Search

Your search keyword '"Manemann, Sheila M."' showing total 228 results
Start Over Author "Manemann, Sheila M."
228 results on '"Manemann, Sheila M."'

8. Discordance Between Very Low‐Density Lipoprotein Cholesterol and Low‐Density Lipoprotein Cholesterol Increases Cardiovascular Disease Risk in a Geographically Defined Cohort

Author

Seehusen, Kristina E., primary, Remaley, Alan T., additional, Sampson, Maureen, additional, Meeusen, Jeffrey W., additional, Larson, Nicholas B., additional, Decker, Paul A., additional, Killian, Jill M., additional, Takahashi, Paul Y., additional, Roger, Véronique L., additional, Manemann, Sheila M., additional, Lam, Reyna, additional, and Bielinski, Suzette J., additional

Published
2024
Full Text
View/download PDF

14. The impact of multimorbidity and functional limitation on quality of life in patients with heart failure: A multi‐site study.

Author

Manemann, Sheila M., Hade, Erinn M., Haller, Irina V., Horne, Benjamin D., Benziger, Catherine P., Lampert, Brent C., Rasmusson, Kismet D., Roger, Veronique L., Weston, Susan A., Killian, Jill M., and Chamberlain, Alanna M.

Subjects
*RESEARCH funding, *FATIGUE (Physiology), *FUNCTIONAL status, *HEART failure, *TREATMENT effectiveness, *ANXIETY, *DESCRIPTIVE statistics, *ODDS ratio, *QUALITY of life, *RESEARCH, *SLEEP, *PAIN, *CONFIDENCE intervals, *COMPARATIVE studies, *COMORBIDITY, *ACTIVITIES of daily living, *MENTAL depression
Abstract

Background: Multimorbidity and functional limitation are associated with poor outcomes in heart failure (HF). However, the individual and combined effect of these on health‐related quality of life in patients with HF is not well understood. Methods: Patients aged ≥30 years with two or more HF diagnostic codes and one or more HF‐related prescription drugs from four U.S. institutions were mailed a survey to measure patient‐centric factors including functional status (activities of daily living [ADLs]) and health‐related quality of life (PROMIS‐29 Health Profile). Patients with HF from January 1, 2013 to February 1, 2018 were included. Multimorbidity was defined as ≥2 non‐cardiovascular comorbidities; functional limitation as any limitation in at least one of eight ADLs. Patients were categorized into four groups by multimorbidity (Yes/No) and functional limitation (Yes/No). We dichotomized the PROMIS‐29 sub‐scale scores at the median and calculated odd ratios for the four multimorbidity/functional limitation groups. Results: A total of 3330 patients with HF returned the survey (response rate 31%); 3020 completed the questions of interest and were retained. Among these patients (45% female; mean age 73 [standard deviation: 12] years), 29% had neither multimorbidity nor functional limitation, 24% had multimorbidity only, 22% had functional limitation only, and 25% had both. After adjustment, having functional limitation only was associated with higher anxiety (odds ratio [OR]: 3.44, 95% confidence interval [CI]: 2.66–4.45), depression (OR: 3.11, 95% CI: 2.39–4.06), and fatigue (OR: 4.19, 95% CI: 3.25–5.40); worse sleep (OR: 2.14, 95% CI: 1.69–2.72) and pain (OR: 6.73, 95% CI: 5.15–8.78); and greater difficulty with social activities (OR: 9.40, 95% CI: 7.19–12.28) compared with having neither. Results were similar for having both multimorbidity and functional limitation. Conclusion: Patients with only functional limitation have similar poor health‐related quality of life scores as those with both multimorbidity and functional limitation, underscoring the important role that physical functioning plays in the well‐being of patients with HF. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias

Author

Moser, Ethan D., primary, Manemann, Sheila M., additional, Larson, Nicholas B., additional, St Sauver, Jennifer L., additional, Takahashi, Paul Y., additional, Mielke, Michelle M., additional, Rocca, Walter A., additional, Olson, Janet E., additional, Roger, Véronique L., additional, Remaley, Alan T., additional, Decker, Paul A., additional, Killian, Jill M., additional, and Bielinski, Suzette J., additional

Published
2023
Full Text
View/download PDF

23. The Metabolic Vulnerability Index

Author

Conners, Katherine M., primary, Shearer, Joseph J., additional, Joo, Jungnam, additional, Park, Hoyoung, additional, Manemann, Sheila M., additional, Remaley, Alan T., additional, Otvos, James D., additional, Connelly, Margery A., additional, Sampson, Maureen, additional, Bielinski, Suzette J., additional, Wolska, Anna, additional, Turecamo, Sarah, additional, and Roger, Véronique L., additional

Published
2023
Full Text
View/download PDF

25. Bridging the Granularity Gap in Family History Information Extracted from Clinical Narratives

Author

Moon, Sungrim, Wang, Liwei, Chen, Xuan, Wang, Nan, Manemann, Sheila M, Larson, Nicholas B, Bielinski, Suzette J, and Liu, Hongfang

Subjects
Articles
Abstract

Family history (FH) is important for disease risk assessment and prevention. However, incorporating FH information derived from electronic health records (EHRs) for downstream analytics is challenging due to the lack of standardization. We aimed to automatically align FH concepts derived from a clinical corpus to disease category resources popularly used, including Clinical Classification System (CCS), Phecode, Comparative Toxicogenomics Database (CTD), Human phenotype ontology, and Human disease ontology (HDO). Leveraging the Unified Medical Language System (UMLS), we achieved high mapping coverages of FH concepts in those resources, using the parent and broader/alike relations available in the UMLS. Among the five resources, CTD has the best coverage (93%) of FH concepts, HDO has the coarsest granularity of FH disease categories, while CCS showed the finest-grained regarding disease categories. The study suggests that we can mitigate the challenge of various degrees of granularity of NLP-derived FH using those ontology or terminological resources.

Published
2023

26. Variability in Lipid Levels and Risk for Cardiovascular Disease: An Electronic Health Record–Based Population Cohort Study

Author

Manemann, Sheila M., primary, Bielinski, Suzette J., additional, Moser, Ethan D., additional, St. Sauver, Jennifer L., additional, Takahashi, Paul Y., additional, Roger, Véronique L., additional, Olson, Janet E., additional, Chamberlain, Alanna M., additional, Remaley, Alan T., additional, Decker, Paul A., additional, Killian, Jill M., additional, and Larson, Nicholas B., additional

Published
2023
Full Text
View/download PDF

46. Additional file 1 of Adhesion pathway proteins and risk of atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis

Author

Mendez, Israel J., Manemann, Sheila M., Bell, Elizabeth J., Larson, Nicholas B., Decker, Paul A., Guerrero, Marco A., Hanson, Naomi Q., Heckbert, Susan R., Pankow, James S., Tsai, Michael Y., and Bielinski, Suzette J.

Abstract

Additional file 1: Table S1. Assay characteristics by protein, Multi-Ethnic Study of Atherosclerosis, 2002-2004. Table S2. Exam 1 characteristics by race/ethnicity, Multi-Ethnic Study of Atherosclerosis, 2000-2002. Table S3. Adjusted hazard ratios for incident atrial fibrillation per one standard deviation increase in protein by ethnicity/race, Multi-Ethnic Study of Atherosclerosis, 2002-2014. Figure S1. Flow diagram of Exam 2 study participation. Figure S2. Distribution of proteins levels.

Published
2021
Full Text
View/download PDF

47. Longitudinal cohorts for harnessing the electronic health record for disease prediction in a US population

Author

Manemann, Sheila M, primary, St Sauver, Jennifer L, additional, Liu, Hongfang, additional, Larson, Nicholas B, additional, Moon, Sungrim, additional, Takahashi, Paul Y, additional, Olson, Janet E, additional, Rocca, Walter A, additional, Miller, Virginia M, additional, Therneau, Terry M, additional, Ngufor, Che G, additional, Roger, Veronique L, additional, Zhao, Yiqing, additional, Decker, Paul A, additional, Killian, Jill M, additional, and Bielinski, Suzette J, additional

Published
2021
Full Text
View/download PDF

48. Abstract P102: Variability In Lipid Levels And Risk For Cardiovascular Disease: An Electronic Health Record-based Population Cohort Study

Author

Manemann, Sheila M, primary, Bielinski, Suzette J, additional, Moser, Ethan D, additional, St. Sauver, Jennifer L, additional, Takahashi, Paul Y, additional, Roger, Veronique L, additional, Olson, Janet E, additional, Decker, Paul A, additional, Killian, Jill M, additional, and Larson, Nicholas B, additional

Published
2021
Full Text
View/download PDF

49. Abstract P103: Association Of Lipid Variability With Incident Alzheimers Disease And Alzheimers Disease Related Dementias

Author

Moser, Ethan D, primary, Manemann, Sheila M, additional, Larson, Nicholas B, additional, St Sauver, Jennifer L, additional, Takahashi, Paul Y, additional, Mielke, Michelle M, additional, Rocca, Walter A, additional, Olson, Janet E, additional, Roger, Veronique L, additional, Decker, Paul A, additional, Killian, Jill M, additional, and Bielinski, Suzette J, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results