1,685 results on '"Mantica, P"'
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2. Quantum Entropies and Decoherence for the Multiparticle Quantum Arnol'd Cat
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Mantica, Giorgio
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Quantum Physics ,Mathematical Physics ,81Q50 (Primary) 37d45, 28d50, 81s22 (Secondary) - Abstract
I study the scaling behavior in the physical parameters of dynamical entropies, classical and quantum, in a specifically devised model of collision-induced decoherence in a chaotic system. The treatment is fully canonical and no approximations are involved or infinite limits taken. I present this model in a detailed way, in order to clarify my views in the debate about the nature, definition, and relevance of quantum chaos.
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- 2024
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3. Behavior of correlation functions in the dynamics of the Multiparticle Quantum Arnol'd Cat
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Mantica, Giorgio
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Quantum Physics ,Mathematical Physics ,Nonlinear Sciences - Chaotic Dynamics ,81Q50 (Primary) 37d45, 81s22 (Secondary) - Abstract
The multi-particle Arnol'd cat is a generalization of the Hamiltonian system, both classical and quantum, whose period evolution operator is the renown map that bears its name. It is obtained following the Joos-Zeh prescription for decoherence, by adding a number of scattering particles in the configuration space of the cat. Quantization follows swiftly, if the Hamiltonian approach, rather than the semiclassical, is adopted. I have studied this system in a series of previous works, focusing on the problem of quantum-classical correspondence. In this paper I test the dynamics of this system by two related yet different indicators: the time autocorrelation function of the canonical position and the out of time correlator of position and momentum.
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- 2024
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4. Conformal Killing gravity in static spherically-symmetric spacetimes
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,83D05 (Primary), 83C20 (Secondary) - Abstract
We identify an anisotropic divergence-free conformal Killing tensor $K_{jl}$ for static spherically symmetric spacetimes, and write the conformal Killing gravity equations as Einstein equations augmented by this tensor. The field equations are of second order: this fact allows for analytic solutions and considerably simplifies the derivation of results of previous studies based on the original Harada equations. In particular, we prove the equivalence of the known third order field equations, with the second order ones obtained by us in the conformal Killing parametrization. The structure of the Ricci tensor and of the conformal Killing tensor are compatible with both anisotropic fluid sources and (non)-linear electrodynamics. We reobtain covariantly and in simple steps the general static spherical solutions for vacuum and linear electrodynamics. Moreover we recover the purely magnetic Lagrangian functions that induce metrics of interest for black holes., Comment: Final version (typos in eqs 19, 20 corrected)
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- 2024
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5. Nuclear Physics Network Requirements Review Final Report
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Zurawski, Jason, Brown, Ben, Rai, Gulshan, Dart, Eli, Dawson, Cian, Hawk, Carol, Mantica, Paul, Margetis, Spyridon, Miller, Kenneth, Miller, Nathan, and Wiedlea, Andrew
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The Energy Sciences Network (ESnet) is the high-performance network user facility for the US Department of Energy (DOE) Office of Science (SC) and delivers highly reliable data transport capabilities optimized for the requirements of data-intensive science. In essence, ESnet is the circulatory system that enables the DOE science mission by connecting all its laboratories and facilities in the US and abroad. ESnet is funded and stewarded by the Advanced Scientific Computing Research (ASCR) program and managed and operated by the Scientific Networking Division at Lawrence Berkeley National Laboratory (LBNL). ESnet is widely regarded as a global leader in the research and education networking community.ESnet interconnects DOE national laboratories, user facilities, and major experiments so that scientists can use remote instruments and computing resources as well as share data with collaborators, transfer large datasets, and access distributed data repositories. ESnet is specifically built to provide a range of network services tailored to meet the unique requirements of the DOE’s data-intensive science.Between July 2023 and October 2023, ESnet and the Nuclear Physics program (NP) of the DOE SC organized an ESnet requirements review of NP-supported activities. Preparation for these events included identification of key stakeholders: program and facility management, research groups, and technology providers. Each stakeholder group was asked to prepare formal case study documents about its relationship to the NP program to build a complete understanding of the current, near-term, and long-term status, expectations, and processes that will support the science going forward.
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- 2024
6. Conformal Killing cosmology -- Geometry, dark sector, growth of structures, and big rip
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,83D05 (Primary) 83F05 (Secondary) - Abstract
We introduce Sinyukov-like tensors, a special kind of conformal Killing tensors. In Robertson-Walker space-times they have the perfect-fluid form and only depend on two constants and the scale factor. They are the candidate for the dark term of the newly proposed Conformal Killing Gravity, by Harada. In addition to ordinary matter, the Friedmann equations contain a dark term and a Lambda term that parametrize the Sinyukov-like tensor. The expression of H(z) is tested on cosmological data based on cosmic chronometers CC or including baryon acoustic oscillations BAO. There is a large incertitude in Omega_Lambda and Omega_dark that may become negative, but their sum is close to Omega_Lambda of Lambda-CDM. In any case, there is a future singularity, that is a big rip for all Omegas positive. We solve the equation for the evolution, in linear approximation, of the density contrast in matter-dominated universe. The dark sector and the Lambda term give no significative deviation from Lambda-CDM and GR results., Comment: 20 pages, 6 figures. Introduction reviewed, with references. Section on H(z) and datasets reviewed with improved figures, evolution of dark energy density and pressure, future singularities
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- 2024
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7. Second Response to the critique of 'Cotton Gravity'
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Sussman, R. A., Mantica, C. A., Molinari, L. G., and Nájera, S.
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General Relativity and Quantum Cosmology ,Astrophysics - Astrophysics of Galaxies - Abstract
Clement and Noiucer submitted a note {\tt arXiv:2401.16008 [gr-qc]} replying to our criticism {\tt arXiv:2401.10479 [gr-qc]} of their previous submission. We reply to the contents of this note and remark that these authors have not addressed our arguments. This will be our last response to them. Readers are advised to look at all material and judge by themselves, Comment: 2 pages, 6 references
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- 2024
8. Response to a critique of 'Cotton Gravity'
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Sussman, Roberto A, Mantica, Carlo Alberto, Molinari, Luca Guido, and Nájera, Sebastián
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General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We address in this article the criticism in a recently submitted article by Clement and Noiucer (arXiv:2312.17662 [gr-qc]) on "Cotton Gravity" (CG), a gravity theory alternative to General Relativity. These authors claim that CG is "not predictive" for producing "too many" spherically symmetric vacuum solutions, while taking the Bianchi I vacuum as test case they argue that geometric constraint on the Cotton tensor lead to an undetermined problem, concluding in the end that CG "is not a physical theory". We provide arguments showing that this critique is incorrect and misrepresents the theory., Comment: Important corrections and extra arguments added. 5 pages, all typos corrected
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- 2024
9. Friedmann equations in the Codazzi parametrization of Cotton and extended theories of gravity and the Dark Sector
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,83D05 (Primary) 83C56 (Secondary) - Abstract
The Friedmann equations of Cotton gravity provide a simple parametrization to reproduce, by tuning a single function, the Friedmann equations of several extensions of gravity, such as f(R), modified Gauss-Bonnet f(G), teleparallel f(T), and more. It also includes the recently proposed Conformal Killing gravity and Mimetic gravity in FRW space-times. The extensions generally have the form of a Codazzi tensor that may be associated to the dark sector. Fixing it by a suitable equation of state accomodates most of the postulated models that extend $\Lambda$CDM, as the Chevallier-Polarski-Lindler model., Comment: Accepted in PRD. Generic Gravity in section 3 and new references
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- 2023
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10. Contact-force local impedance algorithm to guide effective pulmonary vein isolation in AF patients: 1-year outcome from an international multicenter clinical setting
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Solimene, Franscesco, Maggio, Ruggero, De Sanctis, Valerio, Escande, William, Malacrida, Maurizio, Stabile, Giuseppe, Zakine, Cyril, Champ-Rigot, Laure, Anselmino, Matteo, Ferraro, Anna, Mantica, Massimo, Zucchelli, Giulio, Dell’Era, Gabriele, Mascia, Giuseppe, Ricci Maga, Renata, Pandozi, Claudio, Rossi, Pietro, Scaglione, Marco, Zingarini, Gianluca, Garnier, Fabien, Loricchio, Maria Luisa, Pelargonio, Gemma, and Lepillier, Antoine
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- 2024
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11. Evolution of tissue-specific expression of ancestral genes across vertebrates and insects
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Mantica, Federica, Iñiguez, Luis P., Marquez, Yamile, Permanyer, Jon, Torres-Mendez, Antonio, Cruz, Josefa, Franch-Marro, Xavier, Tulenko, Frank, Burguera, Demian, Bertrand, Stephanie, Doyle, Toby, Nouzova, Marcela, Currie, Peter D., Noriega, Fernando G., Escriva, Hector, Arnone, Maria Ina, Albertin, Caroline B., Wotton, Karl R., Almudi, Isabel, Martin, David, and Irimia, Manuel
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- 2024
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12. A note on Harada's Conformal Killing gravity
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,83D05 (Primary) 85-10 (Secondary) - Abstract
We show that "Gravity at cosmological distances: Explaining the accelerating expansion without dark energy" recently proposed by J. Harada [6] is equivalent to the Einstein equation extended by the presence of an arbitrary conformal Killing tensor. This turns Harada's equations of third order in the derivatives of the metric tensor to second order, and offers a simple strategy of solution that shortcuts Harada's derivation and obtains both modified Friedmann equations. An application is presented for the case of flat space and constant curvature., Comment: 5 pages. Last section improved, new references and remark 3 added
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- 2023
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13. The covariant approach to static spacetimes in Einstein and extended gravity theories
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,83C20 (Primary) 83D05 (Secondary) - Abstract
We present a covariant study of static space-times, as such and as solutions of gravity theories. By expressing the relevant tensors through the velocity and the acceleration vectors that characterise static space-times, the field equations provide a natural non-redundant set of scalar equations. The same vectors suggest the form of a Faraday tensor, that is studied in itself and in (non)-linear electrodynamics. In spherical symmetry, we evaluate the explicit expressions of the Ricci, the Weyl, the Cotton and the Bach tensors. Simple restrictions on the coefficients yield well known and new solutions in Einstein, f(R), Cotton and Conformal gravity, with or without charges, in vacuo or with fluid source., Comment: 25 pages. Some misprints corrected and references added
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- 2023
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14. How accurate are flux-tube (local) gyrokinetic codes in modeling energetic particle effects on core turbulence?
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Di Siena, A., Hayward-Schneider, T., Mantica, P., Citrin, J., Vannini, F., Bottino, A., Goerler, T., Poli, E., Bilato, R., Sauter, O., and Jenko, F.
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Physics - Plasma Physics - Abstract
Flux-tube gyrokinetic codes are widely used to simulate drift-wave turbulence in magnetic confinement devices. While a large number of studies show that flux-tube codes provide an excellent approximation for turbulent transport in medium-large devices, it still needs to be determined whether they are sufficient for modeling supra-thermal particle effects on core turbulence. This is called into question given the large temperature of energetic particles (EPs), which makes them hardly confined on a single flux-surface, but also due to the radially broad mode structure of energetic-particle-driven modes. The primary focus of this manuscript is to assess the range of validity of flux-tube codes in modeling fast ion effects by comparing radially global turbulence simulations with flux-tube results at different radial locations for realistic JET parameters using the gyrokinetic code GENE. To extend our study to a broad range of different plasma scenarios, this comparison is made for four different plasma regimes, which differ only by the profile of the ratio between the plasma kinetic and magnetic pressure. The latter is artificially rescaled to address the electrostatic limit and regimes with marginally stable, weakly unstable and strongly unstable fast ion modes. These energetic-particle-driven modes is identified as an AITG/KBAE via linear ORB5 and LIGKA simulations. It is found that the local flux-tube simulations can recover well the global results only in the electrostatic and marginally stable cases. When the AITG/KBAE becomes linearly unstable, the local approximation fails to correctly model the radially broad fast ion mode structure and the consequent global zonal patterns. According to this study, global turbulence simulations are likely required in regimes with linearly unstable AITG/KBAEs. In conditions with different fast ion-driven modes, these results might change.
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- 2023
15. Editorial on Perioperative Complications and In-Hospital Mortality in Partial and Radical Nephrectomy Patients with Heart-Valve Replacement
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Chierigo, Francesco, Tappero, Stefano, Dell’Oglio, Paolo, and Mantica, Guglielmo
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- 2024
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16. Evaluation of predictive factors for i-CLARAS (intraoperative complications in laparoscopic renal and adrenal surgery): a multicentre international retrospective cohort study
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Territo, Angelo, Di Buono, Giuseppe, Buscemi, Salvatore, Mantica, Guglielmo, Falco, Vincenzo, Palacios, Vital Hevia, Verri, Paolo, Antelo, Rodrigo Antelo, Rosas-Nava, Jesus Emmanuel, Crisan, Nicolae, Andras, Iulia, Medas, Fabio, Amato, Giuseppe, Romano, Giorgio, Breda, Alberto, and Agrusa, Antonino
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- 2024
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17. Ultrasound imaging of male urethral stricture disease: a narrative review of the available evidence, focusing on selected prospective studies
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Frankiewicz, Mikołaj, Vetterlein, Malte W., Markiet, Karolina, Adamowicz, Jan, Campos-Juanatey, Felix, Cocci, Andrea, Rosenbaum, Clemens M., Verla, Wesley, Waterloos, Marjan, Mantica, Guglielmo, and Matuszewski, Marcin
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- 2024
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18. Timing of cryoballoon pulmonary vein isolation to prevent atrial fibrillation recurrence
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Stabile, Giuseppe, Verlato, Roberto, Arena, Giuseppe, Pieragnoli, Paolo, Tondo, Claudio, Molon, Giulio, Manfrin, Massimiliano, Perego, Giovan Battista, Rovaris, Giovanni, Sciarra, Luigi, Mantica, Massimo, Sacchi, Riccardo, Nicolis, Daniele, and Iacopino, Saverio
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- 2024
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19. Efficacy of Three Different Injection Techniques for the Endoscopic Treatment of Vesicoureteral Reflux (VUR) in Children: A Review of 10 Years of Experience
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Lanfranchi G, Paraboschi I, Pierucci UM, Mantica G, Costanzo S, Marinoni F, Pansini A, Selvaggio GGO, and Pelizzo G
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vesicoureteral reflux ,injection technique ,endoscopic technique ,pediatrics. ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Giulia Lanfranchi,1 Irene Paraboschi,2 Ugo Maria Pierucci,1 Guglielmo Mantica,3 Sara Costanzo,1 Federica Marinoni,1 Andrea Pansini,1 Giorgio Giuseppe Orlando Selvaggio,1 Gloria Pelizzo1,2 1Department of Pediatric Surgery, Buzzi Children’s Hospital, Milan, 20154, Italy; 2Department of Biomedical and Clinical Sciences “L Sacco”, University of Milano, Milan, 20157, Italy; 3Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, 16131, ItalyCorrespondence: Gloria Pelizzo, Department of Biomedical and Clinical Sciences “L Sacco”, University of Milan, Milan, 20157, Italy, Email gloria.pelizzo@unimi.itAim: To review our 10 years of experience with the endoscopic treatment of vesicoureteral reflux (VUR) in children, emphasizing the long-term efficacy of the “combined STING-HIT” technique.Materials and Methods: A retrospective study was performed including all children with symptomatic VUR undergoing the cystoscopic injection of bulking agents from January 2013 to December 2022 in our pediatric tertiary referral center. Three different endoscopic techniques were adopted: the “combined STING-HIT” technique, the STING technique, and the HIT technique. Treatment success was defined as symptom remission and VUR resolution on the voiding cystourethrogram (VCUG) performed at the 3-month follow-up.Results: In the study period, 140 (F:M = 64:76) patients and 228 ureters were treated at a median patient age of 3 (2.0– 6.0) years. After a single endoscopic treatment, VUR resolved in 203 (88%) ureters. The VUR resolution rate after a single endoscopic treatment was 95% (n=70/74) in case of I–II VUR, 88% (n=87/99) in case of III VUR; 83% (n=38/46) in case of IV VUR; 89% (n=8/9) in case of V VUR (p-value: 0.174). Overall, one or two endoscopic treatments succeeded in 219 (96%) ureters. The overall VUR resolution rate following one or two endoscopic treatments was 100% (74/74) in case of I–II VUR, 93% (n=92/99) in case of III VUR; 96% (n=44/46) in case of IV VUR; 100% (n=9/9) in case of V VUR (p-value: 0.083). Despite not being statistically significant, the VUR resolution rate was higher for the “combined STING-HIT” technique, both after one (92%: n=110/119; versus 85%; n=62/73 versus 86%; n=31/36; p-value: 0.225) or two (98%: n=116/119; versus 95%; n=69/73 versus 94%; n=34/36; p-value: 0.469) endoscopic treatments.Conclusion: The endoscopic approaches were highly successful for the treatment of VUR in children. The “combined STING-HIT” technique was a safe and effective procedure, being associated with the higher resolution rate.Keywords: vesicoureteral reflux, injection technique, endoscopic technique, pediatrics
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- 2024
20. The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy
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Francesco Chierigo, Rocco Simone Flammia, Gabriele Sorce, Benedikt Hoeh, Lukas Hohenhorst, Andrea Panunzio, Zhe Tian, Fred Saad, Marcus Graefen, Michele Gallucci, Alberto Briganti, Francesco Montorsi, Felix K.H. Chun, Shahrokh F. Shariat, Alessandro Antonelli, Giovanni Guano, Guglielmo Mantica, Marco Borghesi, Nazareno Suardi, Carlo Terrone, and Pierre I. Karakiewicz
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract. Objectives. This study aimed to test the association between of type and number of D'Amico high-risk criteria (DHRCs) with cancer-specific mortality (CSM) in high-risk prostate cancer patients treated with radical prostatectomy. Materials and methods. In the Surveillance, Epidemiology, and End Results database (2004–2016), we identified 31,281 radical prostatectomy patients with at least 1 DHRC, namely, prostate-specific antigen (PSA) >20 ng/mL (hrPSA), biopsy Gleason Grade Group (hrGGG) score of 4 and 5, or clinical tumor stage ≥T3 (hrcT). Multivariable Cox regression models and competing risks regression models (adjusting for other cause mortality) tested the association between DHRCs and 5-year CSM. Results. Of 31,281 patients, 14,394 (67%) exclusively harbored hrGGG, 3189 (15%) harbored hrPSA, and 1781 (8.2%) harbored hrcT. Only 2132 patients (6.8%) harbored a combination of the 2 DHRCs, and 138 (0.6%) had all 3 DHRCs. Five-year CSM rates ranged from 0.9% to 3.0% when any individual DHRC was present (hrcT, hrPSA, and hrGGG, in that order), 1.6% to 5.9% when 2 DHRCs were present (hrPSA-hrcT, hrcT-hrGGG, and hrPSA-hrGGG, in that order), and 8.1% when all 3 DHRCs were present. Cox regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses, with hazard ratios from 1.00 to 2.83 for 1 DHRC, 2.35 to 5.88 for combinations of 2 DHRCs, and 7.13 for all 3 DHRCs. Conclusions. Within individual DHRCs, hrcT and hrPSA exhibited weaker effects than hrGGG did. Moreover, a dose-response effect was identified according to the number of DHRCs. Accordingly, the type and number of DHRCs allow further risk stratification within the high-risk subgroup.
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- 2024
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21. Monkeypox: a new threat for healthcare and urology?
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Rosario Leonardi, Angelo Cafarelli, Alessandro Calarco, Renzo Colombo, Ottavio De Cobelli, Ferdinando De Marco, Giovanni Ferrari, Giuseppe Ludovico, Stefano Pecoraro, Domenico Tuzzolo, and Guglielmo Mantica
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Monkeypox ,urology ,resident training ,waiting list ,genital lesions ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Monkeypox is an emerging zoonotic viral disease caused by the Monkeypox virus, traditionally confined to central and west Africa, which has recently spread to other regions worldwide, making it a global health concern...
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- 2024
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22. Comment to 'An unusual 'linitis plastica' like breast cancer bladder metastasis'
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Raquel Diaz, Rosario Leonardi, Federica Murelli, Piero Fregatti, Carlo Terrone, and Guglielmo Mantica
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Breast cancer ,bladder cancer ,metastasis ,linitis plastica ,haematuria ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Dear Editor, We read with interest the recently published article by Farci et al., titled “An unusual ‘linitis plastica’ like breast cancer bladder metastasis” and we congratulate the authors for the very interesting topic and case presented.......
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- 2024
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23. Codazzi tensors and their space-times, and Cotton gravity
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,Mathematics - Differential Geometry ,53B30, 83D05 (Primary) 53B50 (Secondary) - Abstract
We study the geometric properties of certain Codazzi tensors for their own sake, and for their appearance in the recent theory of Cotton gravity. We prove that a perfect-fluid tensor is Codazzi if and only if the metric is a generalized Stephani universe. A trace condition restricts it to a warped space-time, as proven by Merton and Derdzinski. We also give necessary and sufficient conditions for a space-time to host a current-flow Codazzi tensor. In particular, we study the static and spherically symmetric cases, which include the Nariai and Bertotti-Robinson metrics. The latter are a special case of Yang Pure space-times, together with spatially flat FRW space-times with constant curvature scalar. We apply these results to the recent Cotton gravity by Harada. The equations have the freedom of choosing a Codazzi tensor, that constrains the space-time where the theory is staged. The tensor, chosen in forms significative for physics, implies the form of the Ricci tensor, and the two specify the energy-momentum tensor, which is the source in Cotton gravity for the chosen metric. For example, the Stephani, Nariai and Bertotti-Robinson space-times solve Cotton gravity with physically sensible energy-momentum tensors. Finally, we discuss Cotton gravity in De Sitter space-times., Comment: 19 pages, no figures. We added a discussion of Yang Pure spaces, with references. Eq.45 and the Ricci tensor in the proof of Prop.2.3 (this version) are now correct
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- 2022
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24. Integrated modelling and multiscale gyrokinetic validation study of ETG turbulence in a JET hybrid H-mode scenario
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Citrin, J, Maeyama, S, Angioni, C, Bonanomi, N, Bourdelle, C, Casson, F. J, Fable, E, Goerler, T, Mantica, P, Mariani, A, Sertoli, M, Staebler, G, Watanabe, T, and Contributors, JET
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Physics - Plasma Physics - Abstract
Previous studies with first-principle-based integrated modelling suggested that ETG turbulence may lead to an anti-GyroBohm isotope scaling in JET high-performance hybrid H-mode scenarios. A dedicated comparison study against higher-fidelity turbulence modelling invalidates this claim. Ion-scale turbulence with magnetic field perturbations included, can match the power balance fluxes within temperature gradient error margins. Multiscale gyrokinetic simulations from two distinct codes produce no significant ETG heat flux, demonstrating that simple rules-of-thumb are insufficient criteria for its onset.
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- 2022
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25. Spherical doubly warped spacetimes for radiating stars and cosmology
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,Mathematics - Differential Geometry ,83C55 (Primary) 83C20 (Secondary) - Abstract
Spherically symmetric spacetimes are ambient spaces for models of stellar collapse and inhomogeneous cosmology. We obtain results for the Weyl tensor and the covariant form of the Ricci tensor on general doubly warped (DW) spacetimes. In a spherically symmetric metric, the Ricci and electric tensors become rank-2, built with a velocity vector field and its acceleration. Their structure dictates the general form of the energy-momentum tensor in the Einstein equations in DW spherical metrics. The anisotropic pressure and the heat current of an imperfect fluid descend from the gradient of the acceleration and the electric part of the Weyl tensor. For radiating stellar collapse with heat flow, the junction conditions of the doubly warped metric with the Vaidya metric are reviewed, with the boundary condition for the radial pressure. The conditions for isotropy simply accomodate various models in the literature. The anisotropy of the Ricci tensor in the special case of spherical GRW space-times (geodesic velocity), gives Friedmann equations deviating from standard FRW cosmology by terms due to the electric tensor. We introduce "perfect 2-scalars" to discuss f(R) gravity with anisotropic fluid source in a doubly warped spacetime, and show that the new geometric terms in the field equations do not change the tensor structure of the fluid energy-momentum tensor., Comment: 27 pages, submitted to GERG
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- 2022
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26. Evaluation of predictive factors for i-CLARAS (intraoperative complications in laparoscopic renal and adrenal surgery): a multicentre international retrospective cohort study
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Angelo Territo, Giuseppe Di Buono, Salvatore Buscemi, Guglielmo Mantica, Vincenzo Falco, Vital Hevia Palacios, Paolo Verri, Rodrigo Antelo Antelo, Jesus Emmanuel Rosas-Nava, Nicolae Crisan, Iulia Andras, Fabio Medas, Giuseppe Amato, Giorgio Romano, Alberto Breda, Antonino Agrusa, and i-CLARAS (intraoperative Complication in Laparoscopic Renal and Adrenal Surgery) Research Collaborative Study Group
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Medicine ,Science - Abstract
Abstract The laparoscopic approach represents the standard of treatment for renal and adrenal diseases, and its use is increasing even outside referral centres. Although most procedures are routinely performed, intraoperative complications do not occur, and the rate and predictive factors of these complications have not been established. The aim of this study was to evaluate the incidence and type of intraoperative complications and to identify predictive factors in patients undergoing laparoscopic renal and adrenal surgery. This was a cohort, multicentre, international retrospective study. Patients who underwent laparoscopic renal and adrenal surgeries between April 2017 and March 2022 were included in the study. Bivariate analysis was performed using contingency tables and the χ2 test for independent samples to compare qualitative variables and the T test and Mood test for continuous variables. Multivariate analysis was performed using a logistic regression model to obtain adjusted odds ratios. A total of 2374 patients were included in the study. Intraoperative complications were reported for 8.09% of patients who underwent renal surgery, with the most common complications reported being hollow viscus and vascular complications, and for 6.75% of patients who underwent adrenal surgery, with the most common complication reported being parenchymatous viscous complications. Multivariate analysis revealed that both adrenal and renal surgery radiological preoperative factors, such as invasive features during adrenalectomy and the RENAL score during nephrectomy, are predictive factors of intraoperative complications. In contrast to existing data, surgeon experience was not associated with a reduction in the incidence of perioperative complications.
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- 2024
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27. Geometric Perfect Fluids from Extended Gravity
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Capozziello, Salvatore, Mantica, Carlo Alberto, and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
A main issue in cosmology and astrophysics is whether the dark sector phenomenology originates from particle physics, then requiring the detection of new fundamental components, or it can be addressed by modifying General Relativity. Extended Theories of Gravity are possible candidates aimed in framing dark energy and dark matter in a comprehensive geometric view. Considering the concept of perfect scalars, we show that the field equations of such theories naturally contain perfect fluid terms. Specific examples are developed for the Friedman-Lema\^itre-Roberson-Walker metric., Comment: 7 pages, accepted for publication in Europhysics Letters
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- 2022
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28. Phase II study of border zone stereotactic radiosurgery with bevacizumab in patients with recurrent or progressive glioblastoma multiforme
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Mantica, Megan, Drappatz, Jan, Lieberman, Frank, Hadjipanayis, Constantinos G., Lunsford, L. Dade, and Niranjan, Ajay
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- 2023
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29. Role of CHA2DS2-VASc score in predicting atrial fibrillation recurrence in patients undergoing pulmonary vein isolation with cryoballoon ablation
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Rordorf, Roberto, Iacopino, Saverio, Verlato, Roberto, Arena, Giuseppe, Tondo, Claudio, Molon, Giulio, Manfrin, Massimiliano, Rovaris, Giovanni, Perego, Giovanni Battista, Sciarra, Luigi, Mantica, Massimo, Sacchi, Riccardo, and Pieragnoli, Paolo
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- 2023
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30. Adrenocortical carcinoma with venous tumor invasion: is there a role for mini-invasive surgery?
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Olivero, Alberto, Liu, Kan, Checchucci, Enrico, Liu, Lei, Ma, Lulin, Wang, Guoliang, Mantica, Guglielmo, Tappero, Stefano, Amparore, Daniele, Sica, Michele, Fiori, Cristian, Huang, Quingbo, Niu, Shaoxi, Wang, Baojun, Ma, Xin, Hou, Xiaofei, Porpiglia, Francesco, Terrone, Carlo, and Zhang, Xu
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- 2023
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31. Office-based management of non-muscle invasive bladder cancer (NMIBC): a position paper on current state of the art and future perspectives
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Rosario Leonardi, Francesca Ambrosini, Angelo Cafarelli, Alessandro Calarco, Renzo Colombo, Domenico Tuzzolo, Ferdinando De Marco, Giovanni Ferrari, Giuseppe Ludovico, Stefano Pecoraro, Ottavio De Cobelli, Carlo Terrone, and Guglielmo Mantica
- Subjects
Bladder cancer ,office fulguration ,office laser ,local bladder treatment ,NMIBC ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
To the Editor, Bladder cancer is one of the most common cancers in humans, representing the 7th and 17th type of neoplasm in both genders. Its incidence and mortality are quite heterogeneous in different countries and are due to different risk factors, quality and prevalence of healthcare and the possibility of early diagnosis and treatment of the tumor and its potential recurrences. [...]
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- 2024
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32. Does SARS-CoV-2 Affect the Prostate? A Molecular Analysis from a Case Series of COVID-19 Patients
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Sara Stigliani, Claudia Massarotti, Simona Coco, Guglielmo Mantica, Nataniele Piol, Bruno Spina, Elena Maccarini, Monica Colombo, Paola Anserini, and Paola Scaruffi
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covid-19 ,genitalia ,male ,prostate ,real-time polymerase chain reaction ,sars-cov-2 ,Medicine ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) causes COVID-19 that has been spreading worldwide since December 2019. Viral entry into cells requires expression of both angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) on the surface of the host cell. The male reproductive system, including the prostate, was supposed to be a potential target for SARS-CoV-2 since the presence of ACE and TMPRS2 receptors. This paper investigated for the first time the presence of SARS-CoV-2 mRNA in the prostatic tissue of a patient with active infection. In addition, we searched for the virus in the prostate of five patients after their recovery from COVID-19. The SARS-CoV-2 RNA was not detected in any of the prostate tissues tested even during the acute phase of infection. As case series have limitations, causality cannot be excluded and sporadic evidence of prostatic tissue invasion by SARS-CoV-2 may be detectable.
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- 2023
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33. Indocyanine Green (ICG)-Guided One-Stage Delayed Bladder Closure and Radical Soft-Tissue Mobilization (Kelly Procedure) For Bladder Exstrophy Repair: The First Experience
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Paraboschi I, Gnech M, Minoli DG, De Marco EA, Parente G, Mantica G, Bagnara V, Manzoni G, Leclair MD, and Berrettini A
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bladder exstrophy ,radical soft-tissue mobilization ,fluorescence-guided surgery ,indocyanine green ,children. ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Irene Paraboschi,1 Michele Gnech,1 Dario Guido Minoli,1 Erika Adalgisa De Marco,1 Giovanni Parente,2 Guglielmo Mantica,3,4 Vincenzo Bagnara,5 Gianantonio Manzoni,1 Marc-David Leclair,6 Alfredo Berrettini1 1Department of Pediatric Urology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 2Department of Pediatric Surgery, ASST Papa Giovanni XXIII Hospital, Bergamo, 24127 Italy; 3IRCCS Ospedale Policlinico San Martino, Genoa, Italy; 4Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genoa, Genoa, Italy; 5Department of Pediatric Surgery, Policlinico G.B.Morgagni, Catania, Italy; 6Chirurgie Infantile, CHU de Nantes, Nantes, FranceCorrespondence: Guglielmo Mantica, Consultant Urologist, Dirigente Medico, IRCCS Ospedale Policlinico San Martino, Genova, Italy, Email guglielmo.mantica@gmail.comAbstract: The vascular supply of the pelvic structures and the external genitalia can be easily injured during the one-stage delayed bladder closure and radical soft-tissue mobilization (Kelly procedure) for bladder exstrophy surgical repair. Aiming to help surgeons assessing and confirming tissue perfusion and viability, indocyanine green (ICG)-based laser angiography was incorporated into the operative approach to reduce the risk of ischemic injuries. The EleVision IR system (Medtronic Ltd) was adopted to confirm the identification of the vascular pedicles and assess the tissue perfusion in real-time in a 5-month-old with bladder exstrophy undergoing the one-stage delayed bladder closure and radical soft-tissue mobilization (Kelly procedure). ICG (0.15 mg/kg) was intravenously administered at 6 key steps during surgery with the ability to be re-dosed every 15 minutes. ICG-based laser angiography helped to confirm the correct identification of the vascular structures during surgery and to assess tissue perfusion in real-time. Blood flow did not change considerably after initial dissection or upon approximating the pubis symphysis. At the end of the procedure, good penile perfusion was shown, proving that no direct injury or substantial compression of the pudendal vessels had occurred following the mobilization and the reconstructive phase. ICG-based laser angiography proved to be safe, effective, and easy to employ and should be considered as a reasonable adjunct for tissue perfusion assessment and operative decision-making in patients undergoing bladder exstrophy Kelly repair.Keywords: bladder exstrophy, radical soft-tissue mobilization, fluorescence-guided surgery, indocyanine green, children
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- 2023
34. Uncommon Haemorrhagic Cystitis of Infectious Origin: A Narrative Review for Urologists
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Ambrosini F, Riccardi N, Occhineri S, Matucci T, Paraboschi I, Calarco A, Berrettini A, Tiseo G, Canetti D, Van Der Merwe A, Terrone C, and Mantica G
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cystitis ,haemorrhagic cystitis ,schistosomiasis ,tuberculosis ,gutb ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Francesca Ambrosini,1,2 Niccolò Riccardi,3,4 Sara Occhineri,3,4 Tommaso Matucci,3,4 Irene Paraboschi,5 Alessandro Calarco,6 Alfredo Berrettini,5 Giusy Tiseo,3 Diana Canetti,7 André Van Der Merwe,8 Carlo Terrone,1,2 Guglielmo Mantica1,2 1IRCCS Ospedale Policlinico San Martino, Genova, Italy; 2Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, Italy; 3Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 4StopTB Italia Onlus, Milan, Italy; 5Department of Pediatric Urology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; 6Villa Pia Hospital, Via Folco Portinari 5, Rome, Italy; 7Infectious Diseases Unit, San Raffaele Scientific Institute, Milan, Italy; 8Department of Urology, Faculty of Medicine and Health Sciences, 26697 Stellenbosch University, Cape Town, South AfricaCorrespondence: Guglielmo Mantica, Department of Surgical and Diagnostic Intergrated Sciences (DISC), University of Genova, Genova, Italy, Tel +390105555960, Email guglielmo.mantica@gmail.comPurpose: Haemorrhagic cystitis may be due to different etiologies with infectious diseases representing an insidious cause to diagnose. The aim of this narrative review is to provide a comprehensive overview of less common but difficult-to-diagnose causes of infectious haemorrhagic cystitis of bacterial, mycobacterial, and parasitic origin, Moreover, we highlight possible diagnostic tools and currently available treatment options in order to give an updated tool for urologists to use in daily practice.Patients and Methods: The search engine PubMed was used to select peer-reviewed articles published from 1/Jan/2010 to 31/Aug/2022.Results: Bacteria, fungal, TB and schistosomiasis are uncommon causes of haemorrhagic cystitis burdened by high morbidity, especially if not promptly diagnosed.Conclusion: Because haemorrhagic cystitis ranges in severity from mild dysuria associated with pelvic discomfort to severe life-threatening haemorrhage, punctual diagnosis, and immediate treatment are essential to avoid further complications.Keywords: cystitis, haemorrhagic cystitis, schistosomiasis, tuberculosis, GUTB
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- 2023
35. Doubly Torqued Vectors and a classification of Doubly Twisted and Kundt spacetimes
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,Mathematics - Differential Geometry ,83C20 (Primary), 53B30 (Secondary) - Abstract
The simple structure of doubly torqued vectors allows for a natural characterization of doubly twisted down to warped spacetimes, as well as Kundt spacetimes down to PP waves. For the first ones the vectors are timelike, for the others they are null. We also discuss some properties, and their connection to hypersurface orthogonal conformal Killing vectors, and null Killing vectors., Comment: 9 pages, 3 tables. Equation in text (3 lines below table 2) has been corrected
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- 2021
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36. A simple characterization of doubly twisted spacetimes
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Mantica, Carlo Alberto and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,Mathematics - Differential Geometry ,83C20 (Primary), 53B30 (Secondary) - Abstract
In this note we characterize 1+n doubly twisted spacetimes in terms of `doubly torqued' vector fields. They extend Bang-Yen Chen's characterization of twisted and generalized Robertson-Walker spacetimes with torqued and concircular vector fields. The result is a simple classification of 1+n doubly-twisted, doubly-warped, twisted and generalized Robertson-Walker spacetimes., Comment: 6 pages. Theorem 2.2 improved (doubly warped spacetimes)
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- 2021
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37. Behavior of Correlation Functions in the Dynamics of the Multiparticle Quantum Arnol’d Cat
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Giorgio Mantica
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classical and quantum autocorrelation functions ,chaos ,quantum-to-classical transition ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
The multi-particle Arnol’d cat is a generalization of the Hamiltonian system, both classical and quantum, whose period evolution operator is the renowned map that bears its name. It is obtained following the Joos–Zeh prescription for decoherence by adding a number of scattering particles in the configuration space of the cat. Quantization follows swiftly if the Hamiltonian approach, rather than the semiclassical approach, is adopted. The author has studied this system in a series of previous works, focusing on the problem of quantum–classical correspondence. In this paper, the dynamics of this system are tested by two related yet different indicators: the time autocorrelation function of the canonical position and the out-of-time correlator of position and momentum.
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- 2024
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38. General properties of $\mathbf {f(R)}$ gravity vacuum solutions
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Capozziello, Salvatore, Mantica, Carlo Alberto, and Molinari, Luca Guido
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
General properties of vacuum solutions of $f(R)$ gravity are obtained by the condition that the divergence of the Weyl tensor is zero and $f''\neq 0$. Specifically, a theorem states that the gradient of the curvature scalar, $\nabla R$, is an eigenvector of the Ricci tensor and, if it is time-like, the space-time is a Generalized Friedman-Robertson-Walker metric; in dimension four, it is Friedman-Robertson-Walker., Comment: 9 pages, accepted for publication in Int. Jou. Mod. Phys. D
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- 2020
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39. New minimally invasive solutions for Benign Prostatic Obstruction (BPO) management: A position paper from the UrOP (Urologi Ospedalità Gestione Privata)
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Rosario Leonardi, Francesca Ambrosini, Rafaela Malinaric, Angelo Cafarelli, Alessandro Calarco, Renzo Colombo, Ottavio de Cobelli, Ferdinando De Marco, Giovanni Ferrari, Giuseppe Ludovico, Stefano Pecoraro, Domenico Tuzzolo, Carlo Terrone, and Guglielmo Mantica
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Prostatic hyperplasia ,Minimally invasive surgical procedures ,Lower urinary tract symptoms ,Sexual dysfunction ,Urologic surgical procedures ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
To the Editor, In recent years, alternative solutions have been proposed to obtain effective results comparable to TURP, which is currently considered the gold standard, and laser vapo-enucleation techniques (1, 2), but with the possibility of maintaining sexual functions. In recent years there has been a growing trend towards ejaculation preservation. Although the results of TURP (3), and most laser enucleation techniques are undoubted in the Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS) management, they often lack in the preservation of ejaculation. All the alternative recently proposed interventions (Rezum, AquaBeam, Urolift, TPLA, i-TIND, LEST) are procedures considered by some authors to be promising in both managing BPO and preserving sexual functions. However, all these methods are limited by a lack of long-term follow-up that would evaluate the efficacy over time, possible complications related to the method and the correct patient selection for a specific method. The aim of this letter is to summarize the available evidence and provide clinicians with practical recommendations on the use of the brand new minimally invasive techniques for the management of BPO. [...]
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- 2023
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40. A Unique Case of Inflatable Penile Prosthesis (IPP) Implantation and Mesh Phalloplasty in a Patient Born with Congenital Fusiform Megalourethra
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Berrettini A, Paraboschi I, Di Grazia M, Gnech M, Mantica G, Minoli DG, De Marco EA, Manzoni G, Capece M, Palmieri A, Ralph D, and Mirone V
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congenital fusiform megalourethra ,inflatable penile prosthesis ,phalloplasty ,erectile dysfunction. ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Alfredo Berrettini,1 Irene Paraboschi,1 Massimo Di Grazia,1 Michele Gnech,1 Guglielmo Mantica,2 Dario Guido Minoli,1 Erika Adalgisa De Marco,1 Gianantonio Manzoni,1 Marco Capece,3 Alessandro Palmieri,3 David Ralph,3 Vincenzo Mirone3 1Department of Pediatric Urology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 2Department of Urology, IRCCS Ospedale Policlinico San Martino, Genova, Italy; 3Department of Urology, Azienda Ospedaliera Universitaria “Federico II”, Napoli, ItalyCorrespondence: Irene Paraboschi, Department of Pediatric Urology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milano, Italy, Tel +393313229495, Email irene.paraboschi01@gmail.comAbstract: We present the first case of a patient born with congenital fusiform megalourethra who underwent the successful placement of an inflatable penile prosthesis (IPP) and mesh phalloplasty due to primary erectile dysfunction (ED). After an extensive psychosexual assessment and a preoperative MRI scan, an IPP was successfully implanted. The procedure was carried out through a penoscrotal approach, which offered excellent exposure to the crura and the proximal ends of the corpora cavernosa. Following the incision and the dilatation of both corpora cavernosa, the penile cylinders were inserted and a mesh phalloplasty was performed, to replace the erectile tissues lacking in the distal corpora cavernosa. After reservoir and pump placement, the device was tested, and no mechanical issues were recorded. The postoperative course was uneventful, and, at the 2-year follow-up, the patient reported highly satisfactory results, with valid functional erections.Keywords: congenital fusiform megalourethra, inflatable penile prosthesis, phalloplasty, erectile dysfunction
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- 2023
41. Explorando la perspectiva de los residentes sobre las modalidades y contenidos de aprendizaje inteligente para la educación virtual de urología: lección aprendida durante la pandemia de la COVID-19
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Campi, R, Amparore, D, Checcucci, E, Claps, F, Teoh, J Yuen-Chun, Serni, S, Scarpa, RM, Porpiglia, F, Carrion, DM, Rivas, J Gomez, Loeb, S, Cacciamani, GE, Esperto, F, de la European Society of Residents in Urology, en representación, Collaborators, Almeida, Joao Lemos, Fiori, Cristian, Hampson, Lindsay A, Mantica, Guglielmo, Minervini, Andrea, Olivero, Alberto, Polledo, Luis Enrique Ortega, Pang, Karl H, Papalia, Rocco, Pradere, Benjamin, Sandikci, Fatih, Subiela, Jose Daniel, Vallée, Maxime, and Zhuang, Junlong
- Subjects
Information and Computing Sciences ,Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Quality Education ,Adult ,COVID-19 ,Cross-Sectional Studies ,Education ,Distance ,Female ,General Surgery ,Humans ,Internationality ,Internship and Residency ,Male ,Pandemics ,SARS-CoV-2 ,Surveys and Questionnaires ,Urology ,Webcasts as Topic ,Residents ,Smart learning ,Survey ,en representación de la European Society of Residents in Urology ,Collaborators ,Aprendizaje inteligente ,Encuesta ,Residentes ,Urología - Abstract
PurposeThe COVID-19 outbreak has substantially altered residents' training activities. While several new virtual learning programs have been recently implemented, the perspective of urology trainees regarding their usefulness still needs to be investigated.MethodsA cross-sectional, 30-item, web-based Survey was conducted through Twitter from April 4th, 2020 to April 18th, 2020, aiming to evaluate the urology residents' perspective on smart learning (SL) modalities (pre-recorded videos, webinars, podcasts, and social media [SoMe]), and contents (frontal lessons, clinical case discussions, updates on Guidelines and on clinical trials, surgical videos, Journal Clubs, and seminars on leadership and non-technical skills).ResultsOverall, 501 urology residents from 58 countries completed the survey. Of these, 78.4, 78.2, 56.9 and 51.9% of them considered pre-recorded videos, interactive webinars, podcasts and SoMe highly useful modalities of smart learning, respectively. The contents considered as highly useful by the greatest proportion of residents were updates on guidelines (84.8%) and surgical videos (81.0%). In addition, 58.9 and 56.5% of responders deemed seminars on leadership and on non-technical skills highly useful smart learning contents. The three preferred combinations of smart learning modality and content were: pre-recorded surgical videos, interactive webinars on clinical cases, and pre-recorded videos on guidelines.ConclusionOur study provides the first global «big picture» of the smart learning modalities and contents that should be prioritized to optimize virtual Urology education. While this survey was conducted during the COVID-19 outbreak, our findings might have even more impact in the future.
- Published
- 2021
42. Estimating the trace of matrix functions with application to complex networks
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Fuentes, Rafael Díaz, Donatelli, Marco, Fenu, Caterina, and Mantica, Giorgio
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- 2023
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43. Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium)
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Tafuri, Alessandro, Marchioni, Michele, Cerrato, Clara, Mari, Andrea, Tellini, Riccardo, Odorizzi, Katia, Veccia, Alessandro, Amparore, Daniele, Shakir, Aliasger, Carbonara, Umberto, Panunzio, Andrea, Trovato, Federica, Catellani, Michele, Janello, Letizia M. I., Bianchi, Lorenzo, Novara, Giacomo, Dal Moro, Fabrizio, Schiavina, Riccardo, De Lorenzis, Elisa, Parma, Paolo, Cimino, Sebastiano, De Cobelli, Ottavio, Maiorino, Francesco, Bove, Pierluigi, Crocerossa, Fabio, Cantiello, Francesco, D’Andrea, David, Di Cosmo, Federica, Porpiglia, Francesco, Ditonno, Pasquale, Montanari, Emanuele, Soria, Francesco, Gontero, Paolo, Liguori, Giovanni, Trombetta, Carlo, Mantica, Guglielmo, Borghesi, Marco, Terrone, Carlo, Del Giudice, Francesco, Sciarra, Alessandro, Galosi, Andrea, Moschini, Marco, Shariat, Shahrokh F., Di Nicola, Marta, Minervini, Andrea, Ferro, Matteo, Cerruto, Maria Angela, Schips, Luigi, Pagliarulo, Vincenzo, and Antonelli, Alessandro
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- 2022
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44. Antenatal Determinants of Postnatal Renal Function in Fetal Megacystis: A Systematic Review
- Author
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Ugo Maria Pierucci, Irene Paraboschi, Guglielmo Mantica, Sara Costanzo, Angela Riccio, Giorgio Giuseppe Orlando Selvaggio, and Gloria Pelizzo
- Subjects
fetal megacystis ,lower urinary tract obstruction ,posterior urethral valves ,prognosis ,renal function ,Medicine (General) ,R5-920 - Abstract
Introduction: To evaluate the clinical usefulness of demographic data, fetal imaging findings and urinary analytes were used for predicting poor postnatal renal function in children with congenital megacystis. Materials and methods: A systematic review was conducted in MEDLINE’s electronic database from inception to December 2023 using various combinations of keywords such as “luto” [All Fields] OR “lower urinary tract obstruction” [All Fields] OR “urethral valves” [All Fields] OR “megacystis” [All Fields] OR “urethral atresia” [All Fields] OR “megalourethra” [All Fields] AND “prenatal ultrasound” [All Fields] OR “maternal ultrasound” [All Fields] OR “ob-stetric ultrasound” [All Fields] OR “anhydramnios” [All Fields] OR “oligohydramnios” [All Fields] OR “renal echogenicity” [All Fields] OR “biomarkers” [All Fields] OR “fetal urine” [All Fields] OR “amniotic fluid” [All Fields] OR “beta2 microglobulin” [All Fields] OR “osmolarity” [All Fields] OR “proteome” [All Fields] AND “outcomes” [All Fields] OR “prognosis” [All Fields] OR “staging” [All Fields] OR “prognostic factors” [All Fields] OR “predictors” [All Fields] OR “renal function” [All Fields] OR “kidney function” [All Fields] OR “renal failure” [All Fields]. Two reviewers independently selected the articles in which the accuracy of prenatal imaging findings and fetal urinary analytes were evaluated to predict postnatal renal function. Results: Out of the 727 articles analyzed, 20 met the selection criteria, including 1049 fetuses. Regarding fetal imaging findings, the predictive value of the amniotic fluid was investigated by 15 articles, the renal appearance by 11, bladder findings by 4, and ureteral dilatation by 2. The postnatal renal function showed a statistically significant relationship with the occurrence of oligo- or anhydramnion in four studies, with an abnormal echogenic/cystic renal cortical appearance in three studies. Single articles proved the statistical prognostic value of the amniotic fluid index, the renal parenchymal area, the apparent diffusion coefficient (ADC) measured on fetal diffusion-weighted MRI, and the lower urinary tract obstruction (LUTO) stage (based on bladder volume at referral and gestational age at the appearance of oligo- or anhydramnios). Regarding the predictive value of fetal urinary analytes, sodium and β2-microglobulin were the two most common urinary analytes investigated (n = 10 articles), followed by calcium (n = 6), chloride (n = 5), urinary osmolarity (n = 4), and total protein (n = 3). Phosphorus, glucose, creatinine, and urea were analyzed by two articles, and ammonium, potassium, N-Acetyl-l3-D-glucosaminidase, and microalbumin were investigated by one article. The majority of the studies (n = 8) failed to prove the prognostic value of fetal urinary analytes. However, two studies showed that a favorable urinary biochemistry profile (made up of sodium < 100 mg/dL; calcium < 8 mg/dL; osmolality < 200 mOsm/L; β2-microglobulin < 4 mg/L; total protein < 20 mg/dL) could predict good postnatal renal outcomes with statistical significance and urinary levels of β2-microglobulin were significantly higher in fetuses that developed an impaired renal function in childhood (10.9 ± 5.0 mg/L vs. 1.3 ± 0.2 mg/L, p-value < 0.05). Conclusions: Several demographic data, fetal imaging parameters, and urinary analytes have been shown to play a role in reliably triaging fetuses with megacystis for the risk of adverse postnatal renal outcomes. We believe that this systematic review can help clinicians for counseling parents on the prognoses of their infants and identifying the selected cases eligible for antenatal intervention.
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- 2024
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45. Risk Related to Increasing Indications for Retrograde Intrarenal Surgery
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Guglielmo Mantica, Francesca Ambrosini, Rafaela Malinaric, Alessandro Calarco, and Carlo Terrone
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Published
- 2024
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46. Editorial: Minimally-invasive treatment for genitourinary cancers: what comes next?
- Author
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Francesco Chierigo, Rocco Simone Flammia, and Guglielmo Mantica
- Subjects
minimally invasive & robotic surgery ,genitourinary cancer (GU cancer) ,bladder cancer (BCa) ,prostate cancer (PCa) ,kidney cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2023
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47. The Jordan algebras of Riemann, Weyl and curvature compatible tensors
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Mantica, Carlo Alberto and Molinari, Luca Guido
- Subjects
Mathematics - Differential Geometry ,53B20, 53B30 - Abstract
Given the Riemann, or the Weyl, or a generalized curvature tensor K, a symmetric tensor $b_{ij}$ is named `compatible' with the curvature tensor if $b_i{}^m K_{jklm} + b_j{}^m K_{kilm} + b_k{}^m K_{ijlm} = 0$. Amongst showing known and new properties, we prove that they form a special Jordan algebra, i.e. the symmetrized product of K-compatible tensors is K-compatible., Comment: 8 pages
- Published
- 2019
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48. On the uniqueness of a shear-vorticity-acceleration-free velocity field in space-times
- Author
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Molinari, Luca Guido, Tacchini, Adriano, and Mantica, Carlo Alberto
- Subjects
General Relativity and Quantum Cosmology ,Primary 53B30, Secondary 53C80 - Abstract
We prove that in space-times a velocity field that is shear, vorticity and acceleration-free, if any, is unique up to reflection, with these exceptions: generalized Robertson-Walker space-times whose space sub-manifold is warped, and twisted space-times (the scale function is space-time dependent) whose space sub-manifold is doubly twisted. In space-time dimension n = 4, the Ricci and the Weyl tensors are specified, and the Einstein equations yield a mixture of two perfect fluids., Comment: 11 pages
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- 2019
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49. Cosmological perfect fluids in higher-order gravity
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Capozziello, Salvatore, Mantica, Carlo Alberto, and Molinari, Luca Guido
- Subjects
General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
We prove that in Robertson-Walker space-times (and in generalized Robertson-Walker spacetimes of dimension greater than 3 with divergence-free Weyl tensor) all higher-order gravitational corrections of the Hilbert-Einstein Lagrangian density $F(R,\square R, ... , \square^k R)$ have the form of perfect fluids in the field equations. This statement definitively allows to deal with dark energy fluids as curvature effects., Comment: 6 pages
- Published
- 2019
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50. Cosmological perfect fluids in Gauss-Bonnet gravity
- Author
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Capozziello, Salvatore, Mantica, Carlo Alberto, and Molinari, Luca Guido
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
In an $n$-dimensional Friedmann-Robertson-Walker metric, it is rigorously shown that any analytical theory of gravity $f(R,{\cal G})$, where $R$ is the curvature scalar and $\cal G$ is the Gauss-Bonnet topological invariant, can be associated to a perfect-fluid stress-energy tensor. In this perspective, dark components of the cosmological Hubble flow can be geometrically interpreted., Comment: 8 pages, accepted for publication in International Journal of Geometric Methods in Modern Physics
- Published
- 2019
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