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16. La galerie des oiseaux

Author

Vieillot, L. P. (Louis Pierre), 1748-1831, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, Motte, Charles Etienne Pierre, 1785-1836, Oudart, P. L. (Paul Louis), 1796-1860, Jardin du roi (France), Smithsonian Libraries, Vieillot, L. P. (Louis Pierre), 1748-1831, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, Motte, Charles Etienne Pierre, 1785-1836, Oudart, P. L. (Paul Louis), 1796-1860, and Jardin du roi (France)

Subjects
Birds, Pictorial works
Published
1834

17. La galerie des oiseaux

Author

Vieillot, L. P. (Louis Pierre), 1748-1830, Oudart, P. L. (Paul Louis), 1796-1860, Motte, Charles Etienne Pierre, 1785-1836, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, Jardin du roi (France), University Library, University of Illinois Urbana Champaign, Vieillot, L. P. (Louis Pierre), 1748-1830, Oudart, P. L. (Paul Louis), 1796-1860, Motte, Charles Etienne Pierre, 1785-1836, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, and Jardin du roi (France)

Subjects
Birds, Pictorial works

18. La galerie des oiseaux

Author

Vieillot, L. P. (Louis Pierre), 1748-1830, Oudart, P. L. (Paul Louis), 1796-1860, Motte, Charles Etienne Pierre, 1785-1836, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, Jardin du roi (France), University Library, University of Illinois Urbana Champaign, Vieillot, L. P. (Louis Pierre), 1748-1830, Oudart, P. L. (Paul Louis), 1796-1860, Motte, Charles Etienne Pierre, 1785-1836, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, and Jardin du roi (France)

Subjects
Birds, Pictorial works

19. La galerie des oiseaux

Author

Vieillot, L. P. (Louis Pierre), 1748-1830, Oudart, P. L. (Paul Louis), 1796-1860, Motte, Charles Etienne Pierre, 1785-1836, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, Jardin du roi (France), Smithsonian Libraries and Archives, Vieillot, L. P. (Louis Pierre), 1748-1830, Oudart, P. L. (Paul Louis), 1796-1860, Motte, Charles Etienne Pierre, 1785-1836, Last, Carel Christiaan Antony, 1808-1876, Marais, R. des, and Jardin du roi (France)

Subjects
Birds, Pictorial works

30. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution

Author

Abbosh, C, Birkbak, NJ, Wilson, GA, Jamal-Hanjani, M, Constantin, T, Salari, R, Quesne, JL, Moore, DA, Veeriah, S, Rosenthal, R, Marafioti, T, Kirkizlar, E, Watkins, TBK, McGranahan, N, Ward, S, Martinson, L, Riley, J, Fraioli, F, Bakir, MA, GrÖnroos, E, Zambrana, F, Endozo, R, Bi, WL, Fennessy, FM, Sponer, N, Johnson, D, Laycock, J, Shafi, S, Czyzewska-Khan, J, Rowan, A, Chambers, T, Matthews, N, Turajlic, S, Hiley, C, Lee, SM, Forster, MD, Ahmad, T, Falzon, M, Borg, E, Lawrence, D, Hayward, M, Kolvekar, S, Panagiotopoulos, N, Janes, SM, Thakrar, R, Ahmed, A, Blackhall, F, Summers, Y, Hafez, D, Naik, A, Ganguly, A, Kareht, S, Shah, R, Joseph, L, Quinn, AM, Crosbie, P, Naidu, B, Middleton, G, Langman, G, Trotter, S, Nicolson, M, Remmen, H, Kerr, K, Chetty, M, Gomersall, L, Fennell, DA, Nakas, A, Rathinam, S, Anand, G, Khan, S, Russell, P, Ezhil, V, Ismail, B, Irvin-sellers, M, Prakash, V, Lester, JF, Kornaszewska, M, Attanoos, R, Adams, H, Davies, H, Oukrif, D, Akarca, AU, Hartley, JA, Lowe, HL, Lock, S, Iles, N, Bell, H, Ngai, Y, Elgar, G, Szallasi, Z, Schwarz, RF, Herrero, J, Stewart, A, Quezada, SA, Van Loo, P, Dive, C, Lin, CJ, Rabinowitz, M, Aerts, HJWL, Hackshaw, A, Shaw, JA, Zimmermann, BG, Swanton, C, Bosshard-Carter, L, Goh, G, Gorman, P, Murugaesu, N, Hynds, RE, Wilson, G, Horswell, S, Al Bakir, M, Mitter, R, Escudero, M, Xu, H, Goldman, J, Stone, RK, Denner, T, Biggs, J, Costa, M, Begum, S, Phillimore, B, Nye, E, Graca, S, Joshi, K, Furness, A, Aissa, AB, Wong, YNS, Georgiou, A, Quezada, S, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Forster, M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Taylor, M, Choudhary, J, Califano, R, Taylor, P, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Moss, S, Idries, F, Bishop, P, Chaturved, A, Marie Quinn, A, Doran, H, leek, A, Harrison, P, Moore, K, Waddington, R, Novasio, J, Rogan, J, Smith, E, Tugwood, J, Brady, G, Rothwell, DG, Chemi, F, Pierce, J, Gulati, S, Bellamy, M, Bancroft, H, Kerr, A, Kadiri, S, Webb, J, Djearaman, M, Fennell, D, Le Quesne, J, Moore, D, Thomas, A, Walter, H, Monteiro, W, Marshall, H, Nelson, L, Bennett, J, Primrose, L, Amadi, A, Palmer, S, Miller, J, Buchan, K, Lester, J, Edwards, A, Morgan, F, Verjee, A, MacKenzie, M, Wilcox, M, Smith, S, Gower, N, Ottensmeier, C, Chee, S, Johnson, B, Alzetani, A, Shaw, E, Lim, E, De Sousa, P, Tavares Barbosa, M, Bowman, A, Jordan, S, Rice, A, Raubenheimer, H, Proli, C, Elena Cufari, M, Ronquillo, JC, Kwayie, A, Bhayani, H, Hamilton, M, Bakar, Y, Mensah, N, Ambrose, L, Devaraj, A, Buderi, S, Finch, J, Azcarate, L, Chavan, H, Green, S, Mashinga, H, Nicholson, AG, Lau, K, Sheaff, M, Schmid, P, Conibear, J, Light, T, Horey, T, Danson, S, Bury, J, Edwards, J, Hill, J, Matthews, S, Kitsanta, Y, Suvarna, K, Fisher, P, Keerio, AD, Shackcloth, M, Gosney, J, Postmus, P, Feeney, S, Asante-Siaw, J, Constatin, T, Zimmermann, B, Dentro, S, Dessimoz, C, Shiu, K-K, Bridgewater, J, Hochauser, D, Beck, S, Parker, P, Walczak, H, Enver, T, Proctor, I, Sinclair, R, Lok, C-W, Mitchison, M, Trevisan, G, Lynch, M, Brandner, S, Gishen, F, Tookman, A, Stone, P, Sterling, C, Larkin, J, Attard, G, Eeles, R, Foster, C, Bova, S, Sottoriva, A, Chowdhury, S, Ashish, C, Spicer, J, Stares, M, Lynch, J, Caldas, C, Brenton, J, Fitzgerald, R, Jimenez-Linan, M, Provenzano, E, Cluroe, A, Stewart, G, Watts, C, Gilbertson, R, McDermott, U, Tavare, S, Maughan, T, Tomlinson, I, Campbell, P, McNeish, I, Biankin, A, Chambers, A, Fraser, S, Oien, K, Krebs, M, Marais, R, Carter, L, Nonaka, D, Dhomen, N, Shaw, J, Baijal, S, Tanchel, B, Collard, M, Cockcroft, P, Taylor, J, Colloby, P, Olisemeke, B, Wilson, R, Harrison, D, Loda, M, Flanagan, A, McKenzie, M, Lederman, J, Sharp, A, and Farrelly, L

Subjects
0301 basic medicine, Oncology, Lung Neoplasms, IMPACT, Biopsy, DNA Mutational Analysis, Drug resistance, Metastasis, 0302 clinical medicine, Limit of Detection, Carcinoma, Non-Small-Cell Lung, Medicine, Neoplasm Metastasis, Early Detection of Cancer, Multidisciplinary, medicine.diagnostic_test, Phylogenetic tree, DNA, Neoplasm, STATISTICS, 3. Good health, Tumor Burden, Multidisciplinary Sciences, Cell Tracking, PEACE consortium, 030220 oncology & carcinogenesis, Disease Progression, Science & Technology - Other Topics, medicine.medical_specialty, CARCINOMA, Tumour heterogeneity, General Science & Technology, Early detection, Evolution, Molecular, 03 medical and health sciences, Internal medicine, MD Multidisciplinary, Carcinoma, Humans, Cell Lineage, Lung cancer, Postoperative Care, Science & Technology, MUTATIONS, TRACERx consortium, business.industry, CIRCULATING TUMOR DNA, Reproducibility of Results, medicine.disease, R1, NEGATIVE BREAST-CANCER, Clone Cells, 030104 developmental biology, Drug Resistance, Neoplasm, UPTAKE RATIO, Immunology, FDG PET, Neoplasm Recurrence, Local, business, Multiplex Polymerase Chain Reaction
Abstract

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.

Published
2017

31. Circulating tumour DNA analysis predicts relapse following resection in stage II and III melanoma

Author

Tan, L., primary, Sandhu, S.K., additional, Lee, R., additional, Li, J., additional, Callahan, J., additional, Raleigh, J., additional, Hatzimihalis, A., additional, Middlehurst, P., additional, Henderson, M., additional, Shackleton, M., additional, Haydon, A., additional, Gyorki, D., additional, Oudit, D., additional, Hicks, R.J., additional, Lorigan, P., additional, McArthur, G.A., additional, Marais, R., additional, Wong, S.Q., additional, and Dawson, S.-J., additional

Published
2018
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32. Erratum: Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma (Cancer Cell (2015) 27(1) (85–96) (S1535610814004577) (10.1016/j.ccell.2014.11.006))

Author

Girotti, M. R., Lopes, F., Preece, N., Niculescu-Duvaz, D., Zambon, A., Davies, L., Whittaker, S., Saturno, G., Viros, A., Pedersen, M., Suijkerbuijk, B. M. J. M., Menard, D., Mcleary, R., Johnson, L., Fish, L., Ejiama, S., Sanchez-Laorden, B., Hohloch, J., Carragher, N., Macleod, K., Ashton, G., Marusiak, A. A., Fusi, A., Brognard, J., Frame, M., Lorigan, P., Marais, R., and Springer, C.

Published
2017

33. Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

Author

Soo, JK, Mackenzie Ross, AD, Kallenberg, DM, Milagre, C, Heung Chong, W, Chow, J, Hill, L, Hoare, S, Collinson, RS, Hossain, M, Keith, WN, Marais, R, and Bennett, DC

Subjects
Nevus, Pigmented, Telomere, immortalization, Aneuploidy, behavioral disciplines and activities, Signaling & Cell Biology, Neoplasm Proteins, crisis, cell senescence, radial growth-phase, otorhinolaryngologic diseases, Biomarkers, Tumor, Tumor Cells, Cultured, Humans, natural sciences, primary melanoma, Anaphase, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Melanoma, Cellular Senescence, ComputingMethodologies_COMPUTERGRAPHICS, nevus
Abstract

Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. Here, with new explantation methods, we investigated which classes of primary pigmented lesions are typically immortal. Nevi yielded a few proliferating cells, consistent with most nevus cells being senescent. No nevus culture (0/28) appeared immortal. Some thin and thick melanoma cultures proved immortal under these conditions, but surprisingly few (4/37). All arrested cultures displayed three senescence markers in some cells: β-galactosidase, nuclear p16, and heterochromatic foci/aggregates. However, melanoma cultures also showed features of telomeric crisis (arrest because of ultrashort telomeres). Moreover, crisis markers including anaphase bridges were frequent in uncultured vertical growth-phase (VGP) melanomas. Conversely, all immortal melanoma cultures expressed telomerase reverse transcriptase and telomerase, showing aneuploidy. The findings suggest that primary melanomas are typically precrisis, with immortalization/telomere maintenance as a late event.

Published
2011

35. Development of the Manchester Cancer Research Centre Molecular Tumour Board for matching patients to clinical trials based on tumour and ctDNA genetic profiling

Author

Gupta, A., primary, Ayub, M., additional, Miller, C., additional, Rothwell, D., additional, Wallace, A., additional, Jordan, A., additional, Cook, N., additional, Thistlethwaite, F., additional, Carter, L., additional, O’Brien, C., additional, Aruketty, S., additional, Dean, E., additional, Hudson, A., additional, Frese, K., additional, Dransfield, J., additional, Hughes, A., additional, Marais, R., additional, Dive, C., additional, Brady, G., additional, and Krebs, M., additional

Published
2017
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37. MAPK pathway activation in the embryonic pituitary results in stem cell compartment expansion, differentiation defects and provides insights into the pathogenesis of papillary craniopharyngioma

Author

Haston, S., primary, Pozzi, S., additional, Carreno, G., additional, Manshaei, S., additional, Panousopoulos, L., additional, Gonzalez-Meljem, J. M., additional, Apps, J. R., additional, Virasami, A., additional, Thavaraj, S., additional, Gutteridge, A., additional, Forshew, T., additional, Marais, R., additional, Brandner, S., additional, Jacques, T. S., additional, Andoniadou, C. L., additional, and Martinez-Barbera, J. P., additional

Published
2017
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38. UM Cure 2020 - A consortium of European experts in uveal melanoma to identify new therapies for patients with metastatic disease

Author

Coupland, S., primary, Kalirai, H., additional, Jager, M., additional, Jochemsen, A.G., additional, van der Velden, P.A., additional, Snaar-Jagalska, B.E., additional, Dhomen, N., additional, Marais, R., additional, Romanowska Dixon, B., additional, Elas, M., additional, Mione, M.C., additional, Valente, A., additional, Ryll, B., additional, Ruijtenbeek, R., additional, Prestat, A., additional, Hafsi, H., additional, Barnhill, R., additional, Cassoux, N., additional, Decaudin, D., additional, Lantz, O., additional, Piperno-Neumann, S., additional, Stern, M.H., additional, and Roman-Roman, S., additional

Published
2016
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41. Gene-specific interactions between ultraviolet radiation and melanoma

Author

Viriós, A., primary, Pedersen, M., additional, Furney, S.J., additional, Girotti, M.R., additional, Hogan, K., additional, Saturno, G., additional, Galvani, E., additional, Sanchez-Laorden, B., additional, Ng, C., additional, Reis-Filho, J.S., additional, Lorigan, P., additional, Cook, M., additional, and Marais, R., additional

Published
2016
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42. Tumour–microenvironment mediates resistance to immuno and targeted therapies in acral melanoma

Author

Lee, R., primary, Girotti, M.R., additional, Khandelwal, G., additional, Baenke, F., additional, Viros, A., additional, Mandal, A., additional, Bridgeman, J., additional, Galvani, E., additional, Gremel, G., additional, Kalaitsidou, M., additional, Ashton, G., additional, Peset, I., additional, Smith, M., additional, Hawkins, R., additional, Fusi, A., additional, Miller, C., additional, Gilham, D., additional, Dhomen, N., additional, Lorigan, P., additional, and Marais, R., additional

Published
2016
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49. Therapeutic efficacy of the paradox-breaking panRAF and SRC drug CCT3833/BAL3833 in KRAS-driven cancer models

Author

Saturno, G., primary, Lopes, F., additional, Girotti, M.R., additional, Niculescu-Duvaz, I., additional, Niculescu-Duvaz, D., additional, Zambon, A., additional, Davies, L., additional, Johnson, L., additional, Preece, N., additional, Viros, A., additional, Pedersen, M., additional, McLeary, R., additional, Knight, R., additional, Lee, R., additional, Holovanchuk, D., additional, Fusi, A., additional, Lorigan, P., additional, Dhomen, N., additional, Marais, R., additional, and Springer, C., additional

Published
2016
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