16 results on '"Marchand, Jonathan"'
Search Results
2. Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors
- Author
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Bramble, Matthew S, Hoff, Nicole, Gilchuk, Pavlo, Mukadi, Patrick, Lu, Kai, Doshi, Reena H, Steffen, Imke, Nicholson, Bradly P, Lipson, Allen, Vashist, Neerja, Sinai, Cyrus, Spencer, D’andre, Olinger, Garrard, Wemakoy, Emile Okitolonda, Illunga, Benoit Kebela, Pettitt, James, Logue, James, Marchand, Jonathan, Varughese, Justin, Bennett, Richard S, Jahrling, Peter, Cavet, Guy, Serafini, Tito, Saphire, Erica Ollmann, Vilain, Eric, Muyembe-Tamfum, Jean Jacques, Hensely, Lisa E, Simmons, Graham, Crowe, James E, and Rimoin, Anne W
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Vaccine Related ,Orphan Drug ,Rare Diseases ,Emerging Infectious Diseases ,Biodefense ,Infectious Diseases ,Immunization ,Good Health and Well Being ,Antibodies ,Monoclonal ,Antibodies ,Neutralizing ,Antibodies ,Viral ,Antibody Specificity ,Antigens ,Viral ,Democratic Republic of the Congo ,Ebolavirus ,Glycoproteins ,Hemorrhagic Fever ,Ebola ,Humans ,Lassa virus ,Marburgvirus ,Neutralization Tests ,Ebola ,DRC ,filovirus ,immune response ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
One year after a Zaire ebolavirus (EBOV) outbreak occurred in the Boende Health Zone of the Democratic Republic of the Congo during 2014, we sought to determine the breadth of immune response against diverse filoviruses including EBOV, Bundibugyo (BDBV), Sudan (SUDV), and Marburg (MARV) viruses. After assessing the 15 survivors, 5 individuals demonstrated some degree of reactivity to multiple ebolavirus species and, in some instances, Marburg virus. All 5 of these survivors had immunoreactivity to EBOV glycoprotein (GP) and EBOV VP40, and 4 had reactivity to EBOV nucleoprotein (NP). Three of these survivors showed serologic responses to the 3 species of ebolavirus GPs tested (EBOV, BDBV, SUDV). All 5 samples also exhibited ability to neutralize EBOV using live virus, in a plaque reduction neutralization test. Remarkably, 3 of these EBOV survivors had plasma antibody responses to MARV GP. In pseudovirus neutralization assays, serum antibodies from a subset of these survivors also neutralized EBOV, BDBV, SUDV, and Taï Forest virus as well as MARV. Collectively, these findings suggest that some survivors of naturally acquired ebolavirus infection mount not only a pan-ebolavirus response, but also in less frequent cases, a pan-filovirus neutralizing response.
- Published
- 2018
3. Motifs de graphe pour le calcul de d\'ependances syntaxiques compl\`etes
- Author
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Marchand, Jonathan, Guillaume, Bruno, and Perrier, Guy
- Subjects
Computer Science - Computation and Language - Abstract
This article describes a method to build syntactical dependencies starting from the phrase structure parsing process. The goal is to obtain all the information needed for a detailled semantical analysis. Interaction Grammars are used for parsing; the saturation of polarities which is the core of this formalism can be mapped to dependency relation. Formally, graph patterns are used to express the set of constraints which control dependency creations.
- Published
- 2010
4. Analyse en d\'ependances \`a l'aide des grammaires d'interaction
- Author
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Marchand, Jonathan, Guillaume, Bruno, and Perrier, Guy
- Subjects
Computer Science - Computation and Language - Abstract
This article proposes a method to extract dependency structures from phrase-structure level parsing with Interaction Grammars. Interaction Grammars are a formalism which expresses interactions among words using a polarity system. Syntactical composition is led by the saturation of polarities. Interactions take place between constituents, but as grammars are lexicalized, these interactions can be translated at the level of words. Dependency relations are extracted from the parsing process: every dependency is the consequence of a polarity saturation. The dependency relations we obtain can be seen as a refinement of the usual dependency tree. Generally speaking, this work sheds new light on links between phrase structure and dependency parsing.
- Published
- 2009
5. Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay
- Author
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Logue, James, Tuznik, Kaylie, Follmann, Dean, Grandits, Greg, Marchand, Jonathan, Reilly, Cavan, Sarro, Yeya dit Sadio, Pettitt, James, Stavale, Eric J., Fallah, Mosoka, Olinger, Gene G., Bolay, Fatorma K., and Hensley, Lisa E.
- Published
- 2018
- Full Text
- View/download PDF
6. Assessment and Optimization of the GeneXpert Diagnostic Platform for Detection of Ebola Virus RNA in Seminal Fluid
- Author
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Pettitt, James, Higgs, Elizabeth, Fallah, Mosoka, Nason, Martha, Stavale, Eric, Marchand, Jonathan, Reilly, Cavan, Jensen, Kenneth, Dighero-Kemp, Bonnie, Tuznik, Kaylie, Logue, James, Bolay, Fatorma, and Hensley, Lisa
- Published
- 2017
7. Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia
- Author
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Kennedy, Stephen B., Bolay, Fatorma, Kieh, Mark, Grandits, Greg, Badio, Moses, Ballou, Ripley, Eckes, Risa, Feinberg, Mark, Follmann, Dean, Grund, Birgit, Gupta, Swati, Hensley, Lisa, Higgs, Elizabeth, Janosko, Krisztina, Johnson, Melvin, Kateh, Francis, Logue, James, Marchand, Jonathan, Monath, Thomas, Nason, Martha, Nyenswah, Tolbert, Roman, François, Stavale, Eric, Wolfson, Julian, Neaton, James D., and Lane, Clifford H.
- Published
- 2017
- Full Text
- View/download PDF
8. High dose sertraline monotherapy fails to protect rhesus macaques from lethal challenge with Ebola virus Makona
- Author
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Honko, Anna N., primary, Johnson, Joshua C., additional, Marchand, Jonathan S., additional, Huzella, Louis, additional, Adams, Ricky D., additional, Oberlander, Nicholas, additional, Torzewski, Lisa M., additional, Bennett, Richard S., additional, Hensley, Lisa E., additional, Jahrling, Peter B., additional, and Olinger, Gene G., additional
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- 2017
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9. Assessment and Optimization of the GeneXpert Diagnostic Platform for Detection of Ebola Virus RNA in Seminal Fluid
- Author
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Pettitt, James, primary, Higgs, Elizabeth, additional, Fallah, Mosoka, additional, Nason, Martha, additional, Stavale, Eric, additional, Marchand, Jonathan, additional, Reilly, Cavan, additional, Jensen, Kenneth, additional, Dighero-Kemp, Bonnie, additional, Tuznik, Kaylie, additional, Logue, James, additional, Bolay, Fatorma, additional, and Hensley, Lisa, additional
- Published
- 2016
- Full Text
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10. A Categorical Model of Model Merging and Weaving
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Marchand, Jonathan, Combemale, Benoit, Baudry, Benoit, Reliable and efficient component based software engineering (TRISKELL), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria), Marchand, Jonathan, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Inria Rennes – Bretagne Atlantique
- Subjects
[INFO.INFO-SE] Computer Science [cs]/Software Engineering [cs.SE] ,ACM: D.: Software/D.2: SOFTWARE ENGINEERING/D.2.4: Software/Program Verification/D.2.4.3: Formal methods ,ACM: D.: Software/D.2: SOFTWARE ENGINEERING/D.2.2: Design Tools and Techniques/D.2.2.5: Object-oriented design methods ,[INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE] - Abstract
International audience; Model driven engineering advocates the separation of concerns during the design time of a system, which leads to the creation of several different models, using several different syntaxes. However, to reason on the overall system, we need to compose these models. Unfortunately, composition of models is done in an ad hoc way, preventing comparison, capitalisation and reuse of the composition operators. In order to improve comprehension and allow comparison of merging and weaving operators, we use category theory to propose a unified framework to formally define merging and weaving of models. We successfully use this framework to compare them, both through the way they are transformed in the formalism, and through several properties, such as completeness or non-redundancy. Finally, we validate this framework by checking that it correctly identifies three tools as performing merging or weaving of models.
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- 2012
11. WHO collaborative study to assess the suitability of an interim standard for antibodies to Ebola virus
- Author
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Wilkinson, Dianna, Page, M., Almond, Neil, Anderson, Robert, Berry, Neil, Dougall, Thomas, Efstathiou, Stacey, Hassall, Mark, Mattiuzzo, Giada, Peter, Rigsby, Rose, N., Schepelmann, Silke, Stone, Lindsay, Minor, Philip D., Labrosse, Beatrice, Leculier, Christophe, Pannetier, Delphine, Strecker, Thomas, Krahling, Verena, Schnierle, Barbara, Capobianchi, Maria, Castilletti, Concetta, Gatherer, Derek, Bishop, Lisa, Hartman, Katharina, Lauder, Robert, Wright, Edward, Tedder, Richard, Samuel, Dhan, Dicks, Steve, Rudge, Thomas, Simmons, Graham, Kaplan, Gerardo, Khuran, Surender, Weiss, Carol D., Hogrefe, Wayne, Rodriguez, Nicole, Hsu, Allen, Honko, Anna N., Bennett, Richard S., Pettitt, Jamie, Janosko, Krisztina, Marchand, Jonathan, Postnikova, Elena, Wu, Hua, Griffiths, Anthony, Hooper, Jay W., Wilkinson, Dianna, Page, M., Almond, Neil, Anderson, Robert, Berry, Neil, Dougall, Thomas, Efstathiou, Stacey, Hassall, Mark, Mattiuzzo, Giada, Peter, Rigsby, Rose, N., Schepelmann, Silke, Stone, Lindsay, Minor, Philip D., Labrosse, Beatrice, Leculier, Christophe, Pannetier, Delphine, Strecker, Thomas, Krahling, Verena, Schnierle, Barbara, Capobianchi, Maria, Castilletti, Concetta, Gatherer, Derek, Bishop, Lisa, Hartman, Katharina, Lauder, Robert, Wright, Edward, Tedder, Richard, Samuel, Dhan, Dicks, Steve, Rudge, Thomas, Simmons, Graham, Kaplan, Gerardo, Khuran, Surender, Weiss, Carol D., Hogrefe, Wayne, Rodriguez, Nicole, Hsu, Allen, Honko, Anna N., Bennett, Richard S., Pettitt, Jamie, Janosko, Krisztina, Marchand, Jonathan, Postnikova, Elena, Wu, Hua, Griffiths, Anthony, and Hooper, Jay W.
- Abstract
In support of the WHO response to the Ebola crisis, NIBSC is undertaking a project to develop an International Standard for use in the calibration and control of Ebola antibody assays. The availability of International Standards (IS) for antibodies would facilitate the standardization of Ebola serological methods used in epidemiological studies to measure past or present Ebola virus disease and in vaccinology studies to measure antibodies elicited by vaccination in humans. In the absence of such standards, individual laboratories apply their own reference standards which are not harmonized with other laboratories and methods and thus cannot serve to improve the reproducibility between laboratories. Recommendations made by participants attending the Technical Workshop on the Standardisation of Serological and PCR assays for the detection of Ebola virus (NIBSC, UK, 5-6 March 2015), included the urgent prioritization of the development of an interim Ebola standard for serology assays while perusing the longer-term goal of establishing an International Standard according to published WHO guidelines and formally endorsed by the WHO Expert Committee on Biological Standardization (ECBS). This report describes the development and worldwide collaborative study evaluation of a panel of candidate Ebola antibody preparations for the selection of the most appropriate candidate to serve as the interim WHO standard for Ebola antibody assays.
- Published
- 2016
12. Formal and tool-supported operator for multi-formalism modelling
- Author
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Marchand, Jonathan, V. Gouranton Et S. Blazy, Co-Responsables Du Mri, École normale supérieure - Cachan, antenne de Bretagne (ENS Cachan Bretagne), École normale supérieure - Cachan (ENS Cachan), INRIA-IRISA Rennes Bretagne Atlantique, équipe TRISKELL, and Benoît Baudry, Benoît Combemale
- Subjects
category theory ,aspect-oriented programming ,[INFO.INFO-FL]Computer Science [cs]/Formal Languages and Automata Theory [cs.FL] ,Models ,Mathematics::Category Theory ,[INFO.INFO-SE] Computer Science [cs]/Software Engineering [cs.SE] ,model composition ,[INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE] ,[INFO.INFO-FL] Computer Science [cs]/Formal Languages and Automata Theory [cs.FL] - Abstract
We propose, in this master internship report, a unified formal framework for model composition. Indeed, there are various operators of model composition de fined each in its own framework. Defining a unified framework for model composition allows to compare them, to reuse them and to capitalize knowledge. Defining a formal framework allows to consider the system that these compositions represent in its entirety. This framework is built through category theory and the notion of pushout. More precisely, a category of models is defined, and the pushout construction in this category described. Then, this pushout is used to formalize several model composition operators, including model merge, model transformation and aspect weaving.
- Published
- 2011
13. La chaîne d'analyse syntaxique de LEOPAR
- Author
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Perrier, Guy, Guillaume, Bruno, Marchand, Jonathan, Linear logic, proof networks and categorial grammars (CALLIGRAMME), INRIA Lorraine, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), and ATALA
- Subjects
[INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO] ,[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL] - Abstract
National audience; LEOPAR est un analyseur syntaxique fondé sur le formalisme des grammaires d'interaction, intégré dans une chaîne d'outils visant avant tout à la précision et la couverture linguistique. À l'aide de XMG, il est possible de construire des grammaires de façon semi-automatique à partir de connaissances linguistiques. Ces grammaires sont ensuite ancrées à l'aide de lexiques indépendants d'un quelconque formalisme. Les grammaires ancrées sont enfin utilisées par LEOPAR pour analyser des corpus bruts et produire des sorties sous forme d'arbres syntagmatiques ou de structures de dépendances.
- Published
- 2009
14. Analyse en dépendances à l'aide des grammaires d'interaction
- Author
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Marchand, Jonathan, Guillaume, Bruno, Perrier, Guy, Linear logic, proof networks and categorial grammars (CALLIGRAMME), INRIA Lorraine, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), and Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Computer Science - Computation and Language ,grammaires d'interaction ,grammaires de dépendances ,polarité ,[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL] ,analyse syntaxique - Abstract
National audience; This article proposes a method to extract dependency structures from phrase-structure level parsing with Interaction Grammars. Interaction Grammars are a formalism which expresses interactions among words using a polarity system. Syntactical composition is led by the saturation of polarities. Interactions take place between constituents, but as grammars are lexicalized, these interactions can be translated at the level of words. Dependency relations are extracted from the parsing process: every dependency is the consequence of a polarity saturation. The dependency relations we obtain can be seen as a refinement of the usual dependency tree. Generally speaking, this work sheds new light on links between phrase structure and dependency parsing.
- Published
- 2009
15. Analyse en d��pendances �� l'aide des grammaires d'interaction
- Author
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Marchand, Jonathan, Guillaume, Bruno, and Perrier, Guy
- Subjects
FOS: Computer and information sciences ,Computation and Language (cs.CL) - Abstract
This article proposes a method to extract dependency structures from phrase-structure level parsing with Interaction Grammars. Interaction Grammars are a formalism which expresses interactions among words using a polarity system. Syntactical composition is led by the saturation of polarities. Interactions take place between constituents, but as grammars are lexicalized, these interactions can be translated at the level of words. Dependency relations are extracted from the parsing process: every dependency is the consequence of a polarity saturation. The dependency relations we obtain can be seen as a refinement of the usual dependency tree. Generally speaking, this work sheds new light on links between phrase structure and dependency parsing.
- Published
- 2009
- Full Text
- View/download PDF
16. A categorical model of model merging and weaving
- Author
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Marchand, Jonathan Y., primary, Combemale, Benoit, additional, and Baudry, Benoit, additional
- Published
- 2012
- Full Text
- View/download PDF
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