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Green technological innovation has the dual benefit of promoting economic development and limiting environmental pollution and is critical to sustainable development in developing countries. This study assessed the green innovation effects of ecological civilization pilot policies by using the difference-indifferences approach, mediating effects model, and causal forest algorithm. The results showed that: (1) The ecological civilization pilot policy increased the level of green technology innovation in the pilot area by 27.9 %. (2) Urbanization partially mediated the impact process of ecological civilization pilot policies on green technology innovation, and the green innovation effect transmitted through urbanization was about 28%. (3) When energy structure and financial support were taken as the conditions, the green innovation effect of the ecological civilization pilot policy respectively showed an S-shaped curve and an inverted U-shaped curve. The above results can provide a new scientific basis for promoting green development in developing countries. [ABSTRACT FROM AUTHOR]

It has been reported previously that the expression of glucose transporter member 3 (GLUT3) is increased in malignant glioma cells compared with normal glial cells. However, the regulating mechanism that causes this phenomenon remains unknown. The present study investigated the regulating role of transcription factor specific protein 1 (Sp1) in GLUT3 expression in a human glioma cell line. In the present study, Sp1 was identified to directly bind to the GLUT3 5'-untranslated region in human glioma U251 cells. Small interfering RNA- and the Sp1-inhibitor mithramycin A-mediated Sp1 knockdown experiments revealed that Sp1 depletion decreased glucose uptake and inhibited cell growth and invasion of U251 cells by downregulating GLUT3 expression. Therefore Sp1 is an important positive regulator for the expression of GLUT3 in human glioma cells, and may explain the overexpression of GLUT3 in U251 cells. These results suggest that Sp1 may have a role in glioma treatment. [ABSTRACT FROM AUTHOR]