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Soil heavy metal pollution caused by exploitation of nonferrous metal mine has become a severe environment problem. In this paper, the heavy metal elements such as Cu, Pb, Zn, As, Ni, Cr, Cd and Hg in the soil of different areas surrounding a smelter were analyzed. Kriging spatial interpolation method was used to analyze the spatial distribution characteristics of heavy metals in the study area. Nemerow index method was used to evaluate the pollution status. Multivariate statistical analysis was used to analyze the pollution sources of heavy metals. The results show that 80% of the soil sampling points in the study area were in the state of pollution, and the most serious pollution was in the west and south of the smelter affected by the wind direction. The heavy metal elements with serious pollution were Cu, Pb, CD, Zn and As. The pollution sources of heavy metal elements in soil were not only from smelters, but also from motor vehicle emissions, natural factors, coal combustion and pesticide use. [ABSTRACT FROM AUTHOR]

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used pharmaceuticals in animals. In the current study, the biotransformation of five NSAIDs by pig liver microsomes (PLMs) was studied. The pseudo-first-order kinetics mode was obtained for the metabolization of the studied NSAIDs by PLMs in vitro . The metabolites were identified by high performance liquid chromatography with a high-resolution LTQ-Orbitrap mass spectrometry. The hydroxylation of benzene was confirmed to be the dominating metabolic pathway. Finally, the toxicity of the metabolites was predicted by the Estimation Programs Interface Suite software based on quantitative structure-activity relationships. Decreased toxicity was expected for the most metabolites of the studied NSAIDs except flurbiprofen, whose main metabolite exhibited slightly more toxicity. The present study provided a preliminary foundation to understand the metabolites of some NSAIDs and their toxicity, which was of great significance in animal food safety. [ABSTRACT FROM AUTHOR]