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290 results on '"Mao, Duo"'

7. Light-up probe based on AIEgens: dual signal turn-on for caspase cascade activation monitoring

Author

Yuan, Youyong, Zhang, Chong-Jing, Kwok, Ryan TK, Mao, Duo, Tang, Ben Zhong, and Liu, Bin

Subjects
Chemical Sciences, Generic health relevance, Chemical sciences
Abstract

Direct monitoring of multiple enzyme activities in a given biological process is extremely important for disease diagnosis. Herein, we report a single fluorescent probe that targets two caspase activities in living cells. The probe consists of three parts that includes two AIE fluorogens with distinctive green and red emission colors excitable at a single wavelength, and a hydrophilic peptide as the substrate of the apoptosis initiator caspase-8 and the effector caspase-3. The probe is non-fluorescent in aqueous media. The green and red fluorescence can be sequentially turned on when the peptide substrate is cleaved by the cascade activation of caspase-8 and caspase-3 in early apoptotic HeLa cells induced by hydrogen peroxide. This sequential fluorescence turn-on allows real-time monitoring of the caspase cascade activation during the apoptotic process, which was further explored for evaluating the therapeutic efficiency of anticancer drugs. The probe design strategy developed in this study also proved to be general, which opens a new avenue for real-time, multiplexed imaging of cellular enzyme activity in a biological process.

Published
2017

22. Recent Organic Photosensitizer Designs for Evoking Proinflammatory Regulated Cell Death in Antitumor Immunotherapy.

Author

Sun, Xuan, Li, Min, Wang, Peng, Bai, Qingqing, Cao, Xuchen, and Mao, Duo

Abstract

In the past decades, immunotherapy has achieved a series of clinical successes in the field of cancer. However, existing therapeutic options usually show a low immune response to solid tumors caused by immunosuppressive "cold" tumor microenvironment (TME). Several types of proinflammatory regulated cell death (RCD), mainly including ferroptosis and pyroptosis, have been studied recently, which can provide proinflammatory signals and immunogenicity necessary for remodeling TME and activating an antitumor immune response. A variety of chemotherapeutic drugs are proven to be effective in the proinflammatory RCD induction of tumor cells, but several adverse effects and intrinsic drug resistance usually occur in the therapeutic process, greatly hindering their further clinical application. The emerging organic photosensitizer (PS)‐based materials open new possibilities to effectively activate proinflammatory RCD through precise spatiotemporal regulation of intracellular reactive oxygen species‐associated signaling pathways, which can overcome many challenges encountered in current proinflammatory RCD‐mediated immunotherapy. In this review, the recent design strategies of PS probes are detailly summarized and their potential advantages for tumor‐specific proinflammatory RCD induction are discussed. Moreover, the representative examples in cancer immunotherapy are highlighted and future perspectives in this emerging field are proposed. [ABSTRACT FROM AUTHOR]

Published
2023
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25. sj-docx-1-npx-10.1177_1934578X221094107 - Supplemental material for Cembranoids From the Leaves of Nicotiana tabacum and Their Neuroprotective Activities

Author

Yang, Peng-fei, Chen, Mei-yu, Yu, Jian-chun, Yang, Jing, Wang, Qiong-bo, and Mao, Duo-bin

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-npx-10.1177_1934578X221094107 for Cembranoids From the Leaves of Nicotiana tabacum and Their Neuroprotective Activities by Peng-fei Yang, Mei-yu Chen, Jian-chun Yu, Jing Yang and Qiong-bo Wang, Duo-bin Mao in Natural Product Communications

Published
2022
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