, Arvind, additional, Mandlekar, Sandhya, additional, Vuppugalla, Ragini, additional, Zhao, Qihong, additional, and Carter, Percy H., additional

Published
2021
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6. Novel 1,4-homofragmentation via an [alpha]-lactone

Author

Godfrey, Jollie D., Jr., Fox, Rita T., Buono, Frederic G., Gougoutas, Jack Z., and Malley, Mary F.

Subjects
Lactones -- Chemical properties, Esters -- Chemical properties, Biological sciences, Chemistry
Abstract

A novel 1,4-homofragmentation which complicated the conversion of an alpha,alpha-dichloroester to the corresponding alpha-keto acid, was investigated. The results showed a mechanism involving an [alpha]-lactone intermediate, which can lead to both the desired [alpha]-keto acid and the 1,4-homofragmentation with the product distribution being dependent upon reaction conditions.

Published
2006

7. Technetium(V) oxo complexes of substituted propylene diamine dioxime (PnAO) ligands: water-dependent interconversion between syn and anti isomers

Author

Cyr, John E., Nowotnik, David P., Pan, Yolanda, Gougoutas, Jack Z., Malley, Mary F., Di Marco, John, Nunn, Adrian D., and Linder, Karen E.

Subjects
Chemistry, Inorganic -- Research, Technetium -- Physiological aspects, Propylene -- Physiological aspects, Amines -- Physiological aspects, Ligands -- Physiological aspects, Chemistry
Abstract

Research has been conducted on the diamine dioxime ligands' technetium complexes. The substitution of these complexes at the central carbon of the propylene bridge has been examined and the results are discussed.

Published
2001

12. Sulfonation with inversion by Mitsunobu reaction: an improvement on the original conditions

Author

Anderson, Neal G., Lust, David A., Colapret, Kay A., Simpson, James H., Malley, Mary F., and Gougoutas, Jack Z.

Subjects
Chemical reactions -- Research, Alcohol -- Research, Sulfones -- Research, Organosulfur compounds -- Research, Biological sciences, Chemistry
Abstract

The conditions under which the Mitsunobu procedure for sulfonating a secondary alcohol with stereochemical inversion is performed were modified in the context of cis-mesyloxy proline derivative synthesis from L-hydroxyproline. The modifications, which eliminate the use of zinc salts, isolate the product via crystallization and removal of the Mitsunobu redox byproducts to eliminate the need for purification via column chromatography.

Published
1996

13. Regioselective coupling of tetraalkylammonium salts of 6-iodo-2-aminopurine to a cyclobutyl triflate: efficient preparation of homochiral BMS-180,194, a potent antiviral carbocyclic nucleoside

Author

Bisacchi, Gregory S., Singh, Janak, Godfrey, Jollie D., Jr., Kissick, Thomas P., Mitt, Toomas, Malley, Mary F., Di Marco, John D., Gougoutas, Jack Z., Mueller, Richard H., and Zahler, Robert

Subjects
Angular momentum (Nuclear physics) -- Coupling and recoupling, Biological sciences, Chemistry
Abstract

A study was conducted on the regioselective coupling of tetraalkylammonium salts of 6-iodo-2-aminopurine to a cyclobutly triflate. Mild coupling conditions were attained through a Mitsunobu-type strategy with yields ranging from 23%-78%. However, product purification posed constant problems. Results showed that tetraalkylammonium salts of 6-iodo-2-aminopurine coupled easily with equimolar quantities of the corresponding protected cyclobutly triflate at room temperature in methylene chloride.

Published
1995

14. Peptidomimetic synthesis: A novel, highly stereoselective route to substituted freidinger lactams

Author

Robl, Jeffrey A., Cimarusti, Maria P., Simpkins, Ligaya M., Weller, Harold N., Pan, Yolanda Y., Malley, Mary, and DiMarco, John D.

Subjects
Aromatic compounds -- Research, Stereochemistry -- Analysis, Chemistry
Abstract

A novel pathway for the preparation of substituted seven-membered lactams facilitates the stereoslective introduction of substituents at the C-7 site of the azepinone ring and alpha to the acetic acid side chain. The associated bicyclic fused lactams result in good yield and high stereoselectivity from dehydrative cyclization of dipeptidyl aldehydes.

Published
1994

15. Synthesis, characterization, and crystal structures of M(DO3A) (M = Fe, Gd) and Na(M(DOTA)) (M = Fe, Y, Gd)

Author

Chang, C. Allen, Francesconi, Lynn C., Malley, Mary F., Kumar, Krishan, Gougoutas, Jack Z., Tweedle, Michael F., Lee, Daniel W., and Wilson, Lon J.

Subjects
Magnetic resonance imaging -- Analysis, Coordination compounds -- Research, Magnetic susceptibility -- Observations, Chemistry
Abstract

The macrocyclic amino carboxylate complexes, DOTA and DO3A, serve as contrast agents for magnetic resonance imaging. Fe(DO3A).3H2O is synthesized by the reaction of Fe(OH)3 and H3DO3A in water. The resulting suspension, on being stirred and heated at 90 degree celsius for 1 hour, yields a yellow-green solid on evaporation of the solvent. Crystallographic studies of this compound reveals the molecular structure of the neutral Fe(DO3A), which shares identity with the heptacoordinate face-capped trigonal prismatic structure of In(DO3A).

Published
1993

16. Synthesis, characterization, and crystal structure of the gadolinium(III) chelate of (1R,4R,7R)-alpha,alpha',alpha''-trimethyl-1,4,7, 10-tetraazacyclododecane-1,4,7-triacetic acid (DO3MA)

Author

Kang, Sang I., Ranganathan, Rama S., Emswiler, John E., Kumar, Krishan, Gougoutas, Jack Z., Malley, Mary F., and Tweedle, Michael F.

Subjects
Gadolinium -- Research, Chelates -- Research, Coordination compounds -- Research, Chemistry
Abstract

Hydrogenolysis and deformylation of 10-formyl-1,4, 7-tris(benzyloxycarbonylmethyl)- 1,4,7,10-tetraazacyclododecane affords the synthesis of (1R,4R,7R)-alpha,alpha',alpha''-trimethyl-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid (DO3MA). A pure Gd(III) chelate, Gd(DO3MA), is formed by the complex with gadolinium acetate. Structural analysis shows that the chelate crytals have three asymmetric carbons with alpha-methyl groups in (R)-configuration. The x-ray crystallographic and physicochemical properties of the chelates are discussed.

Published
1993

17. The impact of long-term exercise training on psychological function in olderadults

Author

Hill, Robert D., Storandt, Martha, and Malley, Mary

Subjects
Aerobic exercises -- Psychological aspects, Exercise for the aged -- Psychological aspects, Aged -- Psychological aspects, Health, Seniors
Abstract

The psychological effects of long-term aerobic training were assessed in 87 sedentary older group and compared with a nonexercising control group. The exercising group were found to have had bettercardiovascular fitness and a positive disposition in a self-reported survey after a 12-month period. The difference in cognitive function measures was found to be insignificant in the light of the decline in performance from pre- to post-testing in the control group.

Published
1993

18. The ratio of waist-to-hip circumference, plasma insulin level, and glucose intolerance as independent predictors of the HDL2 cholesterol level in older adults

Author

Ostlund, Richard E., Jr., Staten, Myrlene, Kohrt, Wendy M., Schultz, Joan, and Malley, Mary

Subjects
Insulin -- Measurement, Glucose tolerance tests -- Evaluation, Fat -- Analysis, High density lipoproteins -- Measurement, Blood cholesterol -- Measurement
Abstract

An increased level of high-density lipoprotein (HDL) is associated with a lower risk of coronary heart disease. In humans, HDL cholesterol consists of two principal fractions, HDL2 and HDL3, and HDL2 has been linked to protection from heart disease. Hence it is important to determine the factors that control HDL2 cholesterol levels. The relation between HDL2 cholesterol levels and various metabolic and physical characteristics was examined in 146 healthy subjects, who were between 60 and 70 years old. Covariates such as body weight, fatness, distribution of fat, diet, fitness, blood levels of insulin, and glucose tolerance, the ability of the tissue to use glucose, were measured, and the relationships between these covariates and HDL2 levels were determined in a mathematical model. The level of HDL2 cholesterol was inversely related to waist-to-hip circumference, and blood levels of insulin; in other words, increased HDL2 cholesterol levels were associated with decreases in waist-to-hip circumference and blood insulin levels. HDL2 cholesterol levels were associated with the degree of glucose tolerance, but not with body mass and fat, oxygen uptake, diet and sex. Thus, HDL2 cholesterol levels are inversely correlated with fat in the waist and hip region, blood insulin levels, and the presence of glucose intolerance, and are not associated with sex or body fat. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

20. Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672

Author

Yang, Michael G., primary, Xiao, Zili, additional, Cherney, Robert J., additional, Tebben, Andrew J., additional, Batt, Douglas G., additional, Brown, Gregory D., additional, Chen, Jing, additional, Cvijic, Mary Ellen, additional, Dabros, Marta, additional, Duncia, John V., additional, Galella, Michael, additional, Gardner, Daniel S., additional, Khandelwal, Purnima, additional, Ko, Soo S., additional, Malley, Mary F., additional, Mo, Ruowei, additional, Pang, Jian, additional, Rose, Anne V., additional, Santella, Joseph B., additional, Shi, Hong, additional, Srivastava, Anurag, additional, Traeger, Sarah C., additional, Wang, Bei, additional, Xu, Songmei, additional, Zhao, Rulin, additional, Barrish, Joel C., additional, Mandlekar, Sandhya, additional, Zhao, Qihong, additional, and Carter, Percy H., additional

Published
2019
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24. Language assessment of monolingual and multilingual children using non-word and sentence repetition tasks.

Author

Antonijevic-Elliott, Stanislava, Lyons, Rena, O' Malley, Mary Pat, Meir, Natalia, Haman, Ewa, Banasik, Natalia, Carroll, Clare, McMenamin, Ruth, Rodden, Margaret, and Fitzmaurice, Yvonne

Subjects
AGE distribution, ANALYSIS of variance, COMPARATIVE studies, ENGLISH as a foreign language, LANGUAGE acquisition, MOTHERS, QUESTIONNAIRES, REGRESSION analysis, SPEECH therapy, T-test (Statistics), MULTILINGUALISM in children, PILOT projects, SOCIOECONOMIC factors, PHONOLOGICAL awareness, SPECIAL education schools, DESCRIPTIVE statistics, MANN Whitney U Test, CHILDREN
Abstract

The number of children speaking more than one language as well as the number of languages spoken in Ireland has increased significantly posing a problem for timely identification of children with language disorder. The current study aims to profile performance of monolingual and multilingual children on language processing tasks: non-word repetition (NWR) and sentence repetition (SR). We used: (1) Crosslinguistic (CL) and English Language-Specific (LS) NWR and (2) SR in English, Polish and Russian. Children's socioeconomic status, language emergence, the age of exposure (AoE) to English and the percentage of English spoken at home were recorded. The study included 88 children age 5–8 attending a school in a disadvantaged area. CL and LS NWR yielded similar distribution of scores for monolinguals and multilinguals. The tasks identified small number of children who performed significantly lower than the mean while there were no significant differences between the groups. In English SR, monolinguals significantly outperformed multilinguals. Comparison of SR in English and Polish/Russian indicated that some children showed balanced performance in both of their languages while others showed marked differences performing better in either Polish/Russian or English depending on their AoE to English and percentage of English spoken at home. The pilot study suggests that CL-NWR is a promising screening tool for identifying monolingual and multilingual children with language disorder while SR provides more detailed information on children's language performance relative to their language exposure. SR task is recommended to be used only if comparable tasks are available in all of children's languages. [ABSTRACT FROM AUTHOR]

Published
2020
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26. One-pot synthesis and conformational features of N,N'-distributed ketene animals

Author

Shi, Yan, Zhang, Jing, Stein, Philip D, Traeger, Callahan, Sharon A, Malley, Mary F, and Gougoutas, Jack Z.

Subjects
Hydrogen bonding, Methylene chloride, Biological sciences, Chemistry
Abstract

A commodious one-pot synthesis of N,N'-distributed ketene animals from activated methylene compounds and isothiocyanates is described. According to results, the rotamers are stabilized by intramolecular hydrogen bonding both in solution and solid states.

Published
2004

27. Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

Author

Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., and Lam, Patrick Y.S.

Published
2014
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30. Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors

Author

Lin, Shuqun, Wrobleski, Stephen T., Hynes, John, Jr., Pitt, Sidney, Zhang, Rosemary, Fan, Yi, Doweyko, Arthur M., Kish, Kevin F., Sack, John S., Malley, Mary F., Kiefer, Susan E., Newitt, John A., McKinnon, Murray, Trzaskos, James, Barrish, Joel C., Dodd, John H., Schieven, Gary L., and Leftheris, Katerina

Published
2010
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34. Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor Modulators

Author

Xiao, Hai-Yun, primary, Wu, Dauh-Rurng, additional, Malley, Mary F., additional, Gougoutas, Jack Z., additional, Habte, Sium F., additional, Cunningham, Mark D., additional, Somerville, John E., additional, Dodd, John H., additional, Barrish, Joel C., additional, Nadler, Steven G., additional, and Dhar, T. G. Murali, additional

Published
2010
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37. Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT2C Receptor

Author

Wacker, Dean A., primary, Varnes, Jeffrey G., additional, Malmstrom, Sarah E., additional, Cao, Xueying, additional, Hung, Chen-Pin, additional, Ung, Thao, additional, Wu, Ginger, additional, Zhang, Ge, additional, Zuvich, Eva, additional, Thomas, Michael A., additional, Keim, William J., additional, Cullen, Mary Jane, additional, Rohrbach, Kenneth W., additional, Qu, Qinling, additional, Narayanan, Rangaraj, additional, Rossi, Karen, additional, Janovitz, Evan, additional, Lehman-McKeeman, Lois, additional, Malley, Mary F., additional, Devenny, James, additional, Pelleymounter, Mary Ann, additional, Miller, Keith J., additional, and Robl, Jeffrey A., additional

Published
2007
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38. Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold

Author

Sun, Chongqing, primary, Robl, Jeffrey A., additional, Wang, Tammy C., additional, Huang, Yanting, additional, Kuhns, Joyce E., additional, Lupisella, John A., additional, Beehler, Blake C., additional, Golla, Rajasree, additional, Sleph, Paul G., additional, Seethala, Ramakrishna, additional, Fura, Aberra, additional, Krystek, Stanley R., additional, An, Yongmi, additional, Malley, Mary F., additional, Sack, John S., additional, Salvati, Mark E., additional, Grover, Gary J., additional, Ostrowski, Jacek, additional, and Hamann, Lawrence G., additional

Published
2006
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39. Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101)A Small Molecule Antagonist of Leukocyte Function Associated Antigen-1

Author

Potin, Dominique, primary, Launay, Michele, additional, Monatlik, Francoise, additional, Malabre, Patrice, additional, Fabreguettes, Maud, additional, Fouquet, Andre, additional, Maillet, Magali, additional, Nicolai, Eric, additional, Dorgeret, Loïc, additional, Chevallier, François, additional, Besse, Dominique, additional, Dufort, Monique, additional, Caussade, François, additional, Ahmad, Syed Z., additional, Stetsko, Dawn K., additional, Skala, Stacey, additional, Davis, Patricia M., additional, Balimane, Praveen, additional, Patel, Karishma, additional, Yang, Zheng, additional, Marathe, Punit, additional, Postelneck, Jennifer, additional, Townsend, Robert M., additional, Goldfarb, Valentina, additional, Sheriff, Steven, additional, Einspahr, Howard, additional, Kish, Kevin, additional, Malley, Mary F., additional, DiMarco, John D., additional, Gougoutas, Jack Z., additional, Kadiyala, Pathanjali, additional, Cheney, Daniel L., additional, Tejwani, Ravindra W., additional, Murphy, Denette K., additional, Mcintyre, Kim W., additional, Yang, Xiaoxia, additional, Chao, Sam, additional, Leith, Leslie, additional, Xiao, Zili, additional, Mathur, Arvind, additional, Chen, Bang-Chi, additional, Wu, Daugh-Rurng, additional, Traeger, Sarah C., additional, McKinnon, Murray, additional, Barrish, Joel C., additional, Robl, Jeffrey A., additional, Iwanowicz, Edwin J., additional, Suchard, Suzanne J., additional, and Dhar, T. G. Murali, additional

Published
2006
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44. Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

Author

Magnin, David R., primary, Robl, Jeffrey A., additional, Sulsky, Richard B., additional, Augeri, David J., additional, Huang, Yanting, additional, Simpkins, Ligaya M., additional, Taunk, Prakash C., additional, Betebenner, David A., additional, Robertson, James G., additional, Abboa-Offei, Benoni E., additional, Wang, Aiying, additional, Cap, Michael, additional, Xin, Li, additional, Tao, Li, additional, Sitkoff, Doree F., additional, Malley, Mary F., additional, Gougoutas, Jack Z., additional, Khanna, Ashish, additional, Huang, Qi, additional, Han, Song-Ping, additional, Parker, Rex A., additional, and Hamann, Lawrence G., additional

Published
2004
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46. Molecular design and structure–Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664

Author

Das, Jagabandhu, primary, Kimball, S.David, additional, Hall, Steven E., additional, Han, Wen-Ching, additional, Iwanowicz, Edwin, additional, Lin, James, additional, Moquin, Robert V., additional, Reid, Joyce A., additional, Sack, John S., additional, Malley, Mary F., additional, Chang, Chiehying Y., additional, Chong, Saeho, additional, Wang-Iverson, David B., additional, Roberts, Daniel G.M., additional, Seiler, Steven M., additional, Schumacher, William A., additional, and Ogletree, Martin L., additional

Published
2002
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