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OBJETIVO: A peri-implantite é uma doença biofi lme-dependente que afeta os tecidos ao redor do implante dentário, caracterizando-se por infl amação da mucosa peri-implantar e perda óssea progressiva. A fi brina rica em plaquetas é conhecida pelas propriedades de acelerar o processo de cicatrização de feridas e atividade antimicrobiana. Estudos vêm sendo realizados com a aplicação de fi brina rica em plaquetas no campo da implantodontia. No entanto, existem poucas evidências sobre os benefícios no tratamento da peri-implantite. MATERIAL E MÉTODOS: O presente relato de caso descreve o tratamento de defeitos de peri-implantite no segundo quadrante (região de incisivo lateral e canino) na prótese parcial fi xa implantossuportada de uma paciente de 59 anos de idade. O diagnóstico foi baseado na profundidade de sondagem (PS) > 6 mm e nível de perda óssea (NPO) de 5 e 3 mm nas regiões de incisivo lateral e canino. Além disso, uma deiscência em tecido mole vestibular de 1,5 e 3 mm foi observada nas regiões de incisivo lateral e canino, respectivamente. Foi realizada cirurgia a retalho para descontaminação da superfície do implante por meio de implantoplastia associada a membranas de fi brina rica em plaquetas, seguido de medicação antimicrobiana adjuvante por sete dias. RESULTADOS: Uma melhora clínica relevante foi observada em relação à profundidade de sondagem (< 4 mm) após quatro meses. Além disso, nenhum sangramento e supuração à sondagem foram observados. O ganho médio de largura da mucosa queratinizada foi de 1,1 mm após quatro meses de acompanhamento. Em adição, a margem vestibular da mucosa peri-implantar apresentou mínima recessão (0,5 mm cada) após o procedimento cirúrgico. A largura da mucosa queratinizada também aumentou ao fi m do acompanhamento. CONCLUSÃO: A cirurgia a retalho para descontaminação da superfície do implante por meio de implantoplastia associada a membranas de fi brina rica em plaquetas apresentou bons resultados clínicos no tratamento da peri-implantite.

This study evaluated the use of a xenogeneic acellular dermal matrix (XADM) combined with a modified coronally advanced flap (MCAF) and partial resin composite filling (anatomic crown plus 1 mm of the root surface) to treat multiple Type 1 gingival recessions associated with B+ noncarious cervical lesions (NCCLs). The study included 24 recessions in 10 patients. Bleeding on probing, probing depth, combined defect height, relative gingival recession, clinical attachment level, esthetics, and dentin hypersensitivity were recorded. After 6 months, the treatment provided statistically significant outcomes: It reduced the combined defect height by 2.02 ± 0.65 mm, increased clinical attachment level by 1.96 ± 0.83 mm, and increased keratinized tissue thickness by 0.46 ± 0.47 mm, and shallow probing depths were seen. Significant dentin hypersensitivity reduction and esthetic improvements were observed. Therefore, XADM associated with MCAF and partial restoration might be a promising alternative to autogenous grafts used to treat multiple gingival recessions associated with B+ NCCLs.

There are few studies comparing xenogeneic acellular dermal matrixes (XDMs) with connective tissue graft (CTG) to treat single gingival recession (GR). The present study involved a reanalysis of previous studies and comparison of CTG or XDM to treat single RT1/GR.Fifty patients from three previous randomized clinical trials treated either by CTG (n = 25) or XDM (n = 25) were evaluated after 6-month. Clinical, patient-centered, and esthetic parameters were assessed. Pearson's correlation and regression analyses were also performed.Greater recession reduction (RecRed), percentage of root coverage (%RC), and complete root coverage (CRC) were observed in the CTG group (p ≤ 0.02). Gingival thickness (GT) and keratinized tissue width (KTW) gains were higher in the CTG group. The CTG group showed better esthetic at 6-month. Logistic analyses reported that GT([OR] = 1.647CTG was superior for treating RT1/GR, providing better root coverage outcomes and tissue gains over time. GT, PH, and graft type were classified as predictors of CRC.CTG presented better outcomes to treat single RT1 gingival recession when compared to the XDM.

Made available in DSpace on 2022-04-28T17:30:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-28 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Introduction: Gingival recession (GR) is a relevant clinical condition due to its high prevalence worldwide, which leads to aesthetic demands and dentin hypersensitivity. Collagen matrices have been associated with different designs of coronally advanced flaps (CAFs) to treat GR defects. However, the literature lacks long-term follow-up of this treatment option. The aim of this study is to present the long-term follow-up (up to 7 years) of two GR defects (associated or not with noncarious cervical lesion) treated with a CAF and a collagen matrix (CM). Case presentation Case 1 underwent a CAF associated with a CM to treat a single GR defect. After 7 years, Case 1 presented with 3 mm of recession reduction, which corresponds with the 85.7% of root coverage. Case 2 presented two GR defects associated with noncarious cervical lesions (NCCLs). The NCCLs were partially restored with resin composite and then underwent a modified CAF for multiple defects and a CM. After 5 years of follow-up, Case 2 presented with 1.5 and 2.5 mm of recession reduction, which corresponds with the average 83.3% defect coverage. Conclusion These two cases may show that CMs can provide long-term stable outcomes in the treatment of GR defects. Fed Univ Pernambuco UFPE, Dept Prosthesis & Surg Orofacial, Recife, PE, Brazil Sao Paulo State Univ, Inst Sci & Technol, Div Periodont, UNESP, Av Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP, Brazil Private Educ Inst, Sao Paulo, Brazil Sao Paulo State Univ, Inst Sci & Technol, Div Periodont, UNESP, Av Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP, Brazil CAPES: 001 CNPq: 304269/2019-0

Made available in DSpace on 2022-05-01T10:19:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Background: Xenogeneic matrices (XMs) have been increasingly used for root coverage procedures. This study compared the use of two types of XM (collagen matrix [CM] and xenogeneic acellular dermal matrix [XDM]) associated with the coronally advanced flap technique (CAF) to treat single gingival recessions. Methods: Seventy-five patients presenting single RT1 gingival recession were treated by CAF (control group, n = 25), CAF+CM (test group 1, n = 25), or CAF+XDM (test group 2, n = 25) and completed 6-month follow-up. Clinical, patient-centered, and esthetic assessments were performed and intra- and intergroup differences were analyzed. Results: At 6 months, the mean recession reduction for CAF, CAF+CM, and CAF+XDM was 2.4 ± 0.8 mm, 2.4 ± 0.9 mm and 2.1 ± 0.8 mm, respectively (P > 0.05). The corresponding mean percentage of root coverage was 78.9% ± 26.2% for CAF, 78.0% ± 28.5% for CAF+CM, and 65.6% ± 26.9% for CAF+XDM (P > 0.05). Dentin hypersensitivity and esthetic conditions showed significantly improvements in all groups. Test groups presented significant gains in gingival thickness (GT; CAF+CM: 0.4 ± 0.3 mm; CAF+XDM: 0.4 ± 0.2 mm) compared to the control group (CAF: 0.0 ± 0.1 mm; P

Made available in DSpace on 2021-06-25T22:23:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-16 Introduction: Gingival recession (GR) is a prevalent problem that is related to esthetic demands and dentin hypersensitivity. Frequently, GR is associated with non-carious cervical lesion (NCCLs) forming a combined defect (CD), which requires restorative and surgical treatment. Connective tissue graft procedures allow predictable root coverage but can result in patient discomfort. Case Presentation: This first case report describes multiple GRs associated with B+ NCCL at teeth #4 and #6 of a 27-year-old patient with a thin periodontal phenotype. The aim of this report was to evaluate the 6-month outcome of a new volume-stable collagen matrix (VCMX) combined with modified coronally advanced flap (MCAF) and partial restoration to treat CDs. After 6 months, significant improvement was observed regarding CD coverage (69.05%), recession reduction (2.25 mm), gingival thickness gain (0.74 mm), and keratinized tissue width gain (0.75 mm). In addition, excellent esthetic evaluation and patient comfort were achieved by using the biomaterial. Conclusion: VCMX associated with MCAF and partial restoration may be an option to treat multiple recession defects plus B+ NCCLs. Sao Paulo State Univ UNESP, Inst Sci & Technol, Div Periodont, Ave Eng Francisco Jose Longo 777, Sao Jose Dos Campos, SP, Brazil Sao Paulo State Univ UNESP, Inst Sci & Technol, Div Periodont, Ave Eng Francisco Jose Longo 777, Sao Jose Dos Campos, SP, Brazil

Made available in DSpace on 2020-12-12T02:48:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Background: This study was conducted to assess the clinical, immunological, and patient-centered outcomes of microcurrent electrotherapy on palatal wound healing. Methods: This was a parallel, double-masked randomized clinical trial, in which 53 patients with ridge preservation indications were selected and randomly assigned to one of two groups. In the control (sham) group (n = 27), palatal wounds, after free gingival grafts (FGG) harvest, received sham application of electrotherapy. In the test (electrotherapy treatment [EE]) group (n = 26), palatal wounds, after FGG harvest, received application of microcurrent electrotherapy protocol. Clinical parameters, patient-centered outcomes, and inflammatory markers were evaluated, up to 90 days postoperatively. Results: The EE group achieved earlier wound closure (P

Made available in DSpace on 2019-10-06T17:10:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 This study investigated the local effect of photobiomodulation (PBM) for the treatment of periodontal pockets in patients with periodontitis and type 2 diabetes. Thirty-eight periodontal pockets presenting probing depth (PD) and clinical attachment level (CAL) ≥ 5 mm were selected from 19 patients (two pockets/patient). The selected periodontal pockets were randomly assigned to receive mechanical debridement only (control group) or mechanical debridement with PBM (PBM group). Clinical measures, such as PD, CAL, bleeding on probing (BoP), and presence of supragingival biofilm (PI), were collected and compared at baseline, 3, 6, and 12 months. After 12 months, no statistically difference was observed for mean PD and mean CAL when control and PBM groups were compared. The frequency of pockets with PD 5–6 mm was significantly lower for the PBM group at 6 months when compared to the control group. Pockets with PD ≥ 7 mm changed significantly between baseline and 3, 6, and 12 months for the PBM group, while for the control group, statistical significance was only observed between baseline and 6 months. The PBM protocol used in this study did not provide significant changes for PD and CAL in periodontal pockets when compared to mechanical therapy only. However, PBM was more effective in reducing the percentage of moderate periodontal pockets at 6 months in patients with type 2 DM. São Paulo State University (Unesp) Institute of Science and Technology São José dos Campos Department of Diagnosis and Surgery Division of Periodontics University of Araras (Uniararas) Dental School Department of Orthodontics São Paulo State University (Unesp) Institute of Science and Technology São José dos Campos Department of Diagnosis and Surgery Division of Periodontics

Made available in DSpace on 2022-05-01T09:30:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Background: This study was conducted to evaluate the clinical, immunologic, and patient-centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. Materials: Forty-four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient-centered parameters were analyzed for 3 months post-treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. Results: No significant inter-group difference was observed in remaining wound area and re-epithelialization. EMD and control groups achieved wound closure and re-epithelialization 30 days postoperatively (p .05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases-2. Conclusion: Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers. São Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology Division of Operative Dentistry Department of General Dentistry University of Maryland School of Dentistry Department of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental School College of Dentistry Division of Periodontology The Ohio State University (OSU) College of Dentistry - Lexington University of Kentucky São Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology

Made available in DSpace on 2021-06-25T23:35:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-12 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Introduction: The use of platelet-rich fibrin (PRF) membranes has been evaluated for different purposes. However, few studies aimed to assess the effect of PRF membranes on peri-implant mucosal thickness augmentation. Thus, the aim was to evaluate whether the use of PRF membranes placed using the same surgical procedure of single implant installation in the anterior area of the maxilla can result in peri-implant mucosal thickness increase. Case series: Eight patients received single maxillary implants (anterior area), covered by three PRF membranes (2,500 rpm/12 minutes, RCFmax = 719.71 g). Clinical parameters (baseline and 3 months postoperative) and patient-centered parameters were evaluated. The buccal peri-implant mucosal thickness (BMT) and ridge defect (RD) parameters showed a statistically significant difference, with a gain of 0.7 +/- 0.3 mm in BMT and reduction of 0.8 +/- 0.3 mm in RD. Supracrestal tissue height (STH) was >3 mm after 3 months. Postoperative pain and number of analgesics showed low values (0.95 +/- 1.06 and 1.92 +/- 2.75), respectively, using a visual analog scale (VAS). Conclusion: The use of three PRF membranes along with single implant placement in the anterior maxilla led to an increase in the BMT. Sao Paulo State Univ Unesp, Div Periodont, Inst Sci & Technol, Ave Eng Francisco Jose Longo,777, BR-12245000 Sao Jose Dos Campos, SP, Brazil Sao Paulo State Univ Unesp, Div Integrated Clin, Inst Sci & Technol, Sao Paulo, Brazil Sao Paulo State Univ Unesp, Div Periodont, Inst Sci & Technol, Ave Eng Francisco Jose Longo,777, BR-12245000 Sao Jose Dos Campos, SP, Brazil Sao Paulo State Univ Unesp, Div Integrated Clin, Inst Sci & Technol, Sao Paulo, Brazil CNPq: 304269/2019-0

Made available in DSpace on 2021-06-25T10:29:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The aim of this study was to characterize the alveolar bone of edentulous maxillary sites using texture analysis (TA) of cone beam computed tomography (CBCT) images and to correlate the results to the insertion torque, thus verifying whether TA is a predictive tool of final implant treatment. This study was conducted on patients who had received single implants in the maxilla (46 implants) 1 year earlier and whose torque values were properly recorded. Three cross-sections of the sites were selected on CBCT scans. Two regions of interest (ROIs) corresponding to the implant bone site and peri-implant bone were also outlined, according to virtual planning. The CBCT scans were exported to MaZda software, where the two ROIs were delimited following the previously demarcated contours. Values for the co-occurrence matrix were calculated for TA. With regard to the insertion torque value, there was a direct correlation with the contrast of the peri-implant bone (P < 0.001) and an inverse correlation with the entropy of the implant bone site (P = 0.006). A greater contrast indicates a greater torque value for insertion of the implants, and there is a possible association with a lower entropy value of the implant–bone interface. Postgraduate Program in Dentistry Cruzeiro do Sul University (UNICSUL) Department of Diagnosis and Surgery São José dos Campos School of Dentistry São Paulo State University (UNESP) Department of Diagnosis and Surgery São José dos Campos School of Dentistry São Paulo State University (UNESP) FAPESP: 2017/09550-4 FAPESP: 2018/11997-0 FAPESP: 2019/10675-1