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628 results on '"Maniaci, Antonino"'

3. International expert consensus statement: surgical failure in obstructive sleep apnea

Author

Iannella, Giannicola, Pace, Annalisa, Magliulo, Giuseppe, Vicini, Claudio, Lugo, Rodolfo, Vanderveken, Olivier M., de Vries, Nico, Pang, Kenny, Thuler, Eric, Jacobowitz, Ofer, Cahali, Michel Burihan, Maurer, Joachim T., Casale, Manuele, Moffa, Antonio, Salamanca, Fabrizio, Leone, Federico, Olszewska, Ewa, Reina, Carlos O’connor, Zancanella, Edilson, Hoff, Paul T., Baptista, Peter, Bahgat, Ahmed Yassin, Ravesloot, Madeline J. L., van Maanen, Peter, Goldberg, Andrew, Carrasco, Marina, Agrawal, Vikas K., Lechien, Jerome R., De Vito, Andrea, Cammaroto, Giovanni, De Virgilio, Armando, Greco, Antonio, Mancini, Patrizia, Perrone, Tiziano, Amado, Steve, Alkan, Uri, Cheong, Ryan Chin Taw, D’Ecclesia, Aurelio, Galantai, Dorina, RajuAnand, Anand, Calvo-Henriquez, Christian, Cocuzza, Salvatore, Arigliani, Michele, Saibene, Alberto Maria, Aragona, Rosario Marchese, and Maniaci, Antonino

Published
2024
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12. Is generative pre-trained transformer artificial intelligence (Chat-GPT) a reliable tool for guidelines synthesis? A preliminary evaluation for biologic CRSwNP therapy

Author

Maniaci, Antonino, Saibene, Alberto Maria, Calvo-Henriquez, Christian, Vaira, Luigi, Radulesco, Thomas, Michel, Justin, Chiesa-Estomba, Carlos, Sowerby, Leigh, Lobo Duro, David, Mayo-Yanez, Miguel, Maza-Solano, Juan, Lechien, Jerome Rene, La Mantia, Ignazio, and Cocuzza, Salvatore

Published
2024
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28. Perceptual, aerodynamic and acoustic outcomes of surgical technique for sulcus vocalis patients: A systematic review and meta analysis

Author

Bonali, Marco, Cavaliere, Carlo, Fabbris, Cristoforo, Fermi, Matteo, Iannini, Valeria, Mevio, Niccolò, Capasso, Pasquale, Maniaci, Antonino, Guarino, Pierre, Barillari, Maria Rosaria, Del Zompo, Maria Rita, Filauro, Marta, Lionello, Marco, Mannelli, Giuditta, Russo, Gennaro, Tascone, Martina, and Topazio, Davide

Published
2024
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33. Lateral pharyngoplasty vs. traditional uvulopalatopharyngoplasty for patients with OSA: systematic review and meta-analysis

Author

Maniaci, Antonino, Di Luca, Milena, Lechien, Jerome René, Iannella, Giannicola, Grillo, Calogero, Grillo, Caterina Maria, Merlino, Federico, Calvo-Henriquez, Christian, De Vito, Andrea, Magliulo, Giuseppe, Pace, Annalisa, Vicini, Claudio, Cocuzza, Salvatore, Bannò, Vittoria, Pollicina, Isabella, Stilo, Giovanna, Bianchi, Alberto, and La Mantia, Ignazio

Published
2022
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36. Commentary on 'Voice Rehabilitation by Voice Prostheses After Total Laryngectomy: A Systematic Review and Network Meta-Analysis for 11,918 Patients'

Author

Mayo-Yanez, Miguel, Chiesa-Estomba, Carlos Miguel, Lechien, Jerome R., Maniaci, Antonino, and van den Brekel, Michiel

Subjects
Health
Abstract

We have read the article, 'Voice Rehabilitation by Voice Prostheses After Total Laryngectomy: A Systematic Review and Network Meta-Analysis for 11,918 Patients' (Tawfik et al., 2021). We acknowledge the authors [...]

Published
2022
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40. Candidates to Barbed Reposition Pharyngoplasty

Author

Vicini, Claudio, Lechien, Jerome R., Eplite, Angelo, Perrone, Tiziano, Magliulo, Giuseppe, de Vincentiis, Marco, Greco, Antonio, Cocuzza, Salvatore, La Mantia, Ignazio, Maniaci, Antonino, Passali, Desiderio, Eesa, Mohamed, Hendawi, Ehsan, Iannella, Giannicola, Vicini, Claudio, editor, Salamanca, Fabrizio, editor, and Iannella, Giannicola, editor

Published
2022
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44. Impact of COVID-19 pandemic on the incidence of otitis media with effusion in adults and children: a multicenter study

Author

Iannella, Giannicola, Magliulo, Giuseppe, Lechien, Jerome R., Maniaci, Antonino, Perrone, Tiziano, Frasconi, Pier Carlo, De Vito, Andrea, Martone, Chiara, Ferlito, Salvatore, Cocuzza, Salvatore, Cammaroto, Giovanni, Meccariello, Giuseppe, Monticone, Valentina, Greco, Antonio, de Vincentiis, Marco, Ralli, Massimo, Savastano, Vincenzo, Bertin, Serena, Pace, Annalisa, Milani, Alessandro, Polimeni, Roberta, Pelucchi, Stefano, Ciorba, Andrea, and Vicini, Claudio

Published
2022
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47. Differential Nasal Recolonization and Microbial Profiles in Chronic Rhinosinusitis With Nasal Polyps Patients After Endoscopic Sinus Surgery or Dupilumab Treatment: A Prospective Observational Study.

Author

Maniaci, Antonino, Vertillo Aluisio, Gaia, Stefani, Stefania, Cocuzza, Salvatore, Lechien, Jerome Rene, Radulesco, Thomas, Michel, Justin, Santagati, Maria, and La Mantia, Ignazio

Subjects
*STAPHYLOCOCCUS epidermidis, *NASAL polyps, *POLYMERASE chain reaction, *NASAL cavity, *MICROBIAL cultures, *ENDOSCOPIC surgery
Abstract

ABSTRACT Introduction Methods Results Conclusion The role of microbial profiles in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) pathogenesis is increasingly recognised, with microbial imbalances perpetuating inflammation. We performed this study to associate the different nasal microbiological profile changes with the response to surgical or monoclonal treatment.This prospective observational study evaluated changes in the nasal microbial profiles of 44 patients (22 dupilumab, 22 surgery) over 6 months. Clinical assessments were performed at baseline and follow‐ups, including Sino‐Nasal Outcome Test‐22 (SNOT‐22) scores and Sniffin Sticks‐Identification (SS‐I) olfactory testing. Microbial profiling of nasal swabs was carried out by microbial culture and subsequent molecular identification by Polymerase chain reaction (PCR) and sequencing.Baseline characteristics of 44 patients (22 dupilumab, 22 surgery) enrolled in this study were similar between groups. In the dupilumab group, Staphylococcus epidermidis prevalence rose from 37.03% to 59.25%, while Pseudomonas aeruginosa was eradicated. Moreover, dupilumab stabilised Staphylococcus aureus at 63.64%, while its prevalence increased in the surgery group (from 22.72% to 50%). When bacterial groups were associated with clinical scores, P. aeruginosa carriers had worse SNOT‐22 (21.00 ± 1.41) and SS‐I (5.50 ± 0.71) scores. Instead, S. epidermidis‐colonised patients exhibited significantly lower mean SNOT‐22 (15.39 ± 8.54) and greater SS‐I scores (8.39 ± 3.77). The best outcomes were found in the subgroup of S. epidermidis carriers undergoing the dupilumab treatment.The two treatments modulated the microbial profiles differently, and, most importantly, clinical responses might depend on the association between treatment and the dominant bacterial species colonising the nasal cavity. Further investigation into microbial‐restorative strategies could enhance outcomes for better treatment of CRS. [ABSTRACT FROM AUTHOR]

Published
2024
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48. The Integration of Radiomics and Artificial Intelligence in Modern Medicine.

Author

Maniaci, Antonino, Lavalle, Salvatore, Gagliano, Caterina, Lentini, Mario, Masiello, Edoardo, Parisi, Federica, Iannella, Giannicola, Cilia, Nicole Dalia, Salerno, Valerio, Cusumano, Giacomo, and La Via, Luigi

Abstract

With profound effects on patient care, the role of artificial intelligence (AI) in radiomics has become a disruptive force in contemporary medicine. Radiomics, the quantitative feature extraction and analysis from medical images, offers useful imaging biomarkers that can reveal important information about the nature of diseases, how well patients respond to treatment and patient outcomes. The use of AI techniques in radiomics, such as machine learning and deep learning, has made it possible to create sophisticated computer-aided diagnostic systems, predictive models, and decision support tools. The many uses of AI in radiomics are examined in this review, encompassing its involvement of quantitative feature extraction from medical images, the machine learning, deep learning and computer-aided diagnostic (CAD) systems approaches in radiomics, and the effect of radiomics and AI on improving workflow automation and efficiency, optimize clinical trials and patient stratification. This review also covers the predictive modeling improvement by machine learning in radiomics, the multimodal integration and enhanced deep learning architectures, and the regulatory and clinical adoption considerations for radiomics-based CAD. Particular emphasis is given to the enormous potential for enhancing diagnosis precision, treatment personalization, and overall patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Personalized Treatment Strategies via Integration of Gene Expression Biomarkers in Molecular Profiling of Laryngeal Cancer.

Author

Maniaci, Antonino, Giurdanella, Giovanni, Chiesa Estomba, Carlos, Mauramati, Simone, Bertolin, Andy, Lionello, Marco, Mayo-Yanez, Miguel, Rizzo, Paolo Boscolo, Lechien, Jerome R., and Lentini, Mario

Abstract

Laryngeal cancer poses a substantial challenge in head and neck oncology, and there is a growing focus on customized medicine techniques. The present state of gene expression indicators in laryngeal cancer and their potential to inform tailored therapy choices are thoroughly examined in this review. We examine significant molecular changes, such as TP53, CDKN2A, PIK3CA, and NOTCH1 mutations, which have been identified as important participants in the development of laryngeal cancer. The study investigates the predictive and prognostic significance of these genetic markers in addition to the function of epigenetic changes such as the methylation of the MGMT promoter. We also go over the importance of cancer stem cell-related gene expression patterns, specifically CD44 and ALDH1A1 expression, in therapy resistance and disease progression. The review focuses on indicators, including PD-L1, CTLA-4, and tumor mutational burden (TMB) in predicting immunotherapy responses, highlighting recent developments in our understanding of the intricate interactions between tumor genetics and the immune milieu. We also investigate the potential for improving prognosis accuracy and treatment selection by the integration of multi-gene expression panels with clinicopathological variables. The necessity for uniform testing and interpretation techniques is one of the difficulties, in implementing these molecular insights into clinical practice, that are discussed. This review seeks to provide a comprehensive framework for promoting personalized cancer therapy by combining the most recent data on gene expression profiling in laryngeal cancer. Molecularly guided treatment options may enhance patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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50. The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review.

Author

Maniaci, Antonino, Briglia, Marilena, Allia, Fabio, Montalbano, Giuseppe, Romano, Giovanni Luca, Zaouali, Mohamed Amine, H'mida, Dorra, Gagliano, Caterina, Malaguarnera, Roberta, Lentini, Mario, Graziano, Adriana Carol Eleonora, and Giurdanella, Giovanni

Abstract

Simple Summary: Hearing disorders, especially deafness, are highly debilitating diseases that negatively affect the quality of life. Despite the high incidence, the underlying pathophysiology of these disorders remains elusive, and current treatment options are often inadequate. Recent scientific evidence demonstrates the importance of the key role of pericytes as vascular mural cells specialized in maintaining the integrity and functioning of microvasculature. Understanding their activity in inner ear disorders can provide useful knowledge about the pathophysiology of these conditions and ensure the development of new diagnostic strategies. The aim of this comprehensive review is to provide a detailed description of the involvement of these cells in disorders affecting the inner ear by analyzing the mechanisms that cause them. In addition, based on current knowledge, focus is also placed on future prospects and new targeted therapeutic strategies. Inner ear disorders, including sensorineural hearing loss, Meniere's disease, and vestibular neuritis, are prevalent conditions that significantly impact the quality of life. Despite their high incidence, the underlying pathophysiology of these disorders remains elusive, and current treatment options are often inadequate. Emerging evidence suggests that pericytes, a type of vascular mural cell specialized to maintain the integrity and function of the microvasculature, may play a crucial role in the development and progression of inner ear disorders. The pericytes are present in the microvasculature of both the cochlea and the vestibular system, where they regulate blood flow, maintain the blood–labyrinth barrier, facilitate angiogenesis, and provide trophic support to neurons. Understanding their role in inner ear disorders may provide valuable insights into the pathophysiology of these conditions and lead to the development of novel diagnostic and therapeutic strategies, improving the standard of living. This comprehensive review aims to provide a detailed overview of the role of pericytes in inner ear disorders, highlighting the anatomy and physiology in the microvasculature, and analyzing the mechanisms that contribute to the development of the disorders. Furthermore, we explore the potential pericyte-targeted therapies, including antioxidant, anti-inflammatory, and angiogenic approaches, as well as gene therapy strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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