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Cancer is a global health issue that impairs the life quality of patients and origins thousands of deaths annually worldwide. Six-transmembrane epithelial antigen of the prostate (STEAP1) was identified to be overexpressed in several types of cancers, namely in prostate cancer (PCa). Considering its secondary structure, associated with its location in the cell membrane, has been suggested a role in intercellular communication between tumour cells. Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target. Several strategies have been developed during the last few years for targeting STEAP1, including antibody-drug conjugates, monoclonal antibodies (mAbs), DNA vaccines and small noncoding RNAs (ncRNAs). This review presents the current knowledge about STEAP1 protein expression in human tissues, its biochemical properties and targeting strategies with the purpose to evaluate its potential as therapeutic agent for cancer.

Tese de mestrado, Bioquímica (Bioquímica Médica), Universidade de Lisboa, Faculdade de Ciências, 2009 Submitted by Teresa Boa (tdboa@fc.ul.pt) on 2011-10-07T11:05:45Z No. of bitstreams: 1 ulfc055594_tm_Margarida_Ramos.pdf: 5185611 bytes, checksum: 826cdb0a6d53dd9495f064d03476c3ec (MD5) Made available in DSpace on 2011-10-07T11:05:57Z (GMT). No. of bitstreams: 1 ulfc055594_tm_Margarida_Ramos.pdf: 5185611 bytes, checksum: 826cdb0a6d53dd9495f064d03476c3ec (MD5) Previous issue date: 2009

Mestrado em Gestão Pública Nos últimos anos muito se tem escrito e falado sobre a qualidade dos serviços prestados pela administração pública, bem como sobre a sua modernização. A presente investigação versa sobre a qualidade nos serviços públicos e tem por objectivo conhecer a perspectiva dos funcionários de um serviço público sobre a aplicação de alguns parâmetros integrados nos modelos de gestão da qualidade total. De modo a atingirmos o nosso objectivo, recorremos à metodologia do estudo de caso que incidiu sobre um serviço desconcentrado, pertencente à administração central do Estado. As entrevistas e os inquéritos realizados aos funcionários públicos deram-nos uma perspectiva fiel sobre a sua noção de qualidade do serviço público. Este estudo revelou-nos que se, por um lado, a qualidade tem sofrido uma evolução positiva, por outro lado, há ainda parâmetros essenciais na gestão dos modelos de qualidade que não foram aplicados ao organismo e que podem comprometer a prestação de serviços de qualidade. Este trabalho pretende ser um contributo para se perceber a importância da aplicação dos modelos de gestão da qualidade para a melhoria da qualidade dos serviços públicos. ABSTRACT: In the last few years, a lot has been written and spoken about the quality of the services rendered by public administration, as well as about its modernisation. This investigation is about the quality in the public services and it aims at getting to know the perspective of the state employees of a public service about the parameters integrated in the total quality management models. To accomplish our aim we have developed our investigation based on a casestudy methodology, focusing on a decentralised service which belongs to the central administration of the State. The interviews and enquiries done to the inservice public officials have given us a thorough perspective of their opinion about the notion of quality of the public service. Our investigation has showed us that although, on one hand, quality has suffered a positive evolution, on the other hand, there are still essential parameters of the managing quality models, which haven’t been applied by the instittution and which can seriously compromise the rendering of a service of quality. In this sense, this study intends to make explicit the importance of applying quality management models in order to improve the quality of public services.