481 results on '"Maloney, David J."'
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2. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug–unresponsive hyperalgesia in male rats
3. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis
4. High-throughput screening for modulators of cellular contractile force
5. Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase
6. A potent and selective inhibitor targeting human and murine 12/15-LOX.
7. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
8. Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes
9. Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction
10. The potential of 12/15-lipoxygenase inhibitors in stroke therapy
11. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
12. Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer
13. Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies
14. Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy
15. Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction
16. Protein Kinase C Regulation of 12-Lipoxygenase-Mediated Human Platelet Activation
17. Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.
18. Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase
19. Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1
20. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation
21. Supplementary Table 5 from Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4
22. Supplementary Materials from Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4
23. Supplementary Figure 1 from Biochemical Assays for the Discovery of TDP1 Inhibitors
24. Data from Biochemical Assays for the Discovery of TDP1 Inhibitors
25. Data from Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4
26. Supplementary Table 4 from Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4
27. Supplementary Figure 2 from Biochemical Assays for the Discovery of TDP1 Inhibitors
28. Supplementary Materials and Methods from Biochemical Assays for the Discovery of TDP1 Inhibitors
29. Supplementary Table 1 from Biochemical Assays for the Discovery of TDP1 Inhibitors
30. Data from The Skin Cancer Chemotherapeutic Agent Ingenol-3-Angelate (PEP005) Is a Substrate for the Epidermal Multidrug Transporter (ABCB1) and Targets Tumor Vasculature
31. Supplementary Figures 1-5, Tables 1-2 from The Skin Cancer Chemotherapeutic Agent Ingenol-3-Angelate (PEP005) Is a Substrate for the Epidermal Multidrug Transporter (ABCB1) and Targets Tumor Vasculature
32. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds
33. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
34. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes
35. Abstract A018: KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping
36. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell—like diffuse large B-cell lymphoma cells
37. DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1
38. 1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes
39. Abstract 132: VLX-1005 Effectively Treats Heparin-induced Thrombocytopenia (HIT) Without Increasing The Risk For Bleeding
40. High-Throughput Screen Identifies Cyclic Nucleotide Analogs That Inhibit Prostatic Acid Phosphatase
41. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target
42. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
43. CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia
44. Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening
45. A fluorescence-based high throughput assay for the determination of small molecule−human serum albumin protein binding
46. Inhibitors of the Apurinic/Apyrimidinic Endonuclease 1 (APE1)/Nucleophosmin (NPM1) Interaction That Display Anti-Tumor Properties
47. Optimization of ether and aniline based inhibitors of lactate dehydrogenase
48. Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes
49. A quinazoline‐based bromodomain inhibitor, CN210 , ameliorates indomethacin‐induced ileitis in mice by inhibiting inflammatory cytokine expression
50. Inhibitors of DNA polymerase β: Activity and mechanism
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