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This article discusses a new method for synthesizing substituted pyrroles using silica supported catalysis. Pyrroles have various biological activities and properties such as anti-inflammatory, antitumor, and antiviral. The authors present the results of their study, which show good yields for the synthesis of multisubstituted pyrroles with different substituent groups. They hope that this method will contribute to further investigation of complex pyrrole structures. The document also provides a series of chemical reactions and their corresponding products, including various pyrrole derivatives. The yields, physical properties, and spectroscopic data for each compound are provided. The authors acknowledge the institutions that provided laboratory facilities and the Indian Institute of Chemical Technology for spectral data. [Extracted from the article]

An efficient (C6F5)3B catalyzed method has been developed for the synthesis of benzo[b]cyclopenta[e][1,4]oxazin-2(1H)-one and thiazin-2(1H)-one derivatives from furan-2-yl(phenyl)methanol (1) and 2-aminophenol/thiophenol (2) under reflux in acetonitrile. This reaction proceeds through an aza-Piancatelli rearrangement/Michael reaction in one-pot. This strategy provides a facile and rapid access to benzo[b]cyclopenta[e][1,4]oxazin-2(1H)-one and thiazin-2(1H)-one derivatives (3a-l) in good to high yields under mild conditions. Several advantages, such as simple reaction procedure, low catalyst loading, broad substrate scope, easy product isolation, high functional group tolerance, and short reaction time make this strategy more attractive. [ABSTRACT FROM AUTHOR]

A series of oximinoethers of indanone/aryloxy indanone were synthesized and screened for its in vitro antileishmanial activity profile (in promastigote and amastigote models) against Leishmania donovani, the causative agent of leishmaniasis. Compounds 3a–d, 4a–d, 5a, 5b, 6a–d & 7a–d have shown 87–100% inhibition against promastigotes and 47–100% inhibition against amastigotes at a concentration of 05 μg/ml. compounds 3a, 4a–b, 6b–c, 7a–d and 4b, 4d, 6c–d exhibited 100% inhibition against promastigotes and amastigotes respectively. [ABSTRACT FROM AUTHOR]

A series of (E)‐2‐((1H‐imidazol‐1‐yl)methyl)‐2‐((benzyloxy)methyl)‐2,3‐dihydro‐1H‐inden‐1‐one O‐benzyl oximes (6a‐j) were prepared and evaluated for their in vitro antileishmanial potency against Leishmania donovani (in promastigote and amastigote models). At a concentration of 05‐μg/mL, compounds 3a‐d, 4a‐d, 5a, 5b, 6a‐d, and 7a‐d exhibited 97% to 100% and 87% to 100% inhibition against promastigotes and amastigotes, respectively. Compounds 6a, 6d‐6j and 6a, 6i, 6j exhibited equal antileishmanial potency to that of SSG and Pentamidin at lower values of IC50. [ABSTRACT FROM AUTHOR]

A new and efficient B(C6F5)3 catalyzed domino strategy has been developed for the synthesis of 2-substituted quinazolinones. The reaction utilizes 2-aminobenzamide and aldehydes for a one-pot protocol. A wide range of substrate scope, functional group tolerance, and operational simplicity with excellent yield are synthetically useful features. [ABSTRACT FROM AUTHOR]

A simple, efficient, solventless, and one step, B(C6F5)3 catalyzed, synthesis of dihydropyrano[3,2-b]chromenediones from dimedone, aldehyde and kojic acid is described. This protocol proceeds smoothly, accommodates aromatic as well as heteroaromatic aldehydes and gives dihydropyrano[3,2-b]chromenediones in excellent yield. [ABSTRACT FROM AUTHOR]

Domino coupling of furan‐2‐yl (phenyl) methanol and 2‐(1H‐pyrrol‐1‐yl) aniline has been achieved in the presence of 10 mol% phosphomolybdic acid in CH3CN under reflux to afford the corresponding biologically active 10‐aryl‐9a,10,12,12a‐tetrahydrobenzo[b]cyclopenta[f]pyrrolo[1,2‐d][1,4]diazepin‐11(9H)‐ones in good yields. Broad substrate scope, short reaction times, environmentally benign, and operational simplicity makes this method more attractive. [ABSTRACT FROM AUTHOR]

A simple, green, and efficient method is presented for the synthesis of benzoxazoles and benzothiazoles from reaction of oaminophenols, o-aminothiophenols, and aliphatic or aromatic aldehydes using samarium triflate as a reusable acid catalyst under mild reaction conditions in aqueous medium [ABSTRACT FROM AUTHOR]