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Knowledge about genetics is essential to build a society capable of participating in socioscientific and ethical debates. However, this subject remains difficult for students, making it necessary to develop new educational strategies, such as gamification. Thus, two main objectives are established in this work: (a) to design and evaluate BreakoutEDU, a gamified activity to improve understanding of the content of gene expression; and (b) to study the emotions triggered by this activity among students. Using questionnaires and observation templates, the implementation of BreakoutEDU is evaluated in two groups of first-year high school students (15 and 10 students). The results are analyzed qualitatively and quantitatively. Bearing in mind the limitations of this study, it is concluded that the designed BreakoutEDU could support gamification as a good strategy to contextualize and approach the abstract content of gene expression. Moreover, the activity could maintain a balance between time, difficulty and students' skills, encourage teamwork and trigger mainly positive emotions.

The prevalence of mental health issues among young people, including anxiety, depression, and stress, has risen significantly. This study examines the effectiveness of socioformative strategies in enhancing emotional intelligence and reducing mental health issues in university students. A quantitative, pre-experimental study involved 187 students from one university in Peru with diagnosed mental health issues, utilising the Emotional Intelligence Socio-Formation Scale (EOSF), Trait Meta-Mood Scale (TMMS), and Depression, Anxiety, and Stress Scales (DASS). Wilcoxon test analysis revealed significant improvements in emotional intelligence (p = 0.03), depression (p = 0.02), anxiety (p = 0.00), and stress (p = 0.01). These findings show a substantial reduction in mental health symptoms and a 79.68% improvement in emotional intelligence, supporting broader implementation in Peruvian universities.

The prevalence of mental health issues among young people, including anxiety, depression, and stress, has risen significantly. This study examines the effectiveness of socioformative strategies in enhancing emotional intelligence and reducing mental health issues in university students. A quantitative, pre-experimental study involved 187 students from one university in Peru with diagnosed mental health issues, utilising the Emotional Intelligence Socio-Formation Scale (EOSF), Trait Meta-Mood Scale (TMMS), and Depression, Anxiety, and Stress Scales (DASS). Wilcoxon test analysis revealed significant improvements in emotional intelligence (p = 0.03), depression (p = 0.02), anxiety (p = 0.00), and stress (p = 0.01). These findings show a substantial reduction in mental health symptoms and a 79.68% improvement in emotional intelligence, supporting broader implementation in Peruvian universities.

Abstract Background Mice experiments have underscored the efficacy of pharmacological inhibition of advanced glycation endproducts (AGEs) through the use of soluble receptors for advanced glycation endproducts (sRAGE) in mitigating obesity-linked metabolic disruptions and insulin resistance. However, human studies have presented conflicting findings regarding the correlation between circulating sRAGE levels and insulin resistance, as well as glucose tolerance. Here, we aimed to delve deeper into the relationship between sRAGE levels and systemic insulin sensitivity. Methods Plasma sRAGE levels, hyperinsulinemic-euglycemic clamp, and continuous glucose monitoring were measured in two independent cross-sectional case-control studies [cohort 1 (n = 180) and cohort 2 (n = 124)]. In addition, a subgroup of 42 participants with obesity were followed for 12 months. In 14 of these participants, weight loss was achieved through bariatric surgery intervention. Results Our results revealed a significant association between plasma sRAGE levels and both insulin sensitivity and glycemic control parameters, even after adjustments for age, sex, and BMI. Furthermore, longitudinal analysis demonstrated that interventions aimed at weight loss led to reductions in fasting glucose and HbA1c levels, concurrently with increases in sRAGE levels. Conclusions These findings underscore that sRAGE levels were strongly associated with insulin sensitivity and glycemic control, suggesting a possible role of sRAGE in preserving insulin sensitivity and maintaining glycemic control, which should be confirmed in further studies.

The purpose of this paper is to explore the influence of Lesson Study on reconstructing students' practical knowledge during initial training as prospecting teachers. This case study sets out the voice and opinions of a student taking part in a lesson study process. The aim was to further understand how the student's opinions around teaching change both during and after her involvement in the different phases of Lesson Study. Information was obtained through semi-structured interviews, observations, photo and video records, document analysis and field diaries. We were also interested in understanding the student's perception of the influence of mentoring and tutoring on her professional development while accompanying her in her reflection about teaching. The results show that Lesson Study, as a cooperative curriculum creation process, provides prospecting teachers with opportunities to build their identity as professionals within a network of peers in which they interact in order to learn together. Focused on the context of initial teacher training, this article could lead to a new approach to Lesson Study as a strategy that can bring about more relevant transformations while teachers' beliefs, values and dispositions are still at an early stage of construction.

El Burrito Enano (Coturnicops notatus) es un burrito de pequeño tamaño, y muy poco conocido, con una distribución amplia pero muy disyunta en Sudamérica. Según las bases de datos los registros en Argentina son menos de 20 y ocurren entre mayo y noviembre. Hasta el momento existían registros en Formosa, Chaco, Entre Ríos, Santa Fe, Córdoba, La Pampa, Buenos Aires. El 4 de agosto de 2024, cerca de la medianoche, se encontró un individuo desorientado en pleno centro de la ciudad de Corrientes, el cuál fue liberado al día siguiente en una zona de lagunas y bañados. Este registro se suma a otro registro de ciencia ciudadana de noviembre del 2023, y son los primeros documentados para la especie en la provincia de Corrientes.

Abstract Background Lower urinary tract symptoms associated to benign prostatic hyperplasia (LUTS/BPH) is a growing condition in males associated to a high clinical, economic and humanistic burden. Currently, there is a wide range of therapeutic options, both pharmacological and surgical. In recent years, several minimally invasive therapies have emerged, but they still have limitations. In this context, water vapour thermal therapy (WVTT), Rezüm™, is a new minimally invasive surgical technique with a low retreatment rate and the ability to preserve sexual function. The objective of this study is to establish recommendations for the correct execution of WVTT, as well as to define the ideal patient profile for the intervention. Methods A literature search was conducted in PubMed, without date limitations, using the terms ‘benign prostatic hyperplasia’, ‘benign prostatic enlargement’, ‘prostatic hyperplasia’, ‘bph’, ‘Rezūm’, ‘water vapour thermal therapy’, ‘quality of life’ and ‘HRQOL’. A systematic review of the evidence was conducted and subsequently discussed in a face‐to‐face meeting with a panel of five experts in the field of urology. The aspects addressed were classified into patient profile, pre‐intervention, intervention and post‐intervention. Results The search returned 172 results, ultimately leading to the analysis of 49 articles. Evidence and expert opinion showed that WVTT could be a good option for patients with moderate to severe symptomatology, no age restriction, Qmax

Addictions undermine the quality of life of individuals and their families. They generally lead to misadjustment that affects many areas (psychological, family, social, and occupational) and, in the most severe cases, can end in helplessness, loneliness, or early death. The self-esteem of the person with addictions tends to be reduced and this limits their chances of recovery. Through this research, we tried to test the effect of a self-esteem workshop on 58 people with addictions to different substances. A self-esteem workshop was carried out with people who were part of a therapeutic community belonging to the province of Pontevedra (Spain). Several working groups were established and received sessions over a period of two and a half months. Participation was voluntary and the anonymity and confidentiality of the participants were guaranteed. To assess self-esteem, the Coopersmith Self-Esteem Scale Short Form, or Form B, was used at the beginning and at the end of the workshop. The results confirm the existence of statistically significant differences in the Self-Esteem Scale in relation to the pre-treatment and post-treatment assessments: F(1) = 106.44, p = 0.000, η2 = 0.655. The self-esteem workshop resulted in a significant change in this construct and contributed to the psychological improvement of people with addictions.

Abstract A lactate/albumin ratio (LAR) greater than 0.5 measured early in the course of pediatric critical illness is associated with greater mortality. Whether the elevated LAR can be explained by microcirculation disorders in children with sepsis is not known. In this longitudinal retrospective study (January 2021-January 2024), serum albumin and lactate were measured on admission to the pediatric intensive care unit (PICU), with sublingual video microscopy performed simultaneously to measure microcirculation. A total of 178 children were included, 37% of whom had septic shock measured with the Phoenix Sepsis Score. Patients with remote sepsis had greater odds of an elevated LAR (aOR 6.87: 95% CI 1.98–23.73; p

Abstract Marine heatwaves are discrete, albeit prolonged, episodes of extreme ocean temperatures that are significantly impacting marine ecosystems worldwide. However, there is limited research solely focusing on marine heatwaves and their concomitant effects on ecosystem dynamics in the Southern Ocean, known to play a major role in the Earth’s climate system. Here we use daily high-resolution satellite-derived and modelled data from 1982 to 2021 to characterise general spatiotemporal patterns of marine heatwaves in the Southern Ocean, assess their physical drivers and explore their interconnections with marine biogeochemistry. We find that increasing climate change-related marine heatwave activity, primarily explained by sea-air heat fluxes and vertical diffusion anomalies, enhances net primary production through stabilization of the water column. We empirically reveal causal nonlinear relationships between ocean extremes and primary productivity, especially in the southernmost subantarctic areas where the concurrent sea ice decrease also plays a key role. Furthermore, our study shows zonally asymmetric responses of primary producers to changing physical conditions north of the Antarctic polar front. These results provide key insights into the role of marine heatwaves promoting carbon assimilation (and uptake) in the Southern Ocean through the biological carbon pump, which is crucial for constraining the oceanic carbon cycle under climate change.

This study focuses on the forest cover of three districts in the urban area of the province of Andahuaylas, Apurímac region, Peru, which is facing deforestation problems. The objective was to determine the forest cover in the urban area of the province of Andahuaylas until 2030, to reveal future scenarios of forest cover, contributing to the development of urban planning and the creation of sustainable cities. For the study area, data recorded between the years 2017-2023 were used, based on NDVI images from the Sentinelhub portal. This allowed for the availability of information on tropical and temperate forests, shrubs and grasslands, arid rock zones, and urban or artificial areas that have changed due to the urbanization process. The forest surfaces in the study area were determined. Subsequently, linear regression was used with a p-value = 0,046, reaching an R2 of 0,583 in a medium range, managing to estimate future forest scenarios by 2030. It is concluded that the trend is decreasing in forest cover by 26,50% by the year 2030.

Soil organic carbon (organic C) and pH are key soil properties and valuable indicators of soil quality, whereas phosphate retention capacity (P retention) is a diagnostic property to define andic soil properties and andic soils, with all of them typically interrelated in volcanic ash (i.e., andic) soils. In this paper, we examined the potential of a random forest (RF) regression model to predict field-measured soil pH, organic C and P retention capacity from several biophysical (type and fraction of the plant cover), bioclimatic (maximum temperature of the warmest month, precipitation and temperature seasonality, and precipitation of the driest quarter), and topographic (ruggedness and curvature of the slope) predictors in a protected forest area in Tenerife, Canary Islands. Piecewise structural equation modeling (pSEM) was subsequently used to unravel the complex, direct and indirect relationships between the biophysical, bioclimatic and topographic variables, and the selected soil properties. The RF regression model accounted for the properties of interest with varying degrees of accuracy, from organic C (R2 = 0.67; RMSE = 29.86), to P retention capacity (R2 = 0.44; RMSE = 18.84) and soil pH (R2 = 0.31; RMSE = 0.43). The pSEM model revealed that P retention capacity is strongly linked to organic C in volcanic ash soils, and thus indirectly to the environmental variables shaping organic C variability, namely fractional vegetation cover and precipitation seasonality.

IntroductionPembrolizumab stands as a first-line option for patients with advanced non-small cell lung cancer (NSCLC) and high programmed death-ligand 1 (PD-L1) expression (PD-L1 ≥50%). Several factors such as antibiotic exposure, low body mass index (BMI), certain metastatic location or poor performance status may influence outcomes.MethodsWe conducted a multicenter retrospective analysis in a cohort of patients with advanced high PD-L1 expression NSCLC treated with first-line pembrolizumab in clinical practice. We sought to evaluate clinical outcomes according to several factors.ResultsAmong the 494 included patients, median age was 67.29 years, 77% were male, 54% and 38% were former or current smokers, respectively; 84% had an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-1, and 48% had a BMI of

BackgroundThe evolution of the family model in Europe in the 21st century, and particularly in Spain, has led to grandparents playing a major role in caring for their grandchildren. Grandparents are required to take on certain functions and roles in order to provide this care. This results in changes to their daily lives, their family relationships and therefore their quality of life.ObjectiveTo explore grandparents’ lived experience of being involved in the upbringing and care of grandchildren and to determine how this affects their quality of life.MethodologyA descriptive qualitative design was used. The data collection strategy involved two focus groups in two health centres in the province of Alicante (Spain), which were attended by 19 grandparents. Thematic analysis was used to analyse the data.ResultsFour themes and their respective sub-themes emerged from the data analysis: (1) Not only caring, but also raising (implications for upbringing; dealing with their children’s rules; nutrition of grandchildren); (2) Motivation for providing care (it is what families do; financial support; barriers to caregiving that outweigh the reasons for caregiving); (3) Significance of gender (grandmothers bring up, grandfathers help out; cultural burden of caregiving for women) and (4) Implications of care (negative aspects of caregiving; positive aspects of caregiving).ConclusionThe study findings show that while grandparents recognise the value and benefits of providing regular childcare, there are important challenges that need to be addressed. It would therefore be advisable for health professionals to take into account the experience of grandparent caregivers and the process of caring for young children when developing inclusive policies for this population of caregivers.

Introduction: The recent COVID-19 pandemic led to a rise in the number of people bereaved by the death of a loved one. There are many pandemic-related stressors that may have further complicated grief in these people. The aim of this research was to conduct an in-depth the experience of illness and death during the pandemic, as well as obstacles to and factors facilitating grief in people who had lost a loved one during this period, whether due to COVID-19 or to natural or sudden causes. Method: The sample consisted of 42 participants who had lost loved ones to COVID-19 or other causes (both natural and sudden). An inductive approach using grounded theory with open, axial and selective coding was used to analyse the semi-structured open-ended interviews. Results: The resulting theory was structured around a central category: “Processes of Loss and Grief in Pandemics”. The other relevant and related categories were: disease processes during the pandemic, emotional responses to the loss, factors facilitating the grieving process and obstacles to the grieving process. The various analytical categories were then further classified with reference to the Dual Process Model. Conclusion: This study highlights the main features of grief during the pandemic, including the impact of restrictive measures on disease processes; the funeral rituals performed and subsequent coping; responses such as intense shock, anger, fear or loneliness; and the way in which factors facilitating the grief process were adapted to the circumstances.

Some specific lipid molecules in the brain act as signaling molecules, neurotransmitters, or neuromodulators, by binding to specific G protein-coupled receptors (GPCR) for neurolipids. One such receptor, sphingosine 1-phosphate receptor subtype 1 (S1P1), is coupled to Gi/o proteins and is involved in cell proliferation, growth, and neuroprotection. S1P1 constitutes an interesting target for neurodegenerative diseases like multiple sclerosis and Alzheimer's disease (AD), in which changes in the sphingolipid metabolism have been observed. This study analyzes S1P1 receptor-mediated activity in healthy brains and during AD progression using postmortem samples from controls and patients at different Braak's stages. Additionally, the distribution of S1P1 receptor activity in human brains is compared to that in commonly used rodent models, rats and mice, through functional autoradiography, measuring [35S]GTPγS binding stimulated by the S1P1 receptor selective agonist CYM-5442 to obtain the distribution of functional activity of S1P1 receptors.S1P1 receptor-mediated activity, along with that of the cannabinoid CB1 receptor, is one of the highest recorded for any GPCR in many gray matter areas of the brain, reaching maximum values in the cerebellar cortex, specific areas of the hippocampus and the basal forebrain. S1P1 signaling is crucial in areas that regulate learning, memory, motor control, and nociception, such as the basal forebrain and basal ganglia. In AD, S1P1 receptor activity is increased in the inner layers of the frontal cortex and underlying cortical white matter at early stages, but decreases in the hippocampus in advanced stages, indicating ongoing brain impairment. Importantly, we identified significant correlations between S1P1 receptor activity and Braak stages, suggesting that S1P1 receptor dysfunction is associated to disease progression, particularly in memory-related regions. The S1P signaling via S1P1 receptor is a promising neurological target due to its role in key neurophysiological functions and its potential to modify the progression of neurodegenerative diseases. Finally, rats are suggested as a preferred experimental model for studying S1P1 receptor-mediated responses in the human brain.

los cambios, producto de la pandemia, impulsaron a las organizaciones a mantenerse vigentes y competitivas. Por ello fue necesaria la capacidad para responder a las nuevas demandas para adaptarse al cambio, lo que implica innovar en el desarrollo de sus procesos. En ese sentido, la creciente importancia del comportamiento laboral innovador en el desarrollo de las organizaciones impulsó a los investigadores a buscar los mecanismos que estimulen dicho comportamiento en los trabajadores. Por lo expuesto, esta investigación tuvo como objetivo analizar las propiedades psicométricas de la Escala de Clima de Innovación (ECI). El estudio instrumental se realizó en 273 trabajadores peruanos (50.916 % hombres) entre 22 y 76 años (Media = 45.224) pertenecientes en su mayoría a empresas privadas (75.092 %). En cuanto al análisis psicométrico se exploró claridad y relevancia de los ítems por medio de la valoración de jueces expertos (validez de contenido), la estructura interna se evaluó mediante el análisis factorial confirmatorio tanto de los modelos oblicuos como bifactor, y por último se estimó la confiabilidad de las puntuaciones (coeficiente alfa) y del constructo (coeficiente omega). En cuanto a los hallazgos, los ítems de la ECI son claros y relevantes, el modelo unidimensional tiene mayor respaldo empírico como estructura interna, y la confiabilidad es adecuada. Se concluye que la ECI tiene evidencias favorables de validez y confiabilidad para su aplicación en empresas peruanas, constituyendo una herramienta útil para conocer el clima innovador percibido por sus trabajadores, aportando información para la toma de decisiones y planeamiento de estrategias de innovación y creatividad organizacional.

To evaluate and understand the dynamics of citizen participation in social networks concerning the war in Ukraine and delve into the phenomenon of cyberactivism, this study focuses on the conversation generated in Spanish around the conflict on Twitter. The research analyses 1,138,747 original tweets to investigate the general characteristics of the conversation, the user interaction patterns, and the creation and structure of communities and to determine the connecting factors. The study employs machine learning and artificial intelligence techniques via the Graphext data analytics tool. The conversation volume is very high, but the network of interactions is characterized by being unstructured and dominated by white noise, with disjointed interactions setting the tone of the conversation. Verified accounts and emotionality stand out as factors of connection and interconnection in the network. This case study highlights a form of social and political participation oriented towards visibility and information about the cause at a level of deliberation and debate that shows empathy and sympathy in a context close to slacktivism.

En este artículo se toman como ejemplo algunos verbos españoles y alemanes del paradigma que lexicaliza el concepto de prestar (p.ej. alquilar, ausleihen) para explicar las bases y describir las principales características del recurso CombiDigiLex. Se trata de una herramienta lexicográfica digital multilingüe de lexemas verbales y deverbales del español, alemán y portugués, con una organización conceptual del léxico que permite acceder al mismo desde una perspectiva onomasiológica. Está basada en material empírico extraído de corpus lingüísticos y está especialmente destinada a cubrir las necesidades de las consultas que se efectúan con la finalidad de realizar una producción libre o traducción.

El artículo presenta resultados de experiencias de extensión en la Universidad Nacional de Luján, orientadas a atender carencias relativas a herramientas para la gestión de información ambiental en ámbitos públicos de nivel local, y las consecuentes limitaciones en la usabilidad del conocimiento producido para la toma de decisiones, en el caso del Municipio de Luján. Para ello, se describe el diseño y operativización del Sistema de Información Ambiental Integrada de Luján (SIAI), desde sus inicios en el marco del Programa de Proyectos Integrados Desarrollo Local Sostenible (Dpto. Cs. Sociales - UNLu), hasta la fecha. El recorrido permite, por un lado, reflexionar sobre las experiencias de extensión universitaria, ejecutadas y en curso (2019-2022 y 2023-2025); por otro, describir su articulación con un proyecto de investigación orientado a integrar al Sistema funcionalidades basadas en inteligencia artificial y modelos de lenguaje natural. Finalmente, se reseñan logros consolidados, pendientes y proyecciones.

The superficial circumflex iliac artery (SCIA) perforator (SCIP) flap has been used for scrotal reconstruction after Fournier's gangrene, skin cancer, or infections. However, there are few publications with regard to penoscrotal reconstruction after a traumatic injury with this flap. In this article, we propose a new SCIP flap variation, the “extended” or “direct” SCIP flap, to effectively reconstruct a wide scrotal defect after a traumatic injury. The “extended” SCIP flap is designed medial and cranial to the anterosuperior iliac spine (ASIS) using the superficial branch of the SCIA as the main pedicle.

RESUMEN La reciente mercantilización de la innovación educativa obliga a tener muy presente el sentido de los cambios que se introducen. Que estos estén enfocados en la búsqueda de la calidad educativa y no en estrategias comerciales, y que sean acordes a lo que nos indican las diferentes áreas de conocimiento, es definitorio para establecer si se está ante una verdadera innovación educativa. Aquí se defiende un enfoque crítico y centrado en la comunidad, como el propuesto por Paulo Freire, que permita mejorar la educación y la sociedad desde un enfoque crítico y no mercantilizado.

We present a study connecting the physical properties of protostellar envelopes to the morphology of the envelope-scale magnetic field. We used the Atacama Large Millimeter/submillimeter Array (ALMA) polarization observations of 61 young protostars at 0.87 mm on ~400–3000 au scales from the B -field Orion Protostellar Survey to infer the envelope-scale magnetic field, and we used the dust emission to measure the envelope properties on comparable scales. We find that protostars showing standard hourglass magnetic field morphology tend to have larger masses, and the nonthermal velocity dispersion is positively correlated with the bolometric luminosity and dust temperature of the envelope. Combining with the disk properties taken from the Orion VLA/ALMA Nascent Disk and Multiplicity survey, we connect envelope properties to fragmentation. Our results show a positive correlation between the fragmentation level and the angle dispersion of the magnetic field, suggesting that the envelope fragmentation tends to be suppressed by the magnetic field. We also find that protostars exhibiting standard hourglass magnetic field structure tend to have a smaller disk and smaller angle dispersion of the magnetic field than other field configurations, especially the rotated hourglass, but also the spiral and others, suggesting a more effective magnetic braking in the standard hourglass morphology of magnetic fields. Nevertheless, significant misalignment between the magnetic field and outflow axes tends to reduce magnetic braking, leading to the formation of larger disks.

A complete understanding of the initial conditions of high-mass star formation and what processes determine multiplicity requires the study of the magnetic field in young massive cores. Using Atacama Large Millimeter/submillimeter Array (ALMA) 250 GHz polarization observations (0 $\mathop{.}\limits^{^{\prime\prime} }$ 3 = 1000 au) and ALMA 220 GHz high-angular-resolution observations (0 $\mathop{.}\limits^{^{\prime\prime} }$ 05 = 160 au), we have performed a full energy analysis including the magnetic field at core scales and have assessed what influences the multiplicity inside a massive core previously believed to be in the prestellar phase. With a mass of 31 M _⊙ , the G11.92 MM2 core has a young CS molecular outflow with a dynamical timescale of a few thousand years. At high resolution, the MM2 core fragments into a binary system, with a projected separation of 505 au and a binary mass ratio of 1.14. Using the Davis–Chandrasekhar–Fermi method with an angle dispersion function analysis, we estimate in this core a magnetic field strength of 6.2 mG and a mass-to-magnetic-flux ratio of 18. The MM2 core is strongly subvirialized, with a virial parameter of 0.064, including the magnetic field. The high mass-to-magnetic-flux ratio and low virial parameter indicate that this massive core is very likely undergoing runaway collapse, which is in direct contradiction with the core accretion model. The MM2 core is embedded in a filament that has a velocity gradient consistent with infall. In line with clump-fed scenarios, the core can grow in mass at a rate of 1.9–5.6 × 10 ^−4 M _⊙ yr ^−1 . In spite of the magnetic field having only a minor contribution to the total energy budget at core scales (a few thousands of astronomical units), it likely plays a more important role at smaller scales (a few hundreds of astronomical units) by setting the binary properties. Considering energy ratios and a fragmentation criterion at the core scale, the binary system could have been formed by core fragmentation. The binary system properties (projected separation and mass ratio), however, are also consistent with radiation-magnetohydrodynamic simulations with super-Alfvenic or supersonic (or sonic) turbulence that form binaries by disk fragmentation.