10 results on '"Marcel Alexander Kamp"'
Search Results
2. Robot technology identifies a Parkinsonian therapeutics repurpose to target stem cells of glioblastoma
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Andres Vargas-Toscano, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, Wei Zhang, Sajjad Muhammad, Daniel Hänggi, and Ulf Dietrich Kahlert
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cancer stem-like cells ,drug repurposing ,glioblastoma ,in vitro pharmacogenomics ,neurotransmitters ,personalized medicine ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Aim: Glioblastoma is a heterogeneous lethal disease, regulated by a stem-cell hierarchy and the neurotransmitter microenvironment. The identification of chemotherapies targeting individual cancer stem cells is a clinical need. Methodology: A robotic workstation was programmed to perform a drug concentration to cell-growth analysis on an in vitro model of glioblastoma stem cells (GSCs). Mode-of-action analysis of the selected top substance was performed with manual repetition assays and acquisition of further parameters. Results: We identified 22 therapeutic potential substances. Three suggested a repurpose potential of neurotransmitter signal-modulating agents to target GSCs, out of which the Parkinson's therapeutic trihexyphenidyl was most effective. Manual repetition assays and initial mode of action characterization revealed suppression of cell proliferation, cell cycle and survival. Conclusion: Anti-neurotransmitter signaling directed therapy has potential to target GSCs. We established a drug testing facility that is able to define a mid-scale chemo responsome of in vitro cancer models, possibly also suitable for other cell systems. more...
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- 2020
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3. Can the combination of hyperthermia, seizures and ion channel dysfunction cause fatal post-ictal cerebral edema in patients with SCN1A mutations?
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Carina Büren, Marcel Alexander Kamp, Christopher Munoz-Bendix, Hans-Jakob Steiger, Joachim Windolf, and Maxine Dibué-Adjei
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
A 21-year-old male with an SCN1A mutation died of cerebral herniation 3 h after a seizure occurring during physical activity. Cases of fatal cerebral edema in patients with SCN1A mutations after fever and status epilepticus have been recently reported raising the question whether sodium channel dysfunction may contribute to cerebral edema and thereby contribute to the increased premature mortality in Dravet Syndrome. We report on our patient and discuss whether the combination of hyperthermia and ion channel dysfunction may not only trigger seizures but also a fatal pathophysiological cascade of cerebral edema and herniation leading to cardiorespiratory collapse. Keywords: Dravet Syndrome, SCN1A mutation, Fatality, Cerebral edema, Hyperthermia, SUDEP more...
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- 2018
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4. Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage.
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Daniel Hänggi, Jason Perrin, Sven Eicker, Kerim Beseoglu, Nima Etminan, Marcel Alexander Kamp, Hi-Jae Heiroth, Nadia Bege, Stephan Macht, Katrin Frauenknecht, Clemens Sommer, Thomas Kissel, and Hans-Jakob Steiger more...
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Medicine ,Science - Abstract
Background and purposeTo investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH).Methods70 male Wistar rats were categorized into three groups: 1) sham operated animals (control), 2) animals with SAH only (control) and the 3) treatment group. SAH was induced using the double hemorrhage model. The treatment group received different concentrations (20%, 30% or 40%) of nimodipine microparticles. Angiographic vasospasm was assessed 5 days later using digital subtraction angiography (DSA). Histological analysis of frozen sections was performed using H&E-staining as well as Iba1 and MAP2 immunohistochemistry.ResultsDSA images were sufficient for assessment in 42 animals. Severe angiographic vasospasm was present in group 2 (SAH only), as compared to the sham operated group (pConclusionsLocal delivery of high-dose nimodipine prolonged-release microparticles at high concentration resulted in significant reduction in angiographic vasospasm after experimental SAH and with no histological signs for matrix toxicity. more...
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- 2012
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5. Would they do it again? Final treatment decisions in malignant brain tumour patients—a caregiver’s perspective
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Marion Rapp, Christiane von Sass, Clara Backhaus, Daniel Hänggi, Marcel Alexander Kamp, and Michael Sabel
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Oncology - Abstract
Purpose Overall survival of malignant brain tumour patients has significantly been increased over the last years. However, therapy remains palliative, and side effects should be balanced. Once terminal phase is entered, both patients and caregivers may find it hard to accept, and further therapies are demanded. But little is known about this highly sensitive period. Therefore, we analysed the last therapy decisions from the family caregiver’s perspective. Would they support their beloved ones in the same way or would they now recommend a different therapy decision? Methods Caregivers of deceased malignant brain tumour patients, treated at our neurooncological centre between 2011 and 2017, were included. We designed a questionnaire to analyse the impact of the last therapy decision (resection, chemotherapy, radiotherapy), focusing on probable repeat of the choice taken and general therapy satisfaction. Independent variables, for example “satisfaction with therapy”, were analysed using linear regression analysis, the coefficient of determination R2 and the standardized regression coefficient β. The binary logistic regression analyses were taken to illustrate relationships with the dichotomously scaled outcome parameter “re-choice of therapy”. Odds ratio analyses were used to determine the strength of a relationship between two characteristics. Results Data from 102 caregivers (life partners (70.6%)) were analysed retrospectively. Each 40% of patients died in a hospice or at home (20% in a hospital). In 67.6% the last therapy was chemotherapy followed by radiotherapy (16.7%) and surgery (15.7%). A positive evaluation of the last therapy was significantly correlated to re-choosing of respective therapy (chemo-/radiotherapy: p = 0.000) and satisfaction with informed consent (p = 0.000). Satisfaction regarding interpersonal contact was significantly correlated to satisfaction with resection (p = 0.000) and chemotherapy (p = 0.000 27 caregivers (28.7%) felt overburdened with this situation). Conclusion This analysis demonstrates a significant correlation between a positive relation of patient/caregiver/physician and the subjective perception of the latest therapy. It underlines the central role of caregivers, who should be involved in therapy discussions. Neurooncologists should be specially trained in communication and psycho-oncology. more...
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- 2022
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6. Would they do it again? Final treatment decisions in malignant brain tumour patients-a caregiver's perspective
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Marion, Rapp, Christiane, von Sass, Clara, Backhaus, Daniel, Hänggi, Marcel Alexander, Kamp, and Michael, Sabel
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Caregivers ,Brain Neoplasms ,Surveys and Questionnaires ,Palliative Care ,Humans ,Retrospective Studies - Abstract
Overall survival of malignant brain tumour patients has significantly been increased over the last years. However, therapy remains palliative, and side effects should be balanced. Once terminal phase is entered, both patients and caregivers may find it hard to accept, and further therapies are demanded. But little is known about this highly sensitive period. Therefore, we analysed the last therapy decisions from the family caregiver's perspective. Would they support their beloved ones in the same way or would they now recommend a different therapy decision?Caregivers of deceased malignant brain tumour patients, treated at our neurooncological centre between 2011 and 2017, were included. We designed a questionnaire to analyse the impact of the last therapy decision (resection, chemotherapy, radiotherapy), focusing on probable repeat of the choice taken and general therapy satisfaction. Independent variables, for example "satisfaction with therapy", were analysed using linear regression analysis, the coefficient of determination RData from 102 caregivers (life partners (70.6%)) were analysed retrospectively. Each 40% of patients died in a hospice or at home (20% in a hospital). In 67.6% the last therapy was chemotherapy followed by radiotherapy (16.7%) and surgery (15.7%). A positive evaluation of the last therapy was significantly correlated to re-choosing of respective therapy (chemo-/radiotherapy: p = 0.000) and satisfaction with informed consent (p = 0.000). Satisfaction regarding interpersonal contact was significantly correlated to satisfaction with resection (p = 0.000) and chemotherapy (p = 0.000 27 caregivers (28.7%) felt overburdened with this situation).This analysis demonstrates a significant correlation between a positive relation of patient/caregiver/physician and the subjective perception of the latest therapy. It underlines the central role of caregivers, who should be involved in therapy discussions. Neurooncologists should be specially trained in communication and psycho-oncology. more...
- Published
- 2021
7. [Vagus Nerve Stimulation for Affective Disorders]
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Maxine, Dibué-Adjei, Marcel Alexander, Kamp, Jonathan, Vogelsang, Jens, Wiltfang, and Claus, Wolff-Menzler
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Europe ,Depressive Disorder, Treatment-Resistant ,Treatment Outcome ,Vagus Nerve Stimulation ,Humans - Abstract
Vagus nerve stimulation (VNS) is a minimally invasive neurostimulation method and was approved for drug-resistant epilepsy in children and adults in Europe in 1994. The observation that depression -the most common comorbidity in epilepsy - improved with VNS prompted trials of VNS in treatment-resistant depression (TRD) leading to European approval of VNS for TRD in 2001. Use of VNS for TRD patients in Germany is currently limited to a few highly specialized tertiary centers and the method is largely unknown in psychiatric clinical practice. We therefore systematically review the most recent publications on VNS in TRD as well as recommendations in guidelines and discuss the use of VNS in clinical practice. In the past 5 years, 5 level-2 studies and 4 level-3 studies were published on the effect of VNS in TRD patients. Clinical studies have failed to demonstrate short-term efficacy of VNS in TRD patients. Long-term efficacy of VNS in TRD patients is documented by multiple studies: the recently published largest ever investigation on the subject confirms favorable outcomes in TRD patients receiving adjunctive VNS in addition to treatment-as-usual compared to patients receiving treatment-as-usual-only over a 5-year period. Long-term efficacy of VNS is documented by level-2 evidence; however, it is not known which TRD patients have a higher probability of responding to VNS, which may complicate patient selection in clinical practice. Additionally, the unclear and variable definition of TRD may hinder or postpone adequate use of neurostimulation treatments.Vagusnervstimulation (VNS) ist ein minimalinvasives Neurostimulationsverfahren und wurde 1994 in Europa für die Behandlung von Kindern und Erwachsenen mit medikamentenresistenten Epilepsien zugelassen. Die Beobachtung, dass sich Depressionen, die häufigste Komorbidität der Epilepsie, signifikant unter VNS verbesserten, initiierte Studien der VNS bei Patienten mit therapieresistenten Depressionen (TRD), die 2001 zu der europäischen Zulassung der VNS für TRD führten. Heutzutage ist in Deutschland der Einsatz der VNS für TRD-Patienten auf wenige hochspezialisierte (oft universitäre) Zentren limitiert und das Verfahren in der psychiatrischen Praxis weitestgehend unbekannt. In dieser systematischen Übersicht identifizieren und diskutieren wir deshalb die aktuellsten Studien zu VNS bei TRD sowie Empfehlungen von Fachgesellschaften und diskutieren den Einsatz der VNS in der klinischen Praxis. In den letzten fünf Jahren wurden fünf Studien mit Evidenzgrad 2 und vier Studien mit Evidenzgrad 3 zu der Wirkung von VNS bei TRD-Patienten publiziert. Kurzfristige Wirksamkeit der VNS konnte in klinischen Studien nicht gezeigt werden. Mehrere Studien demonstrieren die Langzeitwirksamkeit der VNS. Die kürzlich publizierte größte Untersuchung der Thematik bestätigt signifikant bessere Behandlungsergebnisse bei Patienten, die eine Zusatztherapie mit VNS erhielten – im Vergleich zu Patienten, die nur Behandlung nach Goldstandard über fünf Jahre erhielten. Die langfristige Wirksamkeit der VNS bei TRD-Patienten ist mit Evidenz des Grades 2 belegt, jedoch ist es unklar, welche TRD-Patienten die höchste Wahrscheinlichkeit eines Ansprechens auf VNS haben, was die Patientenselektion in der Praxis erschweren kann. Zusätzlich wirkt sich möglicherweise die unklare und variable Definition der therapieresistenten Depression problematisch auf den rechtzeitigen Einsatz von Neurostimulationsverfahren aus. more...
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- 2020
8. Outcome following surgical treatment of chronic subdural hematoma in the oldest-old population
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Christopher Munoz-Bendix, Robert Pannewitz, Daniel Remmel, Hans-Jakob Steiger, Bernd Turowski, Phillip Jorg Slotty, and Marcel Alexander Kamp
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Adult ,Male ,Aging ,Glasgow Outcome Scale ,Functional Laterality ,Neurosurgical Procedures ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Recurrence ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,General Medicine ,Recovery of Function ,Length of Stay ,Middle Aged ,Treatment Outcome ,030220 oncology & carcinogenesis ,Hematoma, Subdural, Chronic ,Surgery ,Female ,Neurology (clinical) ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery - Abstract
As a result of the demographic shift in western societies, the mean age at presentation of patients suffering from chronic subdural hematomas (cSDH) is increasing. Therapeutic strategies, surgical and non-surgical, need to be reevaluated and adapted accordingly. Age is considered to be a positive risk factor for a higher perioperative morbidity and mortality. The purpose of this study is to determine if old age (≥85 years) should be seen as a contraindication for surgical treatment. Two groups (56 patients each) with cSDH over and below 85 years of age from a single neurosurgical department with well-defined surgical treatment guidelines were retrospectively analyzed. Clinical characteristics of the patients, localization, treatment, prior medication, and complications were compared. Outcome was measured by clinical improvement postoperatively and by the Glasgow Outcome Scale (GOS) at 1 month after surgery. Age ≥85 years was associated with higher GOS 1 month after surgery (p = 0.038). 51.8% (58) of all patients had a complete neurological recovery postoperatively, and 74% (43) of these patients were ≥85 years. Elderly patients suffered from a significantly higher complication rate (p 0.001) with odds of having a complication 18.3 times higher (p 0.001) compared to patients85 years. Both groups had a comparable mean hospitalization time (9.8 days for patients ≥85 years and 9.5 days for patients85 years). Old age has no negative impact on overall outcome after surgical therapy of cSDH. Despite significantly higher complication rate in elderly patients, the outcome assessed by the GOS at 1 month after surgery was significantly better in comparison to patients younger than 85 years. Old age does therefore not seem to be a contraindication for surgical treatment of cSDH. more...
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- 2016
9. Pulmonary adenocarcinoma metastasis to a dorsal root ganglion: a case report and review of the literature.
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Jörg Slotty, Philipp, Frederick Cornelius, Jan, Marcel Schneiderhan, Timo, Marcel Alexander, Kamp, and Bostelmann, Richard
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ADENOCARCINOMA ,METASTASIS ,CAUCASIAN race ,RADICULOPATHY ,BREAST cancer ,SPINAL nerve root diseases ,HEALTH - Abstract
Introduction: The dorsal root ganglion is a rare manifestation of metastatic spread. We report what we believe to be the first case of metastasis of a pulmonary adenocarcinoma to the lumbar dorsal root ganglion. Only four descriptions for different primary tumors spreading to the dorsal root ganglion have been described in the literature so far. Case presentation: A 70-year-old Caucasian woman with a four-month history of left-sided lumbar radiculopathy was admitted to our department under the assumption of a herniated lumbar disc. Her past medical history included a pulmonary adenocarcinoma and invasive ductal breast cancer. Lumbar magnetic resonance imaging revealed a space-occupying mass in her left neuroforamen L3-L4 with compression of her L3 nerve root. Neurinoma was taken into account as a differential diagnosis, although not considered typical. Surgery revealed a metastasis of pulmonary adenocarcinoma to her dorsal root ganglion. Conclusions: Dorsal root ganglion metastases seem to be extremely rare and can mimic primary local nerve sheath tumors. Therefore, they usually present as incidental findings. Resection should be performed strictly under intraoperative monitoring as tumor spread between the nerve fibers is commonly observed. Metastases should be taken into account in spinal nerve tumors involving the dorsal root ganglion, especially in patients harboring known malignant diseases. The low incidence means that no clear treatment advice can be given. Resection is possible under intraoperative monitoring and relieves neurological symptoms. [ABSTRACT FROM AUTHOR] more...
- Published
- 2013
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10. 'Let’s put it this way: you can’t really live without it' - digital technologies in routine palliative care delivery: an explorative qualitative study with patients and their family caregivers in Germany
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Susann May, Anne Gehlhaar, Kerstin Stahlhut, Marcel-Alexander Kamp, Martin Heinze, Matthew Allsop, and Felix Muehlensiepen
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Telemedicine ,Digital Health ,Palliative care ,Health Services Research ,Qualitative research ,User perspectives ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Despite ongoing efforts to integrate palliative care into the German healthcare system, challenges persist, particularly in areas where infrastructure does not fully support digital technologies (DT). The increasing importance of digital technology (DT) in palliative care delivery presents both opportunities and challenges. Objective This study aimed to explore the perspectives and preferences of palliative care patients and their family caregivers regarding the use of DT in care delivery. Methods An exploratory qualitative study was conducted using semi-structured interviews with palliative care patients and their family caregivers across various settings. Participants were selected through gatekeeper-supported purposive sampling. Interviews were analysed using structured qualitative content analysis. Results Nineteen interviews were conducted.Three themes emerged: (1) Application of DTs in palliative care; (2) Potential of DTs; (3) Barriers to the use of DTs. Key findings highlighted the preference for real-time communication using DTs that participants are familiar with. Participants reported limited perceived value for digital transformation in the presence of in-person care. The study identified requirements for DT development and use in palliative care, including the need for direct and immediate functionality, efficiency in healthcare professional (HCP) work, and continuous access to services. Conclusion The findings highlight a demonstrate the importance of familiarity with DTs and real-time access for patients and their families. While DT can enhance palliative care efficiency and accessibility, its integration must complement, not replace, in-person interaction in palliative care. As DTs continue to grow in scope and use in palliative care, maintaining continued user engagement is essential to optimise their adoption and ensure they benefit patients and their caregivers. more...
- Published
- 2024
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