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Your search keyword '"Manuel Ojeda-Ramos"' showing total 4 results
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4 results on '"Manuel Ojeda-Ramos"'

1. Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk

Author

Marta Consegal, Ignasi Barba, Bruno García del Blanco, Imanol Otaegui, José F. Rodríguez-Palomares, Gerard Martí, Bernat Serra, Neus Bellera, Manuel Ojeda-Ramos, Filipa Valente, Maria Ángeles Carmona, Elisabet Miró-Casas, Antonia Sambola, Rosa María Lidón, Jordi Bañeras, José Antonio Barrabés, Cristina Rodríguez, Begoña Benito, Marisol Ruiz-Meana, Javier Inserte, Ignacio Ferreira-González, and Antonio Rodríguez-Sinovas

Subjects
Medicine, Science
Abstract

Abstract Succinate is enhanced during initial reperfusion in blood from the coronary sinus in ST-segment elevation myocardial infarction (STEMI) patients and in pigs submitted to transient coronary occlusion. Succinate levels might have a prognostic value, as they may correlate with edema volume or myocardial infarct size. However, blood from the coronary sinus is not routinely obtained in the CathLab. As succinate might be also increased in peripheral blood, we aimed to investigate whether peripheral plasma concentrations of succinate and other metabolites obtained during coronary revascularization correlate with edema volume or infarct size in STEMI patients. Plasma samples were obtained from peripheral blood within the first 10 min of revascularization in 102 STEMI patients included in the COMBAT-MI trial (initial TIMI 1) and from 9 additional patients with restituted coronary blood flow (TIMI 2). Metabolite concentrations were analyzed by 1H-NMR. Succinate concentration averaged 0.069 ± 0.0073 mmol/L in patients with TIMI flow ≤ 1 and was significantly increased in those with TIMI 2 at admission (0.141 ± 0.058 mmol/L, p

Published
2023
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2. Effect of COMBinAtion therapy with remote ischemic conditioning and exenatide on the Myocardial Infarct size: a two-by-two factorial randomized trial (COMBAT-MI)

Author

Eduard Fernández-Nofrerías, Bruno García del Blanco, Antoni Bayes-Genis, Gerard Martí, Jaime Elízaga, Marisol Ruiz-Meana, Derek J. Hausenloy, Juan Casanova, Neus Bellera, Josep Ramon Marsal, Mónica Fuertes, Javier Inserte, Manuel Ojeda-Ramos, David Garcia-Dorado, Jordi Bañeras, Ignacio Ferreira-González, José A. Barrabés, Ignasi Barba, Rosa María Lidón, José Ramón González-Juanatey, Javier López-Pais, Victoria Vilalta del Olmo, Hug Cuéllar, Xavier Carrillo, Gil Bonet, Antonia Sambola, Borja Ibanez, Imanol Otaegui, Antonio Rodríguez-Sinovas, Fernando Worner, Eva Pueo, Maria Ángeles Carmona, José Rodríguez-Palomares, Sandra Gómez-Talavera, Ferran Padilla, Elisabet Miró-Casas, B. Serra, Filipa Valente, Alfredo Bardají, Instituto de Salud Carlos III, and Government of Catalonia (España)

Subjects
Male, 0301 basic medicine, Time Factors, Physiology, medicine.medical_treatment, 030204 cardiovascular system & hematology, Ventricular Function, Left, law.invention, 0302 clinical medicine, Randomized controlled trial, law, hemic and lymphatic diseases, Prospective Studies, Myocardial infarction, Ischemic Preconditioning, Ejection fraction, Remote ischemic conditioning, Primary percutaneous coronary intervention, Middle Aged, Combined Modality Therapy, Treatment Outcome, Arm, Cardiology, Female, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, Randomization, ST-segment elevation acute myocardial infarction, Magnetic Resonance Imaging, Cine, Placebo, Incretins, 03 medical and health sciences, Percutaneous Coronary Intervention, Double-Blind Method, Physiology (medical), Internal medicine, medicine, Humans, Aged, business.industry, Myocardium, Percutaneous coronary intervention, medicine.disease, Clinical trial, 030104 developmental biology, Regional Blood Flow, Spain, ST Elevation Myocardial Infarction, Exenatide, business
Abstract

Remote ischemic conditioning (RIC) and the GLP-1 analog exenatide activate different cardioprotective pathways and may have additive effects on infarct size (IS). Here, we aimed to assess the efficacy of RIC as compared with sham procedure, and of exenatide, as compared with placebo, and the interaction between both, to reduce IS in humans. We designed a two-by-two factorial, randomized controlled, blinded, multicenter, clinical trial. Patients with ST-segment elevation myocardial infarction receiving primary percutaneous coronary intervention (PPCI) within 6 h of symptoms were randomized to RIC or sham procedure and exenatide or matching placebo. The primary outcome was IS measured by late gadolinium enhancement in cardiac magnetic resonance performed 3-7 days after PPCI. The secondary outcomes were myocardial salvage index, transmurality index, left ventricular ejection fraction and relative microvascular obstruction volume. A total of 378 patients were randomly allocated, and after applying exclusion criteria, 222 patients were available for analysis. There were no significant interactions between the two randomization factors on the primary or secondary outcomes. IS was similar between groups for the RIC (24 ± 11.8% in the RIC group vs 23.7 ± 10.9% in the sham group, P = 0.827) and the exenatide hypotheses (25.1 ± 11.5% in the exenatide group vs 22.5 ± 10.9% in the placebo group, P = 0.092). There were no effects with either RIC or exenatide on the secondary outcomes. Unexpected adverse events or side effects of RIC and exenatide were not observed. In conclusion, neither RIC nor exenatide, or its combination, were able to reduce IS in STEMI patients when administered as an adjunct to PPCI. The trial was sponsored with a Grant from Instituto de Salud Carlos III (PIE 13/00027) and a Grant from Generalitat de Catalunya (PERIS SLT/2381/2016). The sponsors have not been involved in the design, conduct, collection, analysis, interpretation of the data, nor in the preparation, review or approval of the manuscript Sí

Published
2021
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3. Abnormal Pulmonary Venous Drainage With Cor Triatriatum

Author

David Viladés Medel, Rubén Leta Petracca, and Manuel Ojeda Ramos

Subjects
Adult, medicine.medical_specialty, Computed Tomography Angiography, Echocardiography, Three-Dimensional, Magnetic Resonance Imaging, Cine, Rare Diseases, Text mining, Cor Triatriatum, medicine, Humans, Drainage, medicine.diagnostic_test, business.industry, Disease progression, Magnetic resonance imaging, Venous drainage, General Medicine, medicine.disease, Dyspnea, Pulmonary Veins, Cor triatriatum, Disease Progression, Female, Radiology, business
Published
2019
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