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The implementation of wind farms in the Istmo of Tehuantepec is a clear example of the use of the green economy as a strategy for capitalist accumulation, based on the use of the discourse of environmental mitigation to ensure the accumulation of large volumes of capital, for the benefit of national and transnational corporations. All this at the cost of the territorial rights of peasant societies, the dispossession of their resources and the destruction of their cultural landscape. Wind energy has become a symbol of the type of "sustainable" development sought by the new local, state and federal administrations. They promote social and environmental impact studies that consolidate wind projects as the option for the energy transition, where the only difficulty is the lack of adequate negotiation spaces regarding land rent. The wind potential in the Istmo of Tehuantepec is imperative, as it favors the development companies, limiting the benefits for local communities and increasing social rejection to the projects.

Resumen América Central ha experimentado importantes niveles de migración forzada desde las últimas décadas del siglo XX. Las restricciones a la migración implementadas por Estados Unidos han derivado gran parte de estos flujos a España. En este texto se ofrece un análisis estructural de los procesos migratorios ocurridos entre Honduras, El Salvador y España, a través de una perspectiva crítica interdisciplinar que combina el estudio de la migración forzada con el análisis del contexto histórico en las que ocurren estos movimientos de población, arrojando luz sobre la situación de los migrantes procedentes de estos dos países centroamericanos en España.

In this research, I will try to develop a study of the Philippines through a brief review of the bibliography and statistical data analysis. I aim to gather empirical evidence of the causes of extended poverty and unemployment in the country and the high levels of overseas Filipino workers. These social problems and the surge of authoritarianism in the figure of Rodrigo Duterte cannot be adequately explained without referring to the historical legacy of colonialism in the Philippines, the subordinated position of this country in the global division of labour and the structural changes fueled by hegemonic globalization since the last decades of 20th century. Based on scientific research and official data, this article will critically analyze the historical, social, and economic causes that lead to poverty and hardships affecting many Filipino citizens.

Es imprescindible que la Contabilidad Ambiental se genere con base en normas contables formales, emitidas por organismos especializados para ello, que sean completas y comprensibles. Esto se encamina también a que los profesionales de la Contaduría en las empresas sean más incisivos en la presentación de la información cuantitativa, pero también cualitativa, que abarque aspectos relacionados con el medio ambiente. Este artículo tuvo como objetivo mostrar la normatividad que da sustento a la Contabilidad Ambiental tanto a nivel internacional como en México. Se realizó una investigación de tipo documental, cuyos resultados se orientan a afirmar que sí existe una teoría contable de forma explícita e implícita, relacionada con la valuación, presentación y revelación de las operaciones efectuadas por las entidades económicas relacionadas con el deterioro y el resarcimiento del daño medioambiental. Como conclusión general, se infiere que existe un problema latente relacionado con el deterioro del medio ambiente; por tal motivo, es indispensable que, por una parte, los empresarios contribuyan a la solución del mismo mediante acertadas decisiones y, por otra, los contadores públicos establezcan criterios y técnicas contables que den cuenta de esta situación en los estados financieros, que muestren la realidad que viven las organizaciones y las medidas correctivas, en su caso, que se están implementando. Además, no existe una obligatoriedad manifiesta-directa para que los contadores en las organizaciones se apeguen de manera estricta a la normatividad, aunado a que se requieren procedimientos claros y suficientes a seguir para una aplicación pertinente.

A 52-year-old male patient with a background of adaptive personality disorder was admitted for mitral valve repair and cardiac ablation for atrial fibrillation. He suffered intraoperative complications with severe mitral insufficiency that suffered ischemia.. Post-operatively, he demonstrated acute loss of retrograde autobiographical memory, prosopagnosia and a loss of public semantic memory. His CT scan was normal and MRI was not possible due to intra-cardiac leads. An initial diagnosis of hypoxic-ischemic encephalopathy was considered. A neuropsychological examination undertaken 20 days after his surgery showed a severe alteration of retrograde autobiographical memory, marked alteration of semantic knowledge and prosopagnosia. He demonstrated an average performance in tasks measuring constructional praxis, visuospatial ability, and executive functions. 34 days after surgery, and after a short nap, the patient "returns" to the day before admission and consequently recovers his memory. Repeat neuropsychological assessment demonstrated performance within the normal range across all previously tested domains. This sudden recovery of memory, together with a normal MRI, led to a rethinking of the diagnosis of dissociative amnesia. This case illustrates the long-standing discussion about the organic or functional origin of some memory disorders, in which, despite advances in neuroimaging techniques, it is still difficult to know their etiology .

In the early 1980s, the first global environmental crisis occurred with an emphasis on the role of plastics in big cities’ massive solid waste streams [...]

El desarrollo de la ocupación en nuestro país en los últimos años, ha sido promovido por una orientación importante en el constante avance tecnológico. El crecimiento en las instituciones de enseñanza superior debe considerar las innovaciones del mercado laboral. Los universitarios graduados ​​se enfrentan a un fenómeno que ya comenzó y se intensificará en el futuro, excesivos requisitos de habilidades y competencias para crear organizaciones productivas con la finalidad de emprender y propagar vacantes. El objetivo del presente estudio fué determinar las características que buscan los empresarios en el perfil de alumnos universitarios del posgrado de la Maestría en Administración, de la Unidad Académica de Contaduría y Administración (UACyA) de la Universidad Autónoma de Zacatecas (UAZ). Las unidades de análisis estuvieron conformadas por empresarios de alumnos egresados de la maestría, de un total de 65, se recuperaron 30, a quienes se les envió un formulario en Google. Entre los resultados obtenidos, luego de realizar los estudios estadísticos descriptivos, sobresalen las características como la capacidad de poder trabajar en equipo, otra característica que resalta además de la ya mencionada, es el uso de tecnologías para acceder a información, si se desea un programa de maestría pertinente se deben forman posgraduados competentes, capacitados, en el que las instituciones de educación y las organizaciones internacionales, fungan como agentes externos para implementar políticas relacionadas a brindar un servicio de calidad.

To determine the value of low-risk human papillomavirus (HPV) PCR to screen for “high-grade anal squamous intraepithelial lesion and anal cancer” (HSIL-plus), rate of patients with low-grade anal squamous intraepithelial lesion (LSIL) progressing to HSIL-plus, and progression-related factors. Prospective, longitudinal study of consecutive MSM-LHIV attended between May 2010 and December 2021 and followed for 43 months (IQR: 12–76). HIV-related variables were gathered at baseline, performing anal cytology for HPV detection/genotyping, thin-layer cytological study, and high-resolution anoscopy (HRA). Follow-up was annual when HRA was normal or LSIL, and post-treatment in cases of HSIL-plus, re-evaluating sexual behavior, viral-immunological status, and HPV infection of anal mucosa. The 493 participants had mean age of 36 years: CD4 nadir < 200 cells/uL in 23.1%, virological failure in 4.1%, and tetravalent HPV vaccine > 5 years earlier in 15%. HSIL-plus was ruled out in patients with monoinfection by low-risk HPV genotype and normal cytology (100% sensitivity, 91.9% specificity, PPV 2.9%, and NPV 100%). Progression from LISL to HSIL-plus occurred in 4.27% of patients within 12 months (IQR: 12–12): risk factors were acquisition of high-risk (HR: 4.15; 95% CI: 1.14–15.03) and low-risk (HR: 3.68 95% CI: 1.04–12.94) HPV genotypes, specifically genotype 6 (HR: 4.47, 95% CI: 1.34–14.91), and history of AIDS (HR: 5.81 95% CI: 1.78–18.92). Monoinfection by LR-HPV genotypes in patients with normal cytology is not associated with anal cancer or precursor lesions. Progression from LSIL to HSIL-plus, observed in

On 21st century, capitalist development process is going through important economic, political, social and cultural transformation. On this paper I try to contribute with a brief synthesis of some relevant factors related with these political transformations, analyzing the new political battlefield between a nationalism faced against globalization and 21st century progressivism, reflecting on the role of traditional left and socialist movements on the public space of politics opened by the new conditions of contemporary globalization and the harmful consequences of the neoliberal policy spread throughout the world since the last years of 20st century. En el siglo XXI, el proceso de desarrollo capitalista está atravesando por importantes transformaciones económicas, políticas, sociales y culturales. En el presente artículo se realiza una breve síntesis de algunos factores relevantes relacionados con estas transformaciones políticas, analizando el nuevo campo de batalla político entre el nacionalismo enfrentado a la globalización y la corriente política progresista surgida en el siglo XXI, reflexionando sobre el papel que juegan los tradicionales movimientos socialistas y de izquierda en el espacio público de la política abierto por las nuevas condiciones de la globalización contemporánea y las severas consecuencias de la política neoliberal extendida por todo el mundo desde finales del siglo XX.

Objetivo. Identificar y describir los principales temas de investigación, desarrollo e innovación, agentes y artículos más relevantes en los ámbitos de la economía plateada y emprendimiento. Diseño/Metodología/Alcance. Se aplicó una combinación de técnicas, herramientas y metodologías bibliométricas para el análisis de rendimiento, impacto y mapeo científico de las publicaciones y autores, utilizando el software VOSviewer. En primera instancia el análisis de rendimiento e impacto permitió entender la parte cualitativa del área de conocimiento. En ese sentido se identificaron los principales autores, organizaciones, países, fuentes de información y áreas de conocimiento. Este análisis cualitativo, se ha cubierto a través de tres mapas de la ciencia, siendo el primero de este el que describió las principales temáticas, seguido por la evolución y cerrando con la relación existente entre los autores de dichas publicaciones. Finalmente, se analizaron en conjunto los resultados y se estableció un marco de referencia. Resultados/Discusión. La conjunción entre la economía plateada y el emprendimiento está dando lugar a un área de conocimiento nueva, en la cual, se busca fomentar el desarrollo de la sociedad en su conjunto, atendiendo, por un lado, a la economía vinculada a la población adulta y por otro lado al emprendimiento de dicha franja de edad, así como a todos aquellos agentes que promueven el emprendimiento de manera integral. Aunque esta nueva área de conocimiento se encuentra en una etapa temprana, ya es posible identificar cuatro grupos de desarrollo principales: Emprendimiento plateado; Estrategias de emprendimiento; Nuevos modelos de negocio; y Envejecimiento de la población, mismos que refuerzan lo anteriormente expuesto y marcan una visión vertical, pero complementaria, a otras áreas de conocimiento. Conclusiones. La creciente población de adultos mayores en el mundo y la tendencia en esa misma dirección de los cambios económicos, sociales, los sistemas de pensiones y otros no menos importantes como la salud, así como la imperante necesidad de diseñar políticas públicas que permitan el adecuado desarrollo de las personas mayores, han generado interés en investigadores que proponen y estudian aspectos que permitan conocer el fenómeno en el cual estamos inmersos. En esta línea, el emprendimiento desde la perspectiva de la población adulta o emprendimiento plateado se presenta como una oportunidad para dar respuesta a dichos retos, desde ópticas como la investigación, el desarrollo e innovación. Originalidad/Valor. Se establece un marco de referencia entre la economía plateada y el emprendimiento con el fin de identificar las principales líneas de investigación, desarrollo e innovación, así como las oportunidades y retos a los que se enfrentan las comunidades académica, científica, tecnológica, social, empresarial y política.

Este trabajo analiza los cambios operados en España e Italia en las primeras décadas del siglo XXI. Mediante un estudio transdisciplinar en ciencias sociales y el análisis de información recopilada en informes y bases de datos oficiales, se pretende reunir evidencia empírica de las transformaciones políticas operadas en los mercados de trabajo de ambos países a consecuencia de la difusión de la ideología neoliberal y la aplicación de políticas de ajuste estructural. El trabajo abarca tanto la implementación de políticas neoliberales desde finales de la década de 1980 como sus consecuencias sociales, intensificadas a partir de la segunda mitad de la década de 2010. Una de las principales conclusiones obtenidas en este estudio radica en que estas políticas monetaristas, aplicadas por los gobiernos nacionales bajo la batuta de instituciones como el Fondo Monetario Internacional, han conducido a un país como España a una grave situación donde la falta de empleos adecuados y las limitaciones políticas estructurales de acceso al empleo restringen gravemente las expectativas vitales para la mayoría de la población trabajadora, obligando a amplios sectores sociales a migrar a otros países. El artículo aborda las contradicciones entre las políticas neoliberales y las estructuras precapitalistas existentes en Italia y España, con el fin de plantear interrogantes que contribuyan a buscar alternativas políticas en favor de una mayor democratización social y económica.//This paper analyzes the changes operated in Italy and Spain on the first decades of the 21st century. Through a transdisciplinary study on social sciences and the analysis of statistical information compiled in reports and official databases, this article has the aim of gather empirical evidence of the political transformations occurred in both countries as a result of the spread of neoliberal ideology and the implementing of structural adjustment programs. This research comprehends the implementing of neoliberal policies from the decade of the 1980s as well as its social consequences, intensified since the second half of 2010s decade. One of the main conclusions found in this study lies in that the different policies conducted by national governments, under the aegis of Structural Adjustment Programs decreed by institutions such as the International Monetary Fund, drove an economy like Spain to a severe situation where the lack of adequate employment and the structural political constraints prevent a great part of workers from accessing to employment in fair conditions and critically restrict their life expectations, forcing ample sectors of the population to migrate abroad. The article tackles the contradictions between neoliberal policies and precapitalist structures existing in Italy and Spain, with the aim to outline questions that contribute to finding political alternatives in favor of greater social and economic democratization.

Very little scientific research has been done on the Low Imperial period in the Gallaecia province. Our aim is widening our knowledge about this historical time. We will focos on: A revision of classical literary sources. A study of the Economy: monetary treasuries, roadways, ceramic... A study of Society: roman and native onomastics.

During the roman period the cult of luppiter, the most important divinity of the roman pantheon, was very significative in the Conventus Bracaraugustanus, in the Northwest of Spain.In this article, we are going to analyse the repercusion of its cult by people who lived in this part of Hispania.

In this article, it's analized the phenomenon of slavery in the North-west of Hispania during the roman period according to the inscriptions of this moment.

In this article, it's analized a votive roman inscription from Villasumil (León, Spain), that perhaps it's consecrated to the indigeous god Cossus.

The figure of the spiritual guiding is very important in the roman world. In this we article going to analize its presence in the epigraphic monuments of the Hispanic-roman Northwest.

In this article we are going to analyse, through existing votive monuments and scultural remains, religion and religiosity of the population who was establiseh in the Conventus Lucensis.

In this article, we are going to analize the socioeconomic differences that exist inside each conventual capital of the Hispanic-roman Northwest (Asturica Augusta, Bracara Augusta y Lucus Augusti) taking as specimen the funerary monuments remaining from the Roman period as they reflect both the religious belief and the social position of the deceased and of the person who dedicates the epitaph.

The image of the Galizian warrior not only constitutes the most important expression of the hispanic art of the forts in the north-west, but it is also used as an epigraphic support during the Roman period. The present paper will deal with this subject, basing our opinions on the five monuments with Latin text in the peninsular north-west.

During the Roman period women were a very important element for the process of romanization.In this article I would like to offer a global vision of women, both, the roman and the indigenous ones, in the Conventus Asturum, and therefore it has been revised the epigraphy where appears women's names such as funerary, votiv, honorific and monumental inscriptions, from this part of Roman Empire.

Objective. The knowledge structure was analyzed, during the period 1991-2021, on the factors that influenced organizational resilience to distinguish possible synergies, interactions, and new research lines. Design/Methodology/Approach. Using a performance analysis and scientific mapping approach, a bibliometric methodology was used to discover and represent conceptual subdomains and thematic development. This methodology consisted of four phases: (1) detection of research topics, (2) visualization of research topics and the thematic network, (3) discovery of thematic areas, and (4) performance analysis. Results/Discussion. Of the 869 publications on organizational resilience indexed in Scopus, the ones that had the most significant impact on the development of the topic were: Resilience; the concept, a literature review and future directions (2011), Developing a capacity for organizational resilience through strategic human resource management (2011), Developing a tool to measure and compare organizations' resilience (2013), Organizational resilience: Development of a conceptual framework for organizational responses (2011), and Facilitated process for improving organizational resilience (2008). The most important authors were Bhamra, R.; Burnard, K.; Seville, E.; Vargo, J. and Beck, T.E. The driving issues that over time have been closely related to the resilience of organizations were: risk management, standardization and regulation, psychological resilience, ICT resilience, protection and security, health personnel, and reliable organization. Conclusions. In recent years, when the subject has been more developed, it became clear that it is essential to observe risk management, health personnel, reliable organization, and decision-making to manage organizational resilience. Regarding possible future lines of research, the following was found: resilience of security networks, cybersecurity, cyber resilience, disaster management, organizational innovation, sustainable development, and sustainability management.

In the present work, a statistical study of the morphology and thermal behavior of poly(lactic acid) (PLA)/oligomer(lactic acid) (OLA)/magnesium oxide nanoparticles (MgO), electrospun fibers (efibers) has been carried out. The addition of both, OLA and MgO, is expected to modify the final properties of the electrospun PLA-based nanocomposites for their potential use in biomedical applications. Looking for the compositional optimization of these materials, a Box–Wilson design of experiment was used, taking as dependent variables the average fiber diameter as the representative of the fiber morphologies, as well as the glass transition temperature (Tg) and the degree of crystallinity (Xc) as their thermal response. The results show values of 73.76% (diameter), 88.59% (Tg) and 75.61% (Xc) for each polynomial fit, indicating a good correlation between both OLA and MgO, along with the morphological as well as the thermal behavior of the PLA-based efibers in the experimental space scanned., Part of this work was financed with the support of the Spanish Ministry of Science and Innovation through MAT2017-88123-P

Advances in our understanding of the Alzheimer's disease (AD) continuum through in vivo biomarkers have highlighted the need to develop neuropsychological tests that are more sensitive to subtle cognitive changes in the preclinical stages of the disease. Recent data suggest that the assessment of memory retention over extended delays, to detect so-called accelerated long-term forgetting (ALF), may be a reliable way to discriminate between presymptomatic AD and healthy aging. This review aims to present the scientific evidence published to date on this particular aspect of memory.A comprehensive review of all published articles on ALF in AD to the present day.We present findings relating to ALF in neurological disease, discuss theoretical aspects related to the integration of the concept of ALF in the framework of memory models, explain mechanisms that may be involved in its genesis and present supportive work from research in animal models. We focus particularly on aspects relevant to the assessment of ALF in clinical practice.Despite many advances, further research will be needed to define more precisely what ALF is, what neural structures and mechanisms are involved in its occurrence, whether there are distinct patterns of forgetting according to etiology, and when and how to detect ALF most reliably. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Background: Major surgery has been associated with perioperative neurocognitive disorders (PND), but the contributing factors and long-term prognosis are uncertain. We hypothesize that preclinical Alzheimer’s disease (AD) might predispose to cognitive deterioration after surgery. Objective: To analyze the effect of amyloid-β on the cognitive trajectory after orthopedic surgery in a sample of non-demented subjects. Methods: Non-demented individuals older than 65 years that were on the waiting list for orthopedic surgery with spinal anesthesia underwent a neuropsychological assessment before and after surgery. During surgery, cerebrospinal fluid samples were obtained to determine AD biomarkers. Results: Cumulative incidence of PND was 55.2%during a mean follow-up of nine months. The most affected cognitive domains were executive function and constructional praxis. The presence of abnormal levels of amyloid-β was associated to a postoperative impairment in verbal and visual memory tests. According to their AD biomarker profile, participants were categorized as either Amyloid Positive (A+) or Amyloid Negative (A-). The incidence of PND did not differ between both groups. The A- group showed a tendency similar to the global sample, worsening in executive function tests and improving on memory scales due to practice effects. In contrast, the A + group showed a notable worsening on memory performance. Conclusion: Our findings support the hypothesis that surgery may promote or accelerate memory decline in cognitively asymptomatic subjects with brain amyloid-β deposits.

La educación es un requerimiento clave para el siglo XXI. Dadas las exigencias del mundo contemporáneo, la concepción de valores se encuentra dirigida al desarrollo de la personalidad del estudiante universitario, proceso complejo y contradictorio en el que intervienen diversos factores. Así pues, el objetivo de la presente investigación consistió en identificar valores en la educación universitaria que reconocieran la equidad de género en parejas de doble ingreso que laboraron en un departamento gubernamental del estado de Zacatecas en el año 2019. La investigación se desarrolló en un entorno cuantitativo de tipo transaccional. El nivel de investigación es relacional: se encontraron relaciones y discrepancias entre las variables de formación de valores y equidad de género. En los resultados alcanzados, se encontró, mediante la prueba de ji al cuadrado, relación entre el género y las actividades del hogar. Sin embargo, un índice sumativo simple de 91.07 % y 1.79 % consideró lo contrario. Por tanto, se concluyó que, en las parejas de doble ingreso que laboraron en este departamento gubernamental, existieron valores como la libertad, la igualdad, el respeto, la comunicación y la negociación, la equidad de género, los cuales subyacen a los derechos humanos fundamentales como forma de resolución de conflictos.

Frontotemporal dementia (FTD) is a heterogeneous syndrome characterized by the progressive damage of frontal and temporal brain regions. These networks largely overlap with those involved in pain and temperature processing. Although the impaired perception of pain and temperature has been previously described to be relatively common in patients with FTD, these symptoms are often not consistently assessed by Neurologists. We present the case of a patient with a probable behavioral variant FTD who died due to scalding with hot water in the shower. Impairments in the perception of pain and temperature might have played a fundamental role in this accident.

Objective The structure of the semantic network is constructed and organized during childhood development. Previous publications have hypothesized that neurodegenerative diseases would lead to a disruption of this network reversing the steps acquired in childhood. Semantic Dementia (SD) is a subtype of frontotemporal lobe degeneration in which the main symptom is a specific loss of semantic memory. We aimed to describe the sequential acquisition of concepts in 3-8 years old children evaluated through the production of drawings and, in parallel, their progressive loss in SD patients. Methods 104 children between 40 and 96 months categorized into tertiles according to their age, 21 SD patients categorized into tertiles according to their score on a category fluency task and 34 healthy volunteers were asked to draw 12 items with, a priori, different age of acquisition and familiarity, belonging to four different semantic categories. We employed the drawings of the healthy volunteers to build a scoring scheme. We considered that a concept was acquired in children when 50% or more of its features were present in their drawings, and it was lost in patients when more than 50% were missing. Results Those concepts which the children were able to acquire earlier, according to our scoring scheme, tended to remain in patients with more advanced SD. While the items that children acquired later, were, in general, those that the SD patients lost at earlier disease stages. Conclusion The patterns of concept acquisition in children were the mirror image of the loss in patients with SD. Our study supports the hypothesis that the sequence of concept acquisition in childhood is reversed in SD patients.

Time series of European sardine (Sardina pilchardus) landings from 1962 and environmental variables from 1978 in the northern Alboran Sea are analysed. European sardine spawns in the northern Alboran Sea from mid-autumn to late winter at a temperature range slightly higher than the one observed in the nearby Eastern North Atlantic and the North Western Mediterranean. Individuals hatched during autumn and winter are incorporated to the fishery during the following summer and autumn producing the maximum annual landings. These landings show both a decreasing long-term trend and a strong inter-annual variability. Although further research is needed, the warming trend of sea surface temperature and the decrease in upwelling intensity inferred from empirical orthogonal function (EOF) analyses could have some influence on the negative trends of sardine landings. The inter-annual variability of sardine abundance seems to be related to the wind intensity at a local scale, the second principal component of the chlorophyll concentration and the sardine abundance during the preceding year. If the inter-annual variability is considered, a linear model including these three variables with a one-year time lag allows to explain 79% of the sardine landings variance. If the negative linear trend is also considered, the model explains 86% of the variance. These results indicate that the body condition of spawners, linked to the food availability during the preceding year, is the main factor controlling the recruitment success. The possibility of predicting sardine landings 1 year in advance could have important implications for fishery management., Sí

A steel-type ASTM A234 WPB elbow pipe from a gas well, through which water pressurized at 4 kg/cm2 and at 10–30 °C temperature was circulated, was perforated, originating a water leakage. Several tests were carried out in order to determine the cause of the perforation: Visual and radiographic inspection, chemical analysis, hardness test and microstructure, microscopy and fractographic studies. The presence of CO2 in the water might be very important for the corrosion phenomenon in the welding area as a result of the presence of a galvanic couple between the weld bead and the pipeline steel. However, the CO2 was not the only cause of the pipe damage. The fractographic study of the perforations and the flow analysis indicated that cavities have been originated as a consequence of a cavitation–corrosion phenomenon which is a particular erosion process caused by the implosion of gas bubbles on the metal surface.

This work has a two-fold objective. First, it attempts to present the excellent efficiency of a maleated interfacial agent (obtained by the authors by using atactic polypropylene industrial waste) when used as interfacial additive in polypropylene/short carbon fiber composites (iPP/SCF). Second, in this paper, we pay attention to the role played by processing in the final properties of the composite. This work has been performed by considering the emerging crystalline morphologies generated by the different shear forces that the molten material suffers depending on the molding method employed. The interfacial agent analyzed here consists of an atactic polypropylene containing succinic anhydride grafts obtained through a chemical modification process performed in solution. It incorporates different types of succinic grafts, such as succinic bridges between aPP chains and backbone and terminal grafts (aPP-SASA) in its structure, and contains 5.6% (5.6 × 10−4 g/mol) of grafted polar groups in total. The adhesion of the polyamide SCF sizing and the succinic units is followed by Field Emission Scanning Electronic Microscopy (FESEM) and Synchrotron Infrared Microscopy (SIRM). However, the main objective of this work is the study of the thermal and the dynamic mechanical behavior of the materials of a series of both compression- and injection-molded samples to ascertain the enhanced interfacial interactions in the material and further comparison between the results obtained by both processing operations. Therefore, we detect improvements of 200% in stiffness and 400% in the viscous response of the same SCF content composites caused by aPP-SASA, depending on the processing method used.

Background/aim: In the Santander Bay (Cantabria, northern Spain), a ferromanganese alloy plant is located. Our objective was to characterize the Mn personal exposure of adult healthy volunteers living in this highly Mn exposed region, and to determine its association with a poorer cognitive function. Methods: Cross-sectional study analyzing 130 consecutive participants. Cognitive function was assessed by Stroop Color Word, Verbal Fluency tests, Trail Making Test (TMT), Digit Span (WAIS III) and Rey Osterrieth Complex Figure (ROCF) tests and crude scores were standardized according to NEURONORMA norms. Exposure to Mn was assessed in terms of source distance, by Personal Environmental Monitors (PEMs) allowing the separation of fine (PM2.5) and coarse (PM10-2.5) particles (obtaining the bioaccessible fraction by in-vitro bioaccessibility tests), and by biomarkers (blood, hair and fingernails). Age, sex, study level and number of years of residence were predefined as confounding variables and adjusted Mean Differences (MDs) were obtained. Results: Statistically significant lower scores (negative MDs) in all test were observed when living near the industrial emission source, after adjusting for the predefined variables. Regarding PEMs results, statistically significant lower scores in all Stroop parts were obtained in participants with higher levels of Total Mn in All fractions (PM10). For Verbal Fluency tests, negative MDs were obtained for both bioaccessible fractions. Digit Span Backward scores were lower for those with higher levels in the bioaccessible coarse fraction, and negative MDs were also observed for the ROCF Delayed part and the non-bioaccessible fine fraction. As regards to Mn in fingernails, adjusted MDs of -1.60; 95%CI (-2.57 to -0.64) and -1.45; 95%CI (-2.29 to -0.61) for Digit Span Forward and Backward parts were observed. Conclusions: Our results support an association between poorer cognitive function and environmental airborne Mn exposure. This work was supported by the Spanish Ministry of Science, Innovation and Universities through the CTM2017-82636-R Project. This funding source was not involved in the study design; data collection, analysis, or interpretation; the writing of the article; or the decision to submit for publication.

© 2022 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Purpose: Although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy in the DS pediatric population. We aimed to evaluate safety and tolerability of a dietary supplement containing EGCG and if EGCG improves cognitive and functional performance. Methods: A total of 73 children with DS (aged 6-12 years) were randomized. Participants received 0.5% EGCG (10 mg/kg daily dose) or placebo for 6 months with 3 months follow up after treatment discontinuation. Results: In total, 72 children were treated and 66 completed the study. A total of 38 participants were included in theEGCGgroup and 35 in the placebo group. Of 72 treated participants, 62 (86%) had 229 treatment-emergent adverse events (AEs). Of 37 participants in the EGCG group, 13 (35%) had 18 drug-related treatment-emergent AEs and 12 of 35 (34%) from the placebo group had 22 events. In the EGCG group, neither severe AEs nor increase in the incidence of AEs related to safety biomarkers were observed. Cognition and functionality were not improved compared with placebo. Secondary efficacy outcomes in girls point to a need for future work. Conclusion: The use of EGCG is safe and well-tolerated in children with DS, but efficacy results do not support its use in this population. Peer Reviewed Article signat per 26 autors/es: Cécile Cieuta-Walti, Aida Cuenca-Royo, Klaus Langohr, Claire Rakic, Ma Ángeles López-Vílchez, Julián Lirio, Domingo González-Lamuño Leguina, Teresa Bermejo González, Jordi García García, Maria Rimblas Roure, Ana Aldea-Perona, Laura Forcano, Maria Gomis-Gonzalez, Sebastià Videla Cés, Florence Lacaille, Aimé Ravel, Clotilde Mircher, Hervé Walti, Nathalie Janel, Julien Dairou, Marilyne Lévy, Sophie Durand, Mara Dierssen, Silvia Sacco, Rafael de la Torre Fornell, PERSEUS Study Group

There is increasing evidence of the relationship between sleep and neurodegeneration, but this knowledge is not incorporated into clinical practice yet. We aimed to test whether a basic sleep parameter, as total sleep estimated by actigraphy for 1 week, was a valid predictor of CSF Alzheimer’s Disease core biomarkers (amyloid-β-42 and –40, phosphorylated-tau-181, and total-tau) in elderly individuals, considering possible confounders and effect modifiers, particularly the APOE ε4 allele. One hundred and twenty-seven cognitively unimpaired volunteers enrolled in the Valdecilla Study for Memory and Brain Aging participated in this study. Seventy percent of the participants were women with a mean age of 65.5 years. After adjustment for covariates, reduced sleep time significantly predicted higher t-tau and p-tau. This association was mainly due to the APOE ε4 carriers. Our findings suggest that total sleep time, estimated by an actigraphy watch, is an early biomarker of tau pathology and that APOE modulates this relationship. The main limitation of this study is the limited validation of the actigraphy technology used. Sleep monitoring with wearables may be a useful and inexpensive screening test to detect early neurodegenerative changes. This work was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitario, PI08/0139, PI12/02288, PI16/01652, and PI20/01011), the JPND (DEMTEST PI11/03028), the CIBERNED, and the Siemens Healthineers

Constant d’Hermenches, Benjamin Constant, Charles-Emmanuel de Charrière, Camille et Pierre Malarmey ont tous un point en commun, une femme: Isabelle de Charrière. Ces hommes, entre autres, parsemèrent le chemin de Belle et jouèrent un rôle important dans sa vie monotone. Par les documents reccueillis dans cet article, il nous sera possible de savoir si ce rôle se limita à une innocente amitié ou alors, traversa les frontières de la décence faisant de Belle une infidèle. Constant d’Hermenches, Benjamin Constant, Charles-Emmanuel de Charrière, Camille y Pierre Malarmey tienen todos un punto en común, una mujer: Isabelle de Charrière. Estos hombres, entre otros, se cruzaron en el camino de Belle y jugaron un papel importante en su monótona vida. Los documentos recopilados en este artículo nos permitirán averiguar si dicho papel solo fue una inocente amistad o traspasó las fronteras del decoro haciendo de Belle una infiel.