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1. Donor types and outcomes of transplantation in myelofibrosis: a CIBMTR study

Author

Jain, Tania, Estrada-Merly, Noel, Salas, M. Queralt, Kim, Soyoung, DeVos, Jakob, Chen, Min, Fang, Xi, Kumar, Rajat, Andrade-Campos, Marcio, Elmariah, Hany, Agrawal, Vaibhav, Aljurf, Mahmoud, Bacher, Ulrike, Badar, Talha, Badawy, Sherif M., Ballen, Karen, Beitinjaneh, Amer, Bhatt, Vijaya Raj, Bredeson, Christopher, DeFilipp, Zachariah, Dholaria, Bhagirathbhai, Farhadfar, Nosha, Farhan, Shatha, Gandhi, Arpita P., Ganguly, Siddhartha, Gergis, Usama, Grunwald, Michael R., Hamad, Nada, Hamilton, Betty K., Inamoto, Yoshihiro, Iqbal, Madiha, Jamy, Omer, Juckett, Mark, Kharfan-Dabaja, Mohamed A., Krem, Maxwell M., Lad, Deepesh P., Liesveld, Jane, Al Malki, Monzr M., Malone, Adriana K., Murthy, Hemant S., Ortí, Guillermo, Patel, Sagar S., Pawarode, Attaphol, Perales, Miguel-Angel, van der Poel, Marjolein, Ringden, Olle, Rizzieri, David A., Rovó, Alicia, Savani, Bipin N., Savoie, Mary Lynn, Seo, Sachiko, Solh, Melhem, Ustun, Celalettin, Verdonck, Leo F., Wingard, John R., Wirk, Baldeep, Bejanyan, Nelli, Jones, Richard J., Nishihori, Taiga, Oran, Betul, Nakamura, Ryotaro, Scott, Bart, Saber, Wael, and Gupta, Vikas

Published
2024
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2. Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States

Author

Bhatt, Neel S, Brazauskas, Ruta, Salit, Rachel B, Syrjala, Karen, Bo-Subait, Stephanie, Tecca, Heather, Badawy, Sherif M, Baker, K Scott, Beitinjaneh, Amer, Bejanyan, Nelli, Byrne, Michael, Dias, Ajoy, Farhadfar, Nosha, Freytes, César O, Ganguly, Siddhartha, Hashmi, Shahrukh, Hayashi, Robert J, Hong, Sanghee, Inamoto, Yoshihiro, Jamani, Kareem, Kasow, Kimberly A, Khera, Nandita, Krem, Maxwell M, Lazarus, Hillard M, Lee, Catherine J, Lee, Stephanie, Majhail, Navneet S, Malone, Adriana K, Marks, David I, Mau, Lih-Wen, Mayo, Samantha J, Muffly, Lori S, Nathan, Sunita, Nishihori, Taiga, Page, Kristin M, Preussler, Jaime, Rangarajan, Hemalatha G, Rotz, Seth J, Salooja, Nina, Savani, Bipin N, Schears, Raquel, Schechter-Finkelstein, Tal, Schiller, Gary, Shah, Ami J, Sharma, Akshay, Wang, Trent, Wirk, Baldeep, Battiwalla, Minoo, Schoemans, Hélène, Hamilton, Betty, Buchbinder, David, Phelan, Rachel, and Shaw, Bronwen

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Transplantation, Clinical Research, Rehabilitation, Behavioral and Social Science, Quality Education, Female, Hematopoietic Stem Cell Transplantation, Humans, Neoplasm Recurrence, Local, Return to Work, Survivors, Transplantation, Homologous, United States, Young Adult, Hematopoietic cell transplantation, Return to work, Quality of life, Young adult, Immunology, Cardiovascular medicine and haematology
Abstract

Young adult (YA) survivors of allogeneic hematopoietic cell transplantation (HCT) are at risk for late psychosocial challenges, including the inability to return to work post-HCT. Work-related outcomes in this population remain understudied, however. We conducted this study to assess the post-HCT work status of survivors of allogeneic HCT who underwent HCT as YAs and to analyze the patient-, disease-, and HCT-related factors associated with their work status at 1 year post-HCT. Using Center for International Blood and Marrow Transplant Research data, we evaluated the post-HCT work status (full-time, part-time work, unemployed, or medical disability) of 1365 YA HCT survivors who underwent HCT between 2008 and 2015. Percentages of work status categories were reported at 4 time points: 6 months, 1 year, 2 years, and 3 years post-HCT. Percentages of post-HCT work status categories at the 1-year time point were also described in relation to survivors' pre-HCT work status categories. Factors associated with 1-year post-HCT work status (full-time or part-time work) were examined using logistic regression. From 6 months to 3 years post-HCT, the percentage of survivors working full-time increased from 18.3% to 50.7% and the percentage working part-time increased from 6.9% to 10.5%. Of patients in full-time work pre-HCT, 50% were unemployed or on medical disability at 1 year post-HCT. Female sex (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.40 to 0.77), HCT Comorbidity Index score ≥3 (OR, 0.57; 95% CI, 0.39 to 0.82), pre-HCT unemployment (OR, 0.37; 95% CI, 0.24 to 0.56), medical disability (OR, 0.44; 95% CI, 0.28 to 0.70), development of grade III-IV acute graft-versus-host disease (OR, 0.52; 95% CI, 0.34 to 0.80), and relapse within 1 year post-HCT (OR, 0.34; 95% CI, 0.21 to 0.56) were associated with a lower likelihood of employment at 1 year post-HCT. Compared with myeloablative conditioning (MAC) with total body irradiation (TBI), MAC without TBI (OR, 1.71; 95% CI, 1.16 to 2.53) was associated with a greater likelihood of employment at 1 year post-HCT. Graduate school-level education (OR, 2.47; 95% CI, 1.49 to 4.10) was also associated with a greater likelihood of employment at 1 year post-HCT. Although the work status among YA HCT survivors continued to improve over time, a substantial subset became or remained unemployed or on medical disability. These findings underscore the need for effective interventions to support return to work in this population.

Published
2021

3. Bloodstream Infection Due to Vancomycin-resistant Enterococcus Is Associated With Increased Mortality After Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndrome: A Multicenter, Retrospective Cohort Study

Author

Papanicolaou, Genovefa A, Ustun, Celalettin, Young, Jo-Anne H, Chen, Min, Kim, Soyoung, Ahn, Kwang Woo, Komanduri, Krishna, Lindemans, Caroline, Auletta, Jeffery J, Riches, Marcie L, Abdel-Azim, Hisham, Ahmed, Ibrahim A, Aljurf, Mahmoud, Antin, Joseph, Ballen, Karen Kuhn, Beitinjaneh, Amer, Brown, Valerie I, Cerny, Jan, Champlin, Richard, Chao, Nelson, Chhabra, Saurabh, Dahi, Parastoo B, Daly, Andrew, Dandoy, Christopher, Dvorak, Christopher C, Forman, Stephen, Ganguly, Siddhartha, Hashmi, Shahrukh K, Kharfan-Dabaja, Mohamed A, Lazarus, Hillard, Ljungman, Per, Malone, Adriana K, Murthy, Nishihori, Taiga, Page, Kristin, Pingali, Ravi, Reddy, Vijay, Saad, Ayman, Savani, Bipin N, Seftel, Matthew, Szer, Jeffrey, Vij, Ravi, Weisdorf, Daniel, William, Basem M, Williams, Kirsten, Wirk, Baldeep, and Yared, Jean

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cancer, Vaccine Related, Transplantation, Rare Diseases, Hematology, Emerging Infectious Diseases, Clinical Research, Good Health and Well Being, Adolescent, Adult, Aged, Anti-Bacterial Agents, Bacteremia, Child, Child, Preschool, Gram-Positive Bacterial Infections, Hematopoietic Stem Cell Transplantation, Humans, Infant, Leukemia, Myeloid, Acute, Middle Aged, Myelodysplastic Syndromes, Retrospective Studies, Transplantation Conditioning, Vancomycin, Vancomycin-Resistant Enterococci, Young Adult, vancomycin-resistant Enterococcus, bacteremia, hematopoietic stem cell transplantation, mortality, CIBMTR® Infection and Immune Reconstitution Working Committee, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundWe examined the impact of vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI) on outcomes of allogeneic hematopoietic cell transplantation (HCT) utilizing the Center for International Blood and Marrow Transplant Research database.MethodsAdult and pediatric patients (N = 7128) who underwent first HCT for acute leukemia or myelodysplastic syndrome from 2008 through 2012 were analyzed as 3 groups-VRE BSI, non-VRE BSI, without BSI-according to BSI status at 100 days (D100) after allogeneic HCT. Multivariable models examined the effect of VRE BSI for overall survival (OS) and nonrelapse mortality (NRM) at 1 year.ResultsOf 7128 patients, 258 (3.2%) had VRE BSI, 2398 (33.6%) had non-VRE BSI, and 4472 (63%) had no BSI. The median time to VRE BSI and non-VRE BSI were D11 and D15, respectively. Compared with non-VRE BSI patients, VRE BSI patients were older, had advanced-stage acute leukemia, and received umbilical cord blood (UCB) allografts. In multivariable models, VRE BSI was associated with lower OS (relative risk [RR], 2.9;(99% confidence interval [CI], 2.2-3.7) and increased NRM (RR, 4.7; 99% CI, 3.6-6.2) (P < .0001) for both. Other predictors for worse OS and increased NRM were non-VRE BSI, older age, advanced disease stage, UCB allograft, - mismatch, comorbidity index ≥3, and cytomegalovirus seropositivity (P < .001 for all variables).ConclusionsVRE BSI is associated with lowest OS and highest NRM compared with patients without BSI or non-VRE BSI. Novel interventions that address the pathophysiology of VRE BSI have the potential of improving survival after HCT.

Published
2019

5. KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results

Author

Shah, Bijal D., Bishop, Michael R., Oluwole, Olalekan O., Logan, Aaron C., Baer, Maria R., Donnellan, William B., O'Dwyer, Kristen M., Holmes, Houston, Arellano, Martha L., Ghobadi, Armin, Pagel, John M., Lin, Yi, Cassaday, Ryan D., Park, Jae H., Abedi, Mehrdad, Castro, Januario E., DeAngelo, Daniel J., Malone, Adriana K., Mawad, Raya, Schiller, Gary J., Rossi, John M., Bot, Adrian, Shen, Tong, Goyal, Lovely, Jain, Rajul K., Vezan, Remus, and Wierda, William G.

Published
2021
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6. Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma

Author

Radivoyevitch, Tomas, Dean, Robert M., Shaw, Bronwen E., Brazauskas, Ruta, Tecca, Heather R., Molenaar, Remco J., Battiwalla, Minoo, Savani, Bipin N., Flowers, Mary E.D., Cooke, Kenneth R., Hamilton, Betty K., Kalaycio, Matt, Maciejewski, Jaroslaw P., Ahmed, Ibrahim, Akpek, Görgün, Bajel, Ashish, Buchbinder, David, Cahn, Jean-Yves, D’Souza, Anita, Daly, Andrew, DeFilipp, Zachariah, Ganguly, Siddhartha, Hamadani, Mehdi, Hayashi, Robert J., Hematti, Peiman, Inamoto, Yoshihiro, Khera, Nandita, Kindwall-Keller, Tamila, Landau, Heather, Lazarus, Hillard, Majhail, Navneet S., Marks, David I., Olsson, Richard F., Seo, Sachiko, Steinberg, Amir, William, Basem M., Wirk, Baldeep, Yared, Jean A., Aljurf, Mahmoud, Abidi, Muneer H., Allewelt, Heather, Beitinjaneh, Amer, Cook, Rachel, Cornell, Robert F., Fay, Joseph W., Hale, Gregory, Chakrabarty, Jennifer Holter, Jodele, Sonata, Kasow, Kimberly A., Mahindra, Anuj, Malone, Adriana K., Popat, Uday, Rizzo, J. Douglas, Schouten, Harry C., Warwick, Anne B., Wood, William A., Sekeres, Mikkael A., Litzow, Mark R., Gale, Robert P., and Hashmi, Shahrukh K.

Published
2018
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7. Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation

Author

Kelly, Debra Lynch, Buchbinder, David, Duarte, Rafael F., Auletta, Jeffrey J., Bhatt, Neel, Byrne, Michael, DeFilipp, Zachariah, Gabriel, Melissa, Mahindra, Anuj, Norkin, Maxim, Schoemans, Helene, Shah, Ami J., Ahmed, Ibrahim, Atsuta, Yoshiko, Basak, Grzegorz W., Beattie, Sara, Bhella, Sita, Bredeson, Christopher, Bunin, Nancy, Dalal, Jignesh, Daly, Andrew, Gajewski, James, Gale, Robert Peter, Galvin, John, Hamadani, Mehdi, Hayashi, Robert J., Adekola, Kehinde, Law, Jason, Lee, Catherine J., Liesveld, Jane, Malone, Adriana K., Nagler, Arnon, Naik, Seema, Nishihori, Taiga, Parsons, Susan K., Scherwath, Angela, Schofield, Hannah-Lise, Soiffer, Robert, Szer, Jeff, Twist, Ida, Warwick, Anne, Wirk, Baldeep M., Yi, Jean, Battiwalla, Minoo, Flowers, Mary E., Savani, Bipin, and Shaw, Bronwen E.

Published
2018
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8. Survival and Late Effects after Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancy at Less than Three Years of Age

Author

Vrooman, Lynda M., Millard, Heather R., Brazauskas, Ruta, Majhail, Navneet S., Battiwalla, Minoo, Flowers, Mary E., Savani, Bipin N., Akpek, Görgün, Aljurf, Mahmoud, Bajwa, Rajinder, Baker, K. Scott, Beitinjaneh, Amer, Bitan, Menachem, Buchbinder, David, Chow, Eric, Dandoy, Christopher, Dietz, Andrew C., Diller, Lisa, Gale, Robert Peter, Hashmi, Shahrukh K., Hayashi, Robert J., Hematti, Peiman, Kamble, Rammurti T., Kasow, Kimberly A., Kletzel, Morris, Lazarus, Hillard M., Malone, Adriana K., Marks, David I., O'Brien, Tracey A., Olsson, Richard F., Ringden, Olle, Seo, Sachiko, Steinberg, Amir, Yu, Lolie C., Warwick, Anne, Shaw, Bronwen, and Duncan, Christine

Published
2017
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9. Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT

Author

Buchbinder, David, Kelly, Debra Lynch, Duarte, Rafael F., Auletta, Jeffery J., Bhatt, Neel, Byrne, Michael, DeFilipp, Zachariah, Gabriel, Melissa, Mahindra, Anuj, Norkin, Maxim, Schoemans, Helene, Shah, Ami J., Ahmed, Ibrahim, Atsuta, Yoshiko, Basak, Grzegorz W., Beattie, Sara, Bhella, Sita, Bredeson, Christopher, Bunin, Nancy, Dalal, Jignesh, Daly, Andrew, Gajewski, James, Gale, Robert Peter, Galvin, John, Hamadani, Mehdi, Hayashi, Robert J., Adekola, Kehinde, Law, Jason, Lee, Catherine J., Liesveld, Jane, Malone, Adriana K., Nagler, Arnon, Naik, Seema, Nishihori, Taiga, Parsons, Susan K., Scherwath, Angela, Schofield, Hannah-Lise, Soiffer, Robert, Szer, Jeff, Twist, Ida, Warwick, Anne B., Wirk, Baldeep M., Yi, Jean, Battiwalla, Minoo, Flowers, Mary D. E., Savani, Bipin, and Shaw, Bronwen E.

Published
2018
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10. Metabolic Syndrome and Cardiovascular Disease after Hematopoietic Cell Transplantation: Screening and Preventive Practice Recommendations from the CIBMTR and EBMT

Author

DeFilipp, Zachariah, Duarte, Rafael F., Snowden, John A., Majhail, Navneet S., Greenfield, Diana M., Miranda, José López, Arat, Mutlu, Baker, K. Scott, Burns, Linda J., Duncan, Christine N., Gilleece, Maria, Hale, Gregory A., Hamadani, Mehdi, Hamilton, Betty K., Hogan, William J., Hsu, Jack W., Inamoto, Yoshihiro, Kamble, Rammurti T., Lupo-Stanghellini, Maria Teresa, Malone, Adriana K., McCarthy, Philip, Mohty, Mohamad, Norkin, Maxim, Paplham, Pamela, Ramanathan, Muthalagu, Richart, John M., Salooja, Nina, Schouten, Harry C., Schoemans, Helene, Seber, Adriana, Steinberg, Amir, Wirk, Baldeep M., Wood, William A., Battiwalla, Minoo, Flowers, Mary E.D., Savani, Bipin N., and Shaw, Bronwen E.

Published
2016
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11. Significant Improvements in the Practice Patterns of Adult Related Donor Care in US Transplantation Centers

Author

Anthias, Chloe, Shaw, Bronwen E., Kiefer, Deidre M., Liesveld, Jane L., Yared, Jean, Kamble, Rammurti T., D'Souza, Anita, Hematti, Peiman, Seftel, Matthew D., Norkin, Maxim, DeFilipp, Zachariah, Kasow, Kimberly A., Abidi, Muneer H., Savani, Bipin N., Shah, Nirali N., Anderlini, Paolo, Diaz, Miguel A., Malone, Adriana K., Halter, Joerg P., Lazarus, Hillard M., Logan, Brent R., Switzer, Galen E., Pulsipher, Michael A., Confer, Dennis L., and O'Donnell, Paul V.

Published
2016
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12. Impact of Pretransplantation 18F-fluorodeoxy Glucose–Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma

Author

Bachanova, Veronika, Burns, Linda J., Ahn, Kwang Woo, Laport, Ginna G., Akpek, Görgün, Kharfan-Dabaja, Mohamed A., Nishihori, Taiga, Agura, Edward, Armand, Philippe, Jaglowski, Samantha M., Cairo, Mitchell S., Cashen, Amanda F., Cohen, Jonathon B., D'Souza, Anita, Freytes, César O., Gale, Robert Peter, Ganguly, Siddhartha, Ghosh, Nilanjan, Holmberg, Leona A., Inwards, David J., Kanate, Abraham S., Lazarus, Hillard M., Malone, Adriana K., Munker, Reinhold, Mussetti, Alberto, Norkin, Maxim, Prestidge, Tim D., Rowe, Jacob M., Satwani, Prakash, Siddiqi, Tanya, Stiff, Patrick J., William, Basem M., Wirk, Baldeep, Maloney, David G., Smith, Sonali M., Sureda, Anna M., Carreras, Jeanette, and Hamadani, Mehdi

Published
2015
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13. Reduced-Intensity Hematopoietic Cell Transplantation for Patients with Primary Myelofibrosis: A Cohort Analysis from the Center for International Blood and Marrow Transplant Research

Author

Gupta, Vikas, Malone, Adriana K., Hari, Parameswaran N., Ahn, Kwang Woo, Hu, Zhen-Huan, Gale, Robert Peter, Ballen, Karen K., Hamadani, Mehdi, Olavarria, Eduardo, Gerds, Aaron T., Waller, Edmund K., Costa, Luciano J., Antin, Joseph H., Kamble, Rammurti T., van Besien, Koen M., Savani, Bipin N., Schouten, Harry C., Szer, Jeffrey, Cahn, Jean-Yves, de Lima, Marcos J., Wirk, Baldeep, Aljurf, Mahmoud D., Popat, Uday, Bejanyan, Nelli, Litzow, Mark R., Norkin, Maxim, Lewis, Ian D., Hale, Gregory A., Woolfrey, Ann E., Miller, Alan M., Ustun, Celalettin, Jagasia, Madan H., Lill, Michael, Maziarz, Richard T., Cortes, Jorge, Kalaycio, Matt E., and Saber, Wael

Published
2014
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14. Long‐term outcomes among 2‐year survivors of autologous hematopoietic cell transplantation for Hodgkin and diffuse large b‐cell lymphoma

Author

Myers, Regina M., Hill, Brian T., Shaw, Bronwen E., Kim, Soyoung, Millard, Heather R., Battiwalla, Minoo, Majhail, Navneet S., Buchbinder, David, Lazarus, Hillard M., Savani, Bipin N., Flowers, Mary E. D., DʼSouza, Anita, Ehrhardt, Matthew J., Langston, Amelia, Yared, Jean A., Hayashi, Robert J., Daly, Andrew, Olsson, Richard F., Inamoto, Yoshihiro, Malone, Adriana K., DeFilipp, Zachariah, Margossian, Steven P., Warwick, Anne B., Jaglowski, Samantha, Beitinjaneh, Amer, Fung, Henry, Kasow, Kimberly A., Marks, David I., Reynolds, Jana, Stockerl‐Goldstein, Keith, Wirk, Baldeep, Wood, William A., Hamadani, Mehdi, and Satwani, Prakash

Published
2018
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15. Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

Author

Rosenblatt, Joshua, primary, Leung, Annie, additional, Baneman, Emily, additional, Fuller, Risa, additional, Taimur, Sarah, additional, Paniz-Mondolfi, Alberto E, additional, Malone, Adriana K, additional, Kirkman, Laura, additional, and Jacobs, Samantha E, additional

Published
2021
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16. A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma

Author

Kessler, Alaina J., Marcellino, Bridget K., Niglio, Scot A., Petersen, Bruce E., and Malone, Adriana K.

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

Plasmablastic lymphoma (PBL) and plasmablastic plasma cell myeloma (PCM) have many overlapping characteristics. Clinical correlation can help make the distinction between the two entities. Human immunodeficiency virus- (HIV-) negative PBL is a rare disease, making the diagnosis more challenging. While there is no standard of care for PBL, current recommendations include dose-adjusted EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone), with or without bortezomib. We report an aggressive case of HIV-negative plasmablastic lymphoma and discuss the challenge in establishing a diagnosis. We review the literature regarding this disease and current recommendations for treatment.

Published
2019
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18. Updated Phase 1 Results of Zuma-3: Kte-X19, an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy, in Adult Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Author

Wierda, William G, primary, Bishop, Michael R., additional, Oluwole, Olalekan, additional, Logan, Aaron C., additional, Baer, Maria R., additional, Donnellan, William B., additional, O'Dwyer, Kristen M., additional, Castro, Januario E., additional, Schiller, Gary J., additional, Holmes, Houston, additional, Abedi, Mehrdad, additional, Ghobadi, Armin, additional, Arellano, Martha L., additional, Malone, Adriana K., additional, Pagel, John M., additional, Mardiros, Armen, additional, Shen, Tong, additional, Vezan, Remus, additional, Jain, Rajul K., additional, and Shah, Bijal D., additional

Published
2019
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19. Long-Term Outcomes Among Two-Year Survivors of Autologous Hematopoietic Cell Transplant for Hodgkin and Diffuse Large B-Cell Lymphoma

Author

Myers, Regina, Hill, Brian T., Shaw, Bronwen E., Kim, Soyoung, Millard, Heather R., Battiwalla, Minoo, Majhail, Navneet, Buchbinder, David, Lazarus, Hillard M., Savani, Bipin N., Flowers, Mary E.D., D’Souza, Anita, Ehrdardt, Matt, Langston, Amelia, Yared, Jean, Hayashi, Robert J., Daly, Andrew, Olsson, Richard F., Inamoto, Yoshi, Malone, Adriana K., DeFilipp, Zachariah, Margossian, Steven, Warwick, Anne, Jaglowski, Samantha, Beitinjaneh, Amer, Fung, Henry, Kasow, Kimberly, Marks, David I., Reynolds, Jana, Stockerl-Goldstein, Keith, Wirk, Baldeep M., Wood, William, Hamadani, Mehdi, and Satwani, Prakash

Subjects
Adult, Male, Time Factors, Adolescent, Hematopoietic Stem Cell Transplantation, Middle Aged, Hodgkin Disease, Transplantation, Autologous, Article, Disease-Free Survival, Young Adult, Cancer Survivors, Humans, Female, Lymphoma, Large B-Cell, Diffuse, Neoplasm Recurrence, Local, Aged
Abstract

Autologous hematopoietic cell transplantation (auto-HCT) is a standard therapy for relapsed classic Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL); however, long-term outcomes are not well described.This study analyzed survival, nonrelapse mortality, late effects, and subsequent malignant neoplasms (SMNs) in 1617 patients who survived progression-free for ≥2 years after auto-HCT for cHL or DLBCL between 1990 and 2008. The median age at auto-HCT was 40 years; the median follow-up was 10.6 years.The 5-year overall survival rate was 90% (95% confidence interval [CI], 87%-92%) for patients with cHL and 89% (95% CI, 87%-91%) for patients with DLBCL. The risk of late mortality in comparison with the general population was 9.6-fold higher for patients with cHL (standardized mortality ratio [SMR], 9.6) and 3.4-fold higher for patients with DLBCL (SMR, 3.4). Relapse accounted for 44% of late deaths. At least 1 late effect was reported for 9% of the patients. A total of 105 SMNs were confirmed: 44 in the cHL group and 61 in the DLBCL group. According to a multivariate analysis, older age, male sex, a Karnofsky score90, total body irradiation (TBI) exposure, and a higher number of lines of chemotherapy before auto-HCT were risk factors for overall mortality in cHL. Risk factors in DLBCL were older age and TBI exposure. A subanalysis of 798 adolescent and young adult patients mirrored the outcomes of the overall study population.Despite generally favorable outcomes, 2-year survivors of auto-HCT for cHL or DLBCL have an excess late-mortality risk in comparison with the general population and experience an assortment of late complications. Cancer 2018;124:816-25. © 2017 American Cancer Society.

Published
2017

20. Updated Phase 1 Results of Zuma-3: Kte-C19, an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy, in Adult Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Author

Wierda, William G., primary, Bishop, Michael R., additional, Oluwole, Olalekan O., additional, Logan, Aaron C., additional, Baer, Maria R., additional, Donnellan, William B., additional, O'Dwyer, Kristen M., additional, Castro, Januario E., additional, Schiller, Gary J., additional, Holmes, Houston, additional, Abedi, Mehrdad, additional, Ghobadi, Armin, additional, Arellano, Martha L., additional, Malone, Adriana K., additional, Pagel, John M., additional, Mardiros, Armen, additional, Shen, Tong, additional, Vezan, Remus, additional, Jain, Rajul K., additional, and Shah, Bijal D., additional

Published
2018
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21. Ring chromosome 18 abnormality in acute myelogenous leukemia: the clinical dilemma

Author

Malone Adriana K, Gruenstein Stephen, Sivendran Shanthi, and Najfeld Vesna

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract The ring chromosome is a circular, structural abnormality composed of either multiple chromosomes or a single chromosome with loss of genetic material at one or both ends. This chromosomal rearrangement is often unstable with frequent recombinations and may be accompanied by either loss or amplification of genetic material1. Considering that ring chromosomes are rare in acute myelogenous leukemia (AML), it is difficult to risk stratify patient prognosis, particularly when the ring chromosome occurs as the sole abnormality. Here we report a case of a ring chromosome 18 abnormality in a patient with newly diagnosed AML with monocytic differentiation. Cytogenetic analysis demonstrated 46, XY, r(18)(p11q21) karyotype in 19 of 34 evaluated metaphase cells. The patient received induction chemotherapy and subsequent allogeneic cord blood transplant from a sex-matched donor, and remained in hematologic and cytogenetic remission for 120 days post transplant. Soon after, he developed post transplant lymphoproliferative disorder and died of multi-organ failure. Although r(18) chromosomal abnormalities were not classified in the recent updated evidence-and expert opinion-based recommendations for the diagnosis and management of AML (likely due to the small number of reported cases), the patient was treated as high risk with stem cell transplantation. This was based on the unstable nature of the ring chromosome and the poor outcomes described in the literature of patients with sole ring 18 abnormalities.

Published
2010
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22. Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation

Author

El-Jawahri, Areej, Chen, Yi-Bin, Brazauskas, Ruta, He, Naya, Lee, Stephanie J, Knight, Jennifer M, Majhail, Navneet, Buchbinder, David, Schears, Raquel M, Wirk, Baldeep M, Wood, William A, Ahmed, Ibrahim, Aljurf, Mahmoud, Szer, Jeff, Beattie, Sara M, Battiwalla, Minoo, Dandoy, Christopher, Diaz, Miguel-Angel, D'Souza, Anita, Freytes, Cesar O, Gajewski, James, Gergis, Usama, Hashmi, Shahrukh K, Jakubowski, Ann, Kamble, Rammurti T, Kindwall-Keller, Tamila, Lazarus, Hilard M, Malone, Adriana K, Marks, David I, Meehan, Kenneth, Savani, Bipin N, Olsson, Richard F, Rizzieri, David, Steinberg, Amir, Speckhart, Dawn, Szwajcer, David, Schoemans, Helene, Seo, Sachiko, Ustun, Celalettin, Atsuta, Yoshiko, Dalal, Jignesh, Sales-Bonfim, Carmem, Khera, Nandita, Hahn, Theresa, and Saber, Wael

Subjects
Adult, Male, Transplantation Conditioning, Adolescent, Lymphoma, GVHD, Graft vs Host Disease, Transplantation, Autologous, Young Adult, hemic and lymphatic diseases, Humans, Transplantation, Homologous, pre-HCT depression, autologous HCT, Aged, Proportional Hazards Models, Aged, 80 and over, Depressive Disorder, Leukemia, Depression, transplant outcomes, Hematopoietic Stem Cell Transplantation, Middle Aged, Prognosis, surgical procedures, operative, Treatment Outcome, Myelodysplastic Syndromes, Multivariate Analysis, Female, Multiple Myeloma
Abstract

To evaluate the impact of depression before autologous and allogeneic hematopoietic cell transplantation (HCT) on clinical outcomes post-transplantation.

Published
2017

24. Long‐term outcomes among 2‐year survivors of autologous hematopoietic cell transplantation for Hodgkin and diffuse large b‐cell lymphoma

Author

Myers, Regina M., primary, Hill, Brian T., additional, Shaw, Bronwen E., additional, Kim, Soyoung, additional, Millard, Heather R., additional, Battiwalla, Minoo, additional, Majhail, Navneet S., additional, Buchbinder, David, additional, Lazarus, Hillard M., additional, Savani, Bipin N., additional, Flowers, Mary E. D., additional, D'Souza, Anita, additional, Ehrhardt, Matthew J., additional, Langston, Amelia, additional, Yared, Jean A., additional, Hayashi, Robert J., additional, Daly, Andrew, additional, Olsson, Richard F., additional, Inamoto, Yoshihiro, additional, Malone, Adriana K., additional, DeFilipp, Zachariah, additional, Margossian, Steven P., additional, Warwick, Anne B., additional, Jaglowski, Samantha, additional, Beitinjaneh, Amer, additional, Fung, Henry, additional, Kasow, Kimberly A., additional, Marks, David I., additional, Reynolds, Jana, additional, Stockerl‐Goldstein, Keith, additional, Wirk, Baldeep, additional, Wood, William A., additional, Hamadani, Mehdi, additional, and Satwani, Prakash, additional

Published
2017
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25. Impact of pre‐transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation

Author

El‐Jawahri, Areej, primary, Chen, Yi‐Bin, additional, Brazauskas, Ruta, additional, He, Naya, additional, Lee, Stephanie J., additional, Knight, Jennifer M., additional, Majhail, Navneet, additional, Buchbinder, David, additional, Schears, Raquel M., additional, Wirk, Baldeep M., additional, Wood, William A., additional, Ahmed, Ibrahim, additional, Aljurf, Mahmoud, additional, Szer, Jeff, additional, Beattie, Sara M., additional, Battiwalla, Minoo, additional, Dandoy, Christopher, additional, Diaz, Miguel‐Angel, additional, D'Souza, Anita, additional, Freytes, Cesar O., additional, Gajewski, James, additional, Gergis, Usama, additional, Hashmi, Shahrukh K., additional, Jakubowski, Ann, additional, Kamble, Rammurti T., additional, Kindwall‐Keller, Tamila, additional, Lazarus, Hilard M., additional, Malone, Adriana K., additional, Marks, David I., additional, Meehan, Kenneth, additional, Savani, Bipin N., additional, Olsson, Richard F., additional, Rizzieri, David, additional, Steinberg, Amir, additional, Speckhart, Dawn, additional, Szwajcer, David, additional, Schoemans, Helene, additional, Seo, Sachiko, additional, Ustun, Celalettin, additional, Atsuta, Yoshiko, additional, Dalal, Jignesh, additional, Sales‐Bonfim, Carmem, additional, Khera, Nandita, additional, Hahn, Theresa, additional, and Saber, Wael, additional

Published
2017
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26. MALT Lymphoma of the Bladder: A Case Report and Review of the Literature

Author

Vempati, Prashant, Knoll, Miriam A., Alqatari, Mahfood, Strauchen, James, Malone, Adriana K., and Bakst, Richard L.

Subjects
Article Subject, immune system diseases, hemic and lymphatic diseases
Abstract

The presentation of a MALT lymphoma in the bladder is exceedingly rare. Furthermore, the optimal treatment of primary MALT confined to the bladder remains to be defined. Here, we report a case of a 65-year-old female with primary MALT lymphoma treated with definitive radiation therapy. The patient received a total dose of 30 Gy in 20 equal daily fractions to the bladder and tolerated the treatment well. In addition, we have extensively reviewed the relevant literature to better define the optimal management of this rare disease. In conclusion, primary MALT lymphoma of the bladder represents a rare malignancy with excellent prognosis if detected at an early stage. For early stage disease, definitive radiation represents an excellent treatment modality with a minimal side-effect profile.

Published
2015
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27. Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome

Author

Shaffer, Brian C., primary, Ahn, Kwang Woo, additional, Hu, Zhen-Huan, additional, Nishihori, Taiga, additional, Malone, Adriana K., additional, Valcárcel, David, additional, Grunwald, Michael R., additional, Bacher, Ulrike, additional, Hamilton, Betty, additional, Kharfan-Dabaja, Mohamed A., additional, Saad, Ayman, additional, Cutler, Corey, additional, Warlick, Erica, additional, Reshef, Ran, additional, Wirk, Baldeep Mona, additional, Sabloff, Mitchell, additional, Fasan, Omotayo, additional, Gerds, Aaron, additional, Marks, David, additional, Olsson, Richard, additional, Wood, William Allen, additional, Costa, Luciano J., additional, Miller, Alan M., additional, Cortes, Jorge, additional, Daly, Andrew, additional, Kindwall-Keller, Tamila L., additional, Kamble, Rammurti, additional, Rizzieri, David A., additional, Cahn, Jean-Yves, additional, Gale, Robert Peter, additional, William, Basem, additional, Litzow, Mark, additional, Wiernik, Peter H., additional, Liesveld, Jane, additional, Savani, Bipin N., additional, Vij, Ravi, additional, Ustun, Celalettin, additional, Copelan, Edward, additional, Popat, Uday, additional, Kalaycio, Matt, additional, Maziarz, Richard, additional, Alyea, Edwin, additional, Sobecks, Ron, additional, Pavletic, Steven, additional, Tallman, Martin, additional, and Saber, Wael, additional

Published
2016
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28. Survival and Late Effects of Children Undergoing Myeloablative Allogeneic HCT at Less Than Three Years of Age: A Report from the Center for International Blood and Marrow Transplant Research

Author

Vrooman, Lynda, primary, Millard, Heather, additional, Brazauskas, Ruta, additional, Majhail, Navneet S., additional, Battiwalla, Minoo, additional, Flowers, Mary E.D., additional, Savani, Bipin N., additional, Akpek, Görgün, additional, Aljurf, Mahmoud D., additional, Bajwa, Rajinder, additional, Baker, K. Scott, additional, Beitinjaneh, Amer, additional, Bitan, Menachem, additional, Buchbinder, David, additional, Dandoy, Christopher E., additional, Gale, Robert Peter, additional, Hayashi, Robert J., additional, Hematti, Peiman, additional, Kamble, Rammurti T., additional, Kasow, Kimberly A., additional, Kletzel, Morris, additional, Lazarus, Hillard M., additional, Malone, Adriana K., additional, O'Brien, Tracey, additional, Olsson, Richard, additional, Reddy, Vijay, additional, Willert, Jennifer Reikes, additional, Ringden, Olle, additional, Schears, Raquel M., additional, Seo, Sachiko, additional, Steinberg, Amir, additional, Yu, Lolie C., additional, Shaw, Bronwen E., additional, and Duncan, Christine, additional

Published
2016
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29. Success of an International Learning Healthcare System in Hematopoietic Cell Transplantation: The American Society of Blood and Marrow Transplantation Clinical Case Forum

Author

Barba, Pere, primary, Burns, Linda J., additional, Juckett, Mark B., additional, Komanduri, Krishna V., additional, Litzow, Mark R., additional, Lee, Stephanie J., additional, Devlin, Sean M., additional, Costa, Luciano J., additional, Khan, Shakila P., additional, Klein, Andreas K., additional, Krishnan, Amrita, additional, Malone, Adriana K., additional, Moravec, Carina G., additional, Mir, Muhammad, additional, Selby, George B., additional, Vivek, Roy, additional, Cochran, Melissa, additional, Stricherz, Melisa, additional, Westmoreland, Michael, additional, Tierney, D. Kathryn, additional, Wood, William A., additional, and Perales, Miguel-Angel, additional

Published
2016
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34. Acute empathy decline among resident physician trainees on a hematology-oncology ward: an exploratory analysis of house staff empathy, distress, and patient death exposure.

Author

McFarland, Daniel C., Malone, Adriana K., and Roth, Andrew

Subjects
*RESIDENTS (Medicine), *PATIENT-professional relations, *EMPATHY, *PSYCHOLOGICAL distress, *ATTITUDES toward death, *HEMATOLOGY, *ONCOLOGY, *PSYCHOLOGY, *HEMATOLOGIC malignancies, *ATTITUDE (Psychology), *INTERNSHIP programs, *MEDICAL personnel, *PSYCHOLOGICAL resilience
Abstract

Objective: A reason for empathy decline during medical training has not been fully elucidated. Empathy may decrease acutely during an inpatient hematology-oncology rotation because of the acuity of death exposures. This study aimed to explore physician trainee empathy, distress, death exposures, and their attributed meaning for the trainee.Methods: Internal medicine interns and residents at a single academic center were evaluated before and after hematology-oncology ward rotations using Interpersonal Reactivity Index for empathy, previously cited reasons for empathy decline, Impact of Event Scale-Revised for distress, death exposures (no. of dying patients cared for) and attributed sense of meaning (yes/no) (post-rotation).Results: Fifty-six trainees completed both pre-rotation and post-rotation questionnaires (58% response). Empathy averaged 58.9 (SD 12.0) before and 56.8 (SD 11.1) after the rotation (2.1 point decrease) (p = 0.018). Distress was elevated but did not change significantly during the rotation. Residents cared for 4.28 dying patients. Seventy-three percent reported that death was the most stressful event during the rotation, yet 68% reported that they derived a sense of meaning from caring for dying patients. Empathy and distress scales were positively correlated before the rotation (r = 0.277, p = 0.041) but not after (r = .059, p = 0.69).Conclusion: This study suggests that an acute drop in empathy can occur over several weeks in residents rotating through inpatient hematology-oncology, similar to empathy decline associated with years of training in other studies. Empathy decline may be associated with elevated distress and death exposures on the hematology-oncology ward and should be explored further in other medical training environments. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2017
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38. Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome

Author

Nishihori, Taiga, William, Basem, Maziarz, Richard, Grunwald, Michael R., Alyea, Edwin, Costa, Luciano J., Hamilton, Betty, Saber, Wael, Ustun, Celalettin, Kharfan-Dabaja, Mohamed A., Litzow, Mark, Reshef, Ran, Wood, William Allen, Copelan, Edward, Cahn, Jean-Yves, Daly, Andrew, Miller, Alan M., Vij, Ravi, Kalaycio, Matt, Liesveld, Jane, Kindwall-Keller, Tamila L., Warlick, Erica, Rizzieri, David A., Shaffer, Brian C., Marks, David, Gale, Robert Peter, Cutler, Corey, Gerds, Aaron, Cortes, Jorge, Hu, Zhen-Huan, Malone, Adriana K., Bacher, Ulrike, Savani, Bipin N., Kamble, Rammurti, Sobecks, Ron, Sabloff, Mitchell, Pavletic, Steven, Ahn, Kwang Woo, Valcárcel, David, Tallman, Martin, Saad, Ayman, Fasan, Omotayo, Olsson, Richard, Wiernik, Peter H., Popat, Uday, and Wirk, Baldeep Mona

Subjects
surgical procedures, operative, hemic and lymphatic diseases, 3. Good health
Abstract

To develop a system prognostic of outcome in those undergoing allogeneic hematopoietic cell transplantation (allo HCT) for myelodysplastic syndrome (MDS).

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