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1. Infectious Toscana Virus in Seminal Fluid of Young Man Returning from Elba Island, Italy

Author

Matusali, Giulia, D'Abramo, Alessandra, Terrosi, Chiara, Carletti, Fabrizio, Colavita, Francesca, Vairo, Francesco, Savellini, Gianni Gori, Gandolfo, Claudia, Anichini, Gabriele, Lalle, Eleonora, Bordi, Licia, Corpolongo, Angela, Maritti, Micaela, Marchioni, Luisa, Capobianchi, Maria Rosaria, Castilletti, Concetta, Cusi, Maria Grazia, and Nicastri, Emanuele

Subjects
Semen -- Case studies -- Health aspects, Bunyaviruses -- Case studies -- Identification and classification, RNA virus infections -- Case studies -- Risk factors -- Diagnosis, Viral meningitis -- Case studies -- Risk factors -- Diagnosis, Health
Abstract

Toscana virus (TOSV) is an arthropodborne virus, belonging to the genus Phlebovirus, that was first isolated in Monte Argentario in 1971 from the sand flies Phlebotomus perniciosus and P. perfiliewi [...]

Published
2022
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2. Epidemiology of ventilator-associated pneumonia in ICU COVID-19 patients: an alarming high rate of multidrug-resistant bacteria

Author

Tetaj, Nardi, Capone, Alessandro, Stazi, Giulia Valeria, Marini, Maria Cristina, Garotto, Gabriele, Busso, Donatella, Scarcia, Silvana, Caravella, Ilaria, Macchione, Manuela, De Angelis, Giada, Di Lorenzo, Rachele, Carucci, Alessandro, Antonica, Maria Vittoria, Gaviano, Ilaria, Inversi, Carlo, Agostini, Elisabetta, Canichella, Flaminia, Taloni, Giorgia, Evangelista, Francesca, Onnis, Ilaria, Mogavero, Giulia, Lamanna, Maria Elena, Rubino, Dorotea, Di Frischia, Mattia, Porcelli, Candido, Cesi, Elena, Antinori, Andrea, Palmieri, Fabrizio, D’Offizi, Gianpiero, Taglietti, Fabrizio, Nisii, Carla, Cataldo, Maria Adriana, Ianniello, Stefania, Campioni, Paolo, Vaia, Francesco, Nicastri, Emanuele, Girardi, Enrico, and Marchioni, Luisa

Published
2022
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3. Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Published
2022
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4. Predictors of Mortality and Orotracheal Intubation in Patients with Pulmonary Barotrauma Due to COVID-19: An Italian Multicenter Observational Study during Two Years of the Pandemic

Author

Tetaj, Nardi, primary, De Pascale, Gennaro, additional, Antonelli, Massimo, additional, Vargas, Joel, additional, Savino, Martina, additional, Pugliese, Francesco, additional, Alessandri, Francesco, additional, Giordano, Giovanni, additional, Tozzi, Pierfrancesco, additional, Rocco, Monica, additional, Biava, Anna Maria, additional, Maggi, Luigi, additional, Pisapia, Raffaella, additional, Fusco, Francesco Maria, additional, Stazi, Giulia Valeria, additional, Garotto, Gabriele, additional, Marini, Maria Cristina, additional, Piselli, Pierluca, additional, Beccacece, Alessia, additional, Mariano, Andrea, additional, Giancola, Maria Letizia, additional, Ianniello, Stefania, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Antinori, Andrea, additional, Bocci, Maria Grazia, additional, Marchioni, Luisa, additional, and Nicastri, Emanuele, additional

Published
2024
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5. Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia

Author

Camici, Marta, Zuppi, Paolo, Lorenzini, Patrizia, Scarnecchia, Liliana, Pinnetti, Carmela, Cicalini, Stefania, Nicastri, Emanuele, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Marchioni, Luisa, Gagliardini, Roberta, Baldelli, Roberto, Schininà, Vincenzo, Pianura, Elisa, Di Stefano, Federica, Curcio, Stefano, Ciavarella, Lucia, Ippolito, Giuseppe, Girardi, Enrico, Vaia, Francesco, and Antinori, Andrea

Published
2021
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6. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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9. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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10. Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Author

Agrati, Chiara, Sacchi, Alessandra, Bordoni, Veronica, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Casetti, Rita, Tartaglia, Eleonora, Lalle, Eleonora, D’Abramo, Alessandra, Castilletti, Concetta, Marchioni, Luisa, Shi, Yufang, Mariano, Andrea, Song, Jin-Wen, Zhang, Ji-Yuan, Wang, Fu-Sheng, Zhang, Chao, Fimia, Gian Maria, Capobianchi, Maria R., Piacentini, Mauro, Antinori, Andrea, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, and Ippolito, Giuseppe

Published
2020
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12. Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

Author

Sacchi, Alessandra, Grassi, Germana, Bordoni, Veronica, Lorenzini, Patrizia, Cimini, Eleonora, Casetti, Rita, Tartaglia, Eleonora, Marchioni, Luisa, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Notari, Stefania, Tempestilli, Massimo, Capobianchi, Maria Rosaria, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, Locatelli, Franco, Antinori, Andrea, Ippolito, Giuseppe, and Agrati, Chiara

Published
2020
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13. Evolution of SARS‐CoV‐2 variants of concern over a period of Delta and Omicron cocirculation, among patients hospitalized for COVID‐19 in an Italian reference hospital: Impact on clinical outcomes

Author

Mondi, Annalisa, primary, Mastrorosa, Ilaria, additional, Piselli, Pierluca, additional, Cimaglia, Claudia, additional, Matusali, Giulia, additional, Carletti, Fabrizio, additional, Giannico, Giuseppina, additional, Milozzi, Eugenia, additional, Biliotti, Elisa, additional, Di Bari, Silvia, additional, Chinello, Pierangelo, additional, Beccacece, Alessia, additional, Faraglia, Francesca, additional, Vittozzi, Pietro, additional, Mosti, Silvia, additional, Tetaj, Nardi, additional, Stazi, Giulia Valeria, additional, Pinnetti, Carmela, additional, Camici, Marta, additional, D'Annunzio, Alberto, additional, Marani, Alessandra, additional, Fabeni, Lavinia, additional, Specchiarello, Eliana, additional, Gruber, Cesare Ernesto Maria, additional, Villanacci, Alberta, additional, Minicucci, Sabrina, additional, Garbuglia, Anna Rosa, additional, Ianniello, Stefania, additional, Marchioni, Luisa, additional, Taglietti, Fabrizio, additional, D'Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Maggi, Fabrizio, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, and Antinori, Andrea, additional

Published
2023
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15. Aero-Medical Evacuation during SARS-CoV-2 Pandemic: Extraordinary Measure or Emerging Treatment Option?

Author

Benvenuto, Domenico, primary, Ascoli Bartoli, Tommaso, additional, Curtolo, Ambrogio, additional, Palazzolo, Claudia, additional, Vita, Serena, additional, Mariano, Andrea, additional, Scorzolini, Laura, additional, Ippolito, Giuseppe, additional, Marchioni, Luisa, additional, Cerini, Federico, additional, D’Offizi, Gianpiero, additional, Vaia, Francesco, additional, and Nicastri, Emanuele, additional

Published
2022
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16. Gut microbiota composition in COVID-19 hospitalized patients with mild or severe symptoms

Author

Mazzarelli, Antonio, primary, Giancola, Maria Letizia, additional, Fontana, Andrea, additional, Piselli, Pierluca, additional, Binda, Elena, additional, Trivieri, Nadia, additional, Mencarelli, Gandino, additional, Marchioni, Luisa, additional, Vulcano, Antonella, additional, De Giuli, Chiara, additional, Panebianco, Concetta, additional, Villani, Annacandida, additional, Copetti, Massimiliano, additional, Perri, Francesco, additional, Fontana, Carla, additional, Nicastri, Emanuele, additional, and Pazienza, Valerio, additional

Published
2022
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18. Imaging Severity COVID-19 Assessment in Vaccinated and Unvaccinated Patients: Comparison of the Different Variants in a High Volume Italian Reference Center

Author

Granata, Vincenza, primary, Fusco, Roberta, additional, Villanacci, Alberta, additional, Magliocchetti, Simona, additional, Urraro, Fabrizio, additional, Tetaj, Nardi, additional, Marchioni, Luisa, additional, Albarello, Fabrizio, additional, Campioni, Paolo, additional, Cristofaro, Massimo, additional, Di Stefano, Federica, additional, Fusco, Nicoletta, additional, Petrone, Ada, additional, Schininà, Vincenzo, additional, Grassi, Francesca, additional, Girardi, Enrico, additional, and Ianniello, Stefania, additional

Published
2022
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20. Timing and outcomes of noninvasive ventilation in 307 ARDS COVID-19 patients: an observational study in an Italian third level COVID-19 hospital

Author

Tetaj, Nardi, primary, Piselli, Pierluca, additional, Zito, Sara, additional, De Angelis, Giada, additional, Marini, Maria Cristina, additional, Rubino, Dorotea, additional, Onnis, Ilaria, additional, Gaviano, Ilaria, additional, Antonica, Maria Vittoria, additional, Agostini, Elisabetta, additional, Porcelli, Candido, additional, Stazi, Giulia Valeria, additional, Garotto, Gabriele, additional, Busso, Donatella, additional, D’Aprano, Silvana Scarcia, additional, Navarra, Assunta, additional, Cimaglia, Claudia, additional, Topino, Simone, additional, Iacomi, Fabio, additional, D’Abramo, Alessandra, additional, Pinnetti, Carmela, additional, Gualano, Gina, additional, Capone, Alessandro, additional, Villanacci, Alberta, additional, Antinori, Andrea, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Ianniello, Stefania, additional, Taglietti, Fabrizio, additional, Campioni, Paolo, additional, Vaia, Francesco, additional, Nicastri, Emanuele, additional, Girardi, Enrico, additional, and Marchioni, Luisa, additional

Published
2022
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21. Additional file 1 of Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Abstract

Additional file 1: Tables S1: Demographics, clinical baseline characteristics, therapy and cause of death of COVID-19 patients.

Published
2022
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22. Aero-Medical Evacuation during SARS-CoV-2 Pandemic: Extraordinary Measure or Emerging Treatment Option?

Author

Benvenuto, Domenico, Ascoli Bartoli, Tommaso, Curtolo, Ambrogio, Palazzolo, Claudia, Vita, Serena, Mariano, Andrea, Scorzolini, Laura, Ippolito, Giuseppe, Marchioni, Luisa, Cerini, Federico, D'Offizi, Gianpiero, Vaia, Francesco, and Nicastri, Emanuele

Subjects
COVID-19 pandemic, CIVILIAN evacuation, COMMUNICABLE diseases, MIXED infections, HUMAN resources departments, NEONATAL sepsis
Abstract

Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the clinical course of 17 patients medically evacuated to the "L. Spallanzani" Institute in Rome, Italy from foreign countries, mainly Africa and Eastern Europe, who had COVID-19 pneumonia with, or without, coinfections such as malaria, HIV, tuberculosis and microbiologically confirmed sepsis syndrome. The aero-medical evacuation of patients with infectious diseases has become one of the greatest medical achievements we have reached during this pandemic; in fact, only two patients with life threatening coinfections have died. Although logistically difficult and cost consuming, medical evacuation should be considered as a treatment option more than a single extraordinary measure, especially among complex cases that require specific technical and human resources. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Characteristics and Outcomes of COVID-19-Related Hospitalization among PLWH

Author

Gagliardini, Roberta, primary, Vergori, Alessandra, additional, Lorenzini, Patrizia, additional, Cicalini, Stefania, additional, Pinnetti, Carmela, additional, Mazzotta, Valentina, additional, Mondi, Annalisa, additional, Mastrorosa, Ilaria, additional, Camici, Marta, additional, Lanini, Simone, additional, Fusto, Marisa, additional, Paulicelli, Jessica, additional, Plazzi, Maria Maddalena, additional, Marchioni, Luisa, additional, Agrati, Chiara, additional, Garbuglia, Anna Rosa, additional, Piselli, Pierluca, additional, Nicastri, Emanuele, additional, Taglietti, Fabrizio, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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24. Management of Spontaneous Bleeding in COVID-19 Inpatients: Is Embolization Always Needed?

Author

Riu, Pascale, primary, Albarello, Fabrizio, additional, Di Stefano, Federica, additional, Vergori, Alessandra, additional, D’Abramo, Alessandra, additional, Cerini, Carlo, additional, Nocioni, Martina, additional, Morucci, Maurizio, additional, Tetaj, Nardi, additional, Cristofaro, Massimo, additional, Schininà, Vincenzo, additional, Campioni, Paolo, additional, Petrone, Ada, additional, Fusco, Nicoletta, additional, Marchioni, Luisa, additional, Antinori, Andrea, additional, Nicastri, Emanuele, additional, Cianni, Roberto, additional, and Ianniello, Stefania, additional

Published
2021
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26. Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report

Author

De Rienzo, Mafalda, primary, Foddai, Maria Laura, additional, Conti, Laura, additional, Mandoj, Chiara, additional, Iaboni, Stefano, additional, Saladini, Ilenia, additional, Castilletti, Concetta, additional, Matusali, Giulia, additional, Donno, Davide Roberto, additional, Marchioni, Luisa, additional, Ianniello, Stefania, additional, Corpolongo, Angela, additional, Palange, Maria, additional, Ciliberto, Gennaro, additional, Piaggio, Giulia, additional, and De Marco, Federico, additional

Published
2021
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27. Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection

Author

Sacchi, Alessandra, primary, Grassi, Germana, additional, Notari, Stefania, additional, Gili, Simona, additional, Bordoni, Veronica, additional, Tartaglia, Eleonora, additional, Casetti, Rita, additional, Cimini, Eleonora, additional, Mariotti, Davide, additional, Garotto, Gabriele, additional, Beccacece, Alessia, additional, Marchioni, Luisa, additional, Bibas, Michele, additional, Nicastri, Emanuele, additional, Ippolito, Giuseppe, additional, and Agrati, Chiara, additional

Published
2021
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28. Outcomes and Timing of Bedside Percutaneous Tracheostomy of COVID-19 Patients Over a Year in Intensive Care Unit

Author

Tetaj, Nardi, primary, Maritti, Micaela, additional, Stazi, Giulia, additional, Marini, Maria Cristina, additional, Centanni, Daniele, additional, Garotto, Gabriele, additional, Caravella, Ilaria, additional, Dantimi, Cristina, additional, Fusetti, Matteo, additional, Santagata, Carmen, additional, Macchione, Manuela, additional, De Angelis, Giada, additional, Giansante, Filippo, additional, Busso, Donatella, additional, Di Lorenzo, Rachele, additional, Scarcia, Silvana, additional, Carucci, Alessandro, additional, Cabas, Ricardo, additional, Gaviano, Ilaria, additional, Petrosillo, Nicola, additional, Antinori, Andrea, additional, Palmieri, Fabrizio, additional, D'Offizi, Gianpiero, additional, Ianniello, Stefania, additional, Campioni, Paolo, additional, Pugliese, Francesco, additional, Vaia, Francesco, additional, Nicastri, Emanuele, additional, Ippolito, Giuseppe, additional, and Marchioni, Luisa, additional

Published
2021
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29. Outcomes and timing of bedside percutaneous tracheostomy of covid-19 patients over a year in the intensive care unit

Author

Tetaj, Nardi, Maritti, Micaela, Stazi, Giulia, Marini, Maria, Centanni, Daniele, Garotto, Gabriele, Caravella, Ilaria, Dantimi, Cristina, Fusetti, Matteo, Santagata, Carmen, Macchione, Manuela, Angelis, Giada De, Giansante, Filippo, Busso, Donatella, Lorenzo, Rachele Di, Scarcia, Silvana, Carucci, Alessandro, Cabas, Ricardo, Gaviano, Ilaria, Petrosillo, Nicola, Antinori, Andrea, Palmieri, Fabrizio, D’Offizi, Gianpiero, Ianniello, Stefania, Campioni, Paolo, Pugliese, Francesco, Vaia, Francesco, Nicastri, Emanuele, Ippolito, Giuseppe, Marchioni, Luisa, and Group, ICU COVID-19 Study

Subjects
medicine.medical_specialty, Percutaneous, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, early tracheostomy, 030204 cardiovascular system & hematology, mechanical ventilation, Article, law.invention, NO, 03 medical and health sciences, 0302 clinical medicine, law, Case fatality rate, medicine, polycyclic compounds, percutaneous tracheostomy, Intensive care unit, Mechanical ventilation, business.industry, healthcare workers, late tracheostomy, 030208 emergency & critical care medicine, General Medicine, eye diseases, icu stay, covid-19, Emergency medicine, Percutaneous tracheostomy, Breathing, Medicine, icu length of stay, business, therapeutics
Abstract

Background: The benefits and timing of percutaneous dilatational tracheostomy (PDT) in Intensive Care Unit (ICU) COVID-19 patients are still controversial. PDT is considered a high-risk procedure for the transmission of SARS-CoV-2 to healthcare workers (HCWs). The present study analyzed the optimal timing of PDT, the clinical outcomes of patients undergoing PDT, and the safety of HCWs performing PDT. Methods: Of the 133 COVID-19 patients who underwent PDT in our ICU from 1 April 2020 to 31 March 2021, 13 patients were excluded, and 120 patients were enrolled. A trained medical team was dedicated to the PDT procedure. Demographic, clinical history, and outcome data were collected. Patients who underwent PDT were stratified into two groups: an early group (PDT ≤ 12 days after orotracheal intubation (OTI) and a late group (&gt, 12 days after OTI). An HCW surveillance program was also performed. Results: The early group included 61 patients and the late group included 59 patients. The early group patients had a shorter ICU length of stay and fewer days of mechanical ventilation than the late group (p &lt, 0.001). On day 7 after tracheostomy, early group patients required fewer intravenous anesthetic drugs and experienced an improvement of the ventilation parameters PaO2/FiO2 ratio, PEEP, and FiO2 (p &lt, 0.001). No difference in the case fatality ratio between the two groups was observed. No SARS-CoV-2 infections were reported in the HCWs performing the PDTs. Conclusions: PDT was safe and effective for COVID-19 patients since it improved respiratory support parameters, reduced ICU length of stay and duration of mechanical ventilation, and optimized the weaning process. The procedure was safe for all HCWs involved in the dedicated medical team. The development of standardized early PDT protocols should be implemented, and PDT could be considered a first-line approach in ICU COVID-19 patients requiring prolonged mechanical ventilation.

Published
2021

30. Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger?

Author

Del Nonno, Franca, primary, Nardacci, Roberta, additional, Colombo, Daniele, additional, Visco-Comandini, Ubaldo, additional, Cicalini, Stefania, additional, Antinori, Andrea, additional, Marchioni, Luisa, additional, D’Offizi, Gianpiero, additional, Piacentini, Mauro, additional, and Falasca, Laura, additional

Published
2021
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31. No Efficacy of the Combination of Lopinavir/Ritonavir Plus Hydroxychloroquine Versus Standard of Care in Patients Hospitalized With COVID-19: A Non-Randomized Comparison

Author

Gagliardini, Roberta, primary, Cozzi-Lepri, Alessandro, additional, Mariano, Andrea, additional, Taglietti, Fabrizio, additional, Vergori, Alessandra, additional, Abdeddaim, Amina, additional, Di Gennaro, Francesco, additional, Mazzotta, Valentina, additional, Amendola, Alessandra, additional, D’Offizi, Giampiero, additional, Palmieri, Fabrizio, additional, Marchioni, Luisa, additional, Piselli, Pierluca, additional, Agrati, Chiara, additional, Nicastri, Emanuele, additional, Capobianchi, Maria Rosaria, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, and Antinori, Andrea, additional

Published
2021
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32. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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33. Elevated P-Selectin in Severe Covid-19: Considerations for therapeutic options

Author

Agrati, Chiara, primary, Bordoni, Veronica, additional, Sacchi, Alessandra, additional, Grassi, Germana, additional, Petrosillo, Nicola, additional, Nicastri, Emanuele, additional, Del nonno, Franca, additional, D'offizi, Giampiero, additional, Palmieri, Fabrizio, additional, Marchioni, Luisa, additional, Capobianchi, Maria rosaria, additional, Antinori, Andrea, additional, Ippolito, Giuseppe, additional, and Bibas, Michele, additional

Published
2021
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34. Investigation of Nasal/Oropharyngeal Microbial Community of COVID-19 Patients by 16S rDNA Sequencing

Author

Rueca, Martina, primary, Fontana, Andrea, additional, Bartolini, Barbara, additional, Piselli, Pierluca, additional, Mazzarelli, Antonio, additional, Copetti, Massimiliano, additional, Binda, Elena, additional, Perri, Francesco, additional, Gruber, Cesare Ernesto Maria, additional, Nicastri, Emanuele, additional, Marchioni, Luisa, additional, Ippolito, Giuseppe, additional, Capobianchi, Maria Rosaria, additional, Di Caro, Antonino, additional, and Pazienza, Valerio, additional

Published
2021
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35. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
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36. An inflammatory profile correlates with decreased frequency of cytotoxic cells in COVID-19

Author

Bordoni, Veronica, Sacchi, Alessandra, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Tartaglia, Eleonora, Casetti, Rita, Giancola, Letizia, Bevilacqua, Nazario, Maeurer, Markus, Zumla, Alimuddin, Locatelli, Franco, De Benedetti, Fabrizio, Palmieri, Fabrizio, Marchioni, Luisa, Capobianchi, Maria R, D’Offizi, Gianpiero, Petrosillo, Nicola, Antinori, Andrea, Nicastri, Emanuele, Ippolito, Giuseppe, and Agrati, Chiara

Subjects
Inflammation, Male, Perforin, SARS-CoV-2, Brief Report, MDSC, COVID-19, chemical and pharmacologic phenomena, NK cells, Middle Aged, Lymphocyte Activation, Killer Cells, Natural, Intensive Care Units, AcademicSubjects/MED00290, Italy, Cytokines, Humans, Female, cytotoxic cells, Aged, T-Lymphocytes, Cytotoxic
Abstract

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

Published
2020

37. COVID-19 disease—Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study

Author

Lanini, Simone, primary, Montaldo, Chiara, additional, Nicastri, Emanuele, additional, Vairo, Francesco, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Scognamiglio, Paola, additional, Antinori, Andrea, additional, Puro, Vincenzo, additional, Di Caro, Antonino, additional, De Carli, Gabriella, additional, Navarra, Assunta, additional, Agresta, Alessandro, additional, Cimaglia, Claudia, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Marchioni, Luisa, additional, Kobinger, Gary Pignac, additional, Maeurer, Markus, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Zumla, Alimuddin, additional, Locatelli, Franco, additional, and Ippolito, Giuseppe, additional

Published
2020
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38. Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

Author

Carsetti, Rita, primary, Zaffina, Salvatore, additional, Piano Mortari, Eva, additional, Terreri, Sara, additional, Corrente, Francesco, additional, Capponi, Claudia, additional, Palomba, Patrizia, additional, Mirabella, Mattia, additional, Cascioli, Simona, additional, Palange, Paolo, additional, Cuccaro, Ilaria, additional, Milito, Cinzia, additional, Zumla, Alimuddin, additional, Maeurer, Markus, additional, Camisa, Vincenzo, additional, Vinci, Maria Rosaria, additional, Santoro, Annapaola, additional, Cimini, Eleonora, additional, Marchioni, Luisa, additional, Nicastri, Emanuele, additional, Palmieri, Fabrizio, additional, Agrati, Chiara, additional, Ippolito, Giuseppe, additional, Porzio, Ottavia, additional, Concato, Carlo, additional, Onetti Muda, Andrea, additional, Raponi, Massimiliano, additional, Quintarelli, Concetta, additional, Quinti, Isabella, additional, and Locatelli, Franco, additional

Published
2020
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40. Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia

Author

Vergori, Alessandra, primary, Lorenzini, Patrizia, additional, Lepri, Alessandro Cozzi, additional, Donno, Davide Roberto, additional, Gualano, Gina, additional, Nicastri, Emanuele, additional, Iacomi, Fabio, additional, Marchioni, Luisa, additional, Campioni, Paolo, additional, Schininà, Vincenzo, additional, Cicalini, Stefania, additional, Agrati, Chiara, additional, Capobianchi, Maria Rosaria, additional, Girardi, Enrico, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Petrosillo, Nicola, additional, Antinori, Andrea, additional, and Taglietti, Fabrizio, additional

Published
2020
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41. Postmortem Findings in Italian Patients With COVID-19: A Descriptive Full Autopsy Study of Cases With and Without Comorbidities

Author

Falasca, Laura, primary, Nardacci, Roberta, additional, Colombo, Daniele, additional, Lalle, Eleonora, additional, Di Caro, Antonino, additional, Nicastri, Emanuele, additional, Antinori, Andrea, additional, Petrosillo, Nicola, additional, Marchioni, Luisa, additional, Biava, Gianluigi, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Goletti, Delia, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, Piacentini, Mauro, additional, and Del Nonno, Franca, additional

Published
2020
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42. Compartmentalized Replication of SARS-Cov-2 in Upper vs. Lower Respiratory Tract Assessed by Whole Genome Quasispecies Analysis

Author

Rueca, Martina, primary, Bartolini, Barbara, additional, Gruber, Cesare Ernesto Maria, additional, Piralla, Antonio, additional, Baldanti, Fausto, additional, Giombini, Emanuela, additional, Messina, Francesco, additional, Marchioni, Luisa, additional, Ippolito, Giuseppe, additional, Di Caro, Antonino, additional, and Capobianchi, Maria Rosaria, additional

Published
2020
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43. An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019

Author

Bordoni, Veronica, primary, Sacchi, Alessandra, additional, Cimini, Eleonora, additional, Notari, Stefania, additional, Grassi, Germana, additional, Tartaglia, Eleonora, additional, Casetti, Rita, additional, Giancola, Maria Letizia, additional, Bevilacqua, Nazario, additional, Maeurer, Markus, additional, Zumla, Alimuddin, additional, Locatelli, Franco, additional, De Benedetti, Fabrizio, additional, Palmieri, Fabrizio, additional, Marchioni, Luisa, additional, Capobianchi, Maria R, additional, D’Offizi, Gianpiero, additional, Petrosillo, Nicola, additional, Antinori, Andrea, additional, Nicastri, Emanuele, additional, Ippolito, Giuseppe, additional, and Agrati, Chiara, additional

Published
2020
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44. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Albarello, Fabrizio, primary, Pianura, Elisa, additional, Di Stefano, Federica, additional, Cristofaro, Massimo, additional, Petrone, Ada, additional, Marchioni, Luisa, additional, Palazzolo, Claudia, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Petrosillo, Nicola, additional, Campioni, Paolo, additional, Eskild, Petersen, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, Abbonizio, Maria Alessandra, additional, Agrati, Chiara, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonini, Mario, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Branca, Marta, additional, Capobianchi, Maria Rosaria, additional, Caporale, Cinzia, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Castilletti, Concetta, additional, Chiappini, Roberta, additional, Ciaralli, Carmine, additional, Colavita, Francesca, additional, Corpolongo, Angela, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, Angelis, Alessia De, additional, Angelis, Giada De, additional, Lorenzo, Rachele Di, additional, Stefano, Federica Di, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Greci, Maria Cristina, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Marani, Alessandra, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Matusali, Giulia, additional, Meschi, Silvia, additional, Montaldo, Francesco Messina Chiara, additional, Murachelli, Silvia, additional, Noto, Roberto, additional, Pallini, Emanuele, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Petrecchia, Antonella, additional, Pisciotta, Maria, additional, Pittalis, Silvia, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Rinonapoli, Gabriele, additional, Rueca, Martina, additional, Sacchi, Alessandra, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarcia, Silvana, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Vaia, Francesco, additional, Vairo, Francesco, additional, and Valli, Maria Beatrice, additional

Published
2020
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45. National Institute for the Infectious Diseases “L. Spallanzani” IRCCS. Recommendations for COVID-19 Clinical Management

Author

Nicastri, Emanuele, primary, Petrosillo, Nicola, additional, Ascoli Bartoli, Tommaso, additional, Lepore, Luciana, additional, Mondi, Annalisa, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Marchioni, Luisa, additional, Murachelli, Silvia, additional, Ippolito, Giuseppe, additional, and Antinori for ICOTREG, Andrea, additional

Published
2020
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46. Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia.

Author

Vergori, Alessandra, Lorenzini, Patrizia, Cozzi-Lepri, Alessandro, Donno, Davide Roberto, Gualano, Gina, Nicastri, Emanuele, Iacomi, Fabio, Marchioni, Luisa, Campioni, Paolo, Schininà, Vincenzo, Cicalini, Stefania, Agrati, Chiara, Capobianchi, Maria Rosaria, Girardi, Enrico, Ippolito, Giuseppe, Vaia, Francesco, Petrosillo, Nicola, Antinori, Andrea, Taglietti, Fabrizio, and The ReCOVeRI Study Group

Subjects
HEPARIN, COVID-19, PNEUMONIA, SARS-CoV-2, ANTI-inflammatory agents
Abstract

Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia. Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50–77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95% CI 3.2–26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7–15.9) in those exposed to pLMWH; p-value = 0.144. This risk associated with the use of pLMWH appeared to vary by PaO2/FiO2 ratio: aHR 1.40 (95% CI 0.51–3.79) for patients with an admission PaO2/FiO2 ≤ 300 mmHg and 0.27 (0.03–2.18) for those with PaO2/FiO2 > 300 mmHg; p-value at interaction test 0.16. pLMWH does not seem to reduce the risk of OTI/death mild/moderate COVID-19 pneumonia, especially when respiratory function had already significantly deteriorated. Data from clinical trials comparing the effect of prophylactic vs. therapeutic dosage of LMWH at various stages of COVID-19 disease are needed. [ABSTRACT FROM AUTHOR]

Published
2021
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47. 16S rRNA gene sequencing of rectal swab in patients affected by COVID-19.

Author

Mazzarelli, Antonio, Giancola, Maria Letizia, Farina, Anna, Marchioni, Luisa, Rueca, Martina, Gruber, Cesare Ernesto Maria, Bartolini, Barbara, Ascoli Bartoli, Tommaso, Maffongelli, Gaetano, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Di Caro, Antonino, Nicastri, Emanuele, and Pazienza, Valerio

Subjects
GUT microbiome, COVID-19, GENES, RESPIRATORY infections, RIBOSOMAL RNA, INTENSIVE care units
Abstract

COronaVIrus Disease-2019 (COVID-19) is a pandemic respiratory infection caused by a new betacoronavirus, the Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2). Few data are reported on the gut microbiota in COVID-19 patients. 16S rRNA gene sequencing was performed to reveal an altered composition of the gut microbiota in patients with COVID-19 pneumonia admitted in intensive care unit (ICU) (i-COVID19), or in infectious disease wards (w-COVID19) as compared to controls (CTRL). i-COVID19 patients showed a decrease of Chao1 index as compared to CTRL and w-COVID19 patients indicating that patients in ICU displayed a lower microbial richness while no change was observed as for Shannon Index. At the phylum level, an increase of Proteobacteria was detected in w-COVID19 patients as compared to CTRL. A decrease of Fusobacteria and Spirochetes has been found, with the latter decreased in i-COVID19 patients as compared to CTRL. Significant changes in gut microbial communities in patients with COVID-19 pneumonia with different disease severity compared to CTRL have been identified. Our preliminary data may provide valuable information and promising biomarkers for the diagnosis of the disease and, when validated in larger cohort, it could facilitate the stratification of patients based on the microbial signature. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Virological Characterization of the First 2 COVID-19 Patients Diagnosed in Italy: Phylogenetic Analysis, Virus Shedding Profile From Different Body Sites, and Antibody Response Kinetics.

Author

Colavita, Francesca, Lapa, Daniele, Carletti, Fabrizio, Lalle, Eleonora, Messina, Francesco, Rueca, Martina, Matusali, Giulia, Meschi, Silvia, Bordi, Licia, Marsella, Patrizia, Nicastri, Emanuele, Marchioni, Luisa, Mariano, Andrea, Scorzolini, Laura, Bartoli, Tommaso Ascoli, Caro, Antonino Di, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Castilletti, Concetta, and Group, INMI COVID-19 Laboratory Team and INMI COVID-19 Study

Subjects
COVID-19, ANTIBODY formation, VIRAL shedding, SARS-CoV-2, IMMUNOGLOBULIN A
Abstract

Background The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy. Methods We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. Serological analysis was carried out on serial serum samples to evaluate IgM, IgA, IgG, and neutralizing antibody levels. Results SARS-CoV-2 RNA was detected since the early phase of illness, lasting over 2 weeks in both upper and lower respiratory tract samples. Virus isolate was obtained from acute respiratory samples, while no infectious virus was rescued from late respiratory samples with low viral RNA load, collected when serum antibodies had been developed. Several other specimens came back positive, including saliva, vomit, rectal, cutaneous, cervico-vaginal, and ocular swabs. IgM, IgA, and IgG were detected within the first week of diagnosis, with IgG appearing earlier and at higher titers. Neutralizing antibodies developed during the second week, reaching high titers 32 days after diagnosis. Conclusions Our longitudinal analysis showed that SARS-CoV-2 RNA can be detected in different body samples, which may be associated with broad tropism and different spectra of clinical manifestations and modes of transmission. Profiling antibody response and neutralizing activity can assist in laboratory diagnosis and surveillance actions. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

Author

Abbonizio, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vita, Serena, Di Bari, Virginia, Goletti, Delia, Espinosa, Joaquin, Petracca, Sebastiano, and Palmieri, Fabrizio

Published
2021
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