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6. Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Author

Eltchaninoff, Hélène, Bellien, Jérémy, Bertrand, Benjamin, Beygui, Farzin, Béziau-Gasnier, Delphine, Brakenhielm, Ebba, Caligiuri, Giuseppina, Chevreul, Karine, Debroucker, Frédérique, Durand, Eric, Fraschini, Christophe, Gilard, Martine, Iung, Bernard, Kamel, Said, Laschet, Jamila, Manrique, Alain, Messas, Emmanuel, Messika-Zeitoun, David, Pinet, Florence, Richard, Vincent, Saloux, Eric, Thoenes, Martin, Tribouilloy, Christophe, Vézier, Claire, Candellier, Alexandre, Issa, Nervana, Grissi, Maria, Brouette, Théo, Avondo, Carine, Gomila, Cathy, Blot, Gérémy, Gubler, Brigitte, Touati, Gilles, Bennis, Youssef, Caus, Thierry, Brazier, Michel, Choukroun, Gabriel, Kamel, Saïd, Boudot, Cédric, and Hénaut, Lucie

Published
2023
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7. 18F-fluorodeoxyglucose PET-MR characterization of aortic inflammation in ApoE−/− mouse models of accelerated atherosclerosis: comparison of Western diet vs. uremia.

Author

Deshayes, Samuel, Ruello, Pauline, Simard, Christophe, Dupont, Pierre-Antoine, Bauge, Caroline, Abbas, Ahmed, de Boysson, Hubert, Aouba, Achille, and Manrique, Alain

Abstract

ApoE−/− mice are a widely used preclinical model of atherosclerosis, potentially accelerated by a Western diet (WD) or uremia. We aimed to compare hybrid 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-magnetic resonance (PET-MR) and immunostaining in ApoE−/− models of accelerated atherosclerosis. Five groups were studied: standard diet-fed ApoE−/− (n = 7), standard diet-fed and uremic ApoE−/− (n = 7), WD ApoE−/− (n = 7), WD and uremic ApoE−/− (n = 6), and control C57BL/6J mice (n = 6). Uremia was induced by electrocoagulation of the right kidney at 8 weeks old, followed 2 weeks later by a contralateral nephrectomy. 18F-FDG PET-MR imaging and histological staining (anti-CD4, -CD8, -CD11c, -CD20, -CD31, -CD68, -CD163, -interferon-γ, interleukin-1α, -1β, -6, -17 A antibodies) were performed in 18-week-old mice, i.e., 8 weeks after 5/6 nephrectomy and/or WD. 18F-FDG uptake was similar in all groups. In contrast, histological staining highlighted higher percentages of CD8-, CD68-, or CD11c-positive cells in ApoE−/− aortic samples than in wild-type aortic samples. In addition, immunostaining revealed some differences between ApoE−/− mouse groups. Only the WD seemed to contribute to these differences. Using immunostaining, WD appeared to be a stronger accelerator of atherosclerosis than uremia. However, 18F-FDG PET-MR imaging failed to demonstrate in vivo increased aortic glucose uptake in these models. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Improvements of Myocardial Deformation Assessment by Three-Dimensional Speckle-Tracking versus Two-Dimensional Speckle-Tracking Revealed by Cardiac Magnetic Resonance Tagging

Author

Amzulescu, Mihaela S., Langet, Hélène, Saloux, Eric, Manrique, Alain, Slimani, Allison, Allain, Pascal, Roy, Clotilde, de Meester, Christophe, Pasquet, Agnès, Somphone, Oudom, De Craene, Mathieu, Vancraeynest, David, Pouleur, Anne-Catherine, Vanoverschelde, Jean-Louis, and Gerber, Bernhard L.

Published
2018
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24. Added value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Author

Ceccaldi, Mathieu, Guedj, Eric, Felician, Olivier, Didic, Mira, Gueriot, Claude, Koric, Lejla, Kletchkova-Gantchev, Radka, Godefroy, Olivier, Andriuta, Daniela, Devendeville, Agnès, Dupuis, Diane, Binot, Ingrid, Barbay, Mélanie, Meyer, Marc-Etienne, Moullard, Véronique, Magnin, Eloi, Chamard, Ludivine, Haffen, Sophie, Morel, Olivier, Drouet, Clément, Boulahdour, Hatem, Goas, Philippe, Querellou-Lefranc, Solène, de la Sayette, Vincent, Cogez, Julien, Branger, Pierre, Agostini, Denis, Manrique, Alain, Rouaud, Olivier, Bejot, Yannick, Jacquin-Piques, Agnès, Dygai-Cochet, Inna, Berriolo-Riedinger, Alina, Moreaud, Olivier, Sauvee, Mathilde, Crépin, Céline Gallazzani, Pasquier, Florence, Bombois, Stéphanie, Lebouvier, Thibaud, Mackowiak-Cordoliani, Marie-Anne, Deramecourt, Vincent, Rollin-Sillaire, Adeline, Cassagnaud-Thuillet, Pascaline, Chen, Yaohua, Semah, Franck, Petyt, Grégory, Krolak-Salmon, Pierre, Federico, Denis, Danaila, Keren Liora, Guilhermet, Yves, Magnier, Christophe, Makaroff, Zaza, Rouch, Isabelle, Xie, Jing, Roubaud, Caroline, Coste, Marie-Hélène, David, Kenny, Sarciron, Alain, Waissi, Aziza Sediq, Scheiber, Christian, Houzard, Claire, Gabelle-Deloustal, Audrey, Bennys, Karim, Marelli, Cecilia, Touati, Lynda, Mariano-Goulart, Denis, de Verbizier-Lonjon, Delphine, Jonveaux, Thérèse, Benetos, Athanase, Kearney-Schwartz, Anna, Perret-Guillaume, Christine, Verger, Antoine, Vercelletto, Martine, Boutoleau-Bretonniere, Claire, Pouclet-Courtemanche, Hélène, Wagemann, Nathalie, Pallardy, Amandine, Hugon, Jacques, Paquet, Claire, Dumurgier, Julien, Millet, Pascal, Queneau, Mathieu, Dubois, Bruno, Epelbaum, Stéphane, Levy, Marcel, Habert, Marie-Odile, Novella, Jean-Luc, Jaidi, Yacine, Papathanassiou, Dimitri, Morland, David, Belliard, Serge, Salmon, Anne, Lejeune, Florence, Hannequin, Didier, Wallon, David, Martinaud, Olivier, Zarea, Aline, Chastan, Mathieu, Pariente, Jérémie, Thalamas, Claire, Galitzky-Gerber, Monique, Tricoire Ricard, Anne-Marie, Calvas, Fabienne, Rigal, Emilie, Payoux, Pierre, Hitzel, Anne, Delrieu, Julien, Ousset, Pierre-Jean, Lala, Françoise, Sastre-Hengan, Nathalie, Shields, Trevor, Perrotin, Audrey, Gismondi, Rossella, Bullich, Santiago, Jovalekic, Aleksandar, Raffa, Nicola, and Stephens, Andrew

Published
2018
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32. Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Author

Candellier, Alexandre, primary, Issa, Nervana, additional, Grissi, Maria, additional, Brouette, Théo, additional, Avondo, Carine, additional, Gomila, Cathy, additional, Blot, Gérémy, additional, Gubler, Brigitte, additional, Touati, Gilles, additional, Bennis, Youssef, additional, Caus, Thierry, additional, Brazier, Michel, additional, Choukroun, Gabriel, additional, Tribouilloy, Christophe, additional, Kamel, Saïd, additional, Boudot, Cédric, additional, Hénaut, Lucie, additional, Eltchaninoff, Hélène, additional, Bellien, Jérémy, additional, Bertrand, Benjamin, additional, Beygui, Farzin, additional, Béziau-Gasnier, Delphine, additional, Brakenhielm, Ebba, additional, Caligiuri, Giuseppina, additional, Chevreul, Karine, additional, Debroucker, Frédérique, additional, Durand, Eric, additional, Fraschini, Christophe, additional, Gilard, Martine, additional, Iung, Bernard, additional, Kamel, Said, additional, Laschet, Jamila, additional, Manrique, Alain, additional, Messas, Emmanuel, additional, Messika-Zeitoun, David, additional, Pinet, Florence, additional, Richard, Vincent, additional, Saloux, Eric, additional, Thoenes, Martin, additional, and Vézier, Claire, additional

Published
2023
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39. [18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis.

Author

Deshayes, Samuel, Baugé, Caroline, Dupont, Pierre-Antoine, Simard, Christophe, Rida, Hanan, de Boysson, Hubert, Manrique, Alain, and Aouba, Achille

Subjects
MICE, AORTITIS, ARTERITIS, LABORATORY mice, ANIMAL disease models, THORACIC aorta
Abstract

Background: Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical model of aortitis in BALB/c IL1rn−/− mice using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography–magnetic resonance (PET-MR), gamma counting and immunostaining. We used 15 first-generation specific and opportunistic pathogen-free (SOPF) 9-week-old IL1rn−/− mice, 15 wild-type BALB/cAnN mice and 5 s-generation specific pathogen-free (SPF) 9-week-old IL1rn−/−. Aortic [18F]FDG uptake was assessed as the target-to-background ratio (TBR) using time-of-flight MR angiography as vascular landmarks. Results: [18F]FDG uptake measured by PET or gamma counting was similar in the first-generation SOPF IL1rn−/− mice and the wild-type group (p > 0.05). However, the first-generation IL1rn−/− mice exhibited more interleukin-1β (p = 0.021)- and interleukin-6 (p = 0.019)-positive cells within the abdominal aorta than the wild-type mice. In addition, the second-generation SPF group exhibited significantly higher TBR (p = 0.0068) than the wild-type mice on the descending thoracic aorta, unlike the first-generation SOPF IL1rn−/− mice. Conclusions: In addition to the involvement of interleukin-1β and -6 in IL1rn−/− mouse aortitis, this study seems to validate [18F]FDG PET-MR as a useful tool for noninvasive monitoring of aortitis in this preclinical model. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Computational and Physical Phantom Setups for the Second Cardiac Motion Analysis Challenge (cMAC2)

Author

De Craene, Mathieu, Allain, Pascal, Gao, Hang, Prakosa, Adityo, Marchesseau, Stephanie, Somphone, Oudom, Hilpert, Loic, Manrique, Alain, Delingette, Hervé, Makram-Ebeid, Sherif, Villain, Nicolas, D’hooge, Jan, Sermesant, Maxime, Saloux, Eric, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Camara, Oscar, editor, Mansi, Tommaso, editor, Pop, Mihaela, editor, Rhode, Kawal, editor, Sermesant, Maxime, editor, and Young, Alistair, editor

Published
2013
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48. Targeted Radiation Exposure Induces Accelerated Aortic Valve Remodeling in ApoE −/− Mice.

Author

Rucher, Guillaume, Prigent, Kevin, Simard, Christophe, Frelin, Anne-Marie, Coquemont-Guyot, Maëlle, Elie, Nicolas, Delcroix, Nicolas, Perzo, Nicolas, Guinamard, Romain, Berger, Ludovic, and Manrique, Alain

Subjects
AORTIC valve, RADIATION exposure, SINUS of valsalva, AORTIC stenosis, MAGNETIC resonance imaging
Abstract

Thoracic radiation therapy may result in accelerated atherosclerosis and in late aortic valve stenosis (AS). In this study, we assessed the feasibility of inducing radiation-induced AS using a targeted aortic valve irradiation (10 or 20 Grays) in two groups of C57Bl6/J (WT) and ApoE−/− mice compared to a control (no irradiation). Peak aortic jet velocity was evaluated by echocardiography to characterize AS. T2*-weighted magnetic resonance imaging after injection of MPIO-αVCAM-1 was used to examine aortic inflammation resulting from irradiation. A T2* signal void on valve leaflets and aortic sinus was considered positive. Valve remodeling and mineralization were assessed using von Kossa staining. Finally, the impact of radiation on cell viability and cycle from aortic human valvular interstitial cells (hVICs) was also assessed. The targeted aortic valve irradiation in ApoE−/− mice resulted in an AS characterized by an increase in peak aortic jet velocity associated with valve leaflet and aortic sinus remodeling, including mineralization process, at the 3-month follow-up. There was a linear correlation between histological findings and peak aortic jet velocity (r = 0.57, p < 0.01). In addition, irradiation was associated with aortic root inflammation, evidenced by molecular MR imaging (p < 0.01). No significant effect of radiation exposure was detected on WT animals. Radiation exposure did not affect hVICs viability and cell cycle. We conclude that targeted radiation exposure of the aortic valve in mice results in ApoE−/−, but not in WT, mice in an aortic valve remodeling mimicking the human lesions. This preclinical model could be a useful tool for future assessment of therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2023
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