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3. The Effects of an Acceptance and Commitment-Informed Interdisciplinary Rehabilitation Program for Chronic Airway Diseases on Health Status and Psychological Symptoms

Author

Giusti, E. M., Papazian, B., Manna, C., Giussani, V., Perotti, M., Castelli, F., Battaglia, S., Galli, P., Rossi, A., Re, V., Goulene, K., Castelnuovo, G., Stramba-Badiale, M., Giusti E. M. (ORCID:0000-0001-5767-8785), Manna C., Castelnuovo G. (ORCID:0000-0003-2633-9822), Giusti, E. M., Papazian, B., Manna, C., Giussani, V., Perotti, M., Castelli, F., Battaglia, S., Galli, P., Rossi, A., Re, V., Goulene, K., Castelnuovo, G., Stramba-Badiale, M., Giusti E. M. (ORCID:0000-0001-5767-8785), Manna C., and Castelnuovo G. (ORCID:0000-0003-2633-9822)

Abstract

Background: Chronic airway diseases are prevalent and costly conditions. Interdisciplinary rehabilitation programs that include Acceptance and Commitment-based (ACT) components could be important to tackle the vicious circle linking progression of the disease, inactivity, and psychopathological symptoms. Methods: A retrospective evaluation of routinely collected data of an interdisciplinary rehabilitation program was performed. The program included group sessions including patient education, breathing exercise, occupational therapy and an ACT-based psychological treatment, and individual sessions of physical therapy. Demographic data, clinical characteristics of the patients and the values of outcome variables (health status, quality of life, anxiety, and depression) before treatment, at discharge, at 3 months, and at 6 months were extracted from medical records. Multiple imputation was employed to address missing data. Linear mixed models were employed to assess changes over time. Multivariable logistic regression was performed to assess predictors of a minimum clinically important change of health status from baseline to the 6-months follow-up. Results: Data from 31 patients with chronic obstructive pulmonary disease (COPD) and 12 patients with bronchiectasis were extracted. Health status improved from baseline to discharge to the 3 months follow-up, but not to the 6 months follow-up. Anxiety and depression improved across all the time points. Quality of life did not improve over time. Having a worse health status at baseline and fewer depressive symptoms were significantly associated with achieving a minimum clinically important change of health status at 6 months. The effects of the interdisciplinary program were not different for patients with COPD or with bronchiectasis. Discussion: Interdisciplinary programs including ACT-based components are promising treatments for the rehabilitation of patients with chronic airway diseases.

Published
2022

4. Sleep disturbances and sleep disorders as risk factors for chronic postsurgical pain: A systematic review and meta-analysis

Author

Varallo, Giorgia, Giusti, Emanuele Maria, Manna, Chiara, Castelnuovo, Gianluca, Pizza, F., Franceschini, C., Plazzi, G., Varallo G., Giusti E. M. (ORCID:0000-0001-5767-8785), Manna C., Castelnuovo G. (ORCID:0000-0003-2633-9822), Varallo, Giorgia, Giusti, Emanuele Maria, Manna, Chiara, Castelnuovo, Gianluca, Pizza, F., Franceschini, C., Plazzi, G., Varallo G., Giusti E. M. (ORCID:0000-0001-5767-8785), Manna C., and Castelnuovo G. (ORCID:0000-0003-2633-9822)

Abstract

This systematic review and meta-analysis aimed at evaluating the role of sleep disturbances and sleep disorders in influencing presence and intensity of chronic postsurgical pain (CPSP). We included cohort studies which enrolled adults, assessed sleep disturbances or disorders before surgery, measured pain intensity, presence of pain, or opioid use at least three months after surgery. Eighteen studies were included in a narrative synthesis and 12 in a meta-analysis. Sleep disturbances and disorders were significantly related to CPSP, with a small effect size, r = 0.13 (95% CI 0.06–0.20). The certainty of evidence was rated low due to risk of bias and heterogeneity. In subgroup analyses the above association was significant in studies that used pain intensity as the outcome, but not in those that used presence of pain; in studies on patients who underwent total knee arthroplasty or other surgeries, but not in those on patients who had breast cancer surgery or total hip arthroplasty; in the single study that assessed insomnia and in studies that assessed sleep disturbances as predictors. A meta-regression showed that the follow-up length was positively associated with the overall estimate. Our findings suggest that presurgical sleep disturbances and disorders should be evaluated to detect patients at risk for CPSP. Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=272654

Published
2022

5. Psychological factors and trajectories of post-surgical pain: A longitudinal prospective study

Author

Giusti, Emanuele Maria, Lacerenza, M., Gabrielli, S., Manzoni, G. M., Manna, Chiara, D'Amario, F., Marcacci, M., Castelnuovo, Gianluca, Giusti E. M. (ORCID:0000-0001-5767-8785), Manna C., Castelnuovo G. (ORCID:0000-0003-2633-9822), Giusti, Emanuele Maria, Lacerenza, M., Gabrielli, S., Manzoni, G. M., Manna, Chiara, D'Amario, F., Marcacci, M., Castelnuovo, Gianluca, Giusti E. M. (ORCID:0000-0001-5767-8785), Manna C., and Castelnuovo G. (ORCID:0000-0003-2633-9822)

Abstract

A significant proportion of patients do not experience relief from pain during the early postsurgical period after joint arthroplasty and are at risk for developing chronic pain. The objectives of this study were to identify biopsychosocial factors associated with acute postsurgical pain trajectories and with pain intensity and interference after 1, 3, and 12 months. Two hundred ten patients listed for joint arthroplasty filled a presurgical battery of questionnaires assessing presurgical pain intensity, catastrophizing, emotional distress, state anxiety and depression, self-efficacy, central sensitization, and executive functions. From the day after surgery, they were asked to fill a 7-day diary, including questions about postsurgical pain and postsurgical state catastrophizing. Finally, they provided data about pain intensity and interference after 1, 3, and 12 months. Predictors of acute pain trajectories were investigated using multilevel growth curve analysis. Results showed that central sensitization was a predictor of the intercept of pain trajectories and daily postsurgical catastrophizing was a significant covariate of pain intensity in the acute phase. Analyses of follow-up data showed that central sensitization was a predictor of pain intensity and pain interference at 3 and 12 months, that emotional distress was related with pain intensity and interference at 1 month, and with pain interference at 3 months, and that cognitive flexibility was associated with pain interference at 1 month. Assessment of these factors could enable to identify patients at risk for worse outcomes and to plan targeted treatments to be implemented during the patient’s inward stay.

Published
2022

8. Psychological support interventions for healthcare providers and informal caregivers during the covid‐19 pandemic: A systematic review of the literature

Author

Bertuzzi, V., Semonella, M., Bruno, D., Manna, C., Edbrook-childs, J., Giusti, E. M., Castelnuovo, G., Pietrabissa, G., Bertuzzi V., Castelnuovo G. (ORCID:0000-0003-2633-9822), Pietrabissa G. (ORCID:0000-0002-5911-5748), Bertuzzi, V., Semonella, M., Bruno, D., Manna, C., Edbrook-childs, J., Giusti, E. M., Castelnuovo, G., Pietrabissa, G., Bertuzzi V., Castelnuovo G. (ORCID:0000-0003-2633-9822), and Pietrabissa G. (ORCID:0000-0002-5911-5748)

Abstract

Background: During the COVID‐19 pandemic, healthcare providers and informal caregivers were at an increased risk of adverse mental health effects. This systematic review provides a summary of the available evidence on the content and efficacy of the psychological support interventions in increasing mental health among healthcare providers and informal caregivers during the COVID‐19 pandemic. Methods: PubMed, Google Scholar, PsychINFO, and Scopus databases were systematically searched for relevant articles, and the methodological quality of selected articles was assessed using the Quality Assessment Tool for Quantitative Studies. Results: A search of electronic databases identified five reports based on inclusion and exclusion criteria. All psychological support interventions for caregivers were delivered digitally. Despite the large heterogeneity of the selected studies, the findings support the efficacy of mental health interventions in reducing distress and burnout, while promoting self‐efficacy and well‐being in both healthcare providers and informal caregivers. Conclusion: Since mental health problems are expected to increase during, and as a result of, the COVID‐19 pandemic, and digital tools might offer a range of mental health treatments to meet the unique and immediate needs of people, further research is needed to test the cost‐effectiveness of digital psychological interventions.

Published
2021

9. The relationship between emotional intelligence, obesity and eating disorder in children and adolescents: A systematic mapping review

Author

Giusti, Emanuele Maria, Manna, C., Scolari, A., Mestre, J. M., Prevendar, T., Castelnuovo, Gianluca, Pietrabissa, Giada, Giusti E. M. (ORCID:0000-0001-5767-8785), Castelnuovo G. (ORCID:0000-0003-2633-9822), Pietrabissa G. (ORCID:0000-0002-5911-5748), Giusti, Emanuele Maria, Manna, C., Scolari, A., Mestre, J. M., Prevendar, T., Castelnuovo, Gianluca, Pietrabissa, Giada, Giusti E. M. (ORCID:0000-0001-5767-8785), Castelnuovo G. (ORCID:0000-0003-2633-9822), and Pietrabissa G. (ORCID:0000-0002-5911-5748)

Abstract

Eating and weight disorders often develop early in life and cause a long-standing significant health burden. Given the documented role of emotional intelligence (EI) in shaping the body image and predicting the onset of eating disorders, knowledge of the mechanisms involved in EI among youth is fundamental to designing specific interventions for screening and prevention of obesity and eating disorders (EDs). The present systematic mapping review was aimed to explore and quantify the nature and distribution of existing research investigating the impact of EI on EDs in young people. A systematic search for relevant articles was conducted using PubMed, Scopus, PsycINFO and Web of Science databases. The Appraisal tool for Cross-Sectional Studies (AXIS) was used to assess the included studies’ methodological quality. The included studies’ results were mapped based on stratification by age groups (children, preadolescents, and adolescents), population (clinical vs. non-clinical) and disordered eating outcomes. Nine studies were included, supporting the association between EI and body image dissatisfaction, ED risk and bulimic symptomatology, but not with anorexic symptoms. Research on children and clinical populations was scant. Further studies are needed to deepen the role of EI in the genesis and maintenance of EDs.

Published
2021

11. Heterogeneity of PD-L1 Expression in Lung Mixed Adenocarcinomas and Adenosquamous Carcinomas

Author

Zito Marino F., Rossi G., Montella M., Botti G., De Cecio R., Morabito A., La Manna C., Ronchi A., Micheli M., Salatiello G., Micheli P., Rocco D., Accardo M., Franco R., ZITO MARINO, Federica, Zito Marino, F., Rossi, G., Montella, M., Botti, G., De Cecio, R., Morabito, A., La Manna, C., Ronchi, A., Micheli, M., Salatiello, G., Micheli, P., Rocco, D., Accardo, M., Franco, R., and ZITO MARINO, Federica

Subjects
0301 basic medicine, PD-L1, Male, Lung Neoplasms, Biopsy, Adenocarcinoma, B7-H1 Antigen, Pathology and Forensic Medicine, 03 medical and health sciences, Carcinoma, Adenosquamous, 0302 clinical medicine, Cytology, PD-1, Carcinoma, medicine, Biomarkers, Tumor, Humans, Epidermal growth factor receptor, Lung cancer, Aged, Aged, 80 and over, Lung, biology, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, lung adenocarcinoma, Immunohistochemistry, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Biomarker (medicine), Surgery, Female, immunotherapy, lung adenosquamous carcinoma, Anatomy, business
Abstract

Immune checkpoint inhibitors against programmed cell death protein 1/programmed death-ligand 1 (PD-L1) have proven to be remarkably effective in non-small cell lung cancer. PD-L1 represents a predictive biomarker in lung cancer, although its heterogenous expression represents an emerging challenge for accurate biomarker-based patient selection. Lung adenocarcinomas (ADCs) show a high rate of intratumor morphologic heterogeneity that may reflect a heterogenous molecular and immunophenotypic profile. The aim of our study was to analyze the expression of PD-L1 in different intratumor subtypes and/or growth patterns in a series of mixed adenocarcinomas (mADCs) and adenosquamous lung carcinomas (AdSqLCs). As many as 73 mADCs and 6 AdSqLCs were selected. Comprehensive histologic subtyping was performed, and PD-L1 expression was assessed by immunohistochemistry assay using different primary antibodies and automated immunostainers. Overall, PD-L1 expression was observed in 37 of 79 cases (39.2%) (31 mADCs and all AdSqLCs). PD-L1 expression was heterogenous in 22 of 37 PD-L1-positive cases (23.2% mADC and 83% AdSqLC). PD-L1 expression was observed more frequently in ADC with solid pattern. Heterogeneity of PD-L1 expression was significantly related to the presence of micropapillary (P=0.028) and solid (P=0.017) patterns. All PD-L1-positive cases were epidermal growth factor receptor wild-type, 2 cases harbored concomitantly PD-L1 expression and ALK rearrangement. Our data suggest that PD-L1 expression is quite heterogenous in mADCs and AdSqLCs, partly contributing to explaining the discrepant results between biopsy and surgical resections and discordant clinical effectiveness in regard to PD-L1-positive or negative ADC diagnosed on cytology/small biopsy.

Published
2019

13. The predictive role of executive functions and psychological factors on chronic pain after orthopaedic surgery: A longitudinal cohort study

Author

Giusti, Emanuele Maria, Manna, C., Varallo, Giorgia, Cattivelli, Roberto, Manzoni, G. M., Gabrielli, S., D'Amario, F., Lacerenza, M., Castelnuovo, Gianluca, Giusti E. M. (ORCID:0000-0001-5767-8785), Varallo G., Cattivelli R. (ORCID:0000-0002-5995-5456), Castelnuovo G. (ORCID:0000-0003-2633-9822), Giusti, Emanuele Maria, Manna, C., Varallo, Giorgia, Cattivelli, Roberto, Manzoni, G. M., Gabrielli, S., D'Amario, F., Lacerenza, M., Castelnuovo, Gianluca, Giusti E. M. (ORCID:0000-0001-5767-8785), Varallo G., Cattivelli R. (ORCID:0000-0002-5995-5456), and Castelnuovo G. (ORCID:0000-0003-2633-9822)

Abstract

Prevention and treatment of chronic post-surgical pain should be based on the early identification of patients at risk. The presence of a deficit in executive functions, along with the presence of psychological risk factors, could impair the use of appropriate pain coping strategies and might facilitate the transition to chronic post-surgical pain. A longitudinal cohort study was implemented. Patients listed for orthopaedic surgery were enrolled. Variables measured before surgery were pain intensity, the sensory, affective, cognitive and mixed components of pain, state and trait variables associated with the psychological status of the patient, fear of movement, pain catastrophizing, visual attention and cognitive flexibility. Pain intensity and the components of pain were re-evaluated after surgery and after three months. A linear mixed model was used to assess the predictors of pain intensity, and a multivariate linear mixed model was used to assess the predictors of the pain components. 167 patients were enrolled. Controlling for sex, age, pain duration and surgical procedure, catastrophizing and visual attention were predictors of pain intensity at follow-up. The sensory component of pain was predicted by state anxiety, healthcare-related fears, pain catastrophizing and visual attention. Anxiety and catastrophizing were predictors of the affective and evaluative components of pain. The mixed component of pain was predicted by state anxiety, healthcare-related fears and pain catastrophizing. Executive functions, along with psychological risk factors, shape the course of post-surgical pain. The efficacy of preventive and rehabilitation treatment could be possibly enhanced if these factors are treated.

Published
2020

14. The Psychological Impact of the COVID-19 Outbreak on Health Professionals: A Cross-Sectional Study

Author

Giusti, E. M., Pedroli, E., D'Aniello, G. E., Stramba Badiale, C., Pietrabissa, G., Manna, C., Stramba Badiale, M., Riva, G., Castelnuovo, G., Molinari, E., Giusti E. M. (ORCID:0000-0001-5767-8785), D'Aniello G. E., Pietrabissa G. (ORCID:0000-0002-5911-5748), Riva G. (ORCID:0000-0003-3657-106X), Castelnuovo G. (ORCID:0000-0003-2633-9822), Molinari E. (ORCID:0000-0001-8132-694X), Giusti, E. M., Pedroli, E., D'Aniello, G. E., Stramba Badiale, C., Pietrabissa, G., Manna, C., Stramba Badiale, M., Riva, G., Castelnuovo, G., Molinari, E., Giusti E. M. (ORCID:0000-0001-5767-8785), D'Aniello G. E., Pietrabissa G. (ORCID:0000-0002-5911-5748), Riva G. (ORCID:0000-0003-3657-106X), Castelnuovo G. (ORCID:0000-0003-2633-9822), and Molinari E. (ORCID:0000-0001-8132-694X)

Abstract

Background: The COVID-19 pandemic had a massive impact on health care systems, increasing the risks of psychological distress in health professionals. This study aims at assessing the prevalence of burnout and psychopathological conditions in health professionals working in a health institution in the Northern Italy, and to identify socio-demographic, work-related and psychological predictors of burnout. Methods: Health professionals working in the hospitals of the Istituto Auxologico Italiano were asked to participate to an online anonymous survey investigating socio-demographic data, COVID-19 emergency-related work and psychological factors, state anxiety, psychological distress, post-traumatic symptoms and burnout. Predictors of the three components of burnout were assessed using elastic net regression models. Results: Three hundred and thirty health professionals participated to the online survey. Two hundred and thirty-five health professionals (71.2%) had scores of state anxiety above the clinical cutoff, 88 (26.8%) had clinical levels of depression, 103 (31.3%) of anxiety, 113 (34.3%) of stress, 121 (36.7%) of post-traumatic stress. Regarding burnout, 107 (35.7%) had moderate and 105 (31.9%) severe levels of emotional exhaustion; 46 (14.0%) had moderate and 40 (12.1%) severe levels of depersonalization; 132 (40.1%) had moderate and 113 (34.3%) severe levels of reduced personal accomplishment. Predictors of all the three components of burnout were work hours, psychological comorbidities, fear of infection and perceived support by friends. Predictors of both emotional exhaustion and depersonalization were female gender, being a nurse, working in the hospital, being in contact with COVID-19 patients. Reduced personal accomplishment was also predicted by age. Conclusions: Health professionals had high levels of burnout and psychological symptoms during the COVID-19 emergency. Monitoring and timely treatment of these conditions is needed.

Published
2020

22. Nutritional Aspects of Food Toxicology: Mercury Toxicity and Protective Effects of Olive Oil Hydroxytyrosol

Author

Officioso A, Manna C, and Tortora F

Subjects
0301 basic medicine, Food toxicology, business.industry, chemistry.chemical_element, Metal toxicity, 010501 environmental sciences, Health benefits, Biology, 01 natural sciences, Mercury (element), Biotechnology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Nutraceutical, chemistry, Toxicity, Hydroxytyrosol, Food science, business, 0105 earth and related environmental sciences, Olive oil
Abstract

Mercury represents one of the main environmental pollutants and human exposure to this heavy metal occurs primarily through nutritional sources, including contaminated fish. This highly toxic compound is known to pose serious threats to human health, including neurological alterations. Moreover, based on its effects on cardiovascular health, mercury exposure is now considered an independent risk factor for cardiovascular diseases. The possibility of reducing heavy metal toxicity through diet has attracted the interest of those responsible for the public health service. In this respect, the use of phytochemicals able to significantly counteract oxidative alterations as an attractive tool for the reduction of mercury toxicity has been proposed. Here we review recent evidence supporting the beneficial role of olive oil hydroxytyrosol in preventing mercury-induced alterations in both human erythrocytes and neuroblastoma cells. This novel biological effect exerted by hydroxytyrosol represents an additional mechanism responsible for the much-claimed health benefits of this dietary phenol. Taken together the reported findings encourage the use of virgin olive oil, characterized by a high hydroxytyrosol content, as an innovative approach in designing combined dietary and/or nutraceutical strategies to contrast mercury toxicity in humans.

Published
2016
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23. Microbiological quality of finfish and shellfish with special reference to shiga toxin-producing Escherichia coli O157

Author

Manna, S.K., Das, R., and Manna, C.

Subjects
Escherichia coli -- Environmental aspects, Escherichia coli -- Health aspects, Microbial contamination -- Prevention, Shellfish -- Storage, Business, Food/cooking/nutrition
Abstract

Shellfish and finfish from Kolkata, India were studied to determine the microbiological quality, with special emphasis on E. coli O157, which is a regular contaminant of food and water causing life-threatening foodborne outbreaks. Results indicated that due to poor hygiene and sanitary conditions fishes were contaminated with coliforms, including E. coli but none of the sample was contaminated with E. coli O157.

Published
2008

24. A telemedicine home care based activity monitor device

Author

D'Addio G., Cimmino P., Manna C., Pasquale C., Arpaia P., D'Addio, Giovanni, Cimmino, Pasquale, Manna, Carlo, Arpaia, Pasquale, D'Addio, G., Cimmino, P., Manna, C., Pasquale, C., and Arpaia, P.

Subjects
Engineering, Telemedicine, SIMPLE (military communications protocol), business.industry, Remote patient monitoring, styling, Gold standard (test), insert, Activity monitor, Upload, Disk formatting, style, Embedded system, Wireless, formatting, business
Abstract

A minimally invasive low-cost actigraph, with simple on-line movements features extraction, but with performance enhanced by off-line post-processing, is proposed. Despite its cost significantly lower, the proposed actigraph has performance similar to commercially available solutions. Moreover, its open downloading system and wireless integration capabilities make it apposite for telemedicine home care settings. The proposed device has been characterized experimentally by comparing its performance with an emerging gold standard in clinical monitoring physical activity assessment. © 2011 IEEE.

Published
2011

25. A data mining approach for the prediction of pregnancy during IVF treatment

Author

Alessandra Lumini, Nanni, L., Manna, C., Pappalardo, S., Lumini, Alessandra, Manna, C., Nanni, Lori, and Pappalardo, S.

Abstract

Introduction: One of the most relevant clinical aspects during IVF-ICSI treatments is to decide if endometrium is receptive for embryo implantation, in order to perform embryo transfer or to postpone it in another cycle. This might increase both patients’ convenience and the cost-effectiveness of ART procedure. Different strategies have been developed to evaluate non-invasive endometrial receptivity mainly based on ultrasound examination of endometrial features including thickness, pattern, volume and blood flow. To the best of our knowledge, almost all the published works analyze all these features singularly, without taking into account their possible interaction. The aim of this work is to approach the problem by a data mining technique able to consider an optimal combination of features for designing a system that may predict pregnancy during IVF-ICSI treatment. Material & methods: A total of 62 cycles of ICSI, each related to a different patient, resulting in 27 pregnancy and 35 failures were included in this study. All the ultrasound scans and measurements were performed on the day of hCG administration by the same observer with the digital platform VOLUSON i System using a standard acquisition procedure. Ten features were measured in each cycle: age of the woman (AGE), endometrial vascularization index (E-VI), endometrial flow index (E-FI), endometrial vascularization/flow index (E-VFI), sub-endometrial vascularization index (S-VI), sub-endometrial flow index (S-FI), sub-endometrial vascularization/flow index (S-VFI), endometrial thickness (E-T), endometrial volume (E-V), sub-endometrial volume (S-V). In order to evaluate if each feature is significant for this prediction problem the area under the ROC curve (AUC) was calculated. Then, a data mining approach based on support vector machines (SVM) was designed, combining a set of features to give a prediction score to the IVF-ICSI treatment. The proposed system needs a training phase for the optimization of internal SVM parameters, that is performed according to the leave-one-out testing protocol, which involves the use of a single cycle from the dataset as testing data (each once), and the remaining ones as training. Results: The analysis of the AUC for each feature revealed that the three best features are: S-VI (0.703), E-VI (0.685) and E-VFI (0.677). Using a SVM system trained by the best three features above cited the performance does not appreciably change, probably due to the fact that these features contain similar information. If a feature selection approach is used to choose the three most suited features to be combined, the performance increases to 0.78. This very encouraging result has been obtained training a SVM by the combination of the following three features: S-VI, E-FI and AGE. In our experiments the well-known Sequential Forward Floating Selection (SFFS) algorithm for selecting a subset of features was used. SFFS is based on a search strategy that checks whether, at each sequential step, removing any feature in the selected set and adding a new one can improve the resultant set. Conclusions: Our experiments confirm that vascularization data, measured from both the endometrium and the subendometrium in the day of hCG administration, are significant for the problem of predicting pregnancy. More interestingly our main practical finding is that it is possible to build and use a reliable data mining technique, with the optimal combination of a small set of non invasive measurable features, to predict pregnancy during IVF treatment.

Published
2010

26. High-yield production of the vaccinia virus A27L and A33R immunogenic proteins in transgenic and transplastomic tobacco plants

Author

RIGANO, MARIA MANUELA, Manna C., Giulini A., Pedrazzini E., Capobianchi M., Castilletti C., Di Caro A., Ippolito G., Beggio P., De Giuli Morghen C., Vitale A., Cardi T., Rigano, MARIA MANUELA, Manna, C., Giulini, A., Pedrazzini, E., Capobianchi, M., Castilletti, C., Di Caro, A., Ippolito, G., Beggio, P., De Giuli Morghen, C., Vitale, A., and Cardi, T.

Published
2010

29. High expression of the vaccinia virus A27L protein in transgenic and transplastomic plants

Author

Manna C., Rigano M. M., Giulini A., Capobianchi M., Castilletti C., Di Caro A., Ippollito G., Beggio P., De Giuli Morghen C., Vitale A., Cardi T, Manna, C., Rigano, MARIA MANUELA, Giulini, A., Capobianchi, M., Castilletti, C., Di Caro, A., Ippolito, G., Beggio, P., De Giuli Morghen, C., Vitale, A., and Cardi, T.

Subjects
piante transgeniche, vaccini, sintesi proteica
Published
2008

30. IN VIVO EFFECT OF THE NATURAL ANTIOXIDANT HYDROXYTYROSOL ON CYCLOSPORINE NEPHROTOXICITY

Author

CAPASSO G, DI GENNARO C, INDACO S, DELLA RAGIONE F, MANNA C, PERNA A, POLLASTRO R, DAMIANO S, MAZZONI O, GALLETTI P, ZAPPIA V., CIARCIA, ROBERTO, FLORIO, SALVATORE, Capasso, G, DI GENNARO, C, Indaco, S, DELLA RAGIONE, F, Manna, C, Ciarcia, Roberto, Florio, Salvatore, Perna, A, Pollastro, R, Damiano, S, Mazzoni, O, Galletti, P, and Zappia, V.

Abstract

BACKGROUND: Cyclosporine A (CsA) is the first-line immunosuppressant used in transplant patients and in auto- immune diseases. Nephrotoxicity is the major limitation of CsA use. Although the mechanisms of nephrotoxicity have not been completely defined, some evidence suggests that reactive oxygen species (ROS) play a causal role. The present study was designed to investigate in vivo effects of hydroxytyrosol (DOPET), a natural olive oil antioxidant, on oxidative stress, renal histology and haemodynamic alterations induced in rats by CsA treatment. METHODS: Adult Sprague-Dawley rats were treated i.p. with CsA (15 mg/kg) alone or in combination with DOPET (20 mg/kg) for 3 weeks. At the end of the treatment, superoxide concentration within the cells of the abdominal aorta and renal artery was quantified from the oxidation of dihydroethidium (DHE) using fluorescence microscopic imaging analysis. In kidney tissues, lipid peroxidation was measured by thiobarbituric acid-reacting substances (TBARS) assay, glutathione level was assessed enzymatically and the expression of haem oxygenase-1 (HO-1) gene was evaluated by semiquantitative RT-PCR. Renal morphology was studied by classical histological techniques, while the glomerular filtration rate (GFR) was estimated by inulin clearance. Systemic blood pressure was monitored by the tail method and through the catheterization of the carotid artery. RESULTS: CsA administration increased superoxide concentration both in the aorta and in the renal artery, while DOPET completely prevented this effect. Higher levels of TBARS, a significant decrease in GSH and an upregulation of HO-1 mRNA were observed in the kidneys of CsA-treated rats. DOPET treatment reversed quantitatively these effects. However, CsA-dependent changes in renal histology were only partially reversed by DOPET. Finally, CsA induced a severe reduction in GFR and a significant increase in both systolic and diastolic blood pressure; the DOPET treatment had no significant effect on these haemodynamic alterations. CONCLUSION: The reported data indicate that effective DOPET protection from CsA-induced oxidative stress is associated with a mild effect on histological damages and does not affect the altered glomerular function and the hypertension, thus indicating that kidney injury by CsA is only in part dependent on oxidative stress.

Published
2008

34. Influence of steric bulk around the vinyl sulfone bond on the reaction patterns of vinyl sulfone-modified carbohydrates. An experimental and theoretical investigation

Author

Bhattacharya, R., Kesharwani, M. K., Manna, C., Ganguly, B., and Tanmaya Pathak

Subjects
carbohydrate, Michael addition, Vinyl sulfone, steric bulk
Abstract

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur-721 302, West Bengal. India E-mail : tpathak@chem. iitkgp.ernet.in Computation and Simulation Unit (Analytical Discipline and Centralized Instrument Facility), CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364 002, Gujarat, India E-mail : ganguly@csmcri.org Manuscript received 13 June 2013, accepted 14 June 2013 Steric bulks attached to sulfur atom of vinyl sulfone-modified hex-2-enopyranosides and the anomeric centre control the rate of reactions of these Michael acceptors. Amongst the two, the steric bulk at C-1 is more efficient in retarding the reaction rate of Michael addition reaction. The conformational analysis performed with 2a and 2e using quantum chemical calculations suggests that the addition of isopropylamine would be slower for 2e compared to 2a due to the more steric hindrance in the former case.

Published
2013
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35. The impact of decreasing cutoff values for maximal oxygen consumption (VO2max) in the decision-making process for candidates to lung cancer surgery

Author

Rocco, G, Gatani, T, DI MAIO, Massimo, Meoli, I, La Rocca, A, Martucci, N, La Manna, C, and Stefanelli, F.

Subjects
Original Article
Abstract

Maximal oxygen consumption (VO(2)max) is considered a decisive test for risk prediction in patients with borderline cardiopulmonary reserve. Guidelines have adopted decreasing VO(2)max cut-off values to define operability within acceptable mortality and morbidity limits. We wanted to investigate how the adoption of decreasing VO(2)max cut-off-values assessment contributed to better select lung surgery candidates.One hundred and nineteen consecutive surgical candidates have been prospectively analyzed as a sample population. Preoperative work-up included spirometry and transfer factor (DLco); irrespective of the spirometric values, these patients were subjected to VO(2)max assessment. Surgical eligibility was decided by the same surgeon throughout the series. In the postoperative period, overall mortality and the occurrence of any, major or minor complications was recorded and graded according to the Common Terminology Criteria for Adverse Events v.4.3.Three arbitrary cut-offs were introduced at 15, 14 and 12 mL(.)kg(-1) (.)min(-1). Notably, 15 and 12 mL(.)kg(-1) (.)min(-1) correlated with percentage VO(2)max values of 50% and 35% of predicted (P0.0001 and 0.0079), respectively. Accordingly, the patients were subdivided into groups in which the prevalence of postoperative morbidity was recorded. The groups were homogeneous as to age, BMI, preoperative absolute and percentage FEV1 and DLco. In the Cox proportionate-hazards multivariate analysis, VO(2)max less than 35% (P=0.0017) and CTCAE2 (P=0.0457) emerged as significant predictors of survival after surgery. Conversely on logistic regression analysis, age over 70 years (P=0.03) and pneumonectomy (P=0.001), but not VO(2)max cut-off values, were significant predictors of major (CTCAE2) morbidity.Since VO(2)max is increasingly used to contribute to risk prediction for the individual patient, surgeons need to be advised that the concept of a definitive, generalized cut-off value for VO(2)max is probably a contradiction in terms. Patient-specific VO(2)max values are more likely to contribute to risk assessment since they may reflect the primarily affected component among the determinants of maximal oxygen consumption. Whether patient-specific VO(2)max should be routinely used by surgeons to define operability for borderline patients needs further evaluation.

Published
2013

40. A minimally-invasive system for free-living activity monitoring in home care

Author

Clemente F and Manna C

Abstract

A minimal wearable system to monitoring remotely normal free-living activity (e.g. laying, sitting, standing, and slow walking) of patients in their home space is proposed. Owing to its wireless features, the system can represent a useful tool to be implemented in a long-time patient monitoring system. These systems are useful for the clinical out coming or for minor chronic pathologies not requiring hospitalization

Published
2009

44. Measurement of D-s(-)->tau(-)(nu)over-bar(tau) and a new limit for B-->tau(-)(nu)over-bar(tau center dot) RID C-4549-2008 RID C-5719-2008

Author

Acciarri M, Adriani O, AguilarBenitez M, Ahlen S, Alpat B, Alcaraz J, Alemanni G, Allaby J, Aloisio A, Alverson G, Alviggi MG, Ambrosi G, Anderhub H, Andreev VP, Angelescu T, Anselmo F, Antreasyan D, Arefiev A, Azemoon T, Aziz T, Bagnaia P, Baksay L, Ball RC, Banerjee S, Banicz K, Barillere R, Barone L, Bartalini P, Baschirotto A, Basile M, Battiston R, Bay A, Becattini F, Becker U, Behner F, Berdugo J, Berges P, Bertucci B, Betev VL, Bhattacharya S, Biasini M, Biland A, Bilei GM, Blaising JJ, Blyth SC, Bobbink GJ, Bock R, Bohm A, Borgia B, Boucham A, Bourilkov D, Bourquin M, Boutigny D, Branson JG, Brigljevic V, Brock IC, Buffini A, Buijs A, Burger JD, Burger WJ, Busenitz J, Cai XD, Campanelli M, Capell M, Romeo GC, Caria M, Carlino G, Cartacci AM, Casaus J, Castellini G, Cavallari F, Cavallo N, Cecchi C, Cerrada M, Cesaroni F, Chamizo M, Chan A, Chang YH, Chaturvedi UK, Chekanov SV, Chemarin M, Chen G, Chen GM, Chen HF, Chen HS, Chen M, Chiefari G, Chien CY, Choi MT, Cifarelli L, Cindolo F, Civinini C, Clare I, Clare R, Cohn HO, Coignet G, Colijn AP, Colino N, Commichau V, Costantini S, Cotorobai F, dellaCruz B, Csilling A, Dai TS, DAlessandro R, deAsmundis R, Degre A, Deiters K, Denes P, DE NOTARISTEFANI, Francesco, DiBitonto D, Diemoz M, vanDierendonck D, DiLodovico F, Dionisi C, Dittmar M, Dominguez A, Doria A, Dorne I, Dova MT, Drago E, Duchesneau D, Duinker P, Duran I, Dutta S, Easo S, Efremenko Y, ElMamouni H, Engler A, Eppling FJ, Erne FC, Ernenwein JP, Extermann P, Fabre M, Faccini R, Falciano S, Favara A, Fay J, Fedin O, Felcini M, Fenyi B, Ferguson T, Fernandez D, Ferroni F, Fesefeldt H, Fiandrini E, Field JH, Filthaut F, Fisher PH, Forconi G, Fredj L, Freudenreich K, Furetta C, Galaktionov Y, Ganguli SN, GarciaAbia P, Gau SS, Gentile S, Gerald J, Gheordanescu N, Giagu S, Goldfarb S, Goldstein J, Gong ZF, Gougas A, Gratta G, Gruenewald MW, Gupta VK, Gurtu A, Gutay LJ, Hartmann B, Hasan A, Hatzifotiadou D, Hebbeker T, Herve A, vanHoek WC, Hofer H, Hoorani H, Hou SR, Hu G, Innocente V, Janssen H, Jenkes K, Jin BN, Jones LW, deJong P, JosaMutuberria I, Kasser A, Khan RA, Kamrad D, Kamyshkov Y, Kapustinsky JS, Karyotakis Y, Kaur M, KienzleFocacci MN, Kim D, Kim JK, Kim SC, Kim YG, Kinnison WW, Kirkby A, Kirkby D, Kirkby J, Kiss D, Kittel W, Klimentov A, Konig AC, Korolko I, Koutsenko V, Kraemer RW, Krenz W, Kunin A, deGuevara PLD, Landi G, Lapoint C, LassilaPerini K, Laurikainen P, Lebeau M, Lebedev A, Lebrun P, Lecomte P, Lecoq P, LeCoultre P, Lee JS, Lee KY, Leggett C, LeGoff JM, Leiste R, Leonardi E, Levtchenko P, Li C, Lieb E, Lin WT, Linde FL, Lista L, Liu ZA, Lohmann W, Longo E, Lu W, Lu YS, Lubelsmeyer K, Luci C, Luckey D, Luminari L, Lustermann W, Ma WG, Maity M, Majumder G, Malgeri L, Malinin A, Manna C, Mangeol D, Mangla S, Marchesini P, Marin A, Martin JP, Marzano F, Massaro GGG, McNally D, Mele S, Merola L, Meschini M, Metzger WJ, vonderMey M, Mi Y, Mihul A, vanMil AJW, Mirabelli G, Mnich J, Molnar P, Monteleoni B, Moore R, Morganti S, Moulik T, Mont R, Muller S, Muheim F, Muijs AJM, Nagy E, Nahn S, Napolitano M, NessiTedaldi F, Newman H, Niessen T, Nippe A, Nisati A, Nowak H, Opitz H, Organtini G, Ostonen R, Pakhlov P, Pandoulas D, Paoletti S, Paolucci P, Park HK, Pascale G, Passaleva G, Patricelli S, Paul T, Pauluzzi M, Paus C, Pauss F, Peach D, Pei YJ, Pensotti S, PerretGallix D, Petersen B, Petrak S, Pevsner A, Piccolo D, Pieri M, Pinto JC, Piroue PA, Pistolesi E, Plyaskin V, Pohl M, Pojidaev V, Postema H, Produit N, Prokofiev D, RahalCallot G, Rancoita PG, Rattaggi M, Raven G, Razis P, Read K, Ren D, Rescigno M, Reucroft S, vanRhee T, Riemann S, Riles K, Rind O, Ro S, Robohm A, Rodin J, Rodriguez FJ, Roe BP, Romero L, RosierLees S, Rosselet P, vanRossum W, Roth S, Rubio JA, Rykaczewski H, Salicio J, Sanchez E, Sanders MP, Santocchia A, Sarakinos ME, Sarkar S, Sassowsky M, Sauvage G, Schafer C, Schegelsky V, SchmidtKaerst S, Schmitz D, Schmitz P, Schneegans M, Scholz N, Schopper H, Schotanus DJ, Schwenke J, Schwering G, Sciacca C, Sciarrino D, Sens JC, Servoli L, Shevchenko S, Shivarov N, Shoutko V, Shukla J, Shumilov E, Shvorob A, Siedenburg T, Son D, Sopczak A, Soulimov V, Smith B, Spillantini P, Steuer M, Stickland DP, Stone H, Stoyanov B, Straessner A, Strauch K, Sudhakar K, Sultanov G, Sun LZ, Susinno GF, Suter H, Swain JD, Tang XW, Tauscher L, Taylor L, Ting SCC, Ting SM, Tonutti M, Tonwar SC, Toth J, Tully C, Tuchscherer H, Tung KL, Uchida Y, Ulbricht J, Uwer U, Valente E, VandeWalle RT, Vesztergombi G, Vetlitsky I, Viertel G, Vivargent M, Volkert R, Vogel H, Vogt H, Vorobiev I, Vorobyov AA, Vorvolakos A, Wadhwa M, Wallraff W, Wang JC, Wang XL, Wang ZM, Weber A, Wittgenstein F, Wu SX, Wynhoff S, Xu J, Xu ZZ, Yang BZ, Yang CG, Yao XY, Ye JB, Yeh SC, You JM, Zalite A, Zalite Y, Zemp P, Zeng Y, Zhang Z, Zhang ZP, Zhou B, Zhou Y, Zhu GY, Zhu RY, Zichichi A, Ziegler F., Acciarri, M, Adriani, O, Aguilarbenitez, M, Ahlen, S, Alpat, B, Alcaraz, J, Alemanni, G, Allaby, J, Aloisio, A, Alverson, G, Alviggi, Mg, Ambrosi, G, Anderhub, H, Andreev, Vp, Angelescu, T, Anselmo, F, Antreasyan, D, Arefiev, A, Azemoon, T, Aziz, T, Bagnaia, P, Baksay, L, Ball, Rc, Banerjee, S, Banicz, K, Barillere, R, Barone, L, Bartalini, P, Baschirotto, A, Basile, M, Battiston, R, Bay, A, Becattini, F, Becker, U, Behner, F, Berdugo, J, Berges, P, Bertucci, B, Betev, Vl, Bhattacharya, S, Biasini, M, Biland, A, Bilei, Gm, Blaising, Jj, Blyth, Sc, Bobbink, Gj, Bock, R, Bohm, A, Borgia, B, Boucham, A, Bourilkov, D, Bourquin, M, Boutigny, D, Branson, Jg, Brigljevic, V, Brock, Ic, Buffini, A, Buijs, A, Burger, Jd, Burger, Wj, Busenitz, J, Cai, Xd, Campanelli, M, Capell, M, Romeo, Gc, Caria, M, Carlino, G, Cartacci, Am, Casaus, J, Castellini, G, Cavallari, F, Cavallo, N, Cecchi, C, Cerrada, M, Cesaroni, F, Chamizo, M, Chan, A, Chang, Yh, Chaturvedi, Uk, Chekanov, Sv, Chemarin, M, Chen, G, Chen, Gm, Chen, Hf, Chen, H, Chen, M, Chiefari, G, Chien, Cy, Choi, Mt, Cifarelli, L, Cindolo, F, Civinini, C, Clare, I, Clare, R, Cohn, Ho, Coignet, G, Colijn, Ap, Colino, N, Commichau, V, Costantini, S, Cotorobai, F, Dellacruz, B, Csilling, A, Dai, T, Dalessandro, R, Deasmundis, R, Degre, A, Deiters, K, Denes, P, DE NOTARISTEFANI, Francesco, Dibitonto, D, Diemoz, M, Vandierendonck, D, Dilodovico, F, Dionisi, C, Dittmar, M, Dominguez, A, Doria, A, Dorne, I, Dova, Mt, Drago, E, Duchesneau, D, Duinker, P, Duran, I, Dutta, S, Easo, S, Efremenko, Y, Elmamouni, H, Engler, A, Eppling, Fj, Erne, Fc, Ernenwein, Jp, Extermann, P, Fabre, M, Faccini, R, Falciano, S, Favara, A, Fay, J, Fedin, O, Felcini, M, Fenyi, B, Ferguson, T, Fernandez, D, Ferroni, F, Fesefeldt, H, Fiandrini, E, Field, Jh, Filthaut, F, Fisher, Ph, Forconi, G, Fredj, L, Freudenreich, K, Furetta, C, Galaktionov, Y, Ganguli, Sn, Garciaabia, P, Gau, S, Gentile, S, Gerald, J, Gheordanescu, N, Giagu, S, Goldfarb, S, Goldstein, J, Gong, Zf, Gougas, A, Gratta, G, Gruenewald, Mw, Gupta, Vk, Gurtu, A, Gutay, Lj, Hartmann, B, Hasan, A, Hatzifotiadou, D, Hebbeker, T, Herve, A, Vanhoek, Wc, Hofer, H, Hoorani, H, Hou, Sr, Hu, G, Innocente, V, Janssen, H, Jenkes, K, Jin, Bn, Jones, Lw, Dejong, P, Josamutuberria, I, Kasser, A, Khan, Ra, Kamrad, D, Kamyshkov, Y, Kapustinsky, J, Karyotakis, Y, Kaur, M, Kienzlefocacci, Mn, Kim, D, Kim, Jk, Kim, Sc, Kim, Yg, Kinnison, Ww, Kirkby, A, Kirkby, D, Kirkby, J, Kiss, D, Kittel, W, Klimentov, A, Konig, Ac, Korolko, I, Koutsenko, V, Kraemer, Rw, Krenz, W, Kunin, A, Deguevara, Pld, Landi, G, Lapoint, C, Lassilaperini, K, Laurikainen, P, Lebeau, M, Lebedev, A, Lebrun, P, Lecomte, P, Lecoq, P, Lecoultre, P, Lee, J, Lee, Ky, Leggett, C, Legoff, Jm, Leiste, R, Leonardi, E, Levtchenko, P, Li, C, Lieb, E, Lin, Wt, Linde, Fl, Lista, L, Liu, Za, Lohmann, W, Longo, E, Lu, W, Lu, Y, Lubelsmeyer, K, Luci, C, Luckey, D, Luminari, L, Lustermann, W, Ma, Wg, Maity, M, Majumder, G, Malgeri, L, Malinin, A, Manna, C, Mangeol, D, Mangla, S, Marchesini, P, Marin, A, Martin, Jp, Marzano, F, Massaro, Ggg, Mcnally, D, Mele, S, Merola, L, Meschini, M, Metzger, Wj, Vondermey, M, Mi, Y, Mihul, A, Vanmil, Ajw, Mirabelli, G, Mnich, J, Molnar, P, Monteleoni, B, Moore, R, Morganti, S, Moulik, T, Mont, R, Muller, S, Muheim, F, Muijs, Ajm, Nagy, E, Nahn, S, Napolitano, M, Nessitedaldi, F, Newman, H, Niessen, T, Nippe, A, Nisati, A, Nowak, H, Opitz, H, Organtini, G, Ostonen, R, Pakhlov, P, Pandoulas, D, Paoletti, S, Paolucci, P, Park, Hk, Pascale, G, Passaleva, G, Patricelli, S, Paul, T, Pauluzzi, M, Paus, C, Pauss, F, Peach, D, Pei, Yj, Pensotti, S, Perretgallix, D, Petersen, B, Petrak, S, Pevsner, A, Piccolo, D, Pieri, M, Pinto, Jc, Piroue, Pa, Pistolesi, E, Plyaskin, V, Pohl, M, Pojidaev, V, Postema, H, Produit, N, Prokofiev, D, Rahalcallot, G, Rancoita, Pg, Rattaggi, M, Raven, G, Razis, P, Read, K, Ren, D, Rescigno, M, Reucroft, S, Vanrhee, T, Riemann, S, Riles, K, Rind, O, Ro, S, Robohm, A, Rodin, J, Rodriguez, Fj, Roe, Bp, Romero, L, Rosierlees, S, Rosselet, P, Vanrossum, W, Roth, S, Rubio, Ja, Rykaczewski, H, Salicio, J, Sanchez, E, Sanders, Mp, Santocchia, A, Sarakinos, Me, Sarkar, S, Sassowsky, M, Sauvage, G, Schafer, C, Schegelsky, V, Schmidtkaerst, S, Schmitz, D, Schmitz, P, Schneegans, M, Scholz, N, Schopper, H, Schotanus, Dj, Schwenke, J, Schwering, G, Sciacca, C, Sciarrino, D, Sens, Jc, Servoli, L, Shevchenko, S, Shivarov, N, Shoutko, V, Shukla, J, Shumilov, E, Shvorob, A, Siedenburg, T, Son, D, Sopczak, A, Soulimov, V, Smith, B, Spillantini, P, Steuer, M, Stickland, Dp, Stone, H, Stoyanov, B, Straessner, A, Strauch, K, Sudhakar, K, Sultanov, G, Sun, Lz, Susinno, Gf, Suter, H, Swain, Jd, Tang, Xw, Tauscher, L, Taylor, L, Ting, Scc, Ting, Sm, Tonutti, M, Tonwar, Sc, Toth, J, Tully, C, Tuchscherer, H, Tung, Kl, Uchida, Y, Ulbricht, J, Uwer, U, Valente, E, Vandewalle, Rt, Vesztergombi, G, Vetlitsky, I, Viertel, G, Vivargent, M, Volkert, R, Vogel, H, Vogt, H, Vorobiev, I, Vorobyov, Aa, Vorvolakos, A, Wadhwa, M, Wallraff, W, Wang, Jc, Wang, Xl, Wang, Zm, Weber, A, Wittgenstein, F, Wu, Sx, Wynhoff, S, Xu, J, Xu, Zz, Yang, Bz, Yang, Cg, Yao, Xy, Ye, Jb, Yeh, Sc, You, Jm, Zalite, A, Zalite, Y, Zemp, P, Zeng, Y, Zhang, Z, Zhang, Zp, Zhou, B, Zhou, Y, Zhu, Gy, Zhu, Ry, Zichichi, A, and Ziegler, F.

Published
1997

45. Measurement of D-s(-)->tau(-)(nu)over-bar(tau) and a new limit for B-->tau(-)(nu)over-bar(tau center dot)

Author

Acciarri, M., Oscar Adriani, Aguilarbenitez, M., Ahlen, S., Alpat, B., Alcaraz, J., Alemanni, G., Allaby, J., Aloisio, A., Alverson, G., Alviggi, M. G., Ambrosi, G., Anderhub, H., Andreev, V. P., Angelescu, T., Anselmo, F., Antreasyan, D., Arefiev, A., Azemoon, T., Aziz, T., Bagnaia, P., Baksay, L., Ball, R. C., Banerjee, S., Banicz, K., Barillere, R., Barone, L., Bartalini, P., Baschirotto, A., Basile, M., Battiston, R., Bay, A., Becattini, F., Becker, U., Behner, F., Berdugo, J., Berges, P., Bertucci, B., Betev, V. L., Bhattacharya, S., Biasini, M., Biland, A., Bilei, G. M., Blaising, J. J., Blyth, S. C., Bobbink, G. J., Bock, R., Bohm, A., Borgia, B., Boucham, A., Bourilkov, D., Bourquin, M., Boutigny, D., Branson, J. G., Brigljevic, V., Brock, I. C., Buffini, A., Buijs, A., Burger, J. D., Burger, W. J., Busenitz, J., Cai, X. D., Campanelli, M., Capell, M., Romeo, G. C., Caria, M., Carlino, G., Cartacci, A. M., Casaus, J., Castellini, G., Cavallari, F., Cavallo, N., Cecchi, C., Cerrada, M., Cesaroni, F., Chamizo, M., Chan, A., Chang, Y. H., Chaturvedi, U. K., Chekanov, S. V., Chemarin, M., Chen, G., Chen, G. M., Chen, H. F., Chen, H. S., Chen, M., Chiefari, G., Chien, C. Y., Choi, M. T., Cifarelli, L., Cindolo, F., Civinini, C., Clare, I., Clare, R., Cohn, H. O., Coignet, G., Colijn, A. P., Colino, N., Commichau, V., Costantini, S., Cotorobai, F., Dellacruz, B., Csilling, A., Dai, T. S., Raffaello D'Alessandro, Deasmundis, R., Degre, A., Deiters, K., Denes, P., Denotaristefani, F., Dibitonto, D., Diemoz, M., Vandierendonck, D., Dilodovico, F., Dionisi, C., Dittmar, M., Dominguez, A., Doria, A., Dorne, I., Dova, M. T., Drago, E., Duchesneau, D., Duinker, P., Duran, I., Dutta, S., Easo, S., Efremenko, Y., Elmamouni, H., Engler, A., Eppling, F. J., Erne, F. C., Ernenwein, J. P., Extermann, P., Fabre, M., Faccini, R., Falciano, S., Favara, A., Fay, J., Fedin, O., Felcini, M., Fenyi, B., Ferguson, T., Fernandez, D., Ferroni, F., Fesefeldt, H., Fiandrini, E., Field, J. H., Filthaut, F., Fisher, P. H., Forconi, G., Fredj, L., Freudenreich, K., Furetta, C., Galaktionov, Y., Ganguli, S. N., Garciaabia, P., Gau, S. S., Gentile, S., Gerald, J., Gheordanescu, N., Giagu, S., Goldfarb, S., Goldstein, J., Gong, Z. F., Gougas, A., Gratta, G., Gruenewald, M. W., Gupta, V. K., Gurtu, A., Gutay, L. J., Hartmann, B., Hasan, A., Hatzifotiadou, D., Hebbeker, T., Herve, A., Vanhoek, W. C., Hofer, H., Hoorani, H., Hou, S. R., Hu, G., Innocente, V., Janssen, H., Jenkes, K., Jin, B. N., Jones, L. W., Dejong, P., Josamutuberria, I., Kasser, A., Khan, R. A., Kamrad, D., Kamyshkov, Y., Kapustinsky, J. S., Karyotakis, Y., Kaur, M., Kienzlefocacci, M. N., Kim, D., Kim, J. K., Kim, S. C., Kim, Y. G., Kinnison, W. W., Kirkby, A., Kirkby, D., Kirkby, J., Kiss, D., Kittel, W., Klimentov, A., Konig, A. C., Korolko, I., Koutsenko, V., Kraemer, R. W., Krenz, W., Kunin, A., P. L. D., Landi, G., Lapoint, C., Lassilaperini, K., Laurikainen, P., Lebeau, M., Lebedev, A., Lebrun, P., Lecomte, P., Lecoq, P., Lecoultre, P., Lee, J. S., Lee, K. Y., Leggett, C., Legoff, J. M., Leiste, R., Leonardi, E., Levtchenko, P., Li, C., Lieb, E., Lin, W. T., Linde, F. L., Lista, L., Liu, Z. A., Lohmann, W., Longo, E., Lu, W., Y S, Lu, Lubelsmeyer, K., Luci, C., Luckey, D., Luminari, L., Lustermann, W., W G, Ma, Maity, M., Majumder, G., Malgeri, L., Malinin, A., Manna, C., Mangeol, D., Mangla, S., Marchesini, P., Marin, A., Martin, J. P., Marzano, F., G. G. G., Mcnally, D., Mele, S., Merola, L., Meschini, M., Metzger, W. J., Vondermey, M., Mi, Y., Mihul, A., A. J. W., Mirabelli, G., Mnich, J., Molnar, P., Monteleoni, B., Moore, R., Morganti, S., Moulik, T., Mont, R., Muller, S., Muheim, F., A. J. M., Nagy, E., Nahn, S., Napolitano, M., Nessitedaldi, F., Newman, H., Niessen, T., Nippe, A., Nisati, A., Nowak, H., Opitz, H., Organtini, G., Ostonen, R., Pakhlov, P., Pandoulas, D., Paoletti, S., Paolucci, P., Park, H. K., Pascale, G., Passaleva, G., Patricelli, S., Paul, T., Pauluzzi, M., Paus, C., Pauss, F., Peach, D., Pei, Y. J., Pensotti, S., Perretgallix, D., Petersen, B., Petrak, S., Pevsner, A., Piccolo, D., Pieri, M., Pinto, J. C., Piroue, P. A., Pistolesi, E., Plyaskin, V., Pohl, M., Pojidaev, V., Postema, H., Produit, N., Prokofiev, D., Rahalcallot, G., Rancoita, P. G., Rattaggi, M., Raven, G., Razis, P., Read, K., Ren, D., Rescigno, M., Reucroft, S., Vanrhee, T., Riemann, S., Riles, K., Rind, O., Ro, S., Robohm, A., Rodin, J., Rodriguez, F. J., Roe, B. P., Romero, L., Rosierlees, S., Rosselet, P., Vanrossum, W., Roth, S., Rubio, J. A., Rykaczewski, H., Salicio, J., Sanchez, E., Sanders, M. P., Santocchia, A., Sarakinos, M. E., Sarkar, S., Sassowsky, M., Sauvage, G., Schafer, C., Schegelsky, V., Schmidtkaerst, S., Schmitz, D., Schmitz, P., Schneegans, M., Scholz, N., Schopper, H., Schotanus, D. J., Schwenke, J., Schwering, G., Sciacca, C., Sciarrino, D., Sens, J. C., Servoli, L., Shevchenko, S., Shivarov, N., Shoutko, V., Shukla, J., Shumilov, E., Shvorob, A., Siedenburg, T., Son, D., Sopczak, A., Soulimov, V., Smith, B., Spillantini, P., Steuer, M., Stickland, D. P., Stone, H., Stoyanov, B., Straessner, A., Strauch, K., Sudhakar, K., Sultanov, G., Sun, L. Z., Susinno, G. F., Suter, H., Swain, J. D., Tang, X. W., Tauscher, L., Taylor, L., S. C. C., Ting, S. M., Tonutti, M., Tonwar, S. C., Toth, J., Tully, C., Tuchscherer, H., Tung, K. L., Uchida, Y., Ulbricht, J., Uwer, U., Valente, E., Vandewalle, R. T., Vesztergombi, G., Vetlitsky, I., Viertel, G., Vivargent, M., Volkert, R., Vogel, H., Vogt, H., Vorobiev, I., Vorobyov, A. A., Vorvolakos, A., Wadhwa, M., Wallraff, W., Wang, J. C., Wang, X. L., Wang, Z. 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Subjects
CONSTRUCTION, DECAY, DETECTOR, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Using a data sample of 1475000 Z --> q (q) over bar(gamma) events collected during 1993 with the L3 detector at LEP, we have studied the purely leptonic decays of heavy flavour mesons, D-s(-) --> tau(-)(v) over bar(tau) and B- --> tau(-)(v) over bar(tau). A signal is observed in the invariant mass distribution M(gamma D-s(-)) corresponding to the decay sequence D-s(*-) --> gamma D-s(-), D-s(-) --> tau(-)(v) over bar(tau), tau(-)(v) over bar(tau), tau(-) --> l(-)(v) over bar(l)v(tau). The branching fraction for D-s(-) tau(-) (v) over bar(tau) decays is measured to be B(D-s(-) --> tau(-)(v) over bar(tau)) = 0.074 +/- 0.028(stat) +/- 0.016(syst) +/- 0.018(norm). No signal of B- --> tau-(v) over bar(tau) decays is observed in the data, corresponding to an upper limit on the branching fraction B(B- --> tau(-)(v) over bar(tau)) < 5.7 x 10(-4) at 90% CL. (C) 1997 Elsevier Science B.V.

Published
1997

48. Shallow gas pockets distribution in late Pleistocene Holocene marine shelf sediments off the northern Cilento promontory (southern Tyrrenian)

Author

Aiello G. (1), Marsella E. (1), Giordano F. (2), and Manna C. (2)

Subjects
sacche di gas, mappatura, Promontorio settentrionale del Cilento
Abstract

L'interpretazione di profili sismici di altissima risoluzione recentemente acquisiti sulla piattaforma continentale del Cilento ha evidenziato la presenza di ampie sacche di gas biogenico all'interno dei sedimenti tardo pleistocenici ed olocenici.

Published
2006

49. The effect on clinical results of adding recombinant LH in late phase of ovarian stimulation of patients with repeated implantation failure: a pilot study.

Author

RAHMAN, A., FRANCOMANO, D., SAGNELLA, F., LISI, F., and MANNA, C.

Abstract

OBJECTIVE: To evaluate the efficacy of recombinant LH (r-LH) addition in the late phase of ovarian stimulation in patients with repeated implantation failure (RIF). PATIENTS AND METHODS: 66 i nfertile c ouples undergoing ICSI treatment due to male factor were allocated to group A (33) and to group B (33). Group A (29 subjects) received recombinant FSH (r-FSH) supplemented by r-LH in the late follicular phase starting the same day of GnRH-antagonist (GnRH-ant) administration, and group B (32 subjects) received r-FSH alone. All patients were stimulated with a GnRH-ant flexible protocol starting r-FSH on day 2 of a spontaneous or induced cycle. hCG (10000 IU) was administered by intramuscular route when at least 2 follicles reached 18 mm in diameter. RESULTS: Metaphase II (MII) oocytes with cytoplasmic maturation showed a significant difference in the r-LH group (89.02%) compared to the one with FSH alone (81.15%) (p < 0.01). The number of positive pregnancy test, 14 (48.3%) and 8 (25%), was significantly greater in the r-LH group compared to the group treated with r-FSH alone (p < 0.03). The number of gestational sacs was 20 in the r-LH group vs. 9 in the r-FSH group (p < 0.001). The implantation rate was significantly higher in the r-LH group compared to the r-FSH only group (19% vs. 7% respectively; p < 0.01). Also, a lower abortion rate was found in the r-LH group (21% vs. 37.5% respectively - p < 0.01). CONCLUSIONS: Ovarian stimulation should be personalized because it seems that some subgroups of patients, like those with RIF, reach a better clinical outcome with the addition of r-LH in the advanced follicular phase stimulation. [ABSTRACT FROM AUTHOR]

Published
2017

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