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6 results on '"Marcus Krämer"'

2. Die Wortbildung und Werbebotschaft südspanischer Firmennamen

Author

Marcus Krämer and Marcus Krämer

Abstract

Examensarbeit aus dem Jahr 1999 im Fachbereich Romanistik - Hispanistik, Note: 1,0, Rheinische Friedrich-Wilhelms-Universität Bonn (Romanistisches Institut), Sprache: Deutsch, Abstract: Diese Arbeit hat das Ziel, anhand einer eingehenden Korpusanalyse die geomorphische Dimension in Firmennamen (FN) darzustellen sowie die Funktion der geomorphischen Dimension in FN zu untersuchen. Um abzugrenzen, welche Firmennamensbildungen in den Untersuchungsbereich dieser Arbeit fallen, und um die Kriterien, an denen sich diese Arbeit bei der Wahl des zu untersuchenden Korpus orientierte, für den Leser nachvollziehbar zu machen, soll zuerst eine Bestimmung des in der Themenvorgabe dieser Hausarbeit zentralen Begriffs'geomorphische Dimension'vorgenommen werden.

Published
2021

3. Cellular and humoral immune response in progressive multifocal leukoencephalopathy

Author

F. J. Kaup, Marcus Pickhardt, Wolfgang Lüke, Frank Weber, Peter Young, Claudia Goldmann, Thomas Weber, Harald Petry, and Marcus Krämer

Subjects
Cellular immunity, viruses, medicine.medical_treatment, JC virus, Biology, medicine.disease_cause, Immunoglobulin G, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, 030304 developmental biology, 0303 health sciences, Slow virus, Progressive multifocal leukoencephalopathy, virus diseases, Immunosuppression, medicine.disease, Virology, 3. Good health, Neurology, Humoral immunity, Immunology, biology.protein, Neurology (clinical), 030217 neurology & neurosurgery
Abstract

Progressive multifocal leukoencephalopathy (PML) is a fatal, demyelinating disease caused by JC virus (JCV) in patients with severe immunosuppression. We studied the JCV-specific cellular and humoral immune response in 7 healthy donors (HD), 6 human immunodeficiency virus-1 (HIV-1)-infected patients without PML (HIV), 4 HIV-1-negative patients with PML (PML), and 8 HIV-1-positive patients with PML (HIV/PML). As antigens, recombinant virus-like particles of the major structural protein VP1 (VP1-VLP) of JCV, tetanus toxoid (TT), or the mitogen phytohemagglutinin (PHA) were used. Proliferation of peripheral blood mononuclear cells (PBMC) after stimulation with the VP1-VLP was significantly suppressed in PML and HIV/PML patients compared to HD. After antigen stimulation the production of interferon-γ (IFN-γ) was reduced in PML, in HIV/PML, and in HIV patients. The production of interleukin-10 (IL-10), however, was elevated in HIV/PML patients. Neither proliferation nor cytokine production correlated with the presence of JCV DNA in PBMC. The immunoglobulin G serum antibody titer to the VP1-VLP was slightly elevated in HIV, elevated in PML, and highly elevated in HIV/PML patients compared to HD. The development of PML appears to coincide with a general impairment of the Th1-type T-helper cell function of cell-mediated immunity.

Published
2001

4. Glatiramer acetate (Copolymer-1)-specific, human T cell lines: cytokine profile and suppression of T cell lines reactive against myelin basic protein

Author

Ulrike Schöll, Hayrettin Tumani, Sabine Rösner, Marcus Krämer, Dominik Dabbert, Frank Weber, and Michael Mäder

Subjects
medicine.medical_specialty, T-Lymphocytes, CD3, T cell, Peripheral blood mononuclear cell, Cell Line, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Internal medicine, Humans, Medicine, Glatiramer acetate, 030304 developmental biology, 0303 health sciences, biology, business.industry, General Neuroscience, Myelin Basic Protein, Glatiramer Acetate, T lymphocyte, Molecular biology, 3. Good health, Myelin basic protein, Phenotype, medicine.anatomical_structure, Endocrinology, Cell culture, biology.protein, Cytokines, Peptides, business, Cell Division, Immunosuppressive Agents, 030217 neurology & neurosurgery, CD8, medicine.drug
Abstract

Glatiramer acetate (GA), represents an established treatment of relapsing/remitting multiple sclerosis (MS). The mechanisms responsible for the effect of GA are not fully understood. We generated GA-, myelin basic protein (MBP)- and purified protein derivative (PPD)-specific T cell lines from three MS patients and one healthy donor. The GA-specific lines were CD3+, CD4+, CD8- and produced tumor-necrosis-factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-10 (IL-10) after stimulation with GA in the presence of irradiated peripheral blood mononuclear cells. MBP-specific T cell lines showed an identical phenotype and secreted TNF-alpha, IFN-gamma, IL-4, IL-10, but not IL-6. Co-culture experiments demonstrated, that GA-specific T cell lines have the capability to suppress the proliferation of MBP-specific T cell lines.

Published
2000

5. The Activation and Activity Control of AP-1 (Fos/Jun)

Author

Thomas Oehler, Stephan Gebel, Peter Herrlich, Hans J. Rahmsdorf, Peter Angel, Harald König, Ulf Rapp, Marcus Krämer, Markus Streile, Helmut Ponta, Andrew C.B. Cato, Christoph Sachsenmaier, and Adriana Radler-Pohl

Subjects
Protein Conformation, Proto-Oncogene Proteins c-jun, business.industry, Chemistry, General Neuroscience, Down-Regulation, Zinc Fingers, DNA, General Biochemistry, Genetics and Molecular Biology, Cell biology, Receptors, Glucocorticoid, Text mining, History and Philosophy of Science, Animals, Humans, business, Control (linguistics)
Published
1993

6. Computing Power Indices for Weighted Voting Games Via Dynamic Programming

Author

Jochen Staudacher, László Á. Kóczy, Izabella Stach, Jan Filipp, Marcus Kramer, Till Noffke, Linus Olsson, Jonas Pichler, and Tobias Singer

Subjects
Management. Industrial management, HD28-70, Economic growth, development, planning, HD72-88
Abstract

We study the efficient computation of power indices for weighted voting games using the paradigm of dynamic programming. We survey the state-of-the-art algorithms for computing the Banzhaf and Shapley-Shubik indices and point out how these approaches carry over to related power indices. Within a unified framework, we present new efficient algorithms for the Public Good index and a recently proposed power index based on minimal winning coalitions of the smallest size, as well as a very first method for computing the Johnston indices for weighted voting games efficiently. We introduce a software package providing fast C++ implementations of all the power indices mentioned in this article, discuss computing times, as well as storage requirements. (original abstract)

Published
2021

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