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29 results on '"Mansoorifar, Amin"'

1. Perivascular cells function as mechano-structural sensors of vascular capillaries

Author

Franca, Cristiane M., primary, Lima Verde, Maria Elisa, additional, Silva-Sousa, Alice Correa, additional, Mansoorifar, Amin, additional, Athirasala, Avathamsa, additional, Subbiah, Ramesh, additional, Tahayeri, Anthony, additional, Sousa, Mauricio, additional, Fraga, May Anny, additional, Visalakshan, Rahul M., additional, Doe, Aaron, additional, Beadle, Keith, additional, Finley, McKenna, additional, Dimitriadis, Emilios, additional, Bays, Jennifer, additional, Uroz, Marina, additional, Yamada, Kenneth M., additional, Chen, Christopher, additional, and Bertassoni, Luiz E., additional

Published
2024
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3. High‐Throughput Bioprinting of Geometrically‐Controlled Pre‐Vascularized Injectable Microgels for Accelerated Tissue Regeneration (Adv. Healthcare Mater. 22/2023)

Author

Franca, Cristiane M., primary, Athirasala, Avathamsa, additional, Subbiah, Ramesh, additional, Tahayeri, Anthony, additional, Selvakumar, Prakash, additional, Mansoorifar, Amin, additional, Horsophonphong, Sivaporn, additional, Sercia, Ashley, additional, Nih, Lina, additional, and Bertassoni, Luiz E., additional

Published
2023
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11. 3D Printing: 3D Printing of Microgel‐Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering (Adv. Mater. 36/2020)

Author

Subbiah, Ramesh, primary, Hipfinger, Christina, additional, Tahayeri, Anthony, additional, Athirasala, Avathamsa, additional, Horsophonphong, Sivaporn, additional, Thrivikraman, Greeshma, additional, França, Cristiane Miranda, additional, Cunha, Diana Araujo, additional, Mansoorifar, Amin, additional, Zahariev, Albena, additional, Jones, James M., additional, Coelho, Paulo G., additional, Witek, Lukasz, additional, Xie, Hua, additional, Guldberg, Robert E., additional, and Bertassoni, Luiz E., additional

Published
2020
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12. 3D Printing of Microgel‐Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering

Author

Subbiah, Ramesh, primary, Hipfinger, Christina, additional, Tahayeri, Anthony, additional, Athirasala, Avathamsa, additional, Horsophonphong, Sivaporn, additional, Thrivikraman, Greeshma, additional, França, Cristiane Miranda, additional, Cunha, Diana Araujo, additional, Mansoorifar, Amin, additional, Zahariev, Albena, additional, Jones, James M., additional, Coelho, Paulo G., additional, Witek, Lukasz, additional, Xie, Hua, additional, Guldberg, Robert E., additional, and Bertassoni, Luiz E., additional

Published
2020
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13. 3D printing of Microgel-loaded Modular LEGO-like Cages as Instructive Scaffolds for Tissue Engineering

Author

Hipfinger, Christina, primary, Subbiah, Ramesh, additional, Tahayeri, Anthony, additional, Athirasala, Avathamsa, additional, Horsophonphong, Sivaporn, additional, Thrivikraman, Greeshma, additional, França, Cristiane Miranda, additional, Cunha, Diana Araujo, additional, Mansoorifar, Amin, additional, Zahariev, Albena, additional, Jones, James M., additional, Coelho, Paulo G., additional, Witek, Lukasz, additional, Xie, Hua, additional, Guldberg, Robert E., additional, and Bertassoni, Luiz E., additional

Published
2020
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18. Bone‐on‐a‐Chip: Microfluidic Technologies and Microphysiologic Models of Bone Tissue.

Author

Mansoorifar, Amin, Gordon, Ryan, Bergan, Raymond C., and Bertassoni, Luiz E.

Subjects
*BONES, *TISSUE culture, *BONE products, *TISSUES, *TISSUE engineering, *MICROFLUIDIC devices
Abstract

Bone is an active organ that continuously undergoes an orchestrated process of remodeling throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other changes happening in the body, as well as repairing bone that becomes damaged to maintain tissue integrity. On the other hand, diseases such as osteoporosis and metastatic cancers disrupt normal bone homeostasis leading to compromised function. Historically, the ability to investigate processes related to either physiologic or diseased bone tissue is limited by traditional models that fail to emulate the complexity of native bone. Organ‐on‐a‐chip models are based on technological advances in tissue engineering and microfluidics, enabling the reproduction of key features specific to tissue microenvironments within a microfabricated device. Compared to conventional in vitro and in vivo bone models, microfluidic models, and especially organ‐on‐a‐chip platforms, provide more biomimetic tissue culture conditions, with increased predictive power for clinical assays. In this review, microfluidic and organ‐on‐a‐chip technologies designed for understanding the biology of bone as well as bone‐related diseases and treatments are reported. Finally, the authors discuss the limitations of the current models and point toward future directions for microfluidics and organ‐on‐a‐chip technologies in bone research. [ABSTRACT FROM AUTHOR]

Published
2021
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19. DIELECTROPHORESIS ASSISTED LOADING AND UNLOADING OF MICRO-WELLS FOR IMPEDANCE SPECTROSCOPY

Author

Mansoorifar, Amin, Koklu, Anil, Sabuncu, Ahmet Can, and Beskok, Ali

Subjects
Electrophoresis, Microchip, Ultraviolet Rays, Dielectric Spectroscopy, Lab-On-A-Chip Devices, Microfluidics, Computer Simulation, Equipment Design, Gold, Saccharomyces cerevisiae, Models, Theoretical, Microelectrodes, Article
Abstract

Dielectric spectroscopy (DS) is a non-invasive, label-free, fast, and promising technique for measuring dielectric properties of biological cells in real time. We demonstrate a microchip that consists of electro-activated micro-well arrays for positive dielectrophoresis (pDEP) assisted cell capture, DS measurements, and negative dielectrophoresis (nDEP) driven cell unloading; thus, providing a high throughput cell analysis platform. To the best of our knowledge, this is the first microfluidic chip that combines electro-activated micro-wells and DS to analyze biological cells. Device performance is tested using Saccharomyces Cerevisiae (yeast) cells. DEP response of yeast cells is determined by measuring their Clausius-Mossotti (CM) factor using biophysical models in parallel plate micro-electrode geometry. This information is used to determine the excitation frequency to load and unload wells. Effect of yeast cells on the measured impedance spectrum was examined both experimentally and numerically. Good match between the numerical and experimental results establishes the potential use of the micro-chip device for extracting sub-cellular properties of biological cells in a rapid and non-expensive manner.

Published
2017

29. Vascular inflammation exposes perivascular cells to SARS-CoV-2 infection.

Author

Franca CM, Mansoorifar A, Athirasala A, Subbiah R, Tahayeri A, and Bertassoni L

Abstract

Pericytes stabilize blood vessels and promote vascular barrier function. However, vessels subjected to pro-inflammatory conditions have impaired barrier function, which has been suggested to potentially expose perivascular cells to SARS-CoV-2. To test this hypothesis, we engineered pericyte-supported vascular capillaries on-a-chip, and determined that the extravasation and binding of spike protein (S1) on perivascular cells of inflamed vessels to be significantly higher that in healthy controls, indicating a potential target to understand COVID-19 vascular complications.

Published
2022
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