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Business innovation is fundamental for sustained economic growth at the regional level. Knowing the common characteristics of innovative companies and their location is essential to carry out appropriate economic policies. To this end, we have carried out a double analysis: one grouping of companies according to characteristics and another by geolocation. This study focused on one of Spain’s 17 autonomous communities, the Comunitat Valenciana, a region characterised by significant industrial diversity. Our results show, among other things, that size is not a differentiating factor when it comes to innovation, and that there is a positive relationship between physical clustering and productivity.

This article addresses the challenges and importance of integrating discussions on race and social justice into the classroom. Considering recent legislative actions in various states aimed at restricting such discussions, the article presents an empowering framework designed to support educators in facilitating these conversations. This framework, rooted in culturally responsive pedagogy, offers practical tools and guiding questions to help teachers create an environment that encourages inquiry and exploration of racial complexities without imposing personal viewpoints. The framework aims to move beyond simply identifying disparities to examining systems of oppression and encouraging students to take action. Feedback from teachers who implemented this framework shows significant improvements in their comfort and proficiency in discussing racial issues with students, instilling a sense of confidence and capability. The article also highlights the importance of self-reflection and continuous learning for teachers to lead these conversations effectively. It underscores the need for educators to develop strategies that allow students to engage critically with racial topics and employ counter-narratives to challenge discriminatory rhetoric. In conclusion, the article calls for a concerted effort in teacher education to counteract the resistance to racial equity discussions.

BackgroundScientific literature on posttraumatic growth (PTG) after terrorist attacks has primarily focused on persons who had not been directly exposed to terrorist attacks or persons who had been directly exposed to them, but who were assessed few months or years after the attacks.MethodsWe examined long-term PTG in 210 adults directly exposed to terrorist attacks in Spain a mean of 29.6 years after the attacks (range: 2–47 years). The participants had been injured by a terrorist attack (38.6%) or were first-degree relatives of people who had been killed or injured by a terrorist attack (41.4% and 20%, respectively). They completed diagnostic measures of emotional disorders and measures of PTSD and depression symptomatology, optimism, and PTG.ResultsMultiple regression analyses revealed gender differences (women reported higher levels of PTG than did men) and a positive linear relationship between PTG and cumulative trauma after the terrorist attack. Some PTG dimensions were significantly associated with PTSD symptomatology, these associations being linear, not curvilinear. However, PTG was not associated with depression symptomatology, diagnosis of emotional disorders, age, elapsed time since the attack, or optimism. In comparison with survivors assessed 18 years after the 1995 Oklahoma City bombing, Spanish victims of terrorism showed higher levels of appreciation of life, but lower levels of relating to others and spiritual change.ConclusionThe findings underscore the influence of gender on PTG and provide support to the hypothesis that some emotional distress may be a necessary condition of PTG. Future studies on PTG after terrorist attacks should take into consideration the characteristics of the terrorist attack itself and the contexts of violence and threat in which it occurred. The political, social, and cultural characteristics of the community affected by it and the profile and characteristics of other traumatic events suffered after the attack should also be taken into account in further research.

In a number of situations public sector information analysis uses to be performed empirically without any concrete procedure which should be based on the use of some models or even the use of collected data analysis tools. At the same time, the issue of data turning into conclusive information for a public institution does not benefit from an efficient development framework. On the contrary, the idea of systemized data analysis lacks completely in the case of most public institutions. This paper is intended as a case study of data analysis by means of an Online Analytical Processing (OLAP) system with real data from the Area Labour Inspectorate of Alba County (Romania) to prove both the efficiency and the need to create such a system. The aim is to prove the beneficial role of OLAP technology implementation in public institutions, at any level which may involve a managerial act.

We present the validation of a questionnaire for compulsory secondary school students (seventh to tenth grade), designated "Educational learning environments for ESO pupils" (CEApA_ESO), for the purpose of evaluating learning environments. Although many instruments have been developed in this area, our work attempts to comprehensively cover some factors that most influence learning environments from the students' perspective. Therefore, we included physical, learning, teaching and motivational elements, by adapting different already-validated scales to our intended overall approach and the Spanish context. We conducted a pilot study with 207 students from four grades (two classes per educational level). We performed descriptive and factor analyses with maximum likelihood extraction method and varimax rotation to identify factors underlying each scale. The factors extracted from each scale were used to evaluate the fit of the model, using the AMOS v.18 software for structural equation analysis, taking as reference the criteria set by Byrne (Structural equation modeling with AMOS: Basic concepts, applications, and programming, Taylor & Francis Group, 2010) and Kline (Principles and practice of structural equation modeling, The Guilford Press, 2010) (CMIN/DF between 2 and 5, CFI and IFI > 0.9, RMSEA < 0.06 and HOELTER > 200). Finally, we present the factorial validity of the complete scale and analyse the internal consistency of the scale and its subscales using Cronbach's alpha coefficient. This instrument, with adequate psychometric properties, offers educators and researchers a valid tool for assessing the learning environments of their schools.

Background and objectives: This study aimed to determine the frailty, prognosis, complexity, and palliative care complexity of nursing home residents with palliative care needs and define the characteristics of the cases eligible for receiving advanced palliative care according to the resources available at each nursing home. Materials and Methods: In this multi-centre, descriptive, and cross-sectional study, trained nurses from eight nursing homes in southern Spain selected 149 residents with palliative care needs. The following instruments were used: the Frail-VIG index, the case complexity index (CCI), the Diagnostic Instrument of Complexity in Palliative Care (IDC-Pal), the palliative prognosis index, the Barthel index (dependency), Pfeiffer’s test (cognitive impairment), and the Charlson comorbidity index. A consensus was reached on the complexity criteria of the Diagnostic Instrument of Complexity in Palliative Care that could be addressed in the nursing home (no priority) and those that required a one-off (priority 2) or full (priority 1) intervention of advanced palliative care resources. Non-parametric tests were used to compare non-priority patients and patients with some kind of priority. Results: A high percentage of residents presented frailty (80.6%), clinical complexity (80.5%), and palliative care complexity (65.8%). A lower percentage of residents had a poor prognosis (10.1%) and an extremely poor prognosis (2%). Twelve priority 1 and 14 priority 2 elements were identified as not matching the palliative care complexity elements that had been previously identified. Of the studied cases, 20.1% had priority 1 status and 38.3% had priority 2 status. Residents with some kind of priority had greater levels of dependency (p < 0.001), cognitive impairment (p < 0.001), and poorer prognoses (p < 0.001). Priority 1 patients exhibited higher rates of refractory delirium (p = 0.003), skin ulcers (p = 0.041), and dyspnoea (p = 0.020). Conclusions: The results indicate that there are high levels of frailty, clinical complexity, and palliative care complexity in nursing homes. The resources available at each nursing home must be considered to determine when advanced palliative care resources are required.

In the academic world, the skills of scientific writing and publishing allow for the sharing and dissemination of academic research. The research analysed the scientific publications of university teachers from the Faculty of Humanities and Social Sciences of the Technical University of Manabí (FCHS-UTM), Ecuador, in order to determine their skills and preferences in terms of scientific journals, writing language, type of publication, indexing, and editorial quality. A descriptive quantitative approach study was applied. A survey study was carried out. The sample selection was non-probabilistic and participatory. The sample consisted of 55 teachers from the faculty. A 25-item questionnaire was developed for data collection. The results were analysed using descriptive statistics. Among the results the faculty has a preference for national or local scientific journals. The language most used in studies is Spanish. University researchers are more professional in their use of American Psychological Association (APA) norms. The study presented implications such as the promotion of scientific publication and professional development, preservation of language and culture, professionalism in citation standards, promotion of collaboration, improvement of editorial quality and training strategies.

Abstract The SARS-CoV-2 coronavirus infects cells through the cellular receptor angiotensin-converting enzyme 2 (ACE2), and the protease TMPRSS2 for the priming of viral spike protein. Thus, changes in these key proteins due to chronic conditions can increase risk for SARS-CoV2 infection; but significance of changes may differ is these changes correspond to full-length species or proteolytic fragments. Here, we determined that full-length ACE2 decreased in the plasma of uninfected Crohn’s disease (CD) patients before treatment onset compared to controls. TMPRSS2 is mostly presented in plasma as full-length species and as an active peptidase fragment, but also as a prodomain fragment, which is the unique species remarkably decreased in plasma from CD patients. Patients treated with the anti-TNFα adalimumab showed recovery in ACE2 levels, while those treated with infliximab, or with the anti-IL-12/23 ustekinumab, still displayed a decrease in full-length species, as well as in cleaved fragments. Patients treated with azathioprine displayed similar ACE2 levels to that of controls, except a decrease in one of the ACE2 fragments. Uniquely, patients treated with azathioprine or with ustekinumab showed partial recovery in the reduction of the TMPRSS2-prodomain fragment characterized in treatment-naïve patients. Our data suggest that CD and common therapies are not related to increased susceptibility for SARS-CoV-2.

Abstract Background Longitudinal cohort studies are pivotal to understand how socioeconomic, environmental, biological, and lifestyle factors influence health and disease. The added value of cohort studies increases as they accumulate life course data and expand across generations. Ensuring that participants stay motivated to contribute over decades of follow-up is, however, challenging. Participant engagement and involvement (PEI) aims to secure the long-term commitment of participants and promote researcher-participant interaction. This study explored PEI practices in a selection of pregnancy and birth, twin, and family-based population cohort studies. Methods Purposive sampling was used to identify cohorts in Europe, Australia and New Zealand. Fourteen semi-structured digital interviews were conducted with cohort study representatives to explore strategies for participant recruitment, informed consent, communication of general and individual information to participants, data collection, and participant involvement. Experiences, resources allocated to PEI, and reflections on future PEI, were discussed. The interview data were analyzed using a content analysis approach and summary results were reviewed and discussed by the representatives. Results The cohort studies used various strategies to recruit participants including support from health professionals and organizations combined with information on the studies’ web sites and social media. New approaches such as intra-cohort recruitment, were being investigated. Most cohorts transitioned from paper-based to digital solutions to collect the participants’ consent and data. While digital solutions increased efficiency, they also brought new challenges. The studies experimented with the use of participant advisory panels and focus groups to involve participants in making decisions, although their success varied across age and socio-economic background. Most representatives reported PEI resources to be limited and called for more human, technical, educational and financial resources to maximize the positive effects of PEI. Conclusions This study of PEI among well-established cohort studies underscores the importance of PEI for project sustainability and highlights key factors to consider in developing PEI. Our analysis shows that knowledge gaps exist regarding which approaches have highest impact on retention rates and are best suited for different participant groups. Research is needed to support the development of best practices for PEI as well as knowledge exchange between cohorts through network building.

Abstract Background Glaesserella parasuis (G. parasuis) is the primary agent of Glässer’s disease, significantly affecting nursery and early fattening piglets. Current prophylactic measures, mainly serovar-specific bacterins administered to sows, are limited by maternal immunity, which can interfere with active immunization in piglets. Subunit vaccines containing G. parasuis-specific antigenic molecules show promise but are not yet commercially available. Transferrin-binding proteins (Tbp), which enable G. parasuis to acquire iron in low-iron environments like mucosal surfaces, have been proposed as potential vaccine antigens. The mucosal administration of a TbpB-based subunit vaccine could provide a promising solution to overcome the limitations posed by maternal immunity, offering an effective approach to control the disease in weaning piglets. This study, conducted in two phases, primarily evaluates (days 0–45) the immunogenicity of a two-dose oral mucosal TbpB-based subunit vaccine (TbpBY167A) administered to colostrum-deprived piglets, and subsequently (days 45–52), its heterologous protection by challenging these piglets with four G. parasuis clinical isolates from different TbpB clusters (I, III) and serovars (SV1, SV4, SV5, SV7) recovered from Spanish pig farms. Results The oral mucosal administration of the two-dose TbpB-based vaccine induced a robust humoral immune response in immunized colostrum-deprived piglets, significantly increasing IgA and IgM concentration 15 days after the second dose (p

Abstract The development of biocompatible hybrid nanosystems for advanced functional applications presents significant challenges to the research community. Key obstacles include the poor solubility of these nanosystems in water and the difficulty of precisely controlling their nanostructure dimensions and composition. A promising approach to overcoming these challenges is the self-assembly of surfactant-based building blocks into well-ordered hybrid nanostructures. In this study, we explore the relationship between structure and self-assembly in novel low molecular weight amphiphilic molecules to produce stable and biocompatible hybrid nanostructures. We investigated the self-assembly behavior of two families of amphiphiles derived from alkenyl lipids with one or two double bonds, leading to distinct hybrid supramolecular structures facilitated by the incorporation of hydrophobic iron oxide nanoparticles (IONPs) as templates. The presence of double bonds in the lipid tail and the morphology of the amphiphile influence the arrangement on the hydrophobic NPs. Amphiphiles with a single double bond in the lipid tail form highly water-soluble, well-ordered micellar-like structures on the IONP surfaces, while those with two double bonds create disordered lipid nanoparticles. Furthermore, these amphiphilic molecules can self-organize into higher-order hybrid supramolecular structures, such as vesicles, with potential applications in magnetic resonance imaging (MRI).

Purpose: Higher education institutions (HEIs) offer courses and programmes focusing on sustainability in economics, as courses on sustainable development (SD), which examine the economic, social and environmental dimensions of SD. This paper aims to examine sustainability integration in economics degree programmes. Design/methodology/approach: Through an extensive literature review in Web of Science (WoS) and information search in Google, conducting to 28 relevant case studies, this paper elucidates the emphasis given to sustainability as part of economics degree programmes in HEIs. Findings: The results suggest that, whereas the inclusion of sustainability components in this field is a growing trend, much still needs to be done to ensure that matters related to SD are part of the routine of university students studying economics. Research limitations/implications: It is worth noting that the literature review conducted in WoS was primarily aimed at assisting in the selection of university case studies. The 28 university case studies scrutinised in this study may lack sufficient representation from numerous developing countries. Practical implications: This study highlights challenges in integrating the SD into economics degree programmes, suggesting the need for curriculum adjustments as underscoring operational issues, acting as barriers. The inclusion of sustainability in economics programmes must navigate operational issues stemming from packed timetables and busy schedules, requiring innovative solutions. Social implications: As far as the authors are aware, this study holds substantial importance in its emphasis on implementing sustainability within HEIs' economics programmes, assisting in pursuing SD. Originality/value: The novelty of this study lies in addressing sustainability with the specific economics focus programmes within the HEIs context.

Purpose: Doctoral programs play a crucial role in promoting innovation and technology transfer in universities. To design these programs effectively and with a co-design perspective, it is essential to consider all stakeholders involved in the process, including teachers, students and employers. The main objective of this study is to enhance postgraduate programs to improve students' employability. Design/methodology/approach: This empirical study was conducted over a three-year period and employed semi-structured interviews as its primary research methodology. In the first phase, 21 in-depth semi-structured interviews were conducted with managers from various sectors. The second phase involved 20 interviews, and the final phase of the study included 18 interviews with the same managers from previous phases. Findings: The study's main results revealed that the international networks, language proficiency and analytical skills of doctoral students were highly valued by employers. The main findings come from companies with doctoral students. Therefore, the skills were identified during the learning experience of the PhD graduates in the companies. Practical implications: The study's results can guide improvements in postgraduate program curricula and design to enhance students' employability. Originality/value: This research presents a novel approach to its findings. On the one hand, the study's conclusions may provide valuable insights for business agents, encouraging them to hire PhD students. On the other hand, it aims to drive necessary changes that promote more PhD students' focus on non-academic careers, creating significant value for research and innovation in the private sector.

A number of university educators decided to implement an experience "pilot": the co-creation of a blog with students in which they disseminated some topics of the subject "Spanish political system", taken as part of a joint honors degree in law and political science from the Faculty of Political Sciences and Sociology of the Complutense University of Madrid. Four professors and 42 students participated in this experience. In the first phase, the students, under the supervision of the professors, collaboratively developed each of the assigned topics. To do so, the professors explained the dynamics, provided them with a series of resources, trained them in collaborative work techniques, supervised the whole process, and resolved all their doubts. In a second phase, they jointly evaluated one subject to see the possible deviations that had occurred with respect to the initial model, in order to be able to correct them in the rest. In addition, the professors conducted a student survey to measure teamwork and the impact of the blog, the results of which were shared with the participants and at specialized conferences. Thanks, this pilot program has shown that blogging is an important technological tool for the transformation and improvement of teaching and learning processes, and that it encourages the active role of students and promotes their collaborative learning, generating knowledge with and for students.

BackgroundAnimal-assisted therapy (AAT) is increasingly recognized as beneficial in palliative care, aiming to enhance the well-being of terminally ill patients. Palliative care focuses on holistic support for physical, emotional, social, and spiritual needs. AAT uses animal interactions to alleviate symptoms such as pain, anxiety, and depression, promoting social engagement and emotional comfort. This review assesses AAT’s effectiveness in enhancing the quality of life for palliative care recipients.AimSynthesizing literature on AAT in palliative care, the review examines its impact on physical symptoms, emotional well-being, social interactions, and overall comfort. By analyzing diverse studies, it aims to elucidate AAT’s therapeutic potential and identify research gaps.DesignScoping review.Data sourcesSearches in PubMed, ProQuest, Psychology Database, and Scopus identified relevant studies evaluating AAT interventions in palliative care. Data extraction focused on study characteristics, participant demographics, AAT interventions, and reported outcomes.ResultsStudies consistently report positive outcomes of AAT in palliative care, including reduced pain, anxiety, depression, and improved mood and well-being. AAT also enhances social interactions and emotional support, albeit with variations in study designs.ConclusionAAT holds promise for improving quality of life in palliative care by addressing physical, emotional, and social needs. Future research should standardize methodologies, explore mechanisms of action, and optimize AAT integration into comprehensive palliative care strategies.

Self-care behaviors can be considered a preventive measure for burnout. Therefore, the aim of this paper was to study the relationship of self-care practices with burnout in Ibero-American clinical psychologists who were active during the COVID-19 pandemic. The sample consisted of 160 clinical psychologists (84.4% women) who carried out psychotherapy in different work modalities (i.e., face-to-face, online, mixed). Using different analyses (i.e., structural equation modelling, path analysis, ANOVA), the results indicate that the more self-care behaviors, the lower the levels of burnout. Specifically, self-care behaviors include participating in recreational activities with coworkers, doing physical exercise, maintaining a healthy diet, and considering the physical workspace to be adequate. A greater knowledge of the effect of self-care behaviors on burnout may facilitate the development of good practices that prepare psychologists to face unexpected situations.

El rápido avance de las Tecnologías de la Información y la Comunicación (TIC) representa un desafío y una oportunidad crucial para la sociedad contemporánea. Estas herramientas no solo han transformado la manera en que las personas se comunican y trabajan, sino que también han redefinido los paradigmas pedagógicos, planteando nuevas exigencias y posibilidades para los sistemas de enseñanza. La incorporación de estos recursos en las aulas promueve la equidad y calidad educativa, preparando a los estudiantes con diversidad funcional para un mundo cada vez más digitalizado y favoreciendo procesos de enseñanza-aprendizaje accesibles, innovadores e inclusivos. El objetivo de este estudio es evaluar una escala para medir el conocimiento de los futuros docentes sobre las TIC aplicadas a la inclusión educativa mediante el Modelo de Respuesta Graduada (MRG). Se ha llevado a cabo un estudio psicométrico sobre una muestra no probabilística de 684 estudiantes universitarios del Grado en Educación Primaria de diferentes universidades públicas andaluzas, utilizando una versión reducida de la Escala de Conocimiento de las TIC aplicadas a las personas con diversidad funcional de Cabero-Almenara et al. (2016). Los datos reflejan una diversidad significativa en el conocimiento de los participantes sobre las TIC aplicadas a personas con diversidad funcional. Además, la precisión en la estimación de las puntuaciones latentes respalda la validez del instrumento de medición. Los resultados indican que la escala empleada no solo es efectiva para medir el conocimiento promedio de los participantes, sino que también es capaz de detectar variaciones significativas entre individuos. Por tanto, se concluye que esta escala es una herramienta predictiva útil para identificar deficiencias formativas y diseñar planes de estudios que respondan a estas necesidades.

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for several hematological diseases. Prospective and retrospective studies have associated myeloablative conditioning regimens with increased non-relapse mortality and less intense regimens with disease relapse, leading to similar overall survival rates.Objectives: Analyze the experience with the different RIC schemes in patients transplanted for AML/MDS in our program.Methods: We retrospectively analyzed our program's reduced-intensity conditioning regimens (RIC) between 2012 and 2022 in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).Results: During this period, 450 allogeneic stem cell transplantations were performed, of which 52 patients were treated with RIC for AML, mostly in men. The 3-year overall survival/progression-free survival rates were 52/53%, 51/57%, and 57/55% in the fludarabine-reduced intensity with total-body irradiation, Melphalan, and Busulfan, respectively (p = 0.89). The composite incidences of aGVHD III-IV, cGVHD, and admission to the critical patient unit were 21%, 25%, and 30%, respectively, without statistically significant differences according to the type of conditioning, but with a trend of greater ICU admission in patients who used melphalan-based conditioning.Conclusion: Our study found no differences in overall survival, progression-free survival, and complications between the most commonly used reduced-intensity conditioning regimens.

The decreasing well-being among doctoral candidates, coupled with a high prevalence of distress problems, is a topic of increasing concern in the field of higher education and research policy. The present study aimed to replicate, implement, and evaluate the effectiveness of The Third Half, a multi-component psychoeducational program in doctoral students. To address the limitations of the pilot study, we conducted a non-randomized controlled study using a repeated measures pre-post design with a total of 97 participants (Mage = 32.5; SD = 8.23), of whom 26 participated in the experimental group. Results showed that Third Half program participants reported significant decreases in indicators of negative affect (F = 4.01; p = .04) and anxiety (F = 4.95; p = .02) compared to the general control group; in the matched sample analysis (n = 20) significant decreases were found in indicators of negative affect (F = 4.72; p = .03), anxiety (F = 4.09; p

Introduction: The recent COVID-19 pandemic led to a rise in the number of people bereaved by the death of a loved one. There are many pandemic-related stressors that may have further complicated grief in these people. The aim of this research was to conduct an in-depth the experience of illness and death during the pandemic, as well as obstacles to and factors facilitating grief in people who had lost a loved one during this period, whether due to COVID-19 or to natural or sudden causes. Method: The sample consisted of 42 participants who had lost loved ones to COVID-19 or other causes (both natural and sudden). An inductive approach using grounded theory with open, axial and selective coding was used to analyse the semi-structured open-ended interviews. Results: The resulting theory was structured around a central category: “Processes of Loss and Grief in Pandemics”. The other relevant and related categories were: disease processes during the pandemic, emotional responses to the loss, factors facilitating the grieving process and obstacles to the grieving process. The various analytical categories were then further classified with reference to the Dual Process Model. Conclusion: This study highlights the main features of grief during the pandemic, including the impact of restrictive measures on disease processes; the funeral rituals performed and subsequent coping; responses such as intense shock, anger, fear or loneliness; and the way in which factors facilitating the grief process were adapted to the circumstances.

The goal of the present study was to determine, through a detailed study of the auditory brainstem response (ABR) waves, the possible existence of an early functional marker for the onset of presbycusis in an animal model. Toward this goal, Wistar rats were divided into four age groups: 3-month-old (3M, n = 6, control), 9-month-old (9M, n = 6), 14-month-old (14M, n = 6), and 20-month-old (20M, n = 6). ABR recordings were performed at 0.5, 1, 2, 4, 8, 16, and 32 kHz. The novel result reported here is that wave amplitudes, particularly wave II, were significantly diminished in the 9M group, even though there was no evidence of significant age-related threshold shift at that age. A significant increase in auditory thresholds with age was first detected at 14M, which further progressed at 20M, confirming our previous findings. These findings suggest that measurable alterations in ABR waves may precede age-related threshold shift and could serve as early markers to detect the onset of age-related hearing loss. Upon translation to humans, they could be used to implement early objective diagnosis, crucial to prevent or mitigate the negative consequences of presbycusis, a common, progressive, and irreversible neurodegenerative age-related disorder. This may allow, for instance, a better preservation of residual hearing, thus delaying the progression of the disease and minimizing the impact of hearing loss, ultimately improving the quality of life for those who suffer from this neurodegenerative condition.

Contact tracing of individual exposed to any infectious measles case deserves special attention when in the country the disease is mostly imported. We present the coordinated public health actions triggered after reporting a suspected measles case in an aircraft. Spanish public health authorities and airlines responded promptly to allow a rapid contact tracing. Even one secondary measles case was reported no further transmission was identified, revealing that giving PEP and appropriate information help to avoid transmission and to maintain measles elimination in Spain.

The emergence of tecnhiques such as microwave-assisted extraction (MAE), enzyme-assisted extraction (EAE), ultrasounds-assisted extraction (UAE), and pressurized liquid extraction (PLE) has brough many benefits but their single use does not guarantee the hollistic extraction of target compounds from complex samples. Taking into account their different principles and that one technique may favour the extraction of certain compounds over others, this work proposes the combination of these techniques for improving extraction yields in the recovery of proteins, as example of large molecule, and phenolic compounds, as example of small molecule, from a recalcitrant sample. No single extraction technique recovered all proteins or phenolic compounds, even after a proper optimization. Among them, PLE was the most advantageous, enabling the extraction of 67 % proteins and 1.20 g gallic acid equivalent (GAE)/100 g sample. Analysis of samples by scanning electron microscopy (SEM) and separation of extracts by reversed-phase high performance liquid chromatography (RP-HPLC) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) revealed that PLE showed the most distinct efficiency among EAE, MAE, and UAE, whereas the latter three exhibited more similar results. Based in these results, ten different combinations (sequential and/or simultaneous) of these techniques were proposed. PLE in combination with another technique showed a great potential for the extraction of both large and small molecules. Particularly, the combination of EAE and PLE recovered 100 % of proteins and more than three times the phenolic compounds extracted by other methods reported in the literature, even revealing significant synergistic effects.

This study examines whether auditors are innovating in their audit reports by incorporating material environmental, social, and governance (ESG) issues from companies' sustainability reports into the Key Audit Matters (KAMs) section. Additionally, it assesses whether ESG performance influences this inclusion. Content analysis was conducted on the materiality matrices of sustainability reports and KAMs disclosures for 20 Colombian companies listed on the COLCAP index during the period 2019–2021. Using logistic regression analysis, we examined relationships between ESG scores and KAMs disclosure of material ESG issues. The results obtained show that auditors strongly emphasise governance but tend to overlook social and environmental issues within their KAMs. Furthermore, higher governance scores increase the likelihood of ESG consideration in the KAMs, while lower profitability and leverage also lead to greater ESG inclusion in the KAMs. This pioneering study offers an initial analysis of whether material ESG issues arising from sustainability reports also appear in KAMs disclosures, thus addressing a significant literature gap. The study findings suggest that auditors need appropriate guidance and enhanced competencies to perform holistic ESG risk evaluation, as the acceptance of integrated sustainability reporting is gaining momentum globally.

Public sector organizations are not immune to pressure in order to improve their services to citizens. At this point, a major problem is that of “citizen-customer” satisfaction surveys being prone to focus on individuals’ perceptions on service delivery: what the individual think about the quality of delivered service. Authors have usually considered tools like the SERVQUAL scale (useful at measuring service quality in a diverse number of organizations and situations, both in private and public sector spheres) as a prior reference when researching in the quality field, but as being the “source”, then changed (modified) into a more or less “new” proposal. Following this research guideline, in this paper a new model for measuring perceived quality level in local government activities is presented. Three dimensions are suggested for citizens to valuate service quality: technical, functional and overall features.

Low-cost electrochemical methodologies for the determination of L-ascorbic acid (vitamin C) and the analysis of juices are developed based on its electro-oxidation on carbon screen-printed electrodes. A novel chronoamperometric methodology is developed for the quantification of L-ascorbic acid in fruit juices. The proposed method stands out for its simplicity and rapidity, demonstrating its efficacy in determining L-ascorbic acid content in various fruit juices. Notably, the results obtained with this chronoamperometric approach are compared with those yielded by chromatography, with no significant differences between the two methods being found. Additionally, an electronic tongue is developed for the differentiation of juices based on the square wave voltammetric signals.

Background/Objectives: Obstructive sleep apnea (OSA) is marked by repetitive occurrences of upper airway (UA) obstruction during sleep. Morbidities impacting the metabolic, cardiovascular (CV) and neurological systems are correlated with OSA. Only a few studies have described the existence of different characteristics depending on sex and, to date, the girl phenotype in OSA pediatrics is not well known. The objective of this systematic review is to identify the specific phenotype of OSA in pediatric and adolescent females compared to males. Methods: A systematic review was performed. The terms “pediatric sleep apnea” and “sex differences” were used to look for publications using PubMed, the Cochrane Library and Web of Science. Inclusion criteria: (1) peer-reviewed journal articles written in English; (2) investigations conducted on individuals diagnosed with OSA; and (3) investigations providing information about sex differences. Exclusion criteria: (1) studies carried out with individuals aged 18 years and older; (2) studies involving a sample size of fewer than 10 patients; and (3) editorials, letters and case reports. Results: Fifteen studies were included and classified in sections related to sex-based differences. Conclusions: Limited information related to sex-based OSA differences in the pediatric population exists. These differences are conditioned by hormonal status, and are minimal in the premenarcheal period. Moreover, adolescent women present a lower prevalence of obesity and craniofacial alterations, lower OSA severity related to higher UA area and earlier tonsil regression. Hyperactivity is more frequent in boys. Some studies pointed to a higher risk of high diastolic blood pressure in girls than in boys.

This study compared the performance of Clostridium ljungdahlii and Clostridium aceticum in the fermentation of fructose and C1-gasses (CO, CO2, N2) to produce valuable products such as ethanol and acetic acid. In heterotrophic fermentation (fructose), C. ljungdahlii yielded high ethanol concentrations (350 mg/L) and acetic acid (500 mg/L), with optimal production at pH 8 on the first day of fermentation. Although autotrophic fermentation (C1-gasses) resulted in lower ethanol levels (200 mg/L), it remained a viable option. Conversely, C. aceticum predominantly produced acetic acid in both fermentation modes, with higher concentrations in the heterotrophic fermentation (1600 mg/L) than the autotrophic fermentation (380 mg/L). These findings demonstrate the versatility of both microorganisms for producing valuable metabolites. C. ljungdahlii shows promise for bioethanol production, while C. aceticum excels at generating acetic acid, a crucial component in bioplastics and various industrial processes.

Background: Given the lack of standardization in stimulus types for assessing accommodation, we aimed to evaluate accommodative response (AR) and Zernike coefficients using four different stimuli. Methods: Sixteen healthy subjects aged 22–32 years participated. Four black transilluminated stimuli (Snellen 6/12 “E”, 6/6 “e”, Maltese Cross 6/12 “X”, 6/6 “x”) were used to stimulate accommodation from 0 D to 5 D, in 1 D increments, using the irx3 aberrometer. From the results, AR was calculated with Seidel defocus and the change in Zernike coefficient value between the non-accommodative state and the fully accommodative state (5 D) was determined. Results: Larger pupils were observed with stimulus “E” (p-value < 0.05). The mean AR at the maximum accommodative level (5 D) for the different stimuli was −1.88 ± 1.00 for “E”, −2.60 ± 1.44 for “X”, −2.00 ± 1.32 for “e”, and −2.40 ± 1.27 for “x”. No statistically significant differences were found between AR and Zernike coefficients with the four different accommodative stimuli (p-value > 0.05, one-way ANOVA). Conclusions: The study evaluated accommodative stimulus design and size on AR and Zernike coefficients and found no significant differences. However, stimuli with higher spatial frequencies (“e” and “E”) provided larger ARs compared to the other stimuli.

This article presents SmartRoutes, (version 1) a sensory navigation system designed for the localization and guidance of individuals with cognitive disabilities in both indoor and outdoor environments. The platform facilitates route generation in both contexts and provides detailed instructions, enabling effective task execution and seamless integration into daily activities or high-stress situations, such as emergency evacuations. SmartRoutes aims to enhance users’ independence and quality of life by offering comprehensive support for navigation across various settings. The platform is specifically designed to manage routes in both indoor and outdoor environments, targeting individuals with cognitive disabilities that affect orientation and the ability to follow instructions. This solution seeks to improve route learning and navigation, facilitating the completion of routine tasks in work and social contexts. Additionally, in exceptional situations such as emergencies, SmartRoutes ensures that users do not become disoriented or blocked. The application effectively guides users to the most appropriate exit or evacuation point. This combination of route generation and detailed instructions underscores the platform’s commitment to inclusion and accessibility, ultimately contributing to the well-being and autonomy of individuals with cognitive disabilities.

The way audiovisuals are perceived is not completely understood. Previous works have shown that attention increases when watching audiovisuals compared with looking at real events, but depending on the editing style, and the interpreter, the understanding of the content may be different. The study of brain asymmetries in this context aims to identify potential lateralizations in audiovisual perception. Previous studies have proven that seeing others grasp objects has a contralateral impact on somatosensory areas (C3 and C4) in the alpha band (8–12 Hz). In this work, we investigated whether brain activity could be asymmetrical in that band when looking at real grasping compared with watching grasping on a screen, and whether media expertise would be a determinant in this regard and presented the same narrative content both through live performance and as a movie to 40 participants (half of them media professionals) while recording their electroencephalography (EEG) activity. We conclude that the asymmetry in the alpha band in the somatosensory cortex is not affected by the medium through which the grasping actions are presented, that is, in reality or on screen. We also conclude that media expertise does not impact this asymmetry.

The epidemiology of bacteremia and the antibiotic resistance profile (ARP) of Gram-negative bacilli (GNB) in hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT) patients may differ according to geographic region. In addition, multidrug-resistant organisms (MDROs) may impact mortality. This is a prospective, observational, and multicenter study. The first episodes of bacteremia in adult patients with HM or HSCT were included. The risk factors for 30-day mortality were identified. One thousand two hundred and seventy-seven episodes were included (HM: 920; HSCT: 357). GNB were isolated in 60.3% of episodes, with Enterobacterales (46.9%) and P. aeruginosa (8.5%) being the most frequent. Gram-positive cocci were isolated in 41.9% of episodes, with coagulase-negative staphylococci (19.8%) and S. aureus (10.4%) being the most frequent. MDROs were isolated in 40.2% (24.4% GNB). The ARP of GNB in patients with HM vs. HSCT was cefepime: 36.8% vs. 45.7% (p = 0.026); piperacillin–tazobactam: 31.05% vs. 45.2% (p < 0.0001); carbapenems: 18.9% vs. 27.3% (p = 0.012); and aminoglycosides: 9.3% vs. 15.4% (p = 0.017), respectively. Overall mortality between patients with HM and HSCT was 17.5% vs. 17.6% (p = 0.951), respectively. The risk factors for mortality were relapsed and refractory underlying disease, corticosteroids use, respiratory source, septic shock, and GNB resistant to meropenem, while 7-day clinical response was a protective factor for survival. Bacteremia was frequently caused by GNB, with a large proportion of MDROs and a high level of antibiotic resistance, especially in patients with HSCT. Carbapenem-resistant GNB bacteremia was associated with a significant increase in mortality.

Identity currently features as a prominent theme in digital multimodal composition (DMC), given the significant impact of DMC on identity expression. However, L2 learners' writer identity development and fluctuation in this type of textual composition needs further exploration in light of the absence of clearly established DMC-specific identity categories and a detailed account of writer identity expansion and restriction processes therein. This study attempts to fill this void by scrutinizing how three 11th graders learning English as a foreign language in Spain crafted their writer identities in English in a 16-week genre-based digital storytelling (DST) intervention that followed the genre-based systemic functional linguistics tradition of L2 writing, and included instruction on attitude (Martin & White, 2005). Qualitative data analysis of multi-source data followed Ivanic's (1998) writer identity framework, attitude categories, and key notions in multimodality, as well as the DST and identity literature. Results indicate students' awareness raising of such categories throughout digital story writing, and general preference for appreciation and judgment in writer identity construction, which was contingent upon certain factors. Students' writer identities and their fluctuation revealed types of specific DMC identity categories, and expansion and restriction processes, which illustrated their multimodal composing identity formation and transformation in digital story creation.

In a peer-review of teaching (PRT) program, we aimed to i) use pre- and post-observation questionnaires to enhance self-reflection, and ii) perform a nominal group technique (NGT) to agree on improvements. The questionnaires showed that PRT helped discovering new weaknesses but not new strengths, and that preconceived negative feelings vanished during the teaching observation. The NGT highlighted that ensuring the pairs of teachers belong to different knowledge areas and offering information to future participants may improve the PRT program and increase faculty participation. In conclusion, questionnaires along the PRT program promoted self-reflection and important improvements were made by the NGT.

The use of information and communication technologies (ICTs) has become a fundamental tool in all areas of today's society, including higher education. Lessons cannot be envisaged without the use of tools such as computers, tablets or mobile devices. Many lecturers use audience response systems (ARS) to keep their classes engaged. ARS software allows teachers to interact with students via polls, text responses, or multiple-choice questions displayed via their mobile devices. A new example of the use of this type of devices in education is gamification, a technique that uses a set of activities with ludic character as a learning methodology in order to facilitate the acquisition of knowledge and competences. One of the most used gamification tools is Kahoot!, a free learning application based on a mixture of game and creativity, which encourages attention and participation of students through questions and answers formulated by the teacher and designed in a way that students respond via their mobile phones. This paper examines the use of Kahoot! in a subject belonging to the chemistry area. In order to assess the benefits of this tool, it was tested in a group of students to review the knowledge and skills acquired during the theoretical lessons prior to the exams, and the academic results were compared with those of a control group of students who did not use the tool. The results demonstrate that the use of Kahoot! led to an improvement in the teaching--learning process of the students and a noteworthy rise in their marks, and that its positive effects rise with increasing the frequency of use of this didactic tool.

Olive mill wastewater degradation by Aspergillus terreus and under aerobic conditions at 28°C, was measured by the parameter of phenol content. We have explored the effect of different concentrations of olive mill wastewater upon the activity of Aspergillus terreus. Through HPLC, 10 phenol compounds (90% of the total phenolic content of the olive mill wastewater) were identified.