238 results on '"Mandato, C."'
Search Results
2. Treatment with an ileal bile acid transporter inhibitor in patients with TJP2 deficiency
- Author
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Di Giorgio, A, Sciveres, M, Fuoti, M, Sonzogni, A, Mandato, C, D'Antiga, L, Di Giorgio A., Sciveres M., Fuoti M., Sonzogni A., Mandato C., D'Antiga L., Di Giorgio, A, Sciveres, M, Fuoti, M, Sonzogni, A, Mandato, C, D'Antiga, L, Di Giorgio A., Sciveres M., Fuoti M., Sonzogni A., Mandato C., and D'Antiga L.
- Published
- 2023
3. Thrombotic Features as the Primary Cause of SARS-CoV-2 Related Acute Abdomen in Children
- Author
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Amoroso, A, Di Stasio, F, Ranucci, G, Betalli, P, Cheli, M, Dalla Rosa, D, D'Anna, C, Gaglione, G, Giannotti, G, Licini, L, Mandato, C, Massazza, G, Orlando, F, Morotti, D, Rocco, M, Sonzogni, A, Tipo, V, Verdoni, L, D'Antiga, L, Norsa, L, Amoroso A., Di Stasio F., Ranucci G., Betalli P., Cheli M., Dalla Rosa D., D'anna C., Gaglione G., Giannotti G., Licini L., Mandato C., Massazza G., Orlando F., Morotti D., Rocco M., Sonzogni A., Tipo V., Verdoni L., D'antiga L., Norsa L., Amoroso, A, Di Stasio, F, Ranucci, G, Betalli, P, Cheli, M, Dalla Rosa, D, D'Anna, C, Gaglione, G, Giannotti, G, Licini, L, Mandato, C, Massazza, G, Orlando, F, Morotti, D, Rocco, M, Sonzogni, A, Tipo, V, Verdoni, L, D'Antiga, L, Norsa, L, Amoroso A., Di Stasio F., Ranucci G., Betalli P., Cheli M., Dalla Rosa D., D'anna C., Gaglione G., Giannotti G., Licini L., Mandato C., Massazza G., Orlando F., Morotti D., Rocco M., Sonzogni A., Tipo V., Verdoni L., D'antiga L., and Norsa L.
- Abstract
Objectives: We performed a retrospective case control study to evaluate the histological characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive pediatric patients undergoing laparoscopic exploration for acute abdomen symptoms. To our knowledge this is the first study that analyzes histopathological characteristics of abdominal tissues in SARS-CoV-2 children. Study design: We enrolled 8 multisystem inflammatory syndrome in children (MIS-C) patients and 4 SARS-CoV-2 positive patients who underwent intestinal resection versus 36 control appendectomies from 2 pediatric tertiary referral centers between March 2020 and July 2021. Surgical resection samples were evaluated on several histological sections focusing on general inflammatory pattern and degree of inflammation. Peculiar histological features (endotheliitis and vascular thrombosis) were semi-quantitatively scored respectively in capillary, veins, and arteries. Results: All SARS-CoV-2 related surgical samples showed thrombotic patterns. Those patterns were significantly less frequent in SARS-CoV-2 negative appendectomies (P = 0.004). The semi-quantitative score of thrombosis was significantly higher (P = 0.002) in patients with SARS-CoV-2 related procedures. Conclusions: Our results showed that SARS-CoV-2 can cause thrombotic damage in abdominal tissues both in the acute phase of the infection (SARS-CoV-2 related appendectomies) and secondary to cytokine storm (MIS-C).
- Published
- 2023
4. Humanization of care in pediatric wards: differences between perceptions of users and staff according to department type
- Author
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Mandato, C., Siano, M. A., De Anseris, A. G. E., Tripodi, M., Massa, G., De Rosa, R., Buffoli, M., Lamanna, A., Siani, P., and Vajro, P.
- Published
- 2020
- Full Text
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5. Global multi-stakeholder endorsement of the MAFLD definition
- Author
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Mendez-Sanchez, N, Bugianesi, E, Gish, R, Lammert, F, Tilg, H, Nguyen, M, Sarin, S, Fabrellas, N, Zelber-Sagi, S, Fan, J, Shiha, G, Targher, G, Zheng, M, Chan, W, Vinker, S, Kawaguchi, T, Castera, L, Yilmaz, Y, Korenjak, M, Spearman, C, Ungan, M, Palmer, M, El-Shabrawi, M, Gruss, H, Dufour, J, Dhawan, A, Wedemeyer, H, George, J, Valenti, L, Fouad, Y, Romero-Gomez, M, Eslam, M, Abate, M, Abbas, B, Abbassy, A, Abd El Ghany, W, Abd Elkhalek, A, Abd ElMajeed, E, Abdalgaber, M, Abdallah, M, Abdallah, N, Abdelaleem, S, Abdelghani, Y, Abdelghany, W, Abdelhalim, S, Abdelhamid, W, Abdelhamid, N, Abdelkader, N, Abdelkreem, E, Abdelmohsen, A, Abdelrahman, A, Abd-elsalam, S, Abdeltawab, D, Abduh, A, Abdulhakam, N, Abdulla, M, Abedpoor, N, Abenavoli, L, Aberg, F, Ablack, O, Abo elftouh, M, Abo-Amer, Y, Aboubkr, A, Aboud, A, Abouelnaga, A, Aboufarrag, G, Aboutaleb, A, Abundis, L, Adali, G, Adames, E, Adams, L, Adda, D, Adel, N, Adel Sayed, M, Afaa, T, Afredj, N, Aghayeva, G, Aghemo, A, Aguilar-Salinas, C, Ahlenstiel, G, Ahmady, W, Ahmed, W, Ahmed, A, Ahmed, S, Ahmed, H, Ahmed, R, Aigner, E, Akarsu, M, Akroush, M, Akyuz, U, Al Mahtab, M, Al Qadiri, T, Al Rawahi, Y, AL rubaee, R, Al Saffar, M, Alam, S, Al-Ani, Z, Albillos, A, Alboraie, M, Al-Busafi, S, Al-Emam, M, Alharthi, J, Ali, K, Ali, B, Ali, M, Ali, R, Alisi, A, AL-Khafaji, A, Alkhatry, M, Aller, R, Almansoury, Y, Al-Naamani, K, Alnakeeb, A, Alonso, A, Alqahtani, S, Alrabadi, L, Alswat, K, Altaher, M, Altamimi, T, Altamirano, J, Alvares-da-Silva, M, Aly, E, Alzahaby, A, Alzamzamy, A, Amano, K, Amer, M, Amin, M, Amin, S, Amir, A, Ampuero, J, Anas, N, Andreone, P, Andriamandimby, S, Anees, M, Angela, P, Antonios, M, Arafat, W, Araya, J, Armendariz-Borunda, J, Armstrong, M, Ashktorab, H, Aspichueta, P, Assal, F, Atef, M, Attia, D, Atwa, H, Awad, R, Awad, M, Awny, S, Awolowo, O, Awuku, Y, Ayada, I, Aye, T, Ayman, S, Ayman, H, Ayoub, H, Azmy, H, Babaran, R, Badreldin, O, Badry, A, Bahcecioglu, I, Bahour, A, Bai, J, Balaban, Y, Balasubramanyam, M, Bamakhrama, K, Banales, J, Bangaru, B, Bao, J, Barahona, J, Barakat, S, Barbalho, S, Barbra, B, Barranco, B, Barrera, F, Baumann, U, Bazeed, S, Bech, E, Benayad, A, Benesic, A, Bernstein, D, Bessone, F, Birney, S, Bisseye, C, Blake, M, Bobat, B, Bonfrate, L, Bordin, D, Bosques-Padilla, F, Boursier, J, Boushab, B, Bowen, D, Bravo, P, Brennan, P, Bright, B, Broekaert, I, Buque, X, Burgos-Santamaria, D, Burman, J, Busetto, L, Byrne, C, Cabral-Prodigalidad, P, Cabrera-Alvarez, G, Cai, W, Cainelli, F, Caliskan, A, Canbay, A, Cano-Contreras, A, Cao, H, Cao, Z, Carrion, A, Carubbi, F, Casanovas, T, Castellanos Fernandez, M, Chai, J, Chan, S, Charatcharoenwitthaya, P, Chavez-Tapia, N, Chayama, K, Chen, J, Chen, L, Chen, Z, Chen, H, Chen, S, Chen, Q, Chen, Y, Chen, G, Chen, E, Chen, F, Chen, P, Cheng, R, Cheng, W, Chieh, J, Chokr, I, Cholongitas, E, Choudhury, A, Chowdhury, A, Chukwudike, E, Ciardullo, S, Clayton, M, Clement, K, Cloa, M, Coccia, C, Collazos, C, Colombo, M, Cosar, A, Cotrim, H, Couillerot, J, Coulibaly, A, Crespo, G, Crespo, J, Cruells, M, Cua, I, Dabbous, H, Dalekos, G, D'Alia, P, Dan, L, Dao, V, Darwish, M, Datz, C, Davalos-Moscol, M, Dawoud, H, de Careaga, B, de Knegt, R, de Ledinghen, V, de Silva, J, Debzi, N, Decraecker, M, Del Pozo, E, Delgado, T, Delgado-Blanco, M, Dembinski, L, Depina, A, Derbala, M, Desalegn, H, Desbois-Mouthon, C, Desoky, M, Dev, A, Di Ciaula, A, Diago, M, Diallo, I, Diaz, L, Dirchwolf, M, Dongiovanni, P, Dorofeyev, A, Dou, X, Douglas, M, Doulberis, M, Dovia, C, Doyle, A, Dragojevic, I, Drenth, J, Duan, X, Dulskas, A, Dumitrascu, D, Duncan, O, Dusabejambo, V, Dwawhi, R, Eiketsu, S, El Amrousy, D, El Deeb, A, El Deriny, G, El Din, H, El Kamshishy, S, El Kassas, M, El Raziky, M, Elagamy, O, Elakel, W, Elalfy, D, Elaraby, H, Elawady, H, Elbadawy, R, Eldash, H, Eldefrawy, M, Elecharri, C, Elfaramawy, A, Elfatih, M, Elfiky, M, Elgamsy, M, Elgendy, M, El-Guindi, M, Elhussieny, N, Eliwa, A, Elkabbany, Z, El-Khayat, H, El-Koofy, N, Elmetwalli, A, Elrabat, A, El-Raey, F, Elrashdy, F, Elsahhar, M, Elsaid, E, Elsayed, S, Elsayed, H, Elsayed, A, El-Serafy, M, Elsharkawy, A, Elsheemy, R, Elshemy, E, Elsherbini, S, Eltoukhy, N, Elwakil, R, Emad, O, Emad, S, Embabi, M, Ergenc, I, Ermolova, T, Esmat, G, Esmat, D, Estupinan, E, Ettair, S, Eugen, T, Ezz-Eldin, M, Falcon, L, Fan, Y, Fandari, S, Farag, M, Farahat, T, Fares, E, Fares, M, Fassio, E, Fathy, H, Fathy, D, Fathy, W, Fayed, S, Feng, D, Feng, G, Fernandez-Bermejo, M, Ferreira, C, Ferrer, J, Forbes, A, Fouad, R, Fouad, H, Frisch, T, Fujii, H, Fukunaga, S, Fukunishi, S, Fulya, H, Furuhashi, M, Gaber, Y, Galang, A, Gallardo, J, Galloso, R, Gamal, M, Gamal, R, Gamal, H, Gan, J, Ganbold, A, Gao, X, Garas, G, Garba, T, Garcia-Cortes, M, Garcia-Monzon, C, Garcia-Samaniego, J, Gastaldelli, A, Gatica, M, Gatley, E, Gegeshidze, T, Geng, B, Ghazinyan, H, Ghoneem, S, Giacomelli, L, Giannelli, G, Giannini, E, Giefer, M, Gines, P, Girala, M, Giraudi, P, Goh, G, Gomaa, A, Gong, B, Gonzales, D, Gonzalez, H, Gonzalez-Huezo, M, Graupera, I, Grgurevic, I, Gronbaek, H, Gu, X, Guan, L, Gueye, I, Guingane, A, Gul, O, Gul, C, Guo, Q, Gupta, P, Gurakar, A, Gutierrez, J, Habib, G, Hafez, A, Hagman, E, Halawa, E, Hamdy, O, Hamed, A, Hamed, D, Hamid, S, Hamoudi, W, Han, Y, Haridy, J, Haridy, H, Harris, D, Hart, M, Hasan, F, Hashim, A, Hassan, I, Hassan, A, Hassan, E, Hassan, M, Hassanin, F, Hassnine, A, Haukeland, J, Hawal, A, He, J, He, Q, He, Y, He, F, Hegazy, M, Hegazy, A, Henegil, O, Hernandez, N, Hernandez-Guerra, M, Higuera-de-la-Tijera, F, Hindy, I, Hirota, K, Ho, L, Hodge, A, Hosny, M, Hou, X, Huang, J, Huang, Y, Huang, Z, Huang, A, Huang, X, Hui-ping, S, Hunyady, B, Hussein, M, Hussein, O, Hussien, S, Ibanez-Samaniego, L, Ibdah, J, Ibrahim, L, Ibrahim, M, Ibrahim, I, Icaza-Chavez, M, Idelbi, S, Idilman, R, Ikeda, M, Indolfi, G, Invernizzi, F, Irshad, I, Isa, H, Iskandar, N, Ismaiel, A, Ismail, M, Ismail, Z, Ismail, F, Iwamoto, H, Jack, K, Jacob, R, Jafarov, F, Jafri, W, Jahshan, H, Jalal, P, Jancoriene, L, Janicko, M, Jayasena, H, Jefferies, M, Jha, V, Ji, F, Ji, Y, Jia, J, Jiang, C, Jiang, N, Jiang, Z, Jin, X, Jin, Y, Jing, X, Jingyu, Q, Jinjolava, M, Jong, F, Jucov, A, Julius, I, Kaddah, M, Kamada, Y, Kamal, A, Kamal, E, Kamel, A, Kao, J, Karin, M, Karlas, T, Kashwaa, M, Katsidzira, L, Kaya, E, Kayasseh, M, Keenan, B, Keklikkiran, C, Keml, W, Khalaf, D, Khalefa, R, Khamis, S, Khater, D, Khattab, H, Khavkin, A, Khlynova, O, Khmis, N, Kobyliak, N, Koffas, A, Koike, K, Kok, K, Koller, T, Komas, N, Korochanskaya, N, Koulla, Y, Koya, S, Kraft, C, Kraja, B, Krawczyk, M, Kuchay, M, Kulkarni, A, Kumar, A, Kumar, M, Lakoh, S, Lam, P, Lan, L, Lange, N, Lankarani, K, Lanthier, N, Lapshyna, K, Lashen, S, Laure, K, Lazebnik, L, Lebrec, D, Lee, S, Lee, W, Lee, Y, Leeming, D, Leite, N, Leon, R, Lesmana, C, Li, J, Li, Q, Li, Y, Li, L, Li, M, Liang, H, Lijuan, T, Lim, S, Lim, L, Lin, S, Lin, H, Lin, R, Lithy, R, Liu, Y, Liu, X, Liu, W, Liu, S, Liu, K, Liu, T, Lonardo, A, Lopez, M, Lopez-Benages, E, Lopez-Jaramillo, P, Lu, H, Lu, L, Lu, Y, Lubel, J, Lui, R, Lupasco, I, Luzina, E, Lv, X, Lynch, K, Ma, H, Machado, M, Maduka, N, Madzharova, K, Magdaong, R, Mahadeva, S, Mahfouz, A, Mahmood, N, Mahmoud, E, Mahrous, M, Maiwall, R, Majeed, A, Majumdar, A, Mak, L, Maklouf, M, Malekzadeh, R, Mandato, C, Mangia, A, Mann, J, Mansour, H, Mansouri, A, Mantovani, A, Mao, J, Maramag, F, Marchesini, G, Marcus, C, Marinho, R, Martinez-Chantar, M, Martins, A, Marwan, R, Mason, K, Masoud, G, Massoud, M, Matamoros, M, Mateos, R, Mawed, A, Mbanya, J, Mbendi, C, Mccolaugh, L, Mcleod, D, Medina, J, Megahed, A, Mehrez, M, Memon, I, Merat, S, Mercado, R, Mesbah, A, Meskini, T, Metwally, M, Metwaly, R, Miao, L, Micah, E, Miele, L, Milivojevic, V, Milovanovic, T, Mina, Y, Mishkovik, M, Mishriki, A, Mitchell, T, Mohamed, A, Mohamed, M, Mohamed, S, Mohammed, S, Mohammed, A, Mohan, V, Mohie, S, Mokhtar, A, Moniem, R, Montilla, M, Morales, J, Morata, M, Moreno-Planas, J, Morise, S, Mosaad, S, Moselhy, M, Mostafa, A, Mostafa, E, Mouane, N, Mousa, N, Moustafa, H, Msherif, A, Muller, K, Munoz, C, Munoz-Urribarri, A, Murillo, O, Mustapha, F, Muzurovic, E, Nabil, Y, Nafady, S, Nagamatsu, A, Nakajima, A, Nakano, D, Nan, Y, Nascimbeni, F, Naseef, M, Nashat, N, Natalia, T, Negro, F, Nersesov, A, Neuman, M, Ng'Wanasayi, M, Ni, Y, Nicoll, A, Niizeki, T, Nikolova, D, Ningning, W, Niriella, M, Nogoibaeva, K, Nordien, R, O Sullivan, C, O'Beirne, J, Obekpa, S, Ocama, P, Ochwoto, M, Ogolodom, M, Ojo, O, Okrostsvaridze, N, Oliveira, C, Omana, R, Omar, O, Omar, H, Omar, M, Omran, S, Omran, R, Osman, M, Owise, N, Owusu-Ansah, T, Padilla- Machaca, P, Palle, S, Pan, Z, Pan, X, Pan, Q, Papaefthymiou, A, Paquissi, F, Par, G, Parkash, A, Payawal, D, Peltekian, K, Peng, X, Peng, L, Peng, Y, Pengoria, R, Perez, M, Perez, J, Perez, N, Persico, M, Pessoa, M, Petta, S, Philip, M, Plaz Torres, M, Polavarapu, N, Poniachik, J, Portincasa, P, Pu, C, Purnak, T, Purwanto, E, Qi, X, Qian, Z, Qiang, Z, Qiao, Z, Qiao, L, Queiroz, A, Rabiee, A, Radwan, M, Rahetilahy, A, Ramadan, Y, Ramadan, D, Ramli, A, Ramm, G, Ran, A, Rankovic, I, Rao, H, Raouf, S, Ray, S, Reau, N, Refaat, A, Reiberger, T, Remes-Troche, J, Reyes, E, Richardson, B, Ridruejo, E, Riestra Jimenez, S, Rizk, I, Roberts, S, Roblero, J, Robles, J, Rockey, D, Rodriguez, M, Rodriguez Hernandez, H, Roman, E, Romeiro, F, Romeo, S, Rosales-Zabal, J, Roshdi, G, Rosso, N, Ruf, A, Ruiz, P, Runes, N, Ruzzenente, A, Ryan, M, Saad, A, Sabbagh, E, Sabbah, M, Saber, S, Sabrey, R, Sabry, R, Saeed, M, Said, D, Said, E, Sakr, M, Salah, Y, Salama, R, Salama, A, Saleh, H, Saleh, A, Salem, A, Salifou, A, Salih, A, Salman, A, Samouda, H, Sanai, F, Sanchez-Avila, J, Sanker, L, Sano, T, Sanz, M, Saparbu, T, Sawhney, R, Sayed, F, Sayed, S, Sayed, A, Sayed, M, Sebastiani, G, Secadas, L, Sediqi, K, Seif, S, Semida, N, Senates, E, Serban, E, Serfaty, L, Seto, W, Sghaier, I, Sha, M, Shabaan, H, Shalaby, L, Shaltout, I, Sharara, A, Sharma, V, Shawa, I, Shawkat, A, Shawky, N, Shehata, O, Sheils, S, Shewaye, A, Shi, G, Shi, J, Shimose, S, Shirono, T, Shou, L, Shrestha, A, Shui, G, Sievert, W, Sigurdardottir, S, Sira, M, Siradj, R, Sison, C, Smyth, L, Soliman, R, Sollano, J, Sombie, R, Sonderup, M, Sood, S, Soriano, G, Stedman, C, Stefanyuk, O, Stimac, D, Strasser, S, Strnad, P, Stuart, K, Su, W, Su, M, Sumida, Y, Sumie, S, Sun, D, Sun, J, Suzuki, H, Svegliati-Baroni, G, Swar, M, Taharboucht, S, Taher, Z, Takamura, S, Tan, L, Tan, S, Tanwandee, T, Tarek, S, Tatiana, G, Tavaglione, F, Tecson, G, Tee, H, Teschke, R, Tharwat, M, Thong, V, Thursz, M, Tine, T, Tiribelli, C, Tolmane, I, Tong, J, Tongo, M, Torkie, M, Torre, A, Torres, E, Trajkovska, M, Treeprasertsuk, S, Tsutsumi, T, Tu, T, Tur, J, Turan, D, Turcan, S, Turkina, S, Tutar, E, Tzeuton, C, Ugiagbe, R, Uygun, A, Vacca, M, Vajro, P, Van der Poorten, D, Van Kleef, L, Vashakidze, E, Velazquez, C, Velazquez, M, Vento, S, Verhoeven, V, Vespasiani-Gentilucci, U, Vethakkan, S, Vilaseca, J, Vitek, L, Volkanovska, A, Wallace, M, Wan, W, Wang, Y, Wang, X, Wang, C, Wang, M, Wangchuk, P, Weltman, M, White, M, Wiegand, J, Wifi, M, Wigg, A, Wilhelmi, M, William, R, Wittenburg, H, Wu, S, Wubeneh, A, Xia, H, Xiao, J, Xiao, X, Xiaofeng, W, Xiong, W, Xu, L, Xu, J, Xu, W, Xu, K, Xu, Y, Xu, S, Xu, M, Xu, A, Xu, C, Yan, H, Yang, J, Yang, R, Yang, Y, Yang, Q, Yang, N, Yao, J, Yara, J, Yaras, S, Yilmaz, N, Younes, R, Younes, H, Young, S, Youssef, F, Yu, Y, Yu, M, Yuan, J, Yue, Z, Yuen, M, Yun, W, Yurukova, N, Zakaria, S, Zaky, S, Zaldastanishvili, M, Zapata, R, Zare, N, Zerem, E, Zeriban, N, Zeshuai, X, Zhang, H, Zhang, X, Zhang, Y, Zhang, W, Zhang, Z, Zhao, J, Zhao, R, Zhao, H, Zheng, C, Zheng, Y, Zheng, R, Zheng, T, Zheng, K, Zhou, X, Zhou, Y, Zhou, H, Zhou, L, Zhu, L, Zhu, Y, Zhu, P, Ziada, E, Ziring, D, Ziyi, L, Zou, S, Zou, Z, Zou, H, Zuart Ruiz, R, Mendez-Sanchez N., Bugianesi E., Gish R. G., Lammert F., Tilg H., Nguyen M. H., Sarin S. K., Fabrellas N., Zelber-Sagi S., Fan J. -G., Shiha G., Targher G., Zheng M. -H., Chan W. -K., Vinker S., Kawaguchi T., Castera L., Yilmaz Y., Korenjak M., Spearman C. W., Ungan M., Palmer M., El-Shabrawi M., Gruss H. -J., Dufour J. -F., Dhawan A., Wedemeyer H., George J., Valenti L., Fouad Y., Romero-Gomez M., Eslam M., Abate M. L., Abbas B., Abbassy A. A., Abd El Ghany W., Abd Elkhalek A., Abd ElMajeed E., Abdalgaber M., AbdAllah M., Abdallah M., Abdallah N., Abdelaleem S., Abdelghani Y., Abdelghany W., Abdelhalim S. M., Abdelhamid W., Abdelhamid N., Abdelkader N. A., Abdelkreem E., Abdelmohsen A. M., Abdelrahman A. A., Abd-elsalam S. M., Abdeltawab D., Abduh A., Abdulhakam N., Abdulla M., Abedpoor N., Abenavoli L., Aberg F., Ablack O., Abo elftouh M., Abo-Amer Y. E. -E., Aboubkr A., Aboud A., Abouelnaga A. M., Aboufarrag G. A., Aboutaleb A., Abundis L., Adali G., Adames E., Adams L., Adda D., Adel N., Adel Sayed M., Afaa T. J., Afredj N., Aghayeva G., Aghemo A., Aguilar-Salinas C. A., Ahlenstiel G., Ahmady W., Ahmed W., Ahmed A., Ahmed S. N., Ahmed H. M., Ahmed R., Aigner E., Akarsu M., Akroush M., Akyuz U., Al Mahtab M., Al Qadiri T., Al Rawahi Y., AL rubaee R., Al Saffar M., Alam S., Al-Ani Z., Albillos A., Alboraie M., Al-Busafi S., Al-Emam M., Alharthi J., Ali K., Ali B. A., Ali M., Ali R. A. R., Alisi A., AL-Khafaji A. R., Alkhatry M., Aller R., Almansoury Y., Al-Naamani K., Alnakeeb A., Alonso A., Alqahtani S. A., Alrabadi L., Alswat K., Altaher M., Altamimi T., Altamirano J., Alvares-da-Silva M. R., Aly E. A. M., Alzahaby A., Alzamzamy A., Amano K., Amer M. A., Amin M. A., Amin S. A., Amir A. A., Ampuero J., Anas N., Andreone P., Andriamandimby S. F., Anees M., Angela P., Antonios M., Arafat W., Araya J. M., Armendariz-Borunda J., Armstrong M. J., Ashktorab H., Aspichueta P., Assal F., Atef M., Attia D., Atwa H., Awad R., Awad M. A. E., Awny S., Awolowo O., Awuku Y. A., Ayada I., Aye T. T., Ayman S., Ayman H., Ayoub H., Azmy H. M., Babaran R. P., Badreldin O., Badry A., Bahcecioglu I. H., Bahour A., Bai J., Balaban Y., Balasubramanyam M., Bamakhrama K., Banales J. M., Bangaru B., Bao J., Barahona J. S., Barakat S., Barbalho S. M., Barbra B., Barranco B., Barrera F., Baumann U., Bazeed S., Bech E., Benayad A., Benesic A., Bernstein D., Bessone F., Birney S., Bisseye C., Blake M., Bobat B., Bonfrate L., Bordin D. S., Bosques-Padilla F., Boursier J., Boushab B. M., Bowen D., Bravo P. M., Brennan P. N., Bright B., Broekaert I., Buque X., Burgos-Santamaria D., Burman J., Busetto L., Byrne C. D., Cabral-Prodigalidad P. A. I., Cabrera-Alvarez G., Cai W., Cainelli F., Caliskan A. R., Canbay A., Cano-Contreras A., Cao H. -X., Cao Z., Carrion A., Carubbi F., Casanovas T., Castellanos Fernandez M. I., Chai J., Chan S. P., Charatcharoenwitthaya P., Chavez-Tapia N., Chayama K., Chen J., Chen L., Chen Z. -W., Chen H., Chen S. -D., Chen Q., Chen Y., Chen G., Chen E. -Q., Chen F., Chen P. -J., Cheng R., Cheng W., Chieh J. T. W., Chokr I., Cholongitas E., Choudhury A., Chowdhury A., Chukwudike E. S., Ciardullo S., Clayton M., Clement K., Cloa M. M., Coccia C., Collazos C., Colombo M., Cosar A. M., Cotrim H. P., Couillerot J., Coulibaly A., Crespo G., Crespo J., Cruells M., Cua I. H. Y., Dabbous H. K., Dalekos G. N., D'Alia P., Dan L., Dao V. H., Darwish M., Datz C., Davalos-Moscol M. B., Dawoud H., de Careaga B. O., de Knegt R., de Ledinghen V., de Silva J., Debzi N., Decraecker M., Del Pozo E., Delgado T. C., Delgado-Blanco M., Dembinski L., Depina A., Derbala M., Desalegn H., Desbois-Mouthon C., Desoky M., Dev A., Di Ciaula A., Diago M., Diallo I., Diaz L. A., Dirchwolf M., Dongiovanni P., Dorofeyev A., Dou X., Douglas M. W., Doulberis M., Dovia C. K., Doyle A., Dragojevic I., Drenth J. P., Duan X., Dulskas A., Dumitrascu D. L., Duncan O., Dusabejambo V., Dwawhi R. S. N. A., Eiketsu S., El Amrousy D., El Deeb A., El Deriny G., El Din H. S., El Kamshishy S., El Kassas M., El Raziky M., Elagamy O. A., Elakel W., Elalfy D., Elaraby H., ElAwady H., Elbadawy R., Eldash H. H., Eldefrawy M. S., Elecharri C. L., Elfaramawy A., Elfatih M., Elfiky M., Elgamsy M., Elgendy M., El-Guindi M. A., Elhussieny N., Eliwa A. M., Elkabbany Z., El-Khayat H., El-Koofy N. M., Elmetwalli A., Elrabat A., El-Raey F., Elrashdy F., Elsahhar M., Elsaid E. M., Elsayed S., Elsayed H., Elsayed A., Elsayed A. M., El-Serafy M., Elsharkawy A. M., Elsheemy R. Y., Elshemy E. E., Elsherbini S., Eltoukhy N., Elwakil R., Emad O., Emad S., Embabi M., Ergenc I., Ermolova T., Esmat G., Esmat D. M., Estupinan E. C., Ettair S., Eugen T., Ezz-Eldin M., Falcon L. P. V., Fan Y. -C., Fandari S., Farag M., Farahat T. M., Fares E. M., Fares M., Fassio E., Fathy H., Fathy D., Fathy W., Fayed S., Feng D., Feng G., Fernandez-Bermejo M., Ferreira C. T., Ferrer J. D., Forbes A., Fouad R., Fouad H. M., Frisch T., Fujii H., Fukunaga S., Fukunishi S., Fulya H., Furuhashi M., Gaber Y., Galang A. J. G., Gallardo J. C., Galloso R., Gamal M., Gamal R., Gamal H., Gan J., Ganbold A., Gao X., Garas G., Garba T., Garcia-Cortes M., Garcia-Monzon C., Garcia-Samaniego J., Gastaldelli A., Gatica M., Gatley E., Gegeshidze T., Geng B., Ghazinyan H., Ghoneem S., Giacomelli L., Giannelli G., Giannini E. G., Giefer M., Gines P., Girala M., Giraudi P. J., Goh G. B. -B., Gomaa A. A., Gong B., Gonzales D. H. C., Gonzalez H. C., Gonzalez-Huezo M. S., Graupera I., Grgurevic I., Gronbaek H., Gu X., Guan L., Gueye I., Guingane A. N., Gul O. O., Gul C. B., Guo Q., Gupta P. P., Gurakar A., Gutierrez J. C. R., Habib G., Hafez A., Hagman E., Halawa E., Hamdy O., Hamed A. E., Hamed D. H., Hamid S., Hamoudi W., Han Y., Haridy J., Haridy H., Harris D. C. H. H., Hart M., Hasan F., Hashim A., Hassan I., Hassan A., Hassan E. A., Hassan A. A., Hassan M. S., Hassanin F., Hassnine A., Haukeland J. W., Hawal A. I. M., He J., He Q., He Y., He F. -P., Hegazy M., Hegazy A., Henegil O., Hernandez N., Hernandez-Guerra M., Higuera-de-la-Tijera F., Hindy I., Hirota K., Ho L. C., Hodge A., Hosny M., Hou X., Huang J. -F., Huang Y., Huang Z., Huang A., Huang X. -P., Hui-ping S., Hunyady B., Hussein M. A., Hussein O., Hussien S. M., Ibanez-Samaniego L., Ibdah J., Ibrahim L., Ibrahim M., Ibrahim I., Icaza-Chavez M. E., Idelbi S., Idilman R. I., Ikeda M., Indolfi G., Invernizzi F., Irshad I., Isa H. M. A., Iskandar N. J., Ismaiel A., Ismail M., Ismail Z., Ismail F., Iwamoto H., Jack K., Jacob R., Jafarov F., Jafri W., Jahshan H., Jalal P. K., Jancoriene L., Janicko M., Jayasena H., Jefferies M., Jha V., Ji F., Ji Y., Jia J., Jiang C., Jiang N., Jiang Z. -Z., Jin X., Jin Y., Jing X., Jingyu Q., Jinjolava M., Jong F. H. H., Jucov A., Julius I., Kaddah M., Kamada Y., kamal A., Kamal E. M., Kamel A. S., Kao J. -H., Karin M., Karlas T., Kashwaa M., Katsidzira L., Kaya E., Kayasseh M. A., Keenan B., Keklikkiran C., Keml W., Khalaf D. K., Khalefa R., Khamis S., Khater D., khattab H., Khavkin A., Khlynova O., Khmis N., Kobyliak N., Koffas A., Koike K., Kok K. Y. Y., Koller T., Komas N. P., Korochanskaya N. V., Koulla Y., Koya S., Kraft C., Kraja B., Krawczyk M., Kuchay M. S., Kulkarni A. V., Kumar A., Kumar M., Lakoh S., Lam P., Lan L., Lange N. F., Lankarani K. B., Lanthier N., Lapshyna K., Lashen S. A., Laure K. N. J., Lazebnik L., Lebrec D., Lee S. S., Lee W. S., Lee Y. Y., Leeming D. J., Leite N. C., Leon R., Lesmana C. R. A., Li J., Li Q., Li Y. -Y., Li Y., Li L., Li M., li Y., Liang H., Lijuan T., Lim S. 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G., Lim L. -L., Lin S., Lin H. -C., Lin R., Lithy R., Liu Y., Liu X., Liu W. -Y., Liu S., Liu K., Liu T., Lonardo A., Lopez M. B., Lopez-Benages E., Lopez-Jaramillo P., Lu H., Lu L. G., Lu Y., Lubel J., Lui R., Lupasco I., Luzina E., Lv X. -H., Lynch K., Ma H. -L., Machado M. V., Maduka N., Madzharova K., Magdaong R., Mahadeva S., Mahfouz A., Mahmood N. R. K. N., Mahmoud E., Mahrous M., Maiwall R., Majeed A., Majumdar A., Mak L., Maklouf M. M., Malekzadeh R., Mandato C., Mangia A., Mann J., Mansour H. H., Mansouri A., Mantovani A., Mao J. Q., Maramag F., Marchesini G., Marcus C., Marinho R. A. R. T., Martinez-Chantar M. L., Martins A. A. S., Marwan R., Mason K. F., Masoud G., Massoud M. N., Matamoros M. A., Mateos R. M., Mawed A., Mbanya J. C., Mbendi C., McColaugh L., McLeod D., Medina J. F. R., Megahed A., Mehrez M., Memon I., Merat S., Mercado R., Mesbah A., Meskini T., Metwally M., Metwaly R., Miao L., Micah E., Miele L., Milivojevic V., Milovanovic T., Mina Y. L., Mishkovik M., Mishriki A., Mitchell T., Mohamed A., Mohamed M., Mohamed S., Mohammed S., Mohammed A., Mohan V., Mohie S., Mokhtar A., Moniem R., Montilla M. S., Morales J. A. O., Morata M. M. S., Moreno-Planas J. M., Morise S., Mosaad S., Moselhy M., Mostafa A. M., Mostafa E., Mouane N., Mousa N., Moustafa H. M., Msherif A., Muller K., Munoz C., Munoz-Urribarri A. B., Murillo O. A., Mustapha F. I., Muzurovic E., Nabil Y., Nafady S., Nagamatsu A., Nakajima A., Nakano D., Nan Y., Nascimbeni F., Naseef M. S., Nashat N., Natalia T., Negro F., Nersesov A. V., Neuman M., Ng'wanasayi M., Ni Y., Nicoll A., Niizeki T., Nikolova D., Ningning W., Niriella M., Nogoibaeva K. A., Nordien R., O Sullivan C., O'Beirne J., Obekpa S., Ocama P., Ochwoto M., Ogolodom M. P., Ojo O., Okrostsvaridze N., Oliveira C. P., Omana R. C., Omar O. M., Omar H., Omar M., Omran S., Omran R., Osman M. M., Owise N., Owusu-Ansah T., Padilla- Machaca P. M., Palle S., Pan Z., Pan X. -Y., Pan Q., Papaefthymiou A., Paquissi F. C., Par G., Parkash A., Payawal D., Peltekian K. M., Peng X., Peng L., Peng Y., Pengoria R., Perez M., Perez J. L., Perez N. M., Persico M., Pessoa M. G., Petta S., Philip M., Plaz Torres M. C., Polavarapu N., Poniachik J., Portincasa P., Pu C., Purnak T., Purwanto E., Qi X., Qian Z., Qiang Z., Qiao Z., Qiao L., Queiroz A., Rabiee A., Radwan M., Rahetilahy A. M., Ramadan Y., Ramadan D., Ramli A. S., Ramm G. A., Ran A., Rankovic I., RAO H., Raouf S., Ray S., Reau N., Refaat A., Reiberger T., Remes-Troche J. M., Reyes E. C., Richardson B., Ridruejo E., Riestra Jimenez S., Rizk I., Roberts S., Roblero J. P., Robles J. A. P., Rockey D., Rodriguez M., Rodriguez Hernandez H., Roman E., Romeiro F. G., Romeo S., Rosales-Zabal J. M., Roshdi G. R., Rosso N., Ruf A., Ruiz P. C., Runes N. R., Ruzzenente A., Ryan M., Saad A., Sabbagh E. B., Sabbah M., Saber S., Sabrey R., Sabry R., Saeed M. A., Said D., Said E. M., Sakr M. A., Salah Y., Salama R. M., Salama A., Saleh H., Saleh A., Salem A., Salem A. T., Salifou A., Salih A. F., Salman A., Samouda H., Sanai F., Sanchez-Avila J. F., Sanker L., Sano T., Sanz M., Saparbu T., Sawhney R., Sayed F., Sayed S. A., Sayed A. O., Sayed M., Sebastiani G., Secadas L., Sediqi K. Q., Seif S., Semida N., Senates E., Serban E. D., Serfaty L., Seto W. -K., Sghaier I., Sha M., Shabaan H. M., Shalaby L., Shaltout I., Sharara A. I., Sharma V., Shawa I. T., Shawkat A., Shawky N., Shehata O., Sheils S., Shewaye A. B., Shi G., Shi J., Shimose S., Shirono T., Shou L., Shrestha A., Shui G., Sievert W., Sigurdardottir S., Sira M. M., Siradj R., Sison C., Smyth L., Soliman R., Sollano J. D., Sombie R., Sonderup M., Sood S., Soriano G., Stedman C. A. M., Stefanyuk O., Stimac D., Strasser S., Strnad P., Stuart K., Su W., Su M., Sumida Y., Sumie S., Sun D. -Q., Sun J., Suzuki H., Svegliati-Baroni G., Swar M. O., TAHARBOUCHT S., Taher Z., Takamura S., Tan L., Tan S. -S., Tanwandee T., Tarek S., Tatiana G., Tavaglione F., Tecson G. Y., Tee H. -P., Teschke R., Tharwat M., Thong V. D., Thursz M., Tine T., Tiribelli C., Tolmane I., Tong J., Tongo M., Torkie M., Torre A., Torres E. A., Trajkovska M., Treeprasertsuk S., Tsutsumi T., Tu T., Tur J. A., Turan D., Turcan S., Turkina S., Tutar E., Tzeuton C., Ugiagbe R., Uygun A., Vacca M., Vajro P., Van der Poorten D., Van Kleef L. A., Vashakidze E., Velazquez C. M., Velazquez M. I., Vento S., Verhoeven V., Vespasiani-Gentilucci U., Vethakkan S. R., Vilaseca J., Vitek L., Volkanovska A., Wallace M., Wan W., Wang Y., Wang X., Wang C., Wang M., Wangchuk P., Weltman M., White M., Wiegand J., Wifi M. -N., Wigg A., Wilhelmi M., William R., Wittenburg H., Wu S., Wubeneh A. M., Xia H., Xiao J., Xiao X., Xiaofeng W., Xiong W., Xu L., Xu J., Xu W., Xu J. -H., Xu K., Xu Y., Xu S. -H., Xu M., Xu A., Xu C., Yan H., Yang J., Yang R. -X., Yang Y., Yang Q., Yang N., Yao J., Yara J., Yaras S., Yilmaz N., Younes R., younes H., Young S., Youssef F., Yu Y., Yu M. -L., Yuan J., Yue Z., Yuen M. -F., Yun W., Yurukova N., Zakaria S., Zaky S., Zaldastanishvili M., Zapata R., Zare N., Zerem E., Zeriban N., Zeshuai X., Zhang H., Zhang X., Zhang Y., Zhang W. -H., Zhang Y. -P., Zhang Z. -Q., Zhao J., Zhao R. -R., Zhao H., Zheng C., Zheng Y., Zheng R., Zheng T. -L., Zheng K., Zhou X. Q., Zhou Y., Zhou Y. -J., Zhou H., Zhou L., Zhu L. D., Zhu Y. F., Zhu Y., Zhu P. -W., Ziada E., Ziring D., Ziyi L., Zou S., Zou Z., Zou H., and Zuart Ruiz R.
- Published
- 2022
6. Italian children seem to be spared from the mysterious severe acute hepatitis outbreak: A report by SIGENP Acute Hepatitis Group
- Author
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Di Dato, F, Di Giorgio, A, Mandato, C, Maggiore, G, Iorio, R, Aloi, M, Antonucci, R, Banzato, C, Buccella, V, Calvo, P, Campanozzi, A, Cananzi, M, Cherubini, S, Cristofori, F, D'Antiga, L, Saccomani, M, De Giorgi, A, Dell'Omo, V, Ferrari, F, Francavilla, R, Fuoti, M, Gaio, P, Graziano, F, Indolfi, G, Inferrera, R, Madeo, A, Mesini, A, Moramarco, F, Motta, V, Parma, B, Pinon, M, Provera, S, Ranucci, G, Tulone, A, Valentini, P, Veraldi, S, Villirillo, A, Di Dato F., Di Giorgio A., Mandato C., Maggiore G., Iorio R., Aloi M., Antonucci R., Banzato C., Buccella V., Calvo P. L., Campanozzi A., Cananzi M., Cherubini S., Cristofori F., D'Antiga L., Saccomani M. D., De Giorgi A., Dell'Omo V., Ferrari F., Francavilla R., Fuoti M. G., Gaio P., Graziano F., Indolfi G., Inferrera R., Madeo A., Mesini A., Moramarco F., Motta V., Parma B., Pinon M., Provera S., Ranucci G., Tulone A., Valentini P., Veraldi S., Villirillo A., Di Dato, F, Di Giorgio, A, Mandato, C, Maggiore, G, Iorio, R, Aloi, M, Antonucci, R, Banzato, C, Buccella, V, Calvo, P, Campanozzi, A, Cananzi, M, Cherubini, S, Cristofori, F, D'Antiga, L, Saccomani, M, De Giorgi, A, Dell'Omo, V, Ferrari, F, Francavilla, R, Fuoti, M, Gaio, P, Graziano, F, Indolfi, G, Inferrera, R, Madeo, A, Mesini, A, Moramarco, F, Motta, V, Parma, B, Pinon, M, Provera, S, Ranucci, G, Tulone, A, Valentini, P, Veraldi, S, Villirillo, A, Di Dato F., Di Giorgio A., Mandato C., Maggiore G., Iorio R., Aloi M., Antonucci R., Banzato C., Buccella V., Calvo P. L., Campanozzi A., Cananzi M., Cherubini S., Cristofori F., D'Antiga L., Saccomani M. D., De Giorgi A., Dell'Omo V., Ferrari F., Francavilla R., Fuoti M. G., Gaio P., Graziano F., Indolfi G., Inferrera R., Madeo A., Mesini A., Moramarco F., Motta V., Parma B., Pinon M., Provera S., Ranucci G., Tulone A., Valentini P., Veraldi S., and Villirillo A.
- Published
- 2022
7. Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group
- Author
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Ranucci, G, Della Corte, C, Alberti, D, Bondioni, M, Boroni, G, Calvo, P, Cananzi, M, Candusso, M, Clemente, M, D'Antiga, L, Degrassi, I, De Ville De Goyet, J, Di Dato, F, Di Giorgio, A, Vici, C, Ferrari, F, Francalanci, P, Fuoti, M, Fusaro, F, Gaio, P, Grimaldi, C, Iascone, M, Indolfi, G, Iorio, R, Maggiore, G, Mandato, C, Matarazzo, L, Monti, L, Mosca, F, Nebbia, G, Nuti, F, Paolella, G, Pinon, M, Roggero, P, Sciveres, M, Serranti, D, Spada, M, Vajro, P, Nicastro, E, Ranucci G., Della Corte C., Alberti D., Bondioni M. P., Boroni G., Calvo P. L., Cananzi M., Candusso M., Clemente M. G., D'Antiga L., Degrassi I., De Ville De Goyet J., Di Dato F., Di Giorgio A., Vici C. D., Ferrari F., Francalanci P., Fuoti M., Fusaro F., Gaio P., Grimaldi C., Iascone M., Indolfi G., Iorio R., Maggiore G., Mandato C., Matarazzo L., Monti L., Mosca F., Nebbia G., Nuti F., Paolella G., Pinon M., Roggero P., Sciveres M., Serranti D., Spada M., Vajro P., Nicastro E., Ranucci, G, Della Corte, C, Alberti, D, Bondioni, M, Boroni, G, Calvo, P, Cananzi, M, Candusso, M, Clemente, M, D'Antiga, L, Degrassi, I, De Ville De Goyet, J, Di Dato, F, Di Giorgio, A, Vici, C, Ferrari, F, Francalanci, P, Fuoti, M, Fusaro, F, Gaio, P, Grimaldi, C, Iascone, M, Indolfi, G, Iorio, R, Maggiore, G, Mandato, C, Matarazzo, L, Monti, L, Mosca, F, Nebbia, G, Nuti, F, Paolella, G, Pinon, M, Roggero, P, Sciveres, M, Serranti, D, Spada, M, Vajro, P, Nicastro, E, Ranucci G., Della Corte C., Alberti D., Bondioni M. P., Boroni G., Calvo P. L., Cananzi M., Candusso M., Clemente M. G., D'Antiga L., Degrassi I., De Ville De Goyet J., Di Dato F., Di Giorgio A., Vici C. D., Ferrari F., Francalanci P., Fuoti M., Fusaro F., Gaio P., Grimaldi C., Iascone M., Indolfi G., Iorio R., Maggiore G., Mandato C., Matarazzo L., Monti L., Mosca F., Nebbia G., Nuti F., Paolella G., Pinon M., Roggero P., Sciveres M., Serranti D., Spada M., Vajro P., and Nicastro E.
- Abstract
Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.
- Published
- 2022
8. Diagnostic Approach to Acute Liver Failure in Children: A Position Paper by the SIGENP Liver Disease Working Group
- Author
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Di Giorgio, A, Bartolini, E, Calvo, P, Cananzi, M, Cirillo, F, Della Corte, C, Dionisi-Vici, C, Indolfi, G, Iorio, R, Maggiore, G, Mandato, C, Nebbia, G, Nicastro, E, Pinon, M, Ranucci, G, Sciveres, M, Vajro, P, D'Antiga, L, Di Giorgio A., Bartolini E., Calvo P. L., Cananzi M., Cirillo F., Della Corte C., Dionisi-Vici C., Indolfi G., Iorio R., Maggiore G., Mandato C., Nebbia G., Nicastro E., Pinon M., Ranucci G., Sciveres M., Vajro P., D'Antiga L., Di Giorgio, A, Bartolini, E, Calvo, P, Cananzi, M, Cirillo, F, Della Corte, C, Dionisi-Vici, C, Indolfi, G, Iorio, R, Maggiore, G, Mandato, C, Nebbia, G, Nicastro, E, Pinon, M, Ranucci, G, Sciveres, M, Vajro, P, D'Antiga, L, Di Giorgio A., Bartolini E., Calvo P. L., Cananzi M., Cirillo F., Della Corte C., Dionisi-Vici C., Indolfi G., Iorio R., Maggiore G., Mandato C., Nebbia G., Nicastro E., Pinon M., Ranucci G., Sciveres M., Vajro P., and D'Antiga L.
- Abstract
Acute liver failure (ALF) is a clinical condition characterized by the abrupt onset of coagulopathy and biochemical evidence of hepatocellular injury, leading to rapid deterioration of liver cell function. In children, ALF has been characterized by raised transaminases, coagulopathy, and no known evidence of pre-existing chronic liver disease; unlike in adults, the presence of hepatic encephalopathy is not required to establish the diagnosis. Although rare, ALF has a high mortality rate without liver transplantation (LT). Etiology of ALF varies with age and geographical location, although it may remain indeterminate in a significant proportion of cases. However, identifying its etiology is crucial to undertake disease-specific management and evaluate indication to LT. In this position statement, the Liver Disease Working Group of the Italian Society of Gastroenterology, Hepatology and Nutrition (SIGENP) reviewed the most relevant studies on pediatric ALF to provide recommendations on etiology, clinical features and diagnostic work-up of neonates, infants and children presenting with ALF. Recommendations on medical management and transplant candidacy will be discussed in a following consensus conference.
- Published
- 2021
9. Multiple gut–liver axis abnormalities in children with obesity with and without hepatic involvement
- Author
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Guercio Nuzio, S., Di Stasi, M., Pierri, L., Troisi, J., Poeta, M., Bisogno, A., Belmonte, F., Tripodi, M., Di Salvio, D., Massa, G., Savastano, R., Cavallo, P., Boffardi, M., Ziegenhardt, D., Bergheim, I., Mandato, C., and Vajro, P.
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- 2017
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10. Editorial: The broader aspects of non-alcoholic fatty liver disease in children
- Author
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Mandato, C., Miele, Luca, Socha, P., Vajro, P., Miele L. (ORCID:0000-0003-3464-0068), Mandato, C., Miele, Luca, Socha, P., Vajro, P., and Miele L. (ORCID:0000-0003-3464-0068)
- Abstract
N/A
- Published
- 2022
11. The complexity of diagnosing a drug reaction syndrome in the child|La complessità della diagnosi di una sindrome da reazione a farmaco nel bambino
- Author
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Pepe, A., Colucci, A., Nazzaro, L., Ametrano, O., Barbato, F., Sammarco, E., Ranucci, G., De Brasi, D., Vajro, P., and Mandato, C.
- Published
- 2022
12. Letter to the editor: The burgeoning field of progressive familial intrahepatic cholestasis
- Author
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Mandato, C. and Vajro, P.
- Subjects
Cholestasis ,Hepatology ,Mutation ,Humans ,Cholestasis, Intrahepatic - Published
- 2022
13. Additional file 3 of Humanization of care in pediatric wards: differences between perceptions of users and staff according to department type
- Author
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Mandato, C., M. A. Siano, A. G. E. De Anseris, M. Tripodi, G. Massa, R. De Rosa, M. Buffoli, A. Lamanna, P. Siani, and P. Vajro
- Abstract
Additional file 3 Table S1. Pediatric wards enrolled, categorized in 3 different categories. Table S2. Weight of the different humanization indicators according to the Listening to people to Cure people (LpCp)-tool
- Published
- 2020
- Full Text
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14. Additional file 4 of Humanization of care in pediatric wards: differences between perceptions of users and staff according to department type
- Author
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Mandato, C., M. A. Siano, A. G. E. De Anseris, M. Tripodi, G. Massa, R. De Rosa, M. Buffoli, A. Lamanna, P. Siani, and P. Vajro
- Abstract
Additional file 4 Table S3.Comparison between the degree of humanization existing and perceived, in the seven hospital wards enrolled.
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- 2020
- Full Text
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15. Additional file 5 of Humanization of care in pediatric wards: differences between perceptions of users and staff according to department type
- Author
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Mandato, C., M. A. Siano, A. G. E. De Anseris, M. Tripodi, G. Massa, R. De Rosa, M. Buffoli, A. Lamanna, P. Siani, and P. Vajro
- Abstract
Additional file 5 Table S4. Comparison between the degree of humanization existing and perceived, in the seven hospitals wards categorized under the three types of settings.
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- 2020
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16. Additional file 1 of Humanization of care in pediatric wards: differences between perceptions of users and staff according to department type
- Author
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Mandato, C., M. A. Siano, A. G. E. De Anseris, M. Tripodi, G. Massa, R. De Rosa, M. Buffoli, A. Lamanna, P. Siani, and P. Vajro
- Abstract
Additional file 1 Figure S1 Supplementary. LpCp tool for patients/visitors/parents/companions: percentages of positive responses (dark grey columns) given for each question by parents/ companions interviewed with the LpCp tool in each of the seven pediatric wards. [Children’s Hospital (A), Pediatric Department of University Hospital (B and C) and General Hospital (D, E, F, G)].
- Published
- 2020
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17. Spina bifida, 677T - >C mutation, and role of folate
- Author
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de Franchis, R., Sebastio, G., Mandato, C., Andria, G., and Mastroiacovo, P.
- Published
- 1995
18. The current status of pediatric endoscopy in Italy: a national survey
- Author
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Deganello Saccomani, M., Norsa, L., Bramuzzo, M., Gandullia, P., Romano, C., Miele, E., Chiaro, A., Francavilla, R., Illiceto, M. T., Paci, M., Ravelli, A., Bizzarri, B., Balassone, V., Muscas, A., Campanozzi, A., Alvisi, P., Granata, A., Costa, L., Mandato, C., Di Nardo, G., Malamisura, B., Motta, V., Malaventura, Cristina, Fanti, L., Centenari, C., Dodaro, N., Raffaele, A., and Oliva, S.
- Subjects
NO - Published
- 2018
19. P057 Persistent hypertransaminasemia in an obese child with asymptomatic Wilson disease and familiarity for parkinsonism and cardiomyopathy: a case report
- Author
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Rocco, M.C., primary, Lettieri, M., additional, Biffaro, N., additional, Colantuono, R., additional, Paglia, P., additional, Siano, M.A., additional, Satta, S., additional, Lepori, M.B., additional, Loudianos, G., additional, Mandato, C., additional, Pacifico, R., additional, Nazzaro, L., additional, De Anseris, A.G.E., additional, Di Nuzzi, A., additional, and Vajro, P., additional
- Published
- 2018
- Full Text
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20. P164 A personalized and non-automated mobile-based intervention in the management of paediatric obesity: preliminary results of a pilot study (PediaFit)
- Author
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Delli Bovi, A.P., primary, Di Michele, L., additional, Massa, G., additional, Lettieri, M., additional, Lausi, O., additional, Mandato, C., additional, De Anseris, A.G., additional, and Vajro, P., additional
- Published
- 2018
- Full Text
- View/download PDF
21. P034 TMEM199-CDG: another glycosylation defect with mild hepatic dysfunction and no neurologic involvement
- Author
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D'Acunto, E., primary, Mandato, C., additional, Poeta, M., additional, Lettieri, M., additional, Freeze, H., additional, Eklund, E., additional, and Vajro, P., additional
- Published
- 2018
- Full Text
- View/download PDF
22. P004 The current status of pediatric endoscopy in Italy: a national survey
- Author
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Deganello Saccomani, M., primary, Norsa, L., additional, Bramuzzo, M., additional, Gandullia, P., additional, Romano, C., additional, Miele, E., additional, Chiaro, A., additional, Francavilla, R., additional, Illiceto, M.T., additional, Paci, M., additional, Ravelli, A., additional, Bizzarri, B., additional, Balassone, V., additional, Muscas, A., additional, Campanozzi, A., additional, Alvisi, P., additional, Granata, A., additional, Costa, L., additional, Mandato, C., additional, Di Nardo, G., additional, Malamisura, B., additional, Motta, V., additional, Malaventura, C., additional, Fanti, L., additional, Centenari, C., additional, Dodaro, N., additional, Raffaele, A., additional, and Oliva, S., additional
- Published
- 2018
- Full Text
- View/download PDF
23. P155 Breastfeeding and formula feeding: not just nutrition issues
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Viggiano, C., primary, Occhinegro, A.C., additional, Tripodi, M., additional, Siano, M.A., additional, Fasolino, F., additional, Massa, G., additional, Adinolfi, M., additional, Morabito, G., additional, Tavernise, C., additional, Viggiano, D., additional, Mandato, C., additional, De Anseris, A.G., additional, and Vajro, P., additional
- Published
- 2018
- Full Text
- View/download PDF
24. P028 Establishing a SIGENP Italian network for the study of biliary atresia
- Author
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Ranucci, G., primary, Alberti, D., additional, Bagolan, P., additional, Betalli, P., additional, Calvo, P., additional, Cananzi, M., additional, Candusso, M., additional, Casotti, V., additional, Clemente, M.G., additional, D'Antiga, L., additional, De Ville, J., additional, Di Francesco, F., additional, Fascetti Leon, F., additional, Ferrari, F., additional, Fusaro, F., additional, Gaio, P., additional, Gamba, P., additional, Indolfi, G., additional, Iorio, R., additional, La Pergola, E., additional, Liccardo, D., additional, Lima, M., additional, Maggiore, G., additional, Mandato, C., additional, Matarazzo, L., additional, Nebbia, G., additional, Nobili, V., additional, Nuti, F., additional, Paolella, G., additional, Parolini, F., additional, Romagnoli, R., additional, Sciveres, M., additional, Serranti, D., additional, Spada, M., additional, Tandoi, F., additional, and Vajro, P., additional
- Published
- 2018
- Full Text
- View/download PDF
25. P044 Visceral Leshmaniasis and liver disease: the experience of the Campania Reference Centre for Visceral Leshmaniasis at pediatric age
- Author
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Cozzolino, T., primary, Santoro, C., additional, Acampora, E., additional, Gensini, V., additional, Di Nardo, G., additional, Mastrominico, A., additional, De Brasi, D., additional, Siani, P., additional, and Mandato, C., additional
- Published
- 2018
- Full Text
- View/download PDF
26. Multiple gut-liver axis abnormalities in children with obesity with and without hepatic involvement
- Author
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GUERCIO NUZIO, Salvatore, Di Stasi, M., Pierri, L., Troisi, J., Poeta, M., Bisogno, A., Belmonte, Federica, Tripodi, M., Di Salvio, D., Massa, G., Savastano, R., Cavallo, P., Boffardi, M., Ziegenhardt, D., Bergheim, I., Mandato, C., and Vajro, P.
- Subjects
Male ,Pediatric Obesity ,gut-liver axis ,Nutrition and Dietetics ,Adolescent ,Health Policy ,Liver Diseases ,Environmental and Occupational Health ,Perinatology and Child Health ,Pediatrics ,Permeability ,Intestines ,Endotoxin ,ethanol ,NAFLD ,Breath Tests ,Child ,Female ,Humans ,Liver ,Liver Function Tests ,Risk Factors ,Pediatrics, Perinatology and Child Health ,Public Health, Environmental and Occupational Health ,Public Health - Abstract
Gut-liver axis (GLA) dysfunction appears to play a role in obesity and obesity-related hepatic complications.This study sought to concurrently explore several GLA components in a paediatric obese population with/without liver disease.Thirty-two children (mean age 11.2 years) were enrolled: nine controls with normal weight and 23 patients with obesity (OB+). Of the 23 patients OB(+), 12 had not steatosis (ST-), and 11 had steatosis (ST+) (associated [n = 8] or not [n = 3] with hypertransaminasaemia [ALT +/-]). Subjects were characterized by using auxologic, ultrasonographic and laboratory parameters. A glucose hydrogen breath test was performed to test for small intestinal bacterial overgrowth, a urinary lactulose/mannitol ratio (LMR) was obtained to assess intestinal permeability, and tests for transaminases, blood endogenous ethanol, endotoxin and faecal calprotectin were also conducted.Eleven out of 23 patients OB(+) (p 0.05) exhibited pathological (90th percentile of the control group values) LMR, with values paralleling the grade of liver involvement (normal weight OB[+] OB[+]ST[+]ALT[-] OB[+)]ST[+]ALT[+] [p 0.05]). LMR significantly correlated with ethanolaemia (r = 0.38, p = 0.05) and endotoxaemia (r = 0.48, p = 0.015) concentrations. Increased permeability was a risk factor for the development of steatosis (p 0.002). SIBO was present only in patients with obesity. Faecal calprotectin concentrations were within normal limits in all subjects.Increased permeability, endogenous ethanol and systemic endotoxin concentrations reflect some GLA dysfunction in obesity and its hepatic complications. Pending further results to establish their potential causative roles, the modulation of the GLA appears to represent a possible target for the prevention and treatment of these conditions.
- Published
- 2016
27. Three patients with glycosylation deficiencies, chronically elevated transaminases, and low serum ceruloplasmin and copper, caused by mutations in the gene encoding the transmembrane protein TMEM199
- Author
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Poeta, M., primary, Zielinska, K., additional, Maccarana, M., additional, Mandato, C., additional, Ng, B.G., additional, Di Nuzzi, A., additional, D’Acunto, E., additional, Pierri, L., additional, Ecklund, E., additional, Freeze, H., additional, and Vajro, P., additional
- Published
- 2017
- Full Text
- View/download PDF
28. The challenging diagnosis of hepatosplenic cat scratch disease in children
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Mandato, C., primary, Sarno, M., additional, Zollo, G., additional, Vecchio, A. Lo, additional, Santoro, C., additional, Vajro, P., additional, and Siani, P., additional
- Published
- 2017
- Full Text
- View/download PDF
29. Drug rash with eosinophilia and systemic syndrome (DRESS)/hemofagocytic lymphohistocytosis (HLH) overlap in a child with acute liver failure presentation
- Author
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Mandato, C., primary, Ametrano, O., additional, Lamba, M., additional, Quitadamo, P., additional, De Fusco, C., additional, Vajro, P., additional, and Siani, P., additional
- Published
- 2016
- Full Text
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30. Short bowel syndrome and total parenteral nutrition: Why not a Baby Port?
- Author
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Mandato, C., primary, Calise, L., additional, Chiantone, E., additional, Mambretti, D., additional, Spagnuolo, M.I., additional, Siani, P., additional, Vajro, P., additional, and Graziano, U., additional
- Published
- 2016
- Full Text
- View/download PDF
31. Early onset transient liver disease and rare allelic variants alpha-1 antitrypsin deficiency (A1ATD) Plowell and Mheerlen
- Author
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Mandato, C., primary, Poeta, M., additional, Petrillo, P., additional, Nazzaro, L., additional, Catzola, A., additional, De Anseris, A.G.E., additional, Ferrarotti, I., additional, Siani, P., additional, and Vajro, P., additional
- Published
- 2016
- Full Text
- View/download PDF
32. Randomised clinical trial: a Lactobacillus GG and micronutrient-containing mixture is effective in reducing nosocomial infections in children, vs. placebo
- Author
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Bruzzese, E., primary, Fedele, M. C., additional, Bruzzese, D., additional, Viscovo, S., additional, Giannattasio, A., additional, Mandato, C., additional, Siani, P., additional, and Guarino, A., additional
- Published
- 2016
- Full Text
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33. Spina bifida, 677C->T mutation, and role of folate
- Author
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DE FRANCHIS R, SEBASTIO G., MANDATO C., MASTROIACOVO P., ANDRIA, GENEROSO, DE FRANCHIS, R, Sebastio, Gianfranco, Mandato, C, Andria, G, Mastroiacovo, P., Sebastio, G., Mandato, C., and Andria, Generoso
- Published
- 1995
34. Per-rectal portal scintigraphy is complementary to ultrasonography and endoscopy in the assessment of portal hypertension in children with chronic cholestasis
- Author
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PIetro VAJRO, Celentano, L., Manguso, F., Vallone, G., Lenta, S., Mandato, C., Di Cosmo, N., Capuano, G., Staiano, A., D Arienzo, A., P., Vajro, L., Celentano, F., Manguso, Vallone, Gianfranco, S., Lenta, C., Mandato, N., Di Cosmo, G., Capuano, Staiano, Annamaria, D'Arienzo, Agesilao, Vajro, Pietro, Celentano, L., Manguso, F., Lenta, S., Mandato, C., DI COSMO, Nicolina, Capano, G., and D'Arienzo, A.
- Subjects
Male ,Cholestasis ,Adolescent ,Rectum ,portal hypertension ,Infant ,Reproducibility of Results ,Per-rectal portal scintigraphy ,Sensitivity and Specificity ,Portal System ,children ,Child, Preschool ,Chronic Disease ,Hypertension, Portal ,Humans ,Female ,Endoscopy, Digestive System ,Radiopharmaceuticals ,Child ,Radionuclide Imaging ,chronic cholestasis ,Sodium Pertechnetate Tc 99m ,Ultrasonography - Abstract
We evaluated the clinical usefulness of 99mTc-pertechnetate per-rectal portal scintigraphy (PPS) in the assessment of portal circulation in children with chronic cholestasis.PPS percentage shunt index (%SI) (the amount of radionuclide that shunts the liver and reaches the systemic blood after injection in the rectum) was measured in 22 children (mean age, 7.2 +/- 4.9 y) and compared with established clinical, laboratory, and endoscopic and imaging parameters of portal hypertension (PH). Fourteen children had surgically treated biliary atresia, and 8 had chronic intrahepatic cholestasis. Six clinically well children served as control subjects.The %SI was 14.3 +/- 3.1 and 34.7 +/- 18.8 in controls and in patients, respectively (P0.01). A cutoff of 19% correctly allocated 100% of controls and 86% of patients. Mean %SI values were significantly higher in patients with biliary atresia, a high risk of pretransplantation death, esophageal varices (EV) at endoscopy, and an abnormal value for the ratio of lesser omentum thickness to abdominal aorta diameter (LO/Ao) at ultrasonography. Correlations between %SI values and several ultrasonographic continuous variables were statistically significant only for LO/Ao ratios (r = 0.51; P = 0.005) and spleen longitudinal diameters (r = 0.53; P = 0.01). The presence of EV could correctly be predicted only when values of %SI were greater than 30% (100% specificity; 56% sensitivity). Endoscopic and PPS findings agreed for a diagnosis of PH with EV in 3 of 7 patients with normal or borderline ultrasonographic LO/Ao ratios. PPS patterns and %SI values became normal in 3 children who underwent liver transplantation.In children with chronic cholestasis, PPS may be an advantageous, minimally invasive tool complementary to ultrasonography and endoscopy for better assessment and follow-up of PH before and after liver transplantation.
- Published
- 2004
35. More on vitamin E therapy
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Vajro P, Mandato C, Lucariello S., FRANZESE, ADRIANA, Vajro, P, Mandato, C, Franzese, Adriana, and Lucariello, S.
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- 2004
36. Mitochondria-cytoskeleton associations in mammalian cytokinesis
- Author
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Lawrence, E. J., primary, Boucher, E., additional, and Mandato, C. A., additional
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- 2016
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37. Severe rhabdomyolysis and celiac disease
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Mandato, C., primary, Rossi, A., additional, Lamba, M., additional, Caldore, M., additional, Siani, P., additional, and Vajro, P., additional
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- 2015
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38. The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy
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DE FRANCHIS R., BUONINCONTI A., MANDATO C., SPERANDEO M.P., DEL GADO R., CAPRA V., MATROIACOVO P., ANDRIA, GENEROSO, DE FRANCHIS, R., Buoninconti, A., Mandato, C., Sperandeo, M. P., DEL GADO, R., Capra, V., Andria, Generoso, and Matroiacovo, P.
- Published
- 1998
39. Ipogonadismo ipogonadotropo in adolescente con associazione CHARGE
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Licenziati, Mr, Mandato, C, Plazza, A, Cavaliere, L, and Valerio, Giuliana
- Published
- 2006
40. Metabolic, hormonal, oxidative, and inflammatory factors in pediatricobesity-related liver disease
- Author
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Mandato, C, Lucariello, S, Licenziati, Mr, Franzese, A, Spagnuolo, Mi, Ficarella, R, Pacilio, M, Amitrano, M, Capuano, G, Meli, R, and Vajro, Pietro
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pediatrics - Published
- 2005
41. Human Parvovirus B19 Infection in liver transplanted children with chronic hematologic disorders
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Ciccimarra, E, Zakrewska, K, Broccoletti, T, Crispino, F, Poggi, A, Spaziano, M, Migliaro, F, Mandato, C, Lucariello, S, Azzi, A, and Vajro, Pietro
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pediatrics - Published
- 2002
42. Autoimmune manifestations in pediatric liver transplantation recipients
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Clemente, Mg, De Virgiliis, S, Musu, Mp, Ciccimarra, E, Mandato, C., Gridelli, B., Riva, S., Ricotto, L, and Vajro, Pietro
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pediatrics - Published
- 2001
43. Oral vitamin E has beneficial effects on liver disease of obese children unable to loose weight
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Ciccimarra, E, Vajro, S, Lucariello, S, Francese, A, Mandato, C, Spaziano, M, Savoia, M, Calmieri, D, and Vajro, Pietro
- Subjects
pediatrics - Published
- 2001
44. Non-cirrhotic chronic liver disease in three italian children exposed to moderately high copper intakes
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Vajro, Pietro, Di Maria, F, Mellone, M, Loudianos, G, Spaziano, M, Lovicu, M, Ciccimarra, E, Del Rio, A, Mandato, C, and De Virgilis, S.
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pediatrics - Published
- 2001
45. Antioxidant vitamin E for the treatment of obesità related liver dysfunction in children with poor compliance to hypocaloric diets
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Vajro, Pietro, Francese, A, Formicola, S, Ciccimarra, E, Mandato, C, Spaziano, M, Di Maria, F, Broccoletti, T, and Crispino, F.
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pediatrics - Published
- 2001
46. Chronic ingestion of moderately high copper may cause cryptogenic mild liver disease
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Vajro, Pietro, Di Maria, F, Mellone, C, Loudianos, C, Lucariello, S, Spaziano, M, Ciccimarra, E, Vecchione, R, Mandato, C, and De Virgilis, S.
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pediatrics - Published
- 2001
47. Congenital defects of glycosylation may underlie cryptogenic hepatopathy in asymptomatic children
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Mandato, C, Lucariello, S, Ciccimarra, E, Vajro, Pietro, and Pagliardini, S.
- Subjects
pediatrics - Published
- 2001
48. Scurvy explosion in XXI century: not only for children with an autism disorder.
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Puzone, S., Mosca, C., Carrella, M. C., Del Bene, M., Mastrominico, A., Giannattasio, A., Sabbatino, M. S., Sibilio, M., Tipo, V., Siano, M. A., Pepe, A., Colucci, A., Apicella, A., Raimondo, P., Ranucci, G., and Mandato, C.
- Published
- 2022
- Full Text
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49. Liposoluble vitamins supplementation in infant and children with cholestasis: a tough choice.
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Bene, M. Del, Battagliere, I., Mosca, C., Siano, M. A., Brunetti, B., Pepe, A., Colucci, A., Mirra, V., Ranucci, G., and Mandato, C.
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- 2022
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50. Vitamin D levels in the pre and post Covid-19 pandemic related confinement at pediatric age.
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Mosca, C., Bene, M. Del, Carrella, M. C., Battagliere, I., Brunetti, B., Siano, M. A., Pepe, A., Colucci, A., Mastrominico, A., Ranucci, G., Maglione, A., and Mandato, C.
- Published
- 2022
- Full Text
- View/download PDF
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