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301 results on '"Manera C"'

9. Preliminary Investigation of a Novel 18F Radiopharmaceutical for Imaging CB2 Receptors in a SOD Mouse Model

Author

Pascali, G ; https://orcid.org/0000-0001-7919-8416, Panetta, D, De Simone, M, Burchielli, S, Lucchesi, V, Sanguinetti, E, Zanoni, S, Iozzo, P, Saccomanni, G, Manera, C, Salvadori, PA, Pascali, G ; https://orcid.org/0000-0001-7919-8416, Panetta, D, De Simone, M, Burchielli, S, Lucchesi, V, Sanguinetti, E, Zanoni, S, Iozzo, P, Saccomanni, G, Manera, C, and Salvadori, PA

Abstract

We successfully radiolabelled a novel prospective cannabinoid type 2 receptor ligand with 18F and tested its biodistribution in animal models by positron emission tomography (PET)/computed tomography (CT) imaging. The radiolabelling process was conducted on an alkyl mesylate fragment of the main naphthyridine core, using highly efficient microfluidic technology. No preliminary protection was needed, and the product was purified by semi-prep HPLC and SPE formulation, allowing the desired diastereomeric mixture to be obtained in 29 % radiochemical yield and > 95 % radiochemically pure. SOD1G93A mice were used as model of overexpression of CB2 receptors; PET imaging revealed a significant increase of the tracer distribution volume in the brain of symptomatic subjects compared with the asymptomatic ones.

Published
2021

11. Preventing hepatic fibrogenesis with the two extra-virgin olive oil polyphenols tyrosol and hydroxytyrosol via NOX inhibition

Author

Gabbia, D., primary, Carpi, S., additional, Sarcognato, S., additional, Colognesi, M., additional, Polini, B., additional, Digiacomo, M., additional, Manera, C., additional, Salsano, J.E., additional, Macchia, M., additional, Nieri, P., additional, Invernizzi, P., additional, Russo, F.P., additional, Floreani, A., additional, Cazzagon, N., additional, Guido, M., additional, and De Martin, S., additional

Published
2021
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13. Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6

Author

Vanden Eynde, J.J. Mangoni, A.A. Rautio, J. Leprince, J. Azuma, Y.-T. García-Sosa, A.T. Hulme, C. Jampilek, J. Karaman, R. Li, W. Gomes, P.A.C. Hadjipavlou-Litina, D. Capasso, R. Geronikaki, A. Cerchia, L. Sabatier, J.-M. Ragno, R. Tuccinardi, T. Trabocchi, A. Winum, J.-Y. Luque, F.J. Prokai-Tatrai, K. Spetea, M. Gütschow, M. Kosalec, I. Guillou, C. Vasconcelos, M.H. Kokotos, G. Rastelli, G. De Sousa, M.E. Manera, C. Gemma, S. Mangani, S. Siciliano, C. Galdiero, S. Liu, H. Scott, P.J.H. De Los Ríos, C. Agrofoglio, L.A. Collina, S. Guedes, R.C. Muñoz-Torrero, D.

Published
2020

14. Platelet Transfusion Support by HPA-Genotyped Blood Donors: SP293

Author

Villa, M A, Sr., Paccapelo, C, Sr., Revelli, N, Sr., Cernuschi, M, Sr., Cosco, M, Jr., Drago, F, Sr., Erba, E, Jr., Greppi, N, Sr., Manera, C, Sr., Mantovani, R, Sr., Sala, V, Jr., Truglio, F, Sr., Almini, D, Sr., Torretta, L, Sr., Marconi, M, Sr., and Morelati, F, Sr.

Published
2007

16. Inhibiting NOXs with extra-virgin olive oil polyphenols as a strategy to prevent hepatic fibrogenesis

Author

Gabbia, D., primary, Carpi, S., additional, Sarcognato, S., additional, Munari, S., additional, Colognesi, M., additional, Polini, B., additional, Digiacomo, M., additional, Manera, C., additional, Macchia, M., additional, Nieri, P., additional, Invernizzi, P., additional, Russo, F.P., additional, Floreani, A., additional, Cazzagon, N., additional, Guido, M., additional, and De Martin, S., additional

Published
2020
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24. Andar per arte. Mecenati e collezionisti spagnoli nella Roma di fine Settcento

Author

Avallone, P, Berrino, A, Bertagnoni, G, Bilotti, E, Brogna, M, Capalbo, C, Carera, A, C. a. v. a. l. c. a. n. t. i., Ml, De Lucia, M, Garau, J, Garavaglia, M, Girelli B. o. c. c. i., Am, G. o. n. z. a. l. e. s., Jc, Larrinaga Rodrìguez, C, Leonardi, A, Lombardi, G, Manera, C, Marras, A, Rojo, M, Mocarelli, L, Morelli, R, Moroni, M, Olivieri, Fm, Pelaez Verdet, A, Piccinno, L, Salvemini, R, Scarpelli, L, Syrjamaa, T, Vaccaro, R, Valentino, P, Kimmons Walton, J, Zanini, A, and Zilli, I

Subjects
collezionismo, arte, Roma, età moderna, Roma, Settore SECS-P/12 - Storia Economica, collezionismo, arte, età moderna
Published
2007

30. Exploring the nuclear envelope of herpes simplex virus 1-infected cells by high-resolution microscopy

Author

Wild, P, Senn, C, Manera, C L, Sutter, E, Schraner, E M, Tobler, K, Ackermann, M, Ziegler, U, Lucas, M S, Kaech, A, Wild, P, Senn, C, Manera, C L, Sutter, E, Schraner, E M, Tobler, K, Ackermann, M, Ziegler, U, Lucas, M S, and Kaech, A

Abstract

Herpesviruses are composed of capsid, tegument, and envelope. Capsids assemble in the nucleus and exit the nucleus by budding at the inner nuclear membrane, acquiring tegument and the envelope. This study focuses on the changes of the nuclear envelope during herpes simplex virus 1 (HSV-1) infection in HeLa and Vero cells by employing preparation techniques at ambient and low temperatures for high-resolution scanning and transmission electron microscopy and confocal laser scanning microscopy. Cryo-field emission scanning electron microscopy of freeze-fractured cells showed for the first time budding of capsids at the nuclear envelope at the third dimension with high activity at 10 h and low activity at 15 h of incubation. The mean number of pores was significantly lower, and the mean interpore distance and the mean interpore area were significantly larger than those for mock-infected cells 15 h after inoculation. Forty-five percent of nuclear pores in HSV-1-infected cells were dilated to more than 140 nm. Nuclear material containing capsids protrude through them into the cytoplasm. Examination of in situ preparations after dry fracturing revealed significant enlargements of the nuclear pore diameter and of the nuclear pore central channel in HSV-1-infected cells compared to mock-infected cells. The demonstration of nucleoporins by confocal microscopy also revealed fewer pores but focal enhancement of fluorescence signals in HSV-1-infected cells, whereas Western blots showed no loss of nucleoporins from cells. The data suggest that infection with HSV-1 alters the number, size, and architecture of nuclear pores without a loss of nucleoporins from altered nuclear pore complexes.

Published
2009

34. Anti-Ro/SSA antibodies in rheumatoid arthritis: Clinical and immunologic associations

Author

Cavazzana, I, Franceschini, F, Quinzanini, M, Manera, C, Del Papa, N, Maglione, W, Comina, D, Radice, A, Sinico, R, Cattaneo, R, Cattaneo, R., SINICO, RENATO ALBERTO, Cavazzana, I, Franceschini, F, Quinzanini, M, Manera, C, Del Papa, N, Maglione, W, Comina, D, Radice, A, Sinico, R, Cattaneo, R, Cattaneo, R., and SINICO, RENATO ALBERTO

Published
2006

38. ChemInform Abstract: Conformationally Restrained β-Blocking Oxime Ethers. Part 4. Chiral 2-(3′-(5′-p-Chlorophenyl)isoxazolidinyl)ethanolamines as Conformationally Restrained Analogues of Methyloxyiminomethyl (MOIM) . beta.-Adrenergic Antagonists: Synthesi

Author

BALSAMO, A., primary, BRESCHI, M. C., additional, CHIELLINI, G., additional, COZZINI, P., additional, DOMIANO, P., additional, MACCHIA, M., additional, MANERA, C., additional, MARTINELLI, A., additional, NENCETTI, S., additional, ROSSELLO, A., additional, SACCA, P., additional, and SCATIZZI, R., additional

Published
2010
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39. ChemInform Abstract: New Chiral Methyloxyiminomethyl (MOIM) β-Adrenergic Antagonists. ( S)- and (R)-N-(3-(Alkylamino)-2-hydroxypropylidene)(p- chlorophenylmethyloxy)amines as Probes for Determining Enantiomeric Specificity in the Class of MOIM-Type β-Adre

Author

BALSAMO, A., primary, BRESCHI, M. C., additional, CHIELLINI, G., additional, MACCHIA, B., additional, MACCHIA, M., additional, MANERA, C., additional, SACCA, P., additional, and SCATIZZI, R., additional

Published
2010
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46. Conformationally Restrained Analogs of Sympathomimetic Catecholamines. Synthesis, Conformational Analysis, and Adrenergic Activity of Isochroman Derivatives

Author

Macchia, B., Balsamo, A., Breschi, M. C., Chiellini, G., ANNALINA LAPUCCI, Macchia, M., Manera, C., Martinelli, A., Martini, C., Scatizzi, R., and Barretta, G. U.

Subjects
Male, Models, Molecular, Steric effects, Molecular model, Adrenergic receptor, Bicyclic molecule, Stereochemistry, Chemistry, Guinea Pigs, Molecular Conformation, Adrenergic, Alpha (ethology), Muscle, Smooth, Stereoisomerism, Biological activity, Rats, Rats, Sprague-Dawley, Norepinephrine, Structure-Activity Relationship, Catecholamines, Drug Discovery, Animals, Molecular Medicine, Sympathomimetics, Beta (finance)
Abstract

In previous papers dealing with the study of the conformations and the biopharmacological activity of conformationally restrained analogs of sympathomimetic catecholamines (NE and ISO), proposals were advanced for the three-dimensional molecular models A, B, and C; these models provided information about the steric requirements for the direct activation of alpha 1, alpha 2,beta 1, and beta 2 adrenoceptors, respectively. The 1-(aminomethyl)-6,7-dihydroxyisochromans 11 and 12 and the 1-(aminomethyl)-5,6-dihydroxyisochromans 13 and 14 (1-AMDICs) are two different types of semirigid analogs of NE and ISO. The alpha 1, alpha 2, beta 1, and beta 2 adrenergic properties of the 1-AMDICs 11-14 were evaluated in vitro, both by radioligand binding assays and by functional tests on isolated preparations, and were compared with those of their parent compounds (NE and ISO). The results of a conformational study carried out by means of both 1H NMR spectrometry and theoretical calculations indicated that, in these 1-AMDICs, the presumed active groups (aryl moiety, amine nitrogen and benzylic ethereal oxygen) are in a spatial relationship corresponding to the one found for NE and ISO in their preferred conformations, which also proved to be the pharmacophoric conformation in the models A-C. By means of a comparison of the stereostructures of the 1-AMDICs 11-14 with their biopharmacological properties, it was possible to obtain a further definition of the model B with respect to the activation of the alpha 2 adrenoceptors; the superimposition of the 1-AMDICs 11 and 12 with the molecular model C made it possible to detect an area of the beta-adrenergic receptors which might hinder the fit of adrenergic drugs that are analogs of catecholamines with these receptors.

Published
1993

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