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2. Malignomsuspekte pulmonale Raumforderung

Author

Manner, H., Henrich, R., Manner, N., Pech, O., Nguyen-tat, M., Weckler, B., and Ell, C.

Abstract

Zusammenfassung: Ein 31-jähriger Patient stellte sich mit chronischem Husten und Thoraxschmerzen vor. Radiologisch zeigte sich eine suspekte pulmonale Raumforderung. Es erfolgte eine chirurgische Segmentresektion. Histopathologisch wurde ein Abszess bei thorakaler Aktinomykose diagnostiziert. 3 Monate später trat ein Aktinomykoserezidiv der Thoraxwand auf, und Penicillin wurde i.v. verabreicht. 5 Monate später, unter fortgesetzter antibiotischer Therapie, wurden Thoraxwandabszess und -fistel diagnostiziert. Ein Monat nach Abszessdränage und erneuter i.v. antibiotischer Therapie war der Patient beschwerdefrei, ebenso während der sich anschließenden Nachbeobachtungszeit über 10 Monate.

Published
2024
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5. eQTL Set-Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma.

Author

Wang, Xiaoyu, Gharahkhani, P., Levine, D.M., Fitzgerald, R.C., Gockel, I., Corley, D.A., Risch, H.A., Bernstein, L., Chow, W.H., Onstad, L., Shaheen, N.J., Lagergren, J., Hardie, L.J., Wu, A.H., Pharoah, P.D., Liu, G., Anderson, L.A., Iyer, P.G., Gammon, M.D., Caldas, C., Ye, W., Barr, H., Moayyedi, P., Harrison, R., Watson, R.G.P., Attwood, S., Chegwidden, L., Love, S.B., MacDonald, D., DeCaestecker, J., Prenen, H., Ott, K., Moebus, S., Venerito, M., Lang, H., Mayershofer, R., Knapp, M., Veits, L., Gerges, C., Weismüller, J., Reeh, M., Nöthen, M.M., Izbicki, J.R., Manner, H., Neuhaus, H., Rösch, T., Böhmer, A.C., Hölscher, A.H., Anders, M., Pech, O., Schumacher, B., Schmidt, C., Schmidt, T., Noder, T., Lorenz, D., Vieth, M., May, A., Hess, T., Kreuser, N., Becker, J., Ell, C., Tomlinson, I., Palles, C., Jankowski, J.A., Whiteman, D.C., MacGregor, S., Schumacher, J., Vaughan, T.L., Buas, M.F., Dai, J.Y., Wang, Xiaoyu, Gharahkhani, P., Levine, D.M., Fitzgerald, R.C., Gockel, I., Corley, D.A., Risch, H.A., Bernstein, L., Chow, W.H., Onstad, L., Shaheen, N.J., Lagergren, J., Hardie, L.J., Wu, A.H., Pharoah, P.D., Liu, G., Anderson, L.A., Iyer, P.G., Gammon, M.D., Caldas, C., Ye, W., Barr, H., Moayyedi, P., Harrison, R., Watson, R.G.P., Attwood, S., Chegwidden, L., Love, S.B., MacDonald, D., DeCaestecker, J., Prenen, H., Ott, K., Moebus, S., Venerito, M., Lang, H., Mayershofer, R., Knapp, M., Veits, L., Gerges, C., Weismüller, J., Reeh, M., Nöthen, M.M., Izbicki, J.R., Manner, H., Neuhaus, H., Rösch, T., Böhmer, A.C., Hölscher, A.H., Anders, M., Pech, O., Schumacher, B., Schmidt, C., Schmidt, T., Noder, T., Lorenz, D., Vieth, M., May, A., Hess, T., Kreuser, N., Becker, J., Ell, C., Tomlinson, I., Palles, C., Jankowski, J.A., Whiteman, D.C., MacGregor, S., Schumacher, J., Vaughan, T.L., Buas, M.F., and Dai, J.Y.

Abstract

Item does not contain fulltext, BACKGROUND: Over 20 susceptibility single-nucleotide polymorphisms (SNP) have been identified for esophageal adenocarcinoma (EAC) and its precursor, Barrett esophagus (BE), explaining a small portion of heritability. METHODS: Using genetic data from 4,323 BE and 4,116 EAC patients aggregated by international consortia including the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), we conducted a comprehensive transcriptome-wide association study (TWAS) for BE/EAC, leveraging Genotype Tissue Expression (GTEx) gene-expression data from six tissue types of plausible relevance to EAC etiology: mucosa and muscularis from the esophagus, gastroesophageal (GE) junction, stomach, whole blood, and visceral adipose. Two analytical approaches were taken: standard TWAS using the predicted gene expression from local expression quantitative trait loci (eQTL), and set-based SKAT association using selected eQTLs that predict the gene expression. RESULTS: Although the standard approach did not identify significant signals, the eQTL set-based approach identified eight novel associations, three of which were validated in independent external data (eQTL SNP sets for EXOC3, ZNF641, and HSP90AA1). CONCLUSIONS: This study identified novel genetic susceptibility loci for EAC and BE using an eQTL set-based genetic association approach. IMPACT: This study expanded the pool of genetic susceptibility loci for EAC and BE, suggesting the potential of the eQTL set-based genetic association approach as an alternative method for TWAS analysis.

Published
2022

10. Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett's oesophagus

Author

Pech, O., Behrens, A., May, A., Nachbar, L., Gossner, L., Rabenstein, T., Manner, H., Guenter, E., Huijsmans, J., Vieth, M., Stolte, M., and Ell, C.

Subjects
Barrett's esophagus -- Care and treatment, Barrett's esophagus -- Complications and side effects, Barrett's esophagus -- Research, Endoscopic surgery -- Patient outcomes, Endoscopic surgery -- Research, Adenocarcinoma -- Risk factors, Cancer -- Relapse, Cancer -- Risk factors, Cancer -- Research, Health
Published
2008

11. Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma

Author

Dighe, S.G., Chen, J., Yan, L., He, Q., Gharahkhani, P., Onstad, L., Levine, D.M., Palles, C., Ye, W., Gammon, M.D., Iyer, P.G., Anderson, L.A., Liu, G., Wu, A.H., Dai, J.Y., Chow, W.H., Risch, H.A., Lagergren, J., Shaheen, N.J., Bernstein, L., Corley, D.A., Prenen, H., DeCaestecker, J., MacDonald, D., Moayyedi, P., Barr, H., Love, S.B., Chegwidden, L., Attwood, S., Watson, P., Harrison, R., Ott, K., Moebus, S., Venerito, M., Lang, H., Mayershofer, R., Knapp, M., Veits, L., Gerges, C., Weismüller, J., Gockel, I., Vashist, Y., Nöthen, M.M., Izbicki, J.R., Manner, H., Neuhaus, H., Rösch, T., Böhmer, A.C., Hölscher, A.H., Anders, M., Pech, O., Schumacher, B., Schmidt, C., Schmidt, T., Noder, T., Lorenz, D., Vieth, M., May, A., Hess, T., Kreuser, N., Becker, J., Ell, C., Ambrosone, C.B., Moysich, K.B., MacGregor, S., Tomlinson, I., Whiteman, D.C., Jankowski, J., Schumacher, J., Vaughan, T.L., Madeleine, M.M., Hardie, L.J., Buas, M.F., Dighe, S.G., Chen, J., Yan, L., He, Q., Gharahkhani, P., Onstad, L., Levine, D.M., Palles, C., Ye, W., Gammon, M.D., Iyer, P.G., Anderson, L.A., Liu, G., Wu, A.H., Dai, J.Y., Chow, W.H., Risch, H.A., Lagergren, J., Shaheen, N.J., Bernstein, L., Corley, D.A., Prenen, H., DeCaestecker, J., MacDonald, D., Moayyedi, P., Barr, H., Love, S.B., Chegwidden, L., Attwood, S., Watson, P., Harrison, R., Ott, K., Moebus, S., Venerito, M., Lang, H., Mayershofer, R., Knapp, M., Veits, L., Gerges, C., Weismüller, J., Gockel, I., Vashist, Y., Nöthen, M.M., Izbicki, J.R., Manner, H., Neuhaus, H., Rösch, T., Böhmer, A.C., Hölscher, A.H., Anders, M., Pech, O., Schumacher, B., Schmidt, C., Schmidt, T., Noder, T., Lorenz, D., Vieth, M., May, A., Hess, T., Kreuser, N., Becker, J., Ell, C., Ambrosone, C.B., Moysich, K.B., MacGregor, S., Tomlinson, I., Whiteman, D.C., Jankowski, J., Schumacher, J., Vaughan, T.L., Madeleine, M.M., Hardie, L.J., and Buas, M.F.

Abstract

Contains fulltext : 235640.pdf (Publisher’s version ) (Closed access), Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction. Here, we assessed IGF-related genetic variation and risk of BE and EAC. Principal component analysis was employed to evaluate pathway-level and gene-level associations with BE/EAC, using genotypes for 270 single-nucleotide polymorphisms (SNPs) in or near 12 IGF-related genes, ascertained from 3295 BE cases, 2515 EAC cases and 3207 controls in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) GWAS. Gene-level signals were assessed using Multi-marker Analysis of GenoMic Annotation (MAGMA) and SNP summary statistics from BEACON and an expanded GWAS meta-analysis (6167 BE cases, 4112 EAC cases, 17 159 controls). Global variation in the IGF pathway was associated with risk of BE (P = 0.0015). Gene-level associations with BE were observed for GHR (growth hormone receptor; P = 0.00046, false discovery rate q = 0.0056) and IGF1R (IGF1 receptor; P = 0.0090, q = 0.0542). These gene-level signals remained significant at q < 0.1 when assessed using data from the largest available BE/EAC GWAS meta-analysis. No significant associations were observed for EAC. This study represents the most comprehensive evaluation to date of inherited genetic variation in the IGF pathway and BE/EAC risk, providing novel evidence that variation in two genes encoding cell-surface receptors, GHR and IGF1R, may influence risk of BE.

Published
2021

17. Multizentrische Machbarkeitsstudie der kombinierten Injektions- und Argonplasma-Koagulation (Hybrid-APC) für die Ablationstherapie des neoplastischen Barrett Ösophagus

Author

Wetzka, J, additional, Knabe, M, additional, Manner, H, additional, Schachschal, G, additional, Ehlken, H, additional, Neuhaus, H, additional, Beyna, T, additional, Kandler, J, additional, Bergmann, J, additional, Wuesten, B, additional, Pech, O, additional, Faiss, S, additional, Anders, M, additional, May, A, additional, Ell, C, additional, and Rösch, T, additional

Published
2019
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19. Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma

Author

Becker, J., May, A., Gerges, C., Anders, M., Veits, L., Weise, K., Czamara, D., Lyros, O., Manner, H., Terheggen, G., Venerito, M., Noder, T., Mayershofer, R., Hofer, J., Karch, H., Ahlbrand, C., Arras, M., Hofer, S., Mangold, E., Heilmann-Heimbach, S., Heinrichs, S., Hess, T., Kiesslich, R., Izbicki, J., Hoelscher, A., Bollschweiler, E., Malfertheiner, P., Lang, H., Moehler, M., Lorenz, D., Müller-Myhsok, B., Ott, K., Schmidt, T., Whiteman, D., Vaughan, T., Noethen, M., Hackelsberger, A., Schumacher, B., Pech, O., Vashist, Y., Vieth, M., Weismueller, J., Neuhaus, H., Roesch, T., Ell, C., Gockel, I., and Schumacher, J.

Subjects
Adult, Male, esophageal adenocarcinoma, Adolescent, Esophageal Neoplasms, Genotype, FOXP1, Adenocarcinoma, BARX1, Polymorphism, Single Nucleotide, Young Adult, Odds Ratio, Humans, Genetic Predisposition to Disease, FOXF1, Alleles, Genetic Association Studies, Cancer Biology, Homeodomain Proteins, Forkhead Transcription Factors, Repressor Proteins, Genetic Loci, genetic association study, Case-Control Studies, Female, Genome-Wide Association Study, Transcription Factors
Abstract

The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P< 10(-4) in the BEACON sample. In total, we tested 88 SNPs in an independent sample consisting of 1065 EAC cases and 1019 controls of German descent. We could replicate the association at FOXP1, BARX1, and FOXF1 with nominal significance and thereby confirm that genetic variants at these genes confer EAC risk. In addition, we found association of variants near the genes XRCC2 and GATA6 that were strongly (P

Published
2015

21. Germline genetic variants and risk of Barrett's esophagus and esophageal adenocarcinoma: a large scale meta-analysis of genome-wide association studies

Author

Palles, C, Tomlinson, I, Chegwidden, L, Gharahkhani, P, MacGregor, S, Vaughan, T, Schumacher, J, Jankowski, J, Fitzgerald, R, Gockel, I, Buas, M, May, A, Gerges, C, Anders, M, Becker, J, Kreuser, N, Noder, T, Venerito, M, Veits, L, Schmidt, T, Manner, H, Schmidt, C, Hess, T, Böhmer, A, Izbicki, J, Hölscher, A, Lang, H, Lorenz, D, Schumacher, B, Hackelsberger, A, Mayershofer, R, Pech, O, Vashist, Y, Ott, K, Vieth, M, Weismüller, J, Nöthen, M, Attwood, S, Barr, H, de Caestecker, J, Harrison, R, Love, S, MacDonald, D, Moayyed, P, Prenen, H, Watson, R, Iyer, P, Anderson, L, Bernstein, L, Chow, W, Hardie, L, Lagergren, J, Liu, G, Risch, H, Wu, A, Ye, W, Bird, N, Shaheen, N, Gammon, M, Corley, D, Caldas, C, Moebus, S, Knapp, M, Peters, W, Neuhaus, H, Rösch, T, Ell, C, Pharaoh, P, and Whiteman, D

Abstract

Background Esophageal adenocarcinoma (EA) is one of the fastest rising cancers in western countries. Barrett’s Esophagus (BE) is the premalignant precursor of EA. However, only a subset of BE patients develop EA, which complicates the clinical management in the absence of valid predictors. Genetic risk factors for BE and EA are incompletely understood. This study aimed to identify novel genetic risk factors for BE and EA. Methods Within an international consortium of groups involved in the genetics of BE/EA, we performed the first meta-analysis of all genome-wide association studies (GWAS) available, involving 6,167 BE patients, 4,112 EA patients, and 17,159 representative controls, all of European ancestry, genotyped on Illumina high-density SNP-arrays, collected from four separate studies within North America, Europe, and Australia. Meta-analysis was conducted using the fixed-effects inverse variance-weighting approach. We used the standard genome-wide significant threshold of 5×10-8 for this study. We also conducted an association analysis following reweighting of loci using an approach that investigates annotation enrichment among the genome-wide significant loci. The entire GWAS-data set was also analyzed using bioinformatics approaches including functional annotation databases as well as gene-based and pathway-based methods in order to identify pathophysiologically relevant cellular pathways. Findings We identified eight new associated risk loci for BE and EA, within or near the CFTR (rs17451754, P=4·8×10-10), MSRA (rs17749155, P=5·2×10-10), BLK (rs10108511, P=2·1×10-9), KHDRBS2 (rs62423175, P=3·0×10-9), TPPP/CEP72 (rs9918259, P=3·2×10-9), TMOD1 (rs7852462, P=1·5×10-8), SATB2 (rs139606545, P=2·0×10-8), and HTR3C/ABCC5 genes (rs9823696, P=1·6×10-8). A further novel risk locus at LPA (rs12207195, posteriori probability=0·925) was identified after re-weighting using significantly enriched annotations. This study thereby doubled the number of known risk loci. The strongest disease pathways identified (P Interpretation The identified disease loci and pathways reveal new insights into the etiology of BE and EA. Furthermore, the EA-specific association at HTR3C/ABCC5 may constitute a novel genetic marker for the prediction of transition from BE to EA. Mutations in CFTR, one of the new risk loci identified in this study, cause cystic fibrosis (CF), the most common recessive disorder in Europeans. Gastroesophageal reflux (GER) belongs to the phenotypic CF-spectrum and represents the main risk factor for BE/EA. Thus, the CFTR locus may trigger a common GER-mediated pathophysiology.

Published
2016

22. Multizentrische Machbarkeitsstudie der kombinierten Injektions- und Argonplasma-Koagulation (Hybrid-APC) für die Ablationstherapie des neoplastischen Barrett Ösophagus

Author

Knabe, M, additional, Manner, H, additional, May, A, additional, Schachschal, G, additional, Neuhaus, H, additional, Beyna, T, additional, Bergman, J, additional, Weusten, B, additional, Pech, O, additional, Faiss, S, additional, Anders, M, additional, Ell, C, additional, and Rösch, T, additional

Published
2017
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24. Gemeinsame genetische Ätiologie des Barrett-Ösophagus/-Karzinoms und der Adipositas

Author

Böhmer, AC, additional, Hecker, J, additional, May, A, additional, Gerges, C, additional, Venerito, M, additional, Schmidt, T, additional, Schmidt, C, additional, Manner, H, additional, Vashist, Y, additional, Benner, U, additional, Meyershofer, R, additional, Anders, M, additional, Vieth, M, additional, Hess, T, additional, Becker, J, additional, Knapp, M, additional, Moebus, S, additional, Nöthen, M, additional, Dietrich, A, additional, Thieme, R, additional, Ebigbo, A, additional, Messmann, H, additional, Peters, WH, additional, Büchler, MW, additional, Izbicki, JR, additional, Hölscher, AH, additional, Schumacher, B, additional, Weismüller, J, additional, Neuhaus, H, additional, Rösch, T, additional, Ell, C, additional, Gockel, I, additional, Fier, H, additional, and Schumacher, J, additional

Published
2017
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27. Testing for Asymmetric Dependence

Author

Manner, H., Manner, H., Manner, H., and Manner, H.

Abstract

We study how to measure and test for differences in dependence for small and large realizations of two variables of interest. We introduce a conditional version of Kendall's tau and provide formulas to evaluate it for any copula of interest. Two tests based on well known copulas are proposed to test the null hypothesis of symmetric dependence and these tests outperform the one proposed by Hong et al. (2007) in a Monte Carlo study. Additionally, we suggest three examples of data generating processes that can lead to asymmetric dependence and study these both analytically and in a Monte Carlo framework. Finally, we illustrate the use of our tests on stock market returns and on quarterly US GNP and Unemployment data and we find evidence of asymmetries and nonlinearities.

Published
2008

32. Histologische und makroskopische Risikomerkmale als Prognosefaktoren des Lymphknotenmetastasierungsrisikos bei Patienten mit Barrettkarzinom und mittlerer Submukosainvasion – Ergebnisse prospektiv erfasster Daten einer Arbeitsgruppe

Author

Wetzka, J, primary, Manner, H, additional, May, A, additional, Pech, O, additional, Pauthner, M, additional, Fisseler-Eckhoff, A, additional, Stolte, M, additional, Vieth, M, additional, Lorenz, D, additional, and Ell, C, additional

Published
2016
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48. pT1a Adenokarzinom des Ösophagus: Endoskopische oder chirurgische Resektion? Ergebnisse aus zwei 'High Volume'-Zentren

Author

Bollschweiler, E, Pech, O, Manner, H, Leers, J, Ell, C, and Hölscher, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Studien haben gezeigt, dass Patienten mit auf die Mucosa beschränktem Adenokarzinom des Ösophagus (AC) nur selten Lymphknoten-Metastasen aufweisen. Daher konnte sich die endoskopische Resektion (ER) dieser mukosalen AC in den letzten Jahren als Methode der Wahl etablieren. Bislang[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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49. BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia

Author

Bennett, C., Moayyedi, P., Corley, D.A., DeCaestecker, J., Falck-Ytter, Y., Falk, G., Vakil, N., Sanders, S., Vieth, M., Inadomi, J., Aldulaimi, D., Ho, K.Y., Odze, R., Meltzer, S.J., Quigley, E., Gittens, S., Watson, P., Zaninotto, G., Iyer, P.G., Alexandre, L., Ang, Y., Callaghan, J., Harrison, R., Singh, R., Bhandari, P., Bisschops, R., Geramizadeh, B., Kaye, P., Krishnadath, S., Fennerty, M.B., Manner, H., Nason, K.S., Pech, O., Konda, V., Ragunath, K., Rahman, I., Romero, Y., Sampliner, R., Siersema, P.D., Tack, J., Tham, T.C., Trudgill, N., Weinberg, D.S., Wang, J, Wang, K., Wong, J.Y., Attwood, S., Malfertheiner, P., MacDonald, D., Barr, H., Ferguson, M.K., Jankowski, J., Bennett, C., Moayyedi, P., Corley, D.A., DeCaestecker, J., Falck-Ytter, Y., Falk, G., Vakil, N., Sanders, S., Vieth, M., Inadomi, J., Aldulaimi, D., Ho, K.Y., Odze, R., Meltzer, S.J., Quigley, E., Gittens, S., Watson, P., Zaninotto, G., Iyer, P.G., Alexandre, L., Ang, Y., Callaghan, J., Harrison, R., Singh, R., Bhandari, P., Bisschops, R., Geramizadeh, B., Kaye, P., Krishnadath, S., Fennerty, M.B., Manner, H., Nason, K.S., Pech, O., Konda, V., Ragunath, K., Rahman, I., Romero, Y., Sampliner, R., Siersema, P.D., Tack, J., Tham, T.C., Trudgill, N., Weinberg, D.S., Wang, J, Wang, K., Wong, J.Y., Attwood, S., Malfertheiner, P., MacDonald, D., Barr, H., Ferguson, M.K., and Jankowski, J.

Abstract

Item does not contain fulltext, OBJECTIVES: Barrett's esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical practice. We conducted an international, multidisciplinary, systematic search and evidence-based review of BE and provided consensus recommendations for clinical use in patients with nondysplastic, indefinite, and low-grade dysplasia (LGD). METHODS: We defined the scope, proposed statements, and searched electronic databases, yielding 20,558 publications that were screened, selected online, and formed the evidence base. We used a Delphi consensus process, with an 80% agreement threshold, using GRADE (Grading of Recommendations Assessment, Development and Evaluation) to categorize the quality of evidence and strength of recommendations. RESULTS: In total, 80% of respondents agreed with 55 of 127 statements in the final voting rounds. Population endoscopic screening is not recommended and screening should target only very high-risk cases of males aged over 60 years with chronic uncontrolled reflux. A new international definition of BE was agreed upon. For any degree of dysplasia, at least two specialist gastrointestinal (GI) pathologists are required. Risk factors for cancer include male gender, length of BE, and central obesity. Endoscopic resection should be used for visible, nodular areas. Surveillance is not recommended for <5 years of life expectancy. Management strategies for indefinite dysplasia (IND) and LGD were identified, including a de-escalation strategy for lower-risk patients and escalation to intervention with follow-up for higher-risk patients. CONCLUSIONS: In this uniquely large consensus process in gastroenterology, we made key clinical recommendations for the escalation/de-escalation of BE in clinical practice. We made strong recommendations for the prioritization of future research.

Published
2015

50. Testing for Contagion: A new time-varying Copula Approach

Author

Candelon, B., Manner, H., Macro, International & Labour Economics, Quantitative Economics, and RS: GSBE ERD

Subjects
INTERDEPENDENCE, DEPENDENCE, CHANGE-POINT, MODELS, CONTAGION
Abstract

This paper proposes a new approach based on time-varying copulas to test for the presence of increases in stock market interdependence (also known as shift contagion) after a financial crisis. We discuss the importance of considering simultaneously separate breaks in volatility and dependence. Without such consideration, the contagion test turns out to be biased. A sequential algorithm is proposed to tackle this problem. Applied to the recent 1997 Asian crisis, the analysis confirms that breaks in variances always precede those in the dependence parameter. Moreover, a significant 'J-shape' evolution of the dependence parameter is detected, supporting the idea of shift contagion.

Published
2010

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