Search

Your search keyword '"Malta, Frederico S."' showing total 13 results
Start Over Author "Malta, Frederico S."
13 results on '"Malta, Frederico S."'

2. Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status

Author

Fonseca, Paula L C, primary, Moreira, Filipe R R, additional, de Souza, Rafael M, additional, Guimarães, Natália R, additional, Carvalho, Nara O, additional, Adelino, Talita E R, additional, Alves, Hugo J, additional, Alvim, Luige B, additional, Candido, Darlan S, additional, Coelho, Helena P, additional, Costa, Alana V B, additional, Costa, Walyson C, additional, de Carvalho, Alex F, additional, de Faria, Bruna W F, additional, de Lima, Aline B, additional, de Oliveira, Eneida S, additional, de Souza, Carolina S A, additional, de Souza, Fernanda G, additional, Dias, Rillery C, additional, Geddes, Victor E V, additional, Godinho, Igor P, additional, Gonçalves, Alessandro L, additional, Lourenço, Karine L, additional, Magalhães, Rubens D M, additional, Malta, Frederico S V, additional, Medeiros, Eva L A, additional, Mendes, Fernanda S, additional, Mendes, Pedro H B de P, additional, Mendonça, Cristiane P T B, additional, Menezes, Andre L, additional, Menezes, Diego, additional, Menezes, Mariane T, additional, Miguita, Lucyene, additional, Moreira, Rennan G, additional, Peixoto, Renata B, additional, Queiroz, Daniel C, additional, Ribeiro, Adriana A, additional, Ribeiro, Ana Paula de B, additional, Saliba, Juliana W, additional, Sato, Hugo I, additional, Silva, Joice do P, additional, Silva, Natiely P, additional, Faria, Nuno R, additional, Teixeira, Santuza M R, additional, da Fonseca, Flávio G, additional, Fernandes, Ana Paula S M, additional, Zauli, Danielle A G, additional, Januario, José Nélio, additional, de Oliveira, Jaqueline S, additional, Iani, Felipe C de M, additional, de Aguiar, Renato S, additional, and de Souza, Renan P, additional

Published
2022
Full Text
View/download PDF

3. Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program

Author

Silva, Joice P., primary, de Lima, Aline B., additional, Alvim, Luige B., additional, Malta, Frederico S. V., additional, Mendonça, Cristiane P. T. B., additional, Fonseca, Paula L. C., additional, Moreira, Filipe R. R., additional, Queiroz, Daniel C., additional, Ferreira, Jorge G. G., additional, Ferreira, Alessandro C. S., additional, Souza, Renan P., additional, Aguiar, Renato S., additional, and Zauli, Danielle A. G., additional

Published
2022
Full Text
View/download PDF

4. Additional file 1 of Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

Author

Luiz Henrique Araujo, Souza, Bianca Mendes, Leite, Laura Rabelo, Parma, Sabrina A. F., Lopes, Natália P., Malta, Frederico S. V., and Maíra C. M. Freire

Subjects
endocrine system diseases, neoplasms, digestive system diseases, respiratory tract diseases
Abstract

Additional file 1: Table S1 Distribution of colorectal cancer patients’ characteristics according to KRAS status. Table S2 Distribution of non-small cell lung cancer patients’ characteristics according to KRAS status.

Published
2021
Full Text
View/download PDF

5. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Author

Faria, Nuno R., Mellan, Thomas A., Whittaker, Charles, Claro, Ingra M., Candido, Darlan da S., Mishra, Swapnil, Crispim, Myuki A. E., Sales, Flavia C., Hawryluk, Iwona, McCrone, John T., Hulswit, Ruben J. G., Franco, Lucas A. M., Ramundo, Mariana S., de Jesus, Jaqueline G., Andrade, Pamela S., Coletti, Thais M., Ferreira, Giulia M., Silva, Camila A. M., Manuli, Erika R., Pereira, Rafael H. M., Peixoto, Pedro S., Kraemer, Moritz U., Gaburo, Nelson, Camilo, Cecilia da C., Hoeltgebaum, Henrique, Souza, William M., Rocha, Esmenia C., de Souza, Leandro M., de Pinho, Mariana C., Araujo, Leonardo J. T., Malta, Frederico S., de Lima, Aline B., Silva, Joice do P., Zauli, Danielle A. G., Ferreira, Alessandro C. de S., Schnekenberg, Ricardo P., Laydon, Daniel J., Walker, Patrick G. T., Schlueter, Hannah M., dos Santos, Ana L. P., Vidal, Maria S., Del Caro, Valentina S., Filho, Rosinaldo M. F., dos Santos, Helem M., Aguiar, Renato S., Proenca-Modena, Jose L. P., Nelson, Bruce, Hay, James A., Monod, Melodie, Miscouridou, Xenia, Coupland, Helen, Sonabend, Raphael, Vollmer, Michaela, Gandy, Axel, Prete, Carlos A., Nascimento, Vitor H., Suchard, Marc A., Bowden, Thomas A., Pond, Sergei L. K., Wu, Chieh-Hsi, Ratmann, Oliver, Ferguson, Neil M., Dye, Christopher, Loman, Nick J., Lemey, Philippe, Rambaut, Andrew, Fraiji, Nelson A., Carvalho, Maria do P. S. S., Pybus, Oliver G., Flaxman, Seth, Bhatt, Samir, Sabino, Ester C., Faria, Nuno R., Mellan, Thomas A., Whittaker, Charles, Claro, Ingra M., Candido, Darlan da S., Mishra, Swapnil, Crispim, Myuki A. E., Sales, Flavia C., Hawryluk, Iwona, McCrone, John T., Hulswit, Ruben J. G., Franco, Lucas A. M., Ramundo, Mariana S., de Jesus, Jaqueline G., Andrade, Pamela S., Coletti, Thais M., Ferreira, Giulia M., Silva, Camila A. M., Manuli, Erika R., Pereira, Rafael H. M., Peixoto, Pedro S., Kraemer, Moritz U., Gaburo, Nelson, Camilo, Cecilia da C., Hoeltgebaum, Henrique, Souza, William M., Rocha, Esmenia C., de Souza, Leandro M., de Pinho, Mariana C., Araujo, Leonardo J. T., Malta, Frederico S., de Lima, Aline B., Silva, Joice do P., Zauli, Danielle A. G., Ferreira, Alessandro C. de S., Schnekenberg, Ricardo P., Laydon, Daniel J., Walker, Patrick G. T., Schlueter, Hannah M., dos Santos, Ana L. P., Vidal, Maria S., Del Caro, Valentina S., Filho, Rosinaldo M. F., dos Santos, Helem M., Aguiar, Renato S., Proenca-Modena, Jose L. P., Nelson, Bruce, Hay, James A., Monod, Melodie, Miscouridou, Xenia, Coupland, Helen, Sonabend, Raphael, Vollmer, Michaela, Gandy, Axel, Prete, Carlos A., Nascimento, Vitor H., Suchard, Marc A., Bowden, Thomas A., Pond, Sergei L. K., Wu, Chieh-Hsi, Ratmann, Oliver, Ferguson, Neil M., Dye, Christopher, Loman, Nick J., Lemey, Philippe, Rambaut, Andrew, Fraiji, Nelson A., Carvalho, Maria do P. S. S., Pybus, Oliver G., Flaxman, Seth, Bhatt, Samir, and Sabino, Ester C.

Abstract

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness.

Published
2021

6. Epidemic Spread of SARS-CoV-2 Lineage B.1.1.7 in Brazil

Author

Moreira, Filipe R. R., primary, Bonfim, Diego M., additional, Zauli, Danielle A. G., additional, Silva, Joice P., additional, Lima, Aline B., additional, Malta, Frederico S. V., additional, Ferreira, Alessandro C. S., additional, Pardini, Victor C., additional, Magalhães, Wagner C. S., additional, Queiroz, Daniel C., additional, Souza, Rafael M., additional, Geddes, Victor E. V., additional, Costa, Walyson C., additional, Moreira, Rennan G., additional, Faria, Nuno R., additional, Voloch, Carolina M., additional, Souza, Renan P., additional, and Aguiar, Renato S., additional

Published
2021
Full Text
View/download PDF

7. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Author

Faria, Nuno R., primary, Mellan, Thomas A., additional, Whittaker, Charles, additional, Claro, Ingra M., additional, Candido, Darlan da S., additional, Mishra, Swapnil, additional, Crispim, Myuki A. E., additional, Sales, Flavia C. S., additional, Hawryluk, Iwona, additional, McCrone, John T., additional, Hulswit, Ruben J. G., additional, Franco, Lucas A. M., additional, Ramundo, Mariana S., additional, de Jesus, Jaqueline G., additional, Andrade, Pamela S., additional, Coletti, Thais M., additional, Ferreira, Giulia M., additional, Silva, Camila A. M., additional, Manuli, Erika R., additional, Pereira, Rafael H. M., additional, Peixoto, Pedro S., additional, Kraemer, Moritz U. G., additional, Gaburo, Nelson, additional, Camilo, Cecilia da C., additional, Hoeltgebaum, Henrique, additional, Souza, William M., additional, Rocha, Esmenia C., additional, de Souza, Leandro M., additional, de Pinho, Mariana C., additional, Araujo, Leonardo J. T., additional, Malta, Frederico S. V., additional, de Lima, Aline B., additional, Silva, Joice do P., additional, Zauli, Danielle A. G., additional, Ferreira, Alessandro C. de S., additional, Schnekenberg, Ricardo P., additional, Laydon, Daniel J., additional, Walker, Patrick G. T., additional, Schlüter, Hannah M., additional, dos Santos, Ana L. P., additional, Vidal, Maria S., additional, Del Caro, Valentina S., additional, Filho, Rosinaldo M. F., additional, dos Santos, Helem M., additional, Aguiar, Renato S., additional, Proença-Modena, José L., additional, Nelson, Bruce, additional, Hay, James A., additional, Monod, Mélodie, additional, Miscouridou, Xenia, additional, Coupland, Helen, additional, Sonabend, Raphael, additional, Vollmer, Michaela, additional, Gandy, Axel, additional, Prete, Carlos A., additional, Nascimento, Vitor H., additional, Suchard, Marc A., additional, Bowden, Thomas A., additional, Pond, Sergei L. K., additional, Wu, Chieh-Hsi, additional, Ratmann, Oliver, additional, Ferguson, Neil M., additional, Dye, Christopher, additional, Loman, Nick J., additional, Lemey, Philippe, additional, Rambaut, Andrew, additional, Fraiji, Nelson A., additional, Carvalho, Maria do P. S. S., additional, Pybus, Oliver G., additional, Flaxman, Seth, additional, Bhatt, Samir, additional, and Sabino, Ester C., additional

Published
2021
Full Text
View/download PDF

8. Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil

Author

Faria, Nuno R., primary, Mellan, Thomas A., additional, Whittaker, Charles, additional, Claro, Ingra M., additional, Candido, Darlan da S., additional, Mishra, Swapnil, additional, Crispim, Myuki A. E., additional, Sales, Flavia C., additional, Hawryluk, Iwona, additional, McCrone, John T., additional, Hulswit, Ruben J. G., additional, Franco, Lucas A. M., additional, Ramundo, Mariana S., additional, de Jesus, Jaqueline G., additional, Andrade, Pamela S., additional, Coletti, Thais M., additional, Ferreira, Giulia M., additional, Silva, Camila A. M., additional, Manuli, Erika R., additional, Pereira, Rafael H. M., additional, Peixoto, Pedro S., additional, Kraemer, Moritz U., additional, Gaburo, Nelson, additional, Camilo, Cecilia da C., additional, Hoeltgebaum, Henrique, additional, Souza, William M., additional, Rocha, Esmenia C., additional, de Souza, Leandro M., additional, de Pinho, Mariana C., additional, Araujo, Leonardo J. T, additional, Malta, Frederico S. V., additional, de Lima, Aline B., additional, Silva, Joice do P., additional, Zauli, Danielle A. G., additional, Ferreira, Alessandro C. de S., additional, Schnekenberg, Ricardo P, additional, Laydon, Daniel J., additional, Walker, Patrick G. T., additional, Schlüter, Hannah M., additional, dos Santos, Ana L. P., additional, Vidal, Maria S., additional, Del Caro, Valentina S., additional, Filho, Rosinaldo M. F., additional, dos Santos, Helem M., additional, Aguiar, Renato S., additional, Modena, José L. P., additional, Nelson, Bruce, additional, Hay, James A., additional, Monod, Melodie, additional, Miscouridou, Xenia, additional, Coupland, Helen, additional, Sonabend, Raphael, additional, Vollmer, Michaela, additional, Gandy, Axel, additional, Suchard, Marc A., additional, Bowden, Thomas A., additional, Pond, Sergei L. K., additional, Wu, Chieh-Hsi, additional, Ratmann, Oliver, additional, Ferguson, Neil M., additional, Dye, Christopher, additional, Loman, Nick J., additional, Lemey, Philippe, additional, Rambaut, Andrew, additional, Fraiji, Nelson A., additional, Carvalho, Maria do P. S. S., additional, Pybus, Oliver G., additional, Flaxman, Seth, additional, Bhatt, Samir, additional, and Sabino, Ester C., additional

Published
2021
Full Text
View/download PDF

11. Novel Method Probe-based Real-Time PCR to Detect 2 Single-Nucleotide Polymorphisms Close to Each Other: HFEHemochromatosis Gene Model

Author

Malta, Frederico S. V., Reis, Zilma N., and Cabral, Antônio C. V.

Abstract

Supplemental Digital Content is available in the text.Hereditary hemochromatosis is known as the most common genetic disorder among individuals of European genetic background. It is possible to find 2 mutations closely placed in the HFEgene (H63D and S65C) and this proximity can cause errors when genotyped by real-time polymerase chain reaction (PCR) genotyping assay. The aim of this study was to develop a hydrolysis probe-based PCR assay for detection of the H63D and S65C mutations without interference from on each other. Herein the study involved the standardization of an improvement of the real-time PCR 5′ nuclease assay to detect the desired mutations close placed using a same probe system. The assay analytical properties performances were tested, including the primers selectivity and detection limits. Also, the interexaminer reproducibility and repeatability of assay were estimated in 30 blood samples. Others 153 results of samples were compared with reference method (PCR_RFLP) and the accordance of the results evaluated by Fleiss’ κ method. The results of variation of interexaminer reproducibility and repeatability of assay were not statistically relevant (P<0.001). The comparison between the 2 methods by Fleiss’ κ analysis showed that 5′ nuclease assay identified the H63D and S65C haplotype as well as the reference method in all 153 tested samples. Our results showed that novel method probe-based real-time PCR were capable to detect 2 adjacent polymorphisms without errors in genotyping.

Published
2016
Full Text
View/download PDF

12. Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil.

Author

Faria NR, Mellan TA, Whittaker C, Claro IM, Candido DDS, Mishra S, Crispim MAE, Sales FC, Hawryluk I, McCrone JT, Hulswit RJG, Franco LAM, Ramundo MS, de Jesus JG, Andrade PS, Coletti TM, Ferreira GM, Silva CAM, Manuli ER, Pereira RHM, Peixoto PS, Kraemer MU, Gaburo N Jr, Camilo CDC, Hoeltgebaum H, Souza WM, Rocha EC, de Souza LM, de Pinho MC, Araujo LJT, Malta FSV, de Lima AB, Silva JDP, Zauli DAG, de S Ferreira AC, Schnekenberg RP, Laydon DJ, Walker PGT, Schlüter HM, Dos Santos ALP, Vidal MS, Del Caro VS, Filho RMF, Dos Santos HM, Aguiar RS, Modena JLP, Nelson B, Hay JA, Monod M, Miscouridou X, Coupland H, Sonabend R, Vollmer M, Gandy A, Suchard MA, Bowden TA, Pond SLK, Wu CH, Ratmann O, Ferguson NM, Dye C, Loman NJ, Lemey P, Rambaut A, Fraiji NA, Carvalho MDPSS, Pybus OG, Flaxman S, Bhatt S, and Sabino EC

Abstract

Cases of SARS-CoV-2 infection in Manaus, Brazil, resurged in late 2020, despite high levels of previous infection there. Through genome sequencing of viruses sampled in Manaus between November 2020 and January 2021, we identified the emergence and circulation of a novel SARS-CoV-2 variant of concern, lineage P.1, that acquired 17 mutations, including a trio in the spike protein (K417T, E484K and N501Y) associated with increased binding to the human ACE2 receptor. Molecular clock analysis shows that P.1 emergence occurred around early November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.4-2.2 times more transmissible and 25-61% more likely to evade protective immunity elicited by previous infection with non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness., Competing Interests: Competing interests: Authors declare that they have no competing interests.

Published
2021
Full Text
View/download PDF

13. New CODIS core loci allele frequencies for 96,400 Brazilian individuals.

Author

Aguiar VR, de Castro AM, Almeida VC, Malta FS, Ferreira AC, and Louro ID

Subjects
Brazil, DNA Fingerprinting, Databases, Nucleic Acid, Humans, Polymerase Chain Reaction, Gene Frequency, Genetics, Population, Microsatellite Repeats
Abstract

We have reported the allele frequencies of 15 STR loci, including the original 13 CODIS core loci, in over 100,000 Brazilian individuals. A new CODIS core loci has been proposed, but the recently established Brazilian Integrated Network of DNA Databases made a decision in 2010 to postpone the implementation of this new set of loci due to the lack of allele frequency data for the Brazilian population. We aimed to report allele frequencies of 20 loci, estimated from 96,400 Brazilian individuals undergoing paternity testing during 2011-2013. The percentage of missing data was less than 0.6% for all loci, except for CSF1PO (3.15%) and D7S820 (2.5%). The dropout rates estimated by the MicroDrop software were 0.013 for CSF1PO, 0.000037 for D7S820 and less than 0.000001 for other loci. Small missing data percentages and dropout rates reflect the high quality of the data., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results