1. Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype.
- Author
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Martín-Nares E, Baenas DF, Cuellar Gutiérrez MC, Hernández-Molina G, Ortiz AC, Neira O, Gutiérrez MA, Calvo R, Saad EJ, Elgueta Pinochet S, Gallo J, Herrera Moya A, Mansilla Aravena BA, Crespo Espíndola ME, Cairoli E, Bertoli AM, Córdoba M, Wurmann Kiblisky P, Basualdo Arancibia WJ, Badilla Piñeiro MN, Gobbi CA, Berbotto GA, Pisoni CN, Juárez V, Cosatti MA, Aste NM, Airoldi C, Llanos C, Vergara Melian CF, Erlij Opazo D, Goecke A, Pastenes Montaño PA, Tate P, Pirola JP, Stange Núñez L, Burgos PI, Mezzano Robinson MV, Michalland H S, Silva Labra F, Labarca Solar CH, Lencina MV, Izquierdo Loaiza JH, Del Castillo Gil DJ, Caeiro F, and Paira S
- Subjects
- Adult, Aged, Ethnicity, Female, Humans, Immunoglobulin G, Latin America, Male, Middle Aged, Phenotype, Immunoglobulin G4-Related Disease
- Abstract
Background/objective: Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD., Methods: We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation., Results: The mean age was 50.8 ± 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI, 1.45-20). Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance., Conclusions: Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype., Competing Interests: The authors declare no conflict of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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