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2. A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations

Author

Olivini, Nicole, Calò Carducci, Francesca Ippolita, Santilli, Veronica, De Ioris, Maria Antonietta, Scarselli, Alessia, Alario, Dario, Geremia, Caterina, Lombardi, Mary Haywood, Marabotto, Caterina, Mariani, Rosanna, Papa, Raffaele Edo, Peschiaroli, Emanuela, Scrocca, Raffaella, Sinibaldi, Serena, Smarrazzo, Andrea, Stella, Pietro, Bernardi, Stefania, Chiurchiù, Sara, Pansa, Paola, Romani, Lorenza, Michaela, Carletti, Concato, Carlo, De Rose, Domenico Umberto, Salvatori, Gugliemo, Rossi, Paolo, Villani, Alberto, Dotta, Andrea, D’Argenio, Patrizia, and Campana, Andrea

Published
2020
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3. Quantitative Assessment of Parenchymal Involvement Using 3D Lung Model in Adolescent With Covid-19 Interstitial Pneumonia

Author

Luca Borro, Paolo Ciliberti, Teresa Pia Santangelo, Andrea Magistrelli, Andrea Campana, Francesca Calò Carducci, Marabotto Caterina, Paolo Tomà, and Aurelio Secinaro

Subjects
3D lung reconstructions, 3D modeling in pneumonia, 3D parenchima reconstruction, 3D rendering in pneumonia, 3D in Covid19, 3D quantify in pneumonia, Pediatrics, RJ1-570
Abstract

Background: Amount of parenchymal involvement in patients with interstitial pneumonia Covid-19 related, seems to be associated with a worse prognosis. Nowadays 3D reconstruction imaging is expanding its role in clinical medical practice. We aimed to use 3D lung reconstruction of a young lady affected by Sars-CoV2 infection and interstitial pneumonia, to better visualize, and quantitatively assess the parenchymal involvement.Methods: Volumetric Chest CT scan was performed in a 15 years old girl with interstitial lung pneumonia, Sars-CoV2 infection related. 3D modeling of the lungs, with differentiation of healthy and affected parenchymal area were obtained by using multiple software.Results: 3D reconstruction imaging allowed us to quantify the lung parenchyma involved, Self-explaining 3D images, useful for the understanding, and discussion of the clinical case were also obtained.Conclusions: Quantitative Assessment of Parenchymal Involvement Using 3D Lung Model in Covid-19 Infection is feasible and it provides information which could play a role in the management and risk stratification of these patients.

Published
2020
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4. Quantitative Assessment of Parenchymal Involvement Using 3D Lung Model in Adolescent With Covid-19 Interstitial Pneumonia

Author

Aurelio Secinaro, Marabotto Caterina, Teresa Pia Santangelo, Andrea Campana, Andrea Magistrelli, Luca Borro, Francesca Calò Carducci, Paolo Tomà, and Paolo Ciliberti

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), 3D modeling in pneumonia, 030204 cardiovascular system & hematology, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Parenchyma, Quantitative assessment, Medicine, Interstitial pneumonia, In patient, Lung, business.industry, lcsh:RJ1-570, 3D parenchima reconstruction, Medical practice, lcsh:Pediatrics, Brief Research Report, medicine.disease, 3D quantify in pneumonia, respiratory tract diseases, 3D rendering in pneumonia, Pneumonia, medicine.anatomical_structure, 3D lung reconstructions, Pediatrics, Perinatology and Child Health, Radiology, business, 3D in Covid19
Abstract

Background: Amount of parenchymal involvement in patients with interstitial pneumonia Covid-19 related, seems to be associated with a worse prognosis. Nowadays 3D reconstruction imaging is expanding its role in clinical medical practice. We aimed to use 3D lung reconstruction of a young lady affected by Sars-CoV2 infection and interstitial pneumonia, to better visualize, and quantitatively assess the parenchymal involvement. Methods: Volumetric Chest CT scan was performed in a 15 years old girl with interstitial lung pneumonia, Sars-CoV2 infection related. 3D modeling of the lungs, with differentiation of healthy and affected parenchymal area were obtained by using multiple software. Results: 3D reconstruction imaging allowed us to quantify the lung parenchyma involved, Self-explaining 3D images, useful for the understanding, and discussion of the clinical case were also obtained. Conclusions: Quantitative Assessment of Parenchymal Involvement Using 3D Lung Model in Covid-19 Infection is feasible and it provides information which could play a role in the management and risk stratification of these patients.

Published
2020

5. Dynamic Viral Severe Acute Respiratory Syndrome Coronavirus 2 RNA Shedding in Children: Preliminary Data and Clinical Consideration from a Italian Regional Center

Author

De Ioris, Maria A, primary, Scarselli, Alessia, primary, Ciofi degli Atti, Marta L, primary, Ravà, Lucilla, primary, Smarrazzo, Andrea, primary, Concato, Carlo, primary, Romani, Lorenza, primary, Scrocca, Raffaella, primary, Geremia, Caterina, primary, Carletti, Michaela, primary, Calò Carducci, Francesca I, primary, Bernardi, Stefania, primary, Coltella, Luana, primary, Santilli, Veronica, primary, Chiurchiu, Sara, primary, Peschiaroli, Emanuela, primary, Mariani, Rosanna, primary, Marabotto, Caterina, primary, Perrotta, Daniela, primary, Villani, Alberto, primary, Rossi, Paolo, primary, D’Argenio, Patrizia, primary, Campana, Andrea, primary, and Raponi, Massimiliano, primary

Published
2020
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6. Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results from an Italian Multicenter Study

Author

Garazzino, Silvia, primary, Lo Vecchio, Andrea, additional, Pierantoni, Luca, additional, Calò Carducci, Francesca, additional, Marchetti, Federico, additional, Meini, Antonella, additional, Castagnola, Elio, additional, Vergine, Gianluca, additional, Donà, Daniele, additional, Bosis, Samantha, additional, Dodi, Icilio, additional, Venturini, Elisabetta, additional, Felici, Enrico, additional, Giacchero, Roberta, additional, Denina, Marco, additional, Pierri, Luca, additional, Nicolini, Giangiacomo, additional, Montagnani, Carlotta, additional, Krzysztofiak, Andrzej, additional, Bianchini, Sonia, additional, Marabotto, Caterina, additional, Tovo, Pier-Angelo, additional, Lanari, Marcello, additional, Villani, Alberto, additional, Castelli Gattinara, Guido, additional, and Group, Italian SITIP-SIP Pediatric Infecti, additional

Published
2020
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7. Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Author

Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Bocchino, Marialuisa, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, ANDREA, BOCCHINO, MARIALUISA, Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, Andrea, For the Italian Pediatric TB Study Group, Null, and DI COMITE, Amelia

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Tuberculosi, 030106 microbiology, Drug Resistance, Breastfeeding, Antitubercular Agents, Child, Drug Resistance, Microbial, Humans, Isoniazid, Medication Adherence, Tuberculosis, Pulmonary, Tuberculous meningitis, 03 medical and health sciences, Antitubercular Agent, Microbial, 0302 clinical medicine, Pharmacotherapy, 030225 pediatrics, medicine, Pharmacology (medical), Adverse effect, Ethambutol, Perinatology and Child Health, business.industry, Tuberculous pericarditis, Pulmonary, Pyrazinamide, medicine.disease, Settore MED/38, Surgery, Pediatrics, Perinatology and Child Health, business, medicine.drug, Human
Abstract

This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

Published
2016

8. How to manage children who have come into contact with patients affected by tuberculosis

Author

Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, BOCCHINO, MARIALUISA, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, and Tomà, Paolo

Subjects
Pulmonary and Respiratory Medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, Tuberculosis, Contacts, Tuberculosi, IGRA, LTBI, Multidrug-resistant tuberculosis, Mycobacterium tuberculosis, Disease, Mycobacterium tuberculosi, Article, lcsh:Infectious and parasitic diseases, Molecular typing, Contact, Medicine, lcsh:RC109-216, Index case, lcsh:RC705-779, Immune status, biology, business.industry, Transmission (medicine), lcsh:Diseases of the respiratory system, biology.organism_classification, medicine.disease, Multidrug-resistant tuberculosi, Infectious Diseases, Chemoprophylaxis, Immunology, business
Abstract

Childhood tuberculosis (TB) indicates a recent infection, particularly in children aged

Published
2015

9. Dynamic Viral Severe Acute Respiratory Syndrome Coronavirus 2 RNA Shedding in Children: Preliminary Data and Clinical Consideration from a Italian Regional Center.

Author

Ioris, Maria A De, Scarselli, Alessia, Atti, Marta L Ciofi degli, Ravà, Lucilla, Smarrazzo, Andrea, Concato, Carlo, Romani, Lorenza, Scrocca, Raffaella, Geremia, Caterina, Carletti, Michaela, Carducci, Francesca I Calò, Bernardi, Stefania, Coltella, Luana, Santilli, Veronica, Chiurchiu, Sara, Peschiaroli, Emanuela, Mariani, Rosanna, Marabotto, Caterina, Perrotta, Daniela, and Villani, Alberto

Subjects
RNA physiology, FECAL analysis, CONFIDENCE intervals, CORONAVIRUS diseases, CORONAVIRUSES, CLINICAL pathology, KAPLAN-Meier estimator, CHILDREN
Abstract

We evaluated severe acute respiratory syndrome coronavirus 2 RNA clearance in 22 children. The estimation of positivity at day 14 was 52% for nasopharyngeal swab and 31% for stool samples. These data underline the significance of nasopharyngeal and stoolsample for detecting infected children. Additional studies are needed for transmissibility. [ABSTRACT FROM AUTHOR]

Published
2020
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10. Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis

Author

Galli, Luisa, primary, Lancella, Laura, additional, Tersigni, Chiara, additional, Venturini, Elisabetta, additional, Chiappini, Elena, additional, Bergamini, Barbara, additional, Codifava, Margherita, additional, Venturelli, Cristina, additional, Tosetti, Giulia, additional, Marabotto, Caterina, additional, Cursi, Laura, additional, Boccuzzi, Elena, additional, Garazzino, Silvia, additional, Tovo, Pier, additional, Pinon, Michele, additional, Le Serre, Daniele, additional, Castiglioni, Laura, additional, Lo Vecchio, Andrea, additional, Guarino, Alfredo, additional, Bruzzese, Eugenia, additional, Losurdo, Giuseppe, additional, Castagnola, Elio, additional, Bossi, Grazia, additional, Marseglia, Gian, additional, Esposito, Susanna, additional, Bosis, Samantha, additional, Grandolfo, Rita, additional, Fiorito, Valentina, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Domenici, Raffaele, additional, Montesanti, Marco, additional, Salvini, Filippo, additional, Riva, Enrica, additional, Dodi, Icilio, additional, Maschio, Francesca, additional, Abbagnato, Luisa, additional, Fiumana, Elisa, additional, Fornabaio, Chiara, additional, Ballista, Patrizia, additional, Portelli, Vincenzo, additional, Bottone, Gabriella, additional, Palladino, Nicola, additional, Valenzise, Mariella, additional, Vecchi, Barbara, additional, Di Gangi, Maria, additional, Lupi, Carla, additional, Villani, Alberto, additional, and de Martino, Maurizio, additional

Published
2016
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15. Recommendations for treating children with drug-resistant tuberculosis

Author

Galli L., Lancella L., Garazzino S., Tadolini M., Matteelli A., Migliori G. B., Principi N., Villani A., Esposito S. Italian Pediatric TB Study Group: Samantha Bosis, Claudia Tagliabue, Laura Senatore, Beatrice Ascolese, Laura Cursi, Annalisa Grandin, Caterina Marabotto, Maurizio de Martino, Elena Chiappini, Carlotta Montagnani, Daniele Ciofi, Filippo Festini, Martina Anziati, Sabrina Becciani, Giulia Remaschi, Sara Sollai, Chiara Tersigni, Elisabetta Venturini, Alfredo Guarino, Andrea Lo Vecchio, Riccardo Scotto, Fi lippo Bernardi, Elisa Bertazzoni, Francesco Blasi, Marialuisa Bocchino, Luca Assante, Elio Castagnola, Giuseppe Losurdo, Giannina Gaslini, Luigi Codec, Giuseppe Di Mauro, Marino Faccini, Clara Gabiano, Daniele Le Serre, Irene Raffaldi, Regina Margherita, Gianluigi Marseglia, Amelia Mascolo, Mauro Stronati, Rosella Centis, Lia D'Ambrosio, Angela Pasinato, Cristina Russo, Franco Scaglione, Elisabetta Scala, Paolo Tomà, Susanna Esposito, Luisa Galli, Laura Lancella, Nicola Principi, Samantha Bosis, Silvi a Garazzino, Alberto Villani, Filippo Bernardi, Luigi Codecasa, Alberto Matteelli, Enrico Tortoli, Francesco Scaglione, Daniela Cirillo, Giovanni Battista Migliori, Marina Tadolini, L., Galli, L., Lancella, S., Garazzino, M., Tadolini, A., Matteelli, G. B., Migliori, N., Principi, A., Villani, Italian Pediatric TB Study Group: Samantha Bosis, Esposito S., Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, LO VECCHIO, Andrea, Scotto, Riccardo, lippo Bernardi, Fi, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, LUCA ROSARIO, Castagnola, Elio, Losurdo, Giuseppe, Gaslini, Giannina, Codec, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Le Serre, Daniele, Raffaldi, Irene, Margherita, Regina, Marseglia, Gianluigi, Mascolo, Amelia, Stronati, Mauro, Centis, Rosella, D'Ambrosio, Lia, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Esposito, Susanna, Galli, Luisa, Lancella, Laura, Lo Vecchio, Andrea, Principi, Nicola, Bosis, Samantha, a Garazzino, Silvi, Villani, Alberto, Bernardi, Filippo, Assante, Luca, Codecasa, Luigi, Matteelli, Alberto, Tortoli, Enrico, Scaglione, Francesco, Cirillo, Daniela, Battista Migliori, Giovanni, Tadolini, Marina, Garazzino, Silvia, and Migliori, Giovanni Battista

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Extensively Drug-Resistant Tuberculosis, 030106 microbiology, Antitubercular Agents, Pediatric tuberculosi, Anti-tuberculosis drugs, MDR-TB, Mycobacterium tuberculosi, Mycobacterium tuberculosis, 03 medical and health sciences, Therapeutic approach, Antitubercular Agent, 0302 clinical medicine, Tuberculosis, Multidrug-Resistant, Children, Pediatric tuberculosis, XDR-TB, Pharmacology, Humans, Medicine, 030212 general & internal medicine, Adverse effect, Child, Cause of death, biology, business.industry, Anti-tuberculosis drug, Extensively drug-resistant tuberculosis, medicine.disease, biology.organism_classification, Settore MED/38, Systematic review, Infectious disease (medical specialty), Extensively Drug-Resistant Tuberculosi, Practice Guidelines as Topic, business, Human
Abstract

Tuberculosis (TB) is still one of the most difficult infectious diseases to treat, and the second most frequent cause of death due to infectious disease throughout the world. The number of cases of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which are characterised by high mortality rates, is increasing. The therapeutic management of children with MDR- and XDR-TB is complicated by a lack of knowledge, and the fact that many potentially useful drugs are not registered for pediatric use and there are no formulations suitable for children in the first years of life. Furthermore, most of the available drugs are burdened by major adverse events that need to be taken into account, particularly in the case of prolonged therapy. This document describes the recommendations of a group of scientific societies on the therapeutic approach to pediatric MDR- and XDR-TB. On the basis of a systematic literature review and their personal clinical experience, the experts recommend that children with active TB caused by a drug-resistant strain of Mycobacterium tuberculosis should always be referred to a specialised centre because of the complexity of patient management, the paucity of pediatric data, and the high incidence of adverse events due to second-line anti-TB treatment.

Published
2016

16. Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study.

Author

Garazzino S, Lo Vecchio A, Pierantoni L, Calò Carducci FI, Marchetti F, Meini A, Castagnola E, Vergine G, Donà D, Bosis S, Dodi I, Venturini E, Felici E, Giacchero R, Denina M, Pierri L, Nicolini G, Montagnani C, Krzysztofiak A, Bianchini S, Marabotto C, Tovo PA, Pruccoli G, Lanari M, Villani A, and Castelli Gattinara G

Abstract

Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease. Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020. Results: As of 15 September 2020, 759 children were enrolled (median age 7.2 years, IQR 1.4; 12.4). Among the 688 symptomatic children, fever was the most common symptom (81.9%). Barely 47% of children were hospitalized for COVID-19. Age was inversely related to hospital admission ( p < 0.01) and linearly to length of stay ( p = 0.014). One hundred forty-nine children (19.6%) developed complications. Comorbidities were risk factors for complications ( p < 0.001). Viral coinfections, underlying clinical conditions, age 5-9 years and lymphopenia were statistically related to ICU admission ( p < 0.05). Conclusions: Complications of COVID-19 in children are related to comorbidities and increase with age. Viral co-infections are additional risk factors for disease progression and multisystem inflammatory syndrome temporarily related to COVID-19 (MIS-C) for ICU admission., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Garazzino, Lo Vecchio, Pierantoni, Calò Carducci, Marchetti, Meini, Castagnola, Vergine, Donà, Bosis, Dodi, Venturini, Felici, Giacchero, Denina, Pierri, Nicolini, Montagnani, Krzysztofiak, Bianchini, Marabotto, Tovo, Pruccoli, Lanari, Villani, Castelli Gattinara and the Italian SITIP-SIP Pediatric Infection Study Group.)

Published
2021
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