Search

Schiff bases are useful pharmacophores and form stable complexes with various metal ions in different oxidation states. Schiff base metal complexes show various biological activities such as antioxidant, antimalarial, antimicrobial, antitumor and anti-inflammatory. Schiff base ligands easily form complexes with rare earth metals and show various biological activities; due to paramagnetic nature of complexes, they are primarily used in medicine as a contrast media for magnetic resonance imaging. This review summarizes the synthesis of Schiff base rare earth metal complexes as well as antimicrobial activities especially antibacterial and antifungal from the last two decades and comparison of the result with standard reference drugs. [ABSTRACT FROM AUTHOR]

Structure and biological application based analysis has been carried out for Schiff's base ligand containing nitrogen and sulphur donor atoms and also for a series of its coordination compounds. Ligand benzil-bis(5-amino-1,3,4-thiadiazole-2-thiol) (L) has been prepared and structural features of ligand investigated by elemental analyses, IR, 1H-NMR, mass spectra and molecular modeling studies. The chemical reaction of the prepared ligand with metal ions afforded mononuclear coordination compounds of Mn(II) and Co(II) metal ions. The characterization of the coordination compounds is being based on the techniques i.e. elemental analysis, infra-red, UV-visible as well as melting point, molar conductivity and magnetic moment measurement. A computational study has been done to understand the miscellaneous coordination modes of ligand to metal ions. Characterization result shows that coordination compounds exhibit a six coordinated geometrical arrangement i.e. octahedral geometry. The biological inhibition zone (antifungal and antibacterial activities) of synthesized compounds, i.e. ligand and its coordination compounds, has been monitored using well diffusion technique. [ABSTRACT FROM AUTHOR]