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Objective To present an update of birth cohort study designs and their contributions to allergic risk. Data Sources The PubMed database was used to search for relevant articles. Study Selections Peer-reviewed prospective and retrospective studies involving the assessment of allergy using human birth cohorts between 2014 and 2021 were evaluated. Results Parental history of allergic diseases, especially in cases involving both parents, is associated with increased risk of allergy. Exposure to prenatal and postnatal smoking and limited diet diversity were associated with increased allergic burden. The impact of early-life infections and antibiotics on disease development may be associated with the onset of asthma, though this remains debated. Cohort studies also revealed that the mode of delivery and breastfeeding duration affect the odds ratio of asthma and eczema development. Household exposures, including pets, house dust mites, and scented aeroallergens may confer protective effects, whereas high air pollution exposure and low socioeconomic status may be risk enhancing. Exposure to antibiotics during early life may be associated with increased asthma risk, whereas viral infections may lead to disease protection, though the impact of the coronavirus disease 2019 pandemic on allergic risk is yet to be understood. Conclusion Although evaluating the risk of allergic disease development is complex, clinicians can apply these insights on the multifactorial nature of atopy to better understand and potentially mitigate disease development.

Objective To review birth cohorts with an exposomal approach and their key outcomes and challenges. Exposome encompasses all human environmental exposures from conception onward. The impact of environmental exposures is greatest in critical stages of life, including fetal and early childhood. Birth cohorts provide a good study setting to assess exposome in the sensitive periods of life. Here, we review birth cohorts with an exposomal approach and their key outcomes and challenges. Data Sources MEDLINE was searched for birth cohorts that have used an exposomal approach. Study Selections Relevant studies in English language were selected and reviewed. Results The outcomes of birth cohorts with an exposomal approach improve our understanding of the association between environmental exposures and childhood diseases. For example, results from The Canadian Healthy Infant Longitudinal Development Study suggest an association between first trimester exposure to traffic-related air pollution and increased risk of allergic sensitization at 12 months of age (P = .6). In a smaller Canadian birth cohort study, it was found that regular use of air fresheners (adjusted P = .04) and presence of mold in the residence (adjusted P Conclusion Birth cohort studies with an exposomal approach improve our understanding of the origin of childhood diseases by examining a complex network of environmental exposures during pregnancy and years beyond birth. International collaboration is required to develop large birth cohorts for better and more extensive assessment of exposome with standardized protocols and new statistical frameworks.

Background Previous studies have suggested that exposures to indoor air-polluting factors during pregnancy and early life can influence childhood allergy development. These exposures have been investigated in singularity; however, the effect of simultaneous exposure to multiple factors remains unclear. Objective To evaluate the effect of prenatal and early-life exposure to 7 air-polluting factors on allergic sensitization at 2 years of age. Methods Mother-child pairs (n = 108) enrolled in the Kingston Allergy Birth Cohort were followed up from birth to 2 years of age. Exposure to air fresheners, candles, mold, cats, dogs, carpet, and environmental tobacco smoke (ETS) during the prenatal, 6-month, 1-year, and 2-year time points were obtained. A skin prick test (SPT) was performed on both the mother and the 2-year-old child. Results Exposure to candles during the prenatal window, cats during the 6-month window, and ETS at 2 years significantly increased the odds ratio (OR) of a positive SPT result (candles: OR, 5.096; 95% CI, 1.69-13.86; P = .006; cat: OR, 4.267; 95% CI, 1.096-15.68; P = .048; and ETS: OR, 3.78; 95% CI, 1.189-11.18; P = .04). Children with a positive SPT result had significantly more exposures than SPT-negative children (prenatal P = .005, 1-year P = .03, and 2-year P = .008). As the total number of exposures increased, the percentage of SPT-positive children increased (prenatal P = .005, 1-year P = .03, and 2-year P = .01). Conclusion We have provided evidence supporting the role of the indoor environment on atopic disease development. The combined effect of multiple exposures may be more influential to allergy development than a single exposure.