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8. Claimed effects, outcome variables and methods of measurement for health claims proposed under Regulation (EC) 1924/2006 in the framework of bone health

Author

Martini, Daniela, Guareschi, Cristina, Biasini, Beatrice, Bedogni, Giorgio, Galli, Carlo, Angelino, Donato, Marchi, Laura, Zavaroni, Ivana, Pruneti, Carlo, Ventura, Marco, Galli, Daniela, Mirandola, Prisco, Vitale, Marco, Dei Cas, Alessandra, Bonadonna, Riccardo C., Passeri, Giovanni, and Del Rio, Daniele

Published
2018
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9. Nanoencapsulation of Anthocyanins from Red Cabbage (Brassica oleracea L. var. Capitata f. rubra) through Coacervation of Whey Protein Isolate and Apple High Methoxyl Pectin

Author

Fierri, Ilaria, primary, De Marchi, Laura, additional, Chignola, Roberto, additional, Rossin, Giacomo, additional, Bellumori, Maria, additional, Perbellini, Anna, additional, Mancini, Ines, additional, Romeo, Alessandro, additional, Ischia, Gloria, additional, Saorin, Asia, additional, Mainente, Federica, additional, and Zoccatelli, Gianni, additional

Published
2023
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10. SARS-CoV-2 IgG 'heritage' in newborn: A credit of maternal natural infection

Author

Marchi, Laura, Vidiri, Annalisa, Fera, Emanuele Arturo, Pallottini, Marta, Perelli, Federica, Gardelli, Monica, Brunelli, Tamara, Poggetto, Paolo Dal, Martelli, Elena, Straface, Gianluca, Signore, Fabrizio, Fusco, Ismaele, Vasarri, Pier Luigi, Scambia, Giovanni, Cavaliere, Anna Franca, Scambia, Giovanni (ORCID:0000-0003-2758-1063), Marchi, Laura, Vidiri, Annalisa, Fera, Emanuele Arturo, Pallottini, Marta, Perelli, Federica, Gardelli, Monica, Brunelli, Tamara, Poggetto, Paolo Dal, Martelli, Elena, Straface, Gianluca, Signore, Fabrizio, Fusco, Ismaele, Vasarri, Pier Luigi, Scambia, Giovanni, Cavaliere, Anna Franca, and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

Description of transplacental passage of specific SARS-CoV-2 IgG from mothers who contracted natural infection to their newborns. Retrospective cohort analysis including pregnant women diagnosed with SARS-CoV-2 and their newborns both tested for SARS-CoV-2 specific IgG and IgM with antibody titration at delivery. Nasopharyngeal swab were taken from both mothers and neonates, and tested for SARS-CoV-2 using polymerase chain reaction (PCR). IgM and IgG were analyzed in maternal and neonatal serum of 143 mother-infant dyads. 86% of women with a positive SARS-CoV-2 PCR >14 days before delivery developed specific IgG and 84% of their infants showed transplacental passage of IgG. Pregnant women infected with SARS-CoV-2 achieve antibody seroconversion following the kinetics described in the general population, and transplacental transfer of IgG specific antibodies occurs. No conclusion can be drawn on passive immunity efficacy or duration.

Published
2023

11. Contrast Agents during Pregnancy: Pros and Cons When Really Needed

Author

Perelli, Federica, primary, Turrini, Irene, additional, Giorgi, Maria Gabriella, additional, Renda, Irene, additional, Vidiri, Annalisa, additional, Straface, Gianluca, additional, Scatena, Elisa, additional, D’Indinosante, Marco, additional, Marchi, Laura, additional, Giusti, Marco, additional, Oliva, Antonio, additional, Grassi, Simone, additional, De Luca, Carmen, additional, Catania, Francesco, additional, Vizzielli, Giuseppe, additional, Restaino, Stefano, additional, Gullo, Giuseppe, additional, Eleftheriou, Georgios, additional, Mattei, Alberto, additional, Signore, Fabrizio, additional, Lanzone, Antonio, additional, Scambia, Giovanni, additional, and Cavaliere, Anna Franca, additional

Published
2022
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13. Massive foeto-maternal transfusion: how long are foetal blood cells detectable in the maternal circulation?

Author

Signore, Fabrizio, Marchi, Laura, Conti, Nathalie, Orlandini, Cinzia, Vidiri, Annalisa, Brugnolo, Francesca, Bambi, Franco, Zaami, Simona, Scambia, Giovanni, and Cavaliere, Anna Franca

Subjects
Settore MED/40 - GINECOLOGIA E OSTETRICIA, Fetus, Pregnancy, flow cytometry, perinatal death, foeto-maternal transfusion, Humans, Female, Immunohaematology, Fetal Blood, Fetomaternal Transfusion
Published
2022

14. SARS‐CoV‐2 IgG “heritage” in newborn: A credit of maternal natural infection

Author

Marchi, Laura, primary, Vidiri, Annalisa, additional, Fera, Emanuele Arturo, additional, Pallottini, Marta, additional, Perelli, Federica, additional, Gardelli, Monica, additional, Brunelli, Tamara, additional, Poggetto, Paolo Dal, additional, Martelli, Elena, additional, Straface, Gianluca, additional, Signore, Fabrizio, additional, Fusco, Ismaele, additional, Vasarri, Pier Luigi, additional, Scambia, Giovanni, additional, and Cavaliere, Anna Franca, additional

Published
2022
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17. Sex-Related Differences in Long-COVID-19 Syndrome

Author

Pelà, Giovanna, primary, Goldoni, Matteo, additional, Solinas, Emila, additional, Cavalli, Chiara, additional, Tagliaferri, Sara, additional, Ranzieri, Silvia, additional, Frizzelli, Annalisa, additional, Marchi, Laura, additional, Mori, Pier Anselmo, additional, Majori, Maria, additional, Aiello, Marina, additional, Corradi, Massimo, additional, and Chetta, Alfredo, additional

Published
2022
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19. Distribution of the Clinical Manifestations of Alpha 1 Antitrypsin Deficiency in Respiratory Outpatients from an Area of Northern Italy

Author

Aiello, Marina, primary, Marchi, Laura, additional, Ferrarotti, Ilaria, additional, Frizzelli, Annalisa, additional, Pisi, Roberta, additional, Calzetta, Luigino, additional, Manari, Gaia, additional, Pelà, Giovanna, additional, Russo, Annalisa, additional, Minerba, Roberta, additional, Aloe, Rosalia, additional, Ranzieri, Silvia, additional, Corradi, Massimo, additional, and Chetta, Alfredo, additional

Published
2022
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20. The effects of Transcranial Direct Current Stimulation on food craving and food intake in individuals affected by obesity and overweight: a mini review of the magnitude of the effects

Author

Orrù, Graziella, primary, Cesari, Valentina, additional, Malloggi, Eleonora, additional, Conversano, Ciro, additional, Menicucci, Danilo, additional, Rotondo, Alessandro, additional, Scarpazza, Cristina, additional, Marchi, Laura, additional, and Gemignani, Angelo, additional

Published
2022
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21. 308 Sex-related differences in long COVID-19 syndrome

Author

Pelà, Giovanna, primary, Aiello, Marina, additional, Solinas, Emilia, additional, Mantovanelli, Luca, additional, Cavalli, Chiara, additional, Tagliaferri, Sara, additional, Ranzieri, Silvia, additional, Frizzelli, Annalisa, additional, Marchi, Laura, additional, Corradi, Massimo, additional, Mori, Pier Anselmo, additional, Majori, Maria, additional, Goldoni, Matteo, additional, and Chetta, Alfredo, additional

Published
2021
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22. Coronavirus Disease 2019: COSeSco – A Risk Assessment Score to Predict the Risk of Pulmonary Sequelae in COVID-19 Patients

Author

Aiello, Marina, primary, Marchi, Laura, additional, Calzetta, Luigino, additional, Speroni, Silvia, additional, Frizzelli, Annalisa, additional, Ghirardini, Marianna, additional, Celiberti, Valentina, additional, Sverzellati, Nicola, additional, Majori, Maria, additional, Mori, Pier Anselmo, additional, Ranzieri, Silvia, additional, Pisi, Roberta, additional, Pelà, Giovanna, additional, Corradi, Massimo, additional, and Chetta, Alfredo, additional

Published
2021
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28. Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System

Author

Pisi,Roberta, Aiello,Marina, Frizzelli,Annalisa, Calzetta,Luigino, Marchi,Laura, Bertorelli,Giuseppina, Pisi,Giovanna, Chetta,Alfredo, Pisi,Roberta, Aiello,Marina, Frizzelli,Annalisa, Calzetta,Luigino, Marchi,Laura, Bertorelli,Giuseppina, Pisi,Giovanna, and Chetta,Alfredo

Abstract

Roberta Pisi,1 Marina Aiello,1 Annalisa Frizzelli,1 Luigino Calzetta,1 Laura Marchi,1 Giuseppina Bertorelli,1 Giovanna Pisi,2 Alfredo Chetta1 1Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy; 2Department of Pediatrics, Cystic Fibrosis Center, University Hospital, Parma, ItalyCorrespondence: Luigino CalzettaDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Viale A. Gramsci, 14, Parma, 43126, ItalyEmail luigino.calzetta@unipr.itPurpose: Smoking-induced bronchiolitis with progressive small airway dysfunction (SAD) is a leading cause of chronic obstructive pulmonary disease. We investigated the value of using the impulse oscillometry system (IOS) to detect SAD in asymptomatic smokers with preserved spirometry.Patients and Methods: We included 75 asymptomatic smokers (37 females, mean age 47± 12 years, 26± 17 pack/year) with preserved spirometry [forced expiratory volume at 1st second (FEV1)/forced vital capacity (FVC) ≥ 0.70 and normal FVC] and 34 never-smokers (19 females, mean age 42± 15 years).Results: In smokers, pack/years were significantly related to spirometry and IOS parameters (p < 0.05). The values of the fall in resistance from 5 Hz to 20 Hz (R5 – R20) were significantly and inversely related to the values of the ratio of forced expiratory volume in 3 and in 6 seconds (FEV3/FEV6) (p < 0.05). In addition, the percentage of heavy smokers (≥ 30 pack/year) with R5 – R20 > 0.07 kPa·s·L− 1, considered as IOS index of SAD, but not with FEV3/FEV6 less than a lower limit of normal, a spirometry index of SAD, was significantly higher than that of mild smokers (< 30 pack/year) and never-smokers (p < 0.05).Conclusion: This study demonstrates that IOS has the potential to detect SAD in asymptomatic heavy smokers with preserved spirometry and with FEV3/FEV6 values in the normal range. We confirm that IOS provides parameters whi

Published
2021

31. The AFLATOX® Project: Approaching the Development of New Generation, Natural-Based Compounds for the Containment of the Mycotoxigenic Phytopathogen Aspergillus flavus and Aflatoxin Contamination

Author

Montalbano, Serena, primary, Degola, Francesca, additional, Bartoli, Jennifer, additional, Bisceglie, Franco, additional, Buschini, Annamaria, additional, Carcelli, Mauro, additional, Feretti, Donatella, additional, Galati, Serena, additional, Marchi, Laura, additional, Orsoni, Nicolò, additional, Pelosi, Giorgio, additional, Pioli, Marianna, additional, Restivo, Francesco M., additional, Rogolino, Dominga, additional, Scaccaglia, Mirco, additional, Serra, Olga, additional, Spadola, Giorgio, additional, Viola, Gaia C. V., additional, Zerbini, Ilaria, additional, and Zani, Claudia, additional

Published
2021
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33. Kardiovaskuläre hämodynamische Veränderungen nach antenatalenKortikosteroiden bei Feten mit intrauteriner Wachstumsretar-dierung und bei zeitgerecht entwickelten Feten

Author

Marchi, Laura, Pasquini, Lucia, Elvan-Taşpınar, Ayten, and Bilardo, Caterina Maddalena

Subjects
fetal growth restriction, obstetrics, reproductive and urinary physiology, antenatal corticosteroids, doppler
Abstract

PURPOSE: To investigate hemodynamic effects after antenatal corticosteroids (ACS) administration in appropriate for gestational age (AGA) and early growth restricted (GR) fetuses by measurement of Doppler cardiovascular function parameters. MATERIALS AND METHODS: Prospective cohort study. AGA and GR singleton pregnancies receiving ACS for fetal lung maturation between 24 + 0 - 33 + 6 weeks were enrolled. Feto-placental vascular hemodynamics were studied by: umbilical artery (UA) pulsatility index (PI), middle cerebral artery (MCA) PI, renal artery (RenA) PI. Cardiac function was evaluated by ductus venosus (DV) PI and by echocardiographic parameters: E to A wave ratios (E/A) and mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE) for diastolic function, left and right myocardial performance index (MPI) for overall (diastolic and systolic) function. A single operator performed all the measurements at 3 different time points (E): E0 before or within 4 hours of ACS administration (baseline examination), E1 24 - 48 hours after the first dose and E2 7 days after the second dose of ACS. The values were expressed as z-scores. Pairwise comparisons with paired t-test were performed to compare measurements before and after exposure to ACS. RESULTS: 25 AGA and 20 GR fetuses (mean gestational age: 31 + 1 and 30 + 6, respectively) were included in the analysis. In the AGA group ACS administration was associated with a significant reduction in UA PI. In the GR fetuses ACS temporarily (E0-E1) restored UA-end diastolic flow (EDF) in 6 of 9 fetuses with A/R-EDF ("Return of EDF phenomenon") and produced a significant increase (worsening) in right MPI (both in E1-E2 and in E0-E2). CONCLUSION: ACS administration is associated with UA vasodilation in both AGA and GR fetuses and with an increase in right MPI in the latter group. This suggests a worsening in cardiac function in GR fetuses.

Published
2020

34. The mixed genetic origin of the first farmers of Europe

Author

Nina Marchi*, Laura Winkelbach*, Ilektra Schulz*, Maxime Brami*, Zuzana Hofmanová, Jens Blöcher, Carlos S. Reyna-Blanco, Yoan Diekmann, Alexandre Thiéry, Adamandia Kapopoulou, Vivian Link, Valérie Piuz, Susanne Kreutzer, Sylwia M. Figarska, Elissavet Ganiatsou, Albert Pukaj, Necmi Karul, Fokke Gerritsen, Joachim Pechtl, Joris Peters, Andrea Zeeb-Lanz, Eva Lenneis, Maria Teschler-Nicola, Sevast

Published
2020
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35. Psychological distress among healthcare professionals involved in the COVID-19 emergency: Vulnerability and resilience factors

Author

Conversano, Ciro, Marchi, Laura, and Miniati, Mario

Subjects
Resilience, Healthcare professionals, Perspective Article, Vulnerability, COVID-19, PTSD
Abstract

The aim of this paper is to outline some considerations about the psychological distress in healthcare professional during the COVID-19 pandemic. We summarize available literature both on ‘protective’ and ‘predisposing’ factors potentially involved in the occurrence of psychological distress, including PTSD, in frontline healthcare operators. Valid social support, self-efficacy, internal locus of control (LOC) and sense of coherence (SOC) have been considered as resilience factors, in previous studies. Likewise, several observations pointed on the relevance of individual and environmental vulnerabilities. No real evidence is available about strategies to face the emotional burden for healthcare operators due to present COVID-19 scenario. However, we strongly believe that the containment of isolation anxiety with an appropriate emotional support should be the first instrument to minimise the psychological effect of pandemic on the more exposed healthcare professionals.

Published
2020

41. Case report: vertical transmission of Plesiomonas shigelloides. Is it time to strengthen information on safety concerns for raw seafood dietary exposure in pregnancy?

Author

Cavaliere, Anna Franca, Perelli, Federica, Mattei, Alberto, Dal Poggetto, Paolo, Marchi, Laura, Vidiri, Annalisa, Turrini, Irene, Aquilini, Donatella, Brunelli, Tamara, Scambia, Giovanni, Straface, Gianluca, Orfeo, Luigi, and Vasarri, Pierluigi

Subjects
FOODBORNE diseases, SEAFOOD, NEONATAL infections, FISH pathogens, NEONATAL death, AEROMONAS diseases, NEONATAL diseases
Abstract

The consumption of raw seafood, generally considered to be a healthy food, has greatly increased worldwide. Pathogens of fish can cause foodborne illnesses in humans, especially following the consumption of raw seafood from contaminated water. Foodborne illness in pregnant women is seldom the cause of neonatal infection, but, as in the reported cases, it has been associated with a high degree of morbidity and mortality. We present the case of a newborn with septicemia and meningitis caused by Plesiomonas shigelloides acquired via the transplacental route. There was a maternal history of ingestion of raw seafood 1 week prior to delivery. A few similar cases are described in the existing literature, which reports 7 neonatal deaths. Therefore, the primary objective of this paper is to highlight the fact that the popularity of raw seafood such as sushi, sashimi, and oysters, requires an improvement in dietary advice regarding unsafe choices in pregnancy in order to avoid preventable foodborne diseases, sometimes fatal for the newborn. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Coronavirus Disease 2019: COSeSco – A Risk Assessment Score to Predict the Risk of Pulmonary Sequelae in COVID-19 Patients.

Author

Aiello, Marina, Marchi, Laura, Calzetta, Luigino, Speroni, Silvia, Frizzelli, Annalisa, Ghirardini, Marianna, Celiberti, Valentina, Sverzellati, Nicola, Majori, Maria, Mori, Pier Anselmo, Ranzieri, Silvia, Pisi, Roberta, Pelà, Giovanna, Corradi, Massimo, and Chetta, Alfredo

Subjects
*EXPERIMENTAL design, *COVID-19, *RESEARCH methodology, *LUNGS, *IDIOPATHIC interstitial pneumonias, *RESPIRATORY measurements, *FUNCTIONAL assessment, *DYSPNEA, *HOSPITAL care, *COMPUTED tomography, *BODY mass index, *FIBRIN fibrinogen degradation products
Abstract

Background: The presence of interstitial pneumonia in coronavirus disease 2019 (COVID-19) patients, as diagnosed through laboratory, functional, and radiological data, provides potential predicting factors of pulmonary sequelae. Objectives: The objectives were the creation of a risk assessment score for pulmonary sequelae at high-resolution computed tomography (HRCT) through the assessment of laboratory data, lung function, and radiological changes in patients after the onset of COVID-19 interstitial pneumonia and the identification of predictive factors. Methods: We enrolled 121 subjects hospitalized due to COVID-19 pneumonia in our study. Clinical features, Charlson Comorbidity Index (CCI) score, HRCT score, and blood chemistry data at hospital admission, as well as HRCT score, pulmonary function testing values, exercise capacity by means of a 6-Minute Walk Test (6MWT), and dyspnea perception by the modified Medical Research Council (mMRC) at 4-month follow-up, were all recorded. The variables were elaborated in order to create a predictive model to identify patients at high risk of pulmonary sequelae at HRCT. Results: At the time of follow-up visit, 63% of patients had functional abnormality (diffusion lung capacity and/or total lung capacity <80% of predicted). Age, BMI, CCI, D-dimer, 6MWT, and mMRC were included in the COVID-19 Sequelae Score (COSeSco, ranging 0–15), which was able to individuate COVID-19 patients with radiologic sequelae (HRCT score >10%) at follow-up. The most revelatory COSeSco value that was found to intercept the highest sensitivity (100%) and specificity (77%) was 2. Conclusion: The COSeSco – comprising age, BMI, comorbidities, D-dimer, walking distance, and dyspnea perception – makes it possible to identify particularly at-risk COVID-19 patients who are likely to develop pulmonary sequelae assessed by HRCT. [ABSTRACT FROM AUTHOR]

Published
2022
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43. A by‐product from virgin olive oil production (pâté) encapsulated by fluid bed coating: evaluation of the phenolic profile after shelf‐life test and invitro gastrointestinal digestion.

Author

Bellumori, Maria, De Marchi, Laura, Mainente, Federica, Zanoni, Francesca, Cecchi, Lorenzo, Innocenti, Marzia, Mulinacci, Nadia, and Zoccatelli, Gianni

Subjects
*OLIVE oil, *PHENOLS, *DIGESTION, *COATING processes, *ACCELERATED life testing, *PLANT phenols
Abstract

Pâté is a by‐product of virgin olive oil production presenting a high phenolic content and beneficial health effects. This research aims to evaluate the storage stability of phenolic compounds of pâté and a coated formulation, and to verify the bioaccessibility of the phenolic compounds. An accelerated shelf‐life test at 40 °C/75% relative humidity was carried out for 75 days. Different combinations of degradative and hydrolytic reactions impacted the results. Indeed, at the end of the storage period, 84% of phenols was recovered in pâté with free tyrosol and hydroxytyrosol showing an increase due to secoiridoids hydrolysis. The total phenolic content of coated pâté did not significantly decrease, showing a higher increment of free tyrosol and hydroxytyrosol. Simulated digestion led to the liberation of 15% of phenols by both samples. In conclusion, the coating process improved the stability of pâté phenolic compounds without affecting their bioaccessibility. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Thermal degradation of red cabbage (Brassica oleracea L. var. Capitata f. rubra) anthocyanins in a water model extract under accelerated shelf-life testing.

Author

De Marchi, Laura, Salemi, Laura, Bellumori, Maria, Chignola, Roberto, Mainente, Federica, Santisteban Soto, Diana Vanessa, Fierri, Ilaria, Ciulu, Marco, and Zoccatelli, Gianni

Subjects
*COLE crops, *ACCELERATED life testing, *ANTHOCYANINS, *CABBAGE, *HYDROXYCINNAMIC acids, *FERULIC acid
Abstract

• Red cabbage (RC) anthocyanins (ACNs) degradation followed 1st order kinetics. • Acylation is not always correlated with higher stability of ACNs. • The presence of sinapic acid in acylation pattern negatively affects ACNs stability. • The glycosylation of HCA increases the stability of ACNs. • The radical-scavenging capacity of HCAs negatively influences ACNs stability. Red cabbage (RC) represents a source of anthocyanins acylated with hydroxycinnamic acids (HCA) that are described to enhance their stability. Nevertheless, data about their thermal degradation are still controversial. Our aim was to comprehensively analyse the degradation kinetics of individual RC anthocyanins in a model aqueous extract treated at 40 °C × 30 days to simulate severe but realistic storage conditions. Free anthocyanins and radical-scavenging capacity showed different kinetics. The results confirm the high stability of RC anthocyanins (t 1/2 : 16.4–18.4 days), although HPLC analyses of each molecule displayed distinct kinetics with t 1/2 from 12.6 to 35.1 days. In particular, the sinapoyl acylation negatively affected the stability of the anthocyanins, while the forms monoacylated with glycosyl p -coumaric and ferulic acids exhibited higher stability. In conclusion, our results indicate that acylation is not a prerogative of stability, as this is instead more dependent on specific acylation patterns and the glycosylation of HCA. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Catastrophizing and Fibromyalgia: A Mini-Review

Author

Veronica Mirabelli, Marchi Laura, Ciacchini Rebecca, Gemignani Angelo, Ciro Conversano, and Dr. Francine, M. Benes

Subjects
Catastrophizing, Fibromyalgia, medicine.diagnostic_test, business.industry, Chronic pain, Cognition, Physical examination, medicine.disease, Mini review, [SDV] Life Sciences [q-bio], Emotional distress, medicine, Anxiety, medicine.symptom, business, Depression (differential diagnoses), Clinical psychology
Abstract

Fibromyalgia is a syndrome characterized by widespread muscular-skeletal pain without any significant alterations upon physical examination and laboratory and radiological tests. From an analysis of the literature, it appears that in subjects affected by FM there is a tendency to catastrophize pain (that is, a negative assessment of pain and its consequences) and that this, in turn, is associated with psychological stress (anxiety, depression), with the experience of the pain itself, and adjustment to the illness. The aim of this study is to provide a synthesis of the most recent studies that investigate the relationship between pain, catastrophizing of pain and emotional distress in subjects with fibromyalgia, highlighting also the neurobiological correlates of catastrophizing and the treatments considered efficacious for fibromyalgic patients. Studying the cognitive, affective and biological variables that influence pain in fibromyalgia may help us to set up treatments that are more specific and effective for this type of patient.

Published
2018

49. Passive immunity in newborn from SARS‐CoV‐2‐infected mother.

Author

Cavaliere, Anna F., Marchi, Laura, Aquilini, Donatella, Brunelli, Tamara, and Vasarri, Pier L.

Subjects
SARS-CoV-2, MATERNALLY acquired immunity, AMNIOTIC liquid, IMMUNITY, IMMUNOGLOBULIN G
Abstract

Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) vertical transmission is an open issue. Recent reports call into question in utero or peripartum viral transmission to the offspring. Few data are available on immunoglobulin G (IgG) and/or IgM in newborns. Insufficient evidence is available regarding passive immunity in neonates born from SARS‐CoV‐2 infected women. We report a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal swab. He was born from an asymptomatic SARS‐CoV‐2‐infected mother with positive IgG and IgM. The transplacental passage of specific IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity. Highlights: The risk of vertical transmission of SARS‐CoV‐2 is still an open question.In affected SARS‐CoV‐2 pregnant women, investigation of vertical transmission and passive immunity requires the detection of the virus in the placenta, amniotic fluid and newborn and both the maternal and neonatal IgG and IgM.Passive immunity may offer temporary protection to the newborn. Studies are needed to determine the duration of this protection. [ABSTRACT FROM AUTHOR]

Published
2021
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