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This paper considers a continuous-time bidimensional renewal risk model with subexponential claims. In this model, the claim size vectors and their inter-arrival times form a sequence of independent and identically distributed random vectors following some general dependence structures introduced by [T. Jiang, Y. Wang, Y. Chen and H. Xu, Uniform asymptotic estimate for finite-time ruin probabilities of a time-dependent bidimensional renewal model, Insur. Math. Econom. 64 (2015), pp. 45–53.]. We not only extend the results of [T. Jiang, Y. Wang, Y. Chen and H. Xu, Uniform asymptotic estimate for finite-time ruin probabilities of a time-dependent bidimensional renewal model, Insur. Math. Econom. 64 (2015), pp. 45–53.] under some weak conditions, but we also obtain an asymptotic estimate of the finite-time sum-ruin probability. Furthermore, when the distributions of claim sizes have nonzero lower Karamata indices, some explicit asymptotic formulas are established for the infinite-time ruin probabilities. [ABSTRACT FROM AUTHOR]

Background: The International Pediatric Nephrology Association (IPNA) Global Kidney Replacement Therapy (KRT) Registry was established to evaluate the incidence and outcomes of kidney replacement therapy (dialysis and transplantation) provided to children worldwide. Analysis of registry data for separate regions is feasible. Methods: Three centers located in Shanghai, Guangzhou, and Zhengzhou, which have the greatest number of pediatric kidney transplantation cases in China, participated in this analysis of transplant data. Data were registered by each center for patients under the age of 19 years who received a single-organ kidney transplant for the first time between 2011 and 2018. Results: In total, 415 patients (59.8% male) aged 1.4–18.7 (median 12.1) years were followed for 0.3–97.1 (median 27.7) months. The number of kidney transplants increased from a total of 129 during 2011–2014 to 286 cases during 2015–2018. 85.8% of patients received the transplanted kidney from a pediatric (age < 19 years) donor, and deceased donors accounted for 94% of all donors. 8.0% of grafts were lost. One and 5-year patient survival rates were 97.6% and 95.5%, respectively. The major cause of death was infection (7/14). Similar graft and patient survival rates were observed for organs from pediatric and adult donors in 6–11 and 12–18 year recipient age groups, whereas recipients < 6 years showed inferior patient and graft survival. Conclusions: Pediatric kidney transplantation shows favorable short-term and medium-term outcomes in China. Our experience supports use of pediatric donors in pediatric kidney transplantation, but attention directed to the outcome of recipients aged under 6 is necessary. [ABSTRACT FROM AUTHOR]