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6. Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.

Author

Dejou, Jules, Mandairon, Nathalie, and Didier, Anne

Subjects
GRANULE cells, OLFACTORY bulb, MEMORY disorders, NEUROGENESIS, MENTAL illness, DEVELOPMENTAL neurobiology
Abstract

The olfactory bulb is a unique site of continuous neurogenesis, primarily generating inhibitory interneurons, a process that begins at birth and extends through infancy and adulthood. This review examines the characteristics of olfactory bulb neurogenesis, focusing on granule cells, the most numerous interneurons, and how their age and maturation affect their function. Adult-born granule cells, while immature, contribute to the experience-dependent plasticity of the olfactory circuit by enabling structural and functional synaptic changes. In contrast, granule cells born early in life form the foundational elements of the olfactory bulb circuit, potentially facilitating innate olfactory information processing. The implications of these neonatal cells on early life olfactory memory and their impact on adult perception, particularly in response to aversive events and susceptibility to emotional disorders, warrant further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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15. N

Author

Cohen, Daniel A., Hornung, David E., Mays, Lawrence, Douglas, Rodney, Kennedy, Henry, Knoblauch, Kenneth, Martin, Kevan, Abramov, Valery V., Gontova, Irina A., Abramova, Tatjana Ya., Kozlov, Vladimir A., Kusnecov, Alexander, Benchenane, Karim, Zugaro, Michaël, Wiener, Sidney, Witt, Martin, Moschovakis, Adonis, Braun, Anna Katharina, Kuratani, Shigeru, Murakami, Fujio, Starkweather, Angela, Dalezios, Yannis, Aihara, Kazuyuki, Okada, Masato, Adachi, Masaharu, Watanabe, Masataka, Rokni, Uri, Smith, Peter G., Richter, Diethelm W., Müller, Michael, Griffiths, M., Neal, J. W, Gasque, P., Bernhardi, Rommy von, Guillemin, Gilles J., Buijs, Ruud M., Kalsbeek, Andries, Darlington, Cynthia L., Swaab, Dick F., Lucassen, Paul J., Huitinga, Inge, Bao, Ai-Min, Ladwig, Bernd, Ohl, Frank W., Schnitzler, Hans-Ulrich, Denzinger, Annette, Takahashi, Terry, Warzecha, Anne-Kathrin, Kern, Roland, Oishi, Koji, Nakajima, Kazunori, Bernardino, Liliana, Agasse, Fabienne, Malva, João O., Bird, Thomas D., Alonso, Mariana, Dubayle, David, Menetrey, D., Haddad, John J., Lobell, Anna, Stahel, Philip F., Felderhoff-Mueser, Ursula, Barnum, Scott R., Jafarian-Tehrani, Mehrnaz, Mizuno, Tetsuya, Dietrich, W. Dalton, Keane, Robert W., Han, Jung-Soo, Dhaini, Hassan R., Spain, William J., Mandairon, Nathalie, Didier, Anne, Rich, Mark M., Kudo, Yoshihisa, Ruangkittisakul, Araya, Ballanyi, Klaus, Syed, Naweed I., Petzold, Axel, Rumbaugh, Jeffrey A., Nath, Avindra, Aldskogius, Håkan, Delgado-García, José M., Kengaku, Mineko, Kim, Joanne SM, Zhen, Mei, Mathie, Alistair, Veale, Emma L., Stengel, Maike, Baron, Ralf, Samson, Willis K., Chee, Melissa J. S., Colmers, William F., Smith, Paul F., Pauen, Michael, Elliott, Stacy L., Northoff, Georg, Jorna, René J., Inoue, Kazuhide, Kawabe, Hiroshi, Varoqueaux, Frederique, Brose, Nils, Tanaka, Kohichi, Whelan, Patrick J., Petralia, Ronald S., Wenthold, Robert J., Ramer, Matt S., McPhail, Lowell T., Mullaney, Ian, Widera, Darius, Kaltschmidt, Christian, Kaltschmidt, Barbara, Pennypacker, Keith R., Pollock, Glen, Saporta, Samuel, Koerber, H. Richard, Handwerker, Herrmann O., Smale, Laura, Nunez, Antonio A., Shimkin, Nahum, Tse, Frederick W., Wang, Nan, Yan, Lei, Tse, Amy, Covey, Ellen, Travagli, R. Alberto, Binder, Marc D., editor, Hirokawa, Nobutaka, editor, and Windhorst, Uwe, editor

Published
2009
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25. Neural processing of the reward value of pleasant odorants

Author

Midroit, Maëllie, primary, Chalençon, Laura, additional, Renier, Nicolas, additional, Milton, Adrianna, additional, Thevenet, Marc, additional, Sacquet, Joëlle, additional, Breton, Marine, additional, Forest, Jérémy, additional, Noury, Norbert, additional, Richard, Marion, additional, Raineteau, Olivier, additional, Ferdenzi, Camille, additional, Fournel, Arnaud, additional, Wesson, Daniel W., additional, Bensafi, Moustafa, additional, Didier, Anne, additional, and Mandairon, Nathalie, additional

Published
2021
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29. Norepinephrine, olfactory bulb and memory stability

Author

Linster, Christiane, primary, Midroit, Maellie, additional, Forest, Jeremy, additional, Thenaisie, Yohann, additional, Cho, Christina, additional, Richard, Marion, additional, Didier, Anne, additional, and Mandairon, Nathalie, additional

Published
2020
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30. Odorants as Natural Reward: Behavioral Evidence and Underlying Circuitry of Odorant Attraction from Mice to Humans

Author

Midroit, Maellie, primary, Chalençon, Laura, additional, Renier, Nicolas, additional, Milton, Adriana, additional, Thevenet, Marc, additional, Sacquet, Joelle, additional, Breton, Marine, additional, Forest, Jeremy, additional, Noury, Norbert, additional, Richard, Marion, additional, Raineteau, Olivier, additional, Ferdenzi, Camille, additional, Fournel, Arnaud, additional, Wesson, Dan, additional, Bensafi, Moustafa, additional, Didier, Anne, additional, and Mandairon, Nathalie, additional

Published
2020
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36. Inter-and intra-mouse variability in odor preferences revealed in an olfactory multiple choice test HHS Public Access

Author

Jagetia, Sonum, Milton, Adrianna, Stetzik, Lucas, Liu, Samantha, Pai, Kavya, Arakawa, Keiko, Mandairon, Nathalie, Wesson, Daniel, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and University of Florida [Gainesville] (UF)

Subjects
musculoskeletal, neural, and ocular physiology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, psychological phenomena and processes
Abstract

International audience; Animals choose between sensory stimuli, a highly complex behavior which includes detection, discrimination, preference, and memory processes. Rodents are reported to display robust preferences for some odors, for instance in the context of choosing among possible mates or food items. In contrast to the apparent robustness of responses towards these and other 'ethologically relevant' odors, little is known about the robustness of behaviors towards odors which have no overt role in the rodent ecological niche, so-called 'non-ethologically relevant' odors. We developed an apparatus for monitoring the nose-poking behavior of mice and used this apparatus to explore the prevalence and stability of choices among different odors both across mice, and within mice over successive days. Mice were tested to either a panel of ethologically relevant or non-ethologically relevant odors in an olfactory multiple choice test. Significant preferences to non-ethologically relevant odors were observed across the population of mice, with longer investigation durations to some odors more than to others. However, we found substantial inter-mouse variability in these responses, and that responses to these odors even varied within mice across days of testing. Tests with ethologically-relevant odors revealed that responses towards these odors were also variable across mice, but within individual mice responses were somewhat stable. This work establishes an olfactory multiple choice test for monitoring odor investigation, choice, and preference behaviors and the application of this apparatus to assess across and within-mouse odor preference choice stability. These results highlight that odor preferences, as assayed by measuring choice behaviors, are variable.

Published
2018

37. Role of Adult-Born Versus Preexisting Neurons Born at P0 in Olfactory Perception in a Complex Olfactory Environment in Mice

Author

Forest, Jérémy, primary, Chalençon, Laura, additional, Midroit, Maëllie, additional, Terrier, Claire, additional, Caillé, Isabelle, additional, Sacquet, Joëlle, additional, Benetollo, Claire, additional, Martin, Killian, additional, Richard, Marion, additional, Didier, Anne, additional, and Mandairon, Nathalie, additional

Published
2019
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44. FMRP and dendritic local translation of αCaMKII mRNA are required for the structural plasticity underlying olfactory learning

Author

Daroles, Laura, Gribaudo, Simona, Doulazmi, Mohamed, Scotto-Lomassese, Sophie, Dubacq, Caroline, Mandairon, Nathalie, Greer, Charles August, Didier, Anne, Trembleau, Alain, Caillé, Isabelle, Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of neurosurgery, Yale University School of Medicine, Université Paris Diderot - Paris 7 (UPD7), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Yale School of Medicine [New Haven, Connecticut] (YSM), Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
adult neurogenesis, congenital, hereditary, and neonatal diseases and abnormalities, Fragile X Mental Retardation Protein, learning, local translation, olfactory bulb, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], structural plasticity
Abstract

International audience; BackgroundIn the adult brain, structural plasticity allowing gain or loss of synapses remodels circuits to support learning. In Fragile X Syndrome (FXS), the absence of Fragile X Mental Retardation Protein (FMRP) leads to defects in plasticity and learning deficits. FMRP is a master regulator of local translation but its implication in learning-induced structural plasticity is unknown.MethodsUsing an olfactory learning task requiring adult-born olfactory bulb (OB) neurons and cell-specific ablation of FMRP, we investigated whether learning shapes adult-born neuron morphology during their synaptic integration and its dependence on FMRP. We used αCaMKII mutant mice with altered dendritic localization of αCaMKII mRNA as well as a reporter of αCaMKII local translation to investigate the role of this FMRP mRNA target in learning-dependent structural plasticity.ResultsLearning induces profound changes in dendritic architecture and spine morphology of adult-born neurons that are prevented by ablation of FMRP in adult-born neurons and rescued by an mGLUR5 antagonist. Moreover, dendritically translated αCaMKII is necessary for learning and associated structural modifications and learning triggers an FMRP-dependent increase of αCaMKII dendritic translation in adult-born neurons.ConclusionOur results strongly suggest that FMRP mediates structural plasticity of OB adult-born neurons to support olfactory learning through αCaMKII local translation. This reveals a new role for FMRP-regulated dendritic local translation in learning-induced structural plasticity. This might be of clinical relevance for the understanding of critical periods disruption in autism spectrum disorder patients, among which FXS is the primary monogenic cause.

Published
2015

45. Fragile X Mental Retardation Protein and Dendritic Local Translation of the Alpha Subunit of the Calcium/Calmodulin-Dependent Kinase II Messenger RNA Are Required for the Structural Plasticity Underlying Olfactory Learning

Author

Daroles, Laura, primary, Gribaudo, Simona, additional, Doulazmi, Mohamed, additional, Scotto-Lomassese, Sophie, additional, Dubacq, Caroline, additional, Mandairon, Nathalie, additional, Greer, Charles August, additional, Didier, Anne, additional, Trembleau, Alain, additional, and Caillé, Isabelle, additional

Published
2016
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46. Topographical representation of odor hedonics in the olfactory bulb

Author

Kermen, Florence, primary, Midroit, Maëllie, additional, Kuczewski, Nicola, additional, Forest, Jérémy, additional, Thévenet, Marc, additional, Sacquet, Joëlle, additional, Benetollo, Claire, additional, Richard, Marion, additional, Didier, Anne, additional, and Mandairon, Nathalie, additional

Published
2016
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47. An endogenous vitamin K-dependent mechanism regulates cell proliferation in the brain subventricular stem cell niche

Author

Gély-Pernot, Aurore, Coronas, Valé, Harnois, Thomas, Prestoz, Laetitia, Mandairon, Nathalie, Didier, Anne, Berjeaud, Jean, Monvoisin, Arnaud, Bourmeyster, Nicolas, Garcia, Pablo, Frutos, D, Philippe, Michel, Benzakour, Omar, Institut de physiologie et biologie cellulaires (IPBC), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Neurosciences Sensorielles Comportement Cognition, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Microbiologie de l'Eau (MDE), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigaciones Biomedicas de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Signalisation et Transports Ioniques Membranaires (STIM), Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers, Institut Technique de la Betterave (ITB), Confédération Générale des Planteurs de Betteraves, Université de Bordeaux Ségalen [Bordeaux 2], University of Cadiz, Milieux aquatiques, écologie et pollutions (UR MALY), and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
Vitamin K, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, animal diseases, Apoptosis, brain subventricular zone, Receptor tyrosine kinase, MESH: Length of Stay, Cerebral Ventricles, Mixed Function Oxygenases, Gene Knockout Techniques, Mice, 0302 clinical medicine, Gas6, Stem Cell Niche, vitamin K-dependent proteins, 0303 health sciences, Neurogenesis, Neural stem cell, 3. Good health, Cell biology, medicine.anatomical_structure, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Carbon-Carbon Ligases, Intercellular Signaling Peptides and Proteins, Molecular Medicine, protein S, Subventricular zone, Biology, 03 medical and health sciences, Proto-Oncogene Proteins, Vitamin K Epoxide Reductases, medicine, Animals, Humans, Tissue-Specific Stem Cells, Rats, Wistar, Progenitor cell, Cell Proliferation, 030304 developmental biology, MESH: Adolescent, MESH: Tuberculosis, Pulmonary, MESH: Humans, GAS6, Cell growth, HEK 293 cells, MESH: Hospitals, Special, Receptor Protein-Tyrosine Kinases, Cell Biology, Axl Receptor Tyrosine Kinase, Molecular biology, MESH: Antitubercular Agents, Rats, HEK293 Cells, nervous system, biology.protein, Warfarin, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Neural stem cells (NSC) persist in the adult mammalian brain, within the subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ stem and progenitor cell proliferation are not fully elucidated. Vitamin K-dependent proteins (VKDPs) are mainly secreted factors that were initially discovered as major regulators of blood coagulation. Warfarin ((S(2)-3-acetonylbenzyl)-4- hydroxy-coumarin)), a widespread anticoagulant, is a vitamin K antagonist that inhibits the production of functional VKDP. We demonstrate that the suppression of functional VKDPs production, in vitro, by exposure of SVZ cell cultures to warfarin or, in vivo, by its intracerebroventricular injection to mice, leads to a substantial increase in SVZ cell proliferation. We identify the anticoagulant factors, protein S and its structural homolog Gas6, as the two only VKDPs produced by SVZ cells and describe the expression and activation pattern of their Tyro3, Axl, and Mer tyrosine kinase receptors. Both in vitro and in vivo loss of function studies consisting in either Gas6 gene invalidation or in endogenous protein S neutralization, provided evidence for an important novel regulatory role of these two VKDPs in the SVZ neurogenic niche. Specifically, we show that while a loss of Gas6 leads to a reduction in the numbers of stem-like cells and in olfactory bulb neurogenesis, endogenous protein S inhibits SVZ cell proliferation. Our study opens up new perspectives for investigating further the role of vitamin K, VKDPs, and anticoagulants in NSC biology in health and disease. © AlphaMed Press., This work was supported by La Ligue Contre le Cancer Grand Ouest (Comités de la Vienne, Deux-Sèvres, Charente, Loiret), Région Poitou-Charentes and Retina France. A.Gely holds a Ph.D. fellowship from the French Ministry for Education and Science and P. Garcia de Frutos work is supported by a grant from the Spanish Ministry of Science and Innovation BFU2007-61699/BFI.

Published
2012

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