Congenital heart defects (CHD) constitute the most common congenital malformation and occur in approximately 0.8% of all live-born infants (Eskedal et al., 2005). Advances in medical and surgical treatments have led to approximately 85% of these infants surviving to adulthood (Meberg, Lindberg, & Thaulow, 2005; Nieminen, Jokinen, & Sairanen, 2001; Thorne & Deanfield, 1996) transforming several previously fatal conditions into potentially survivable conditions. Still, although it offers the chance of prolonged or permanent remission of the underlying defect, medical and surgical treatment itself might be highly stressful for the infants and their mothers, possibly leaving them with long-term medical and psychosocial sequelae of the chronic condition (Apley, Barbour, & Westmacott, 1967; Davis, Brown, Bakeman, & Campbell, 1998). The clinical manifestations of the different types of CHD vary greatly, with broad variations in severity (mild, moderate, severe) and in the length and invasiveness of the different treatments. While infants with some forms of mild CHD [e.g., small ventricular septal defects (VSD)] may heal spontaneously within 6 months, infants with severe forms of CHD are usually clearly symptomatic at birth and the most acute medical interventions are carried out during the first year of life. Having a child with severe CHD therefore exposes mothers to a variety of stressors, such as the fear of losing their newborns, concerns related to the medical condition and its prognosis, and frequent, prolonged hospital visits (Glaser, Harrison, & Lynn, 1964; Van Horn, DeMaso, Gonzalez-Heydrich, & Erikson, 2001). Parents often respond with shock when the diagnosis is first made and the postpartum parenting of a child with a chronic illness is considered to be a highly stressful for the parents and family (Cohen, 1999; Davis, 1993). Even if treatment is successful and the infant eventually is discharged, many challenges might remain. The infant may show growth impairment and neurodevelopmental retardation, have respiratory problems, digestive problems, and/or breastfeeding problems (Clemente, Barnes, Shinebourne, & Stein, 2001; Dittrich et al., 2003; Saenz, Beebe, & Triplett, 1999) as a result of the cardiac defect, severe co-morbidities or repeated or prolonged surgical interventions. These challenges entail heightened levels of maternal stress that might complicate the postpartum period and affect mothers’ mental health. In fact, a study by Lawoko and Soares (Lawoko & Soares, 2002) showed that when comparing differences in distress (e.g., depression, anxiety, and suicide ideation) among parents of children with CHD, parents of children with other diseases, and parents of healthy children, mothers of children with CHD were generally at higher risk, reporting the highest levels of distress compared to the mothers in the other groups. Furthermore, the results showed that 24% of the mothers in the CHD group reported global levels of distress within or above norms for psychiatric outpatients. CHD severity was shown to have a weak, but positive correlation with scores on depression, i.e., the more severe the defect, the higher the risk of maternal depression. A second study by the same authors (Lawoko & Soares, 2006) saw these findings withstanding the test of time within a longitudinal design, with a large proportion of the same sample reporting long-standing symptoms of depression, anxiety, and somatisation over a period of 1 year, indicating prolonged psychosocial morbidity. On a similar note, a study by Goldberg, Morris, Simmons, Fowler and Levinson (Goldberg, Morris, Simmons, Fowler, & Levison, 1990) found that parents of infants with CHD reported the highest amount of stress within the child domain of the Parenting stress index compared to parents of infants with cystic fibrosis. On the other hand, Thompson and associates found that maternal adjustment in mothers of children with sickle cell disease was significantly more related to psychosocial processes, such as the presence of social support (Thompson Jr, Gil, Burbach, Keith, & Kinney, 1993). When incorporated in a transactional stress and coping model, the psychosocial processes accounted for variance in maternal adjustment over and above that explained by illness characteristics and/or severity. Moreover, a similar study by Uzark and Jones (Uzark & Jones, 2003) found that parents of children with heart defects were more likely than controls to report excessive parenting stress, but this was especially related to characteristics of the child that made them difficult to parent, not the heart defect severity in itself. The studies by Lawoko and Soares (2002) and Uzark and Jones (2003) included parents of children with a mean age of 8 and 6 years, respectively. Neither study provided information on the critical period from delivery to 6 months, where parents are most vulnerable (Cooper & Murray, 1998). Moreover, although information regarding the children’s CHD diagnosis was obtained, precise information regarding the classification criteria for CHD severity was not presented or deviated from the common CHD grouping of “mild”, “moderate” and “severe”, making it difficult to understand why only a weak association between CHD severity and parental distress was found. Since depression and anxiety in mothers have previously been shown to interfere with the quality and responsiveness of maternal care (Downey & Coyne, 1990), one could speculate that the mothers’ symptoms of depression and anxiety could become an additional burden for infants with CHD and lead to disturbances in their development. It is therefore important to elucidate the above mentioned findings further in order to isolate the impact of illness severity, and to better understand the needs of mothers of infants with CHD with regard to future development of interventions. Furthermore, most studies concerned with the prediction of maternal distress related to their children’s health have utilized retrospective or cross-sectional designs, whereas longitudinal designs with prenatal, maternal symptomatology baselines are missing. It is likely that psychological functioning during pregnancy account for the greatest amount of variance in postpartum functioning, and it is therefore important to assess mothers’ symptomatology both before and after childbirth. Only with this type of longitudinal design, can one begin to move from cross-sectional correlations to analyses that are temporally congruent with the causal ordering of the variables. In light of the aforementioned, the aim of the present study was to chart symptom trajectories of depression and anxiety from pregnancy to 18 months postpartum in mothers of infants with varying degrees of CHD severity. A large pregnancy cohort served as controls, establishing a normative, postpartum mental health trajectory. We hypothesised that CHD severity would affect the mothers’ mental health, i.e. the more severe the defect, the higher the risk of maternal distress, and that mothers of infants with CHD in general would be at greater risk of developing long-standing symptoms of depression and anxiety compared to controls within this especially vulnerable postpartum period.