41 results on '"Mariño-Sánchez, F."'
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2. Reply to the letter to the editor concerning: “Minimally Anterior Medial Maxillary Approach (MAMMA): a novel technique for a wide access to the maxillary sinus”
- Author
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Mariño-Sánchez, F.
- Published
- 2024
- Full Text
- View/download PDF
3. Is it possible to predict the development of diabetes insipidus after pituitary surgery? Study of 241 endoscopic transsphenoidal pituitary surgeries
- Author
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Araujo-Castro, M., Mariño-Sánchez, F., Acitores Cancela, A., García Fernández, A., García Duque, S., and Rodríguez Berrocal, V.
- Published
- 2021
- Full Text
- View/download PDF
4. Minimally Anterior Medial Maxillary Approach (MAMMA): a novel technique for a wide access to the maxillary sinus
- Author
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Yeguas-Ramírez, L., primary, Santamaría-Gadea, A., additional, Vaca-González, M., additional, de los Santos-Granados, G., additional, and Mariño-Sánchez, F., additional
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- 2023
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5. The 8-Odorant Barcelona Olfactory Test (BOT-8): Validation of a New Test in the Spanish Population During the COVID-19 Pandemic
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Rojas-Lechuga, MJ, primary, Ceballos, JC, additional, Valls-Mateus, M, additional, Mackers, P, additional, Izquierdo-Domínguez, A, additional, López-Chacón, M, additional, Langdon, C, additional, Mariño-Sánchez, F, additional, Valero, J, additional, Mullol, J, additional, and Alobid, I, additional
- Published
- 2022
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- View/download PDF
6. An olfactory self-test effectively screens for COVID-19
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Snitz, K., Honigstein, D., Weissgross, R., Ravia, A., Mishor, E., Perl, O., Karagach, S., Medhanie, A., Harel, N., Shushan, S., Roth, Y., Iravani, B., Arshamian, A., Ernst, G., Okamoto, M., Poo, C., Bonacchi, N., Mainen, Z., Monteleone, E., Dinnella, C., Spinelli, S., Mariño-Sánchez, F., Ferdenzi, C., Smeets, M.A.M., Touhara, K., Bensafi, M., Hummel, T., Lundström, J.N., Sobel, N., Social-cognitive and interpersonal determinants of behaviour, Leerstoel Smeets, Social-cognitive and interpersonal determinants of behaviour, and Leerstoel Smeets
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Olfactory system ,Signs and symptoms - Abstract
Background Key to curtailing the COVID-19 pandemic are wide-scale screening strategies. An ideal screen is one that would not rely on transporting, distributing, and collecting physical specimens. Given the olfactory impairment associated with COVID-19, we developed a perceptual measure of olfaction that relies on smelling household odorants and rating them online. Methods Each participant was instructed to select 5 household items, and rate their perceived odor pleasantness and intensity using an online visual analogue scale. We used this data to assign an olfactory perceptual fingerprint, a value that reflects the perceived difference between odorants. We tested the performance of this real-time tool in a total of 13,484 participants (462 COVID-19 positive) from 134 countries who provided 178,820 perceptual ratings of 60 different household odorants. Results We observe that olfactory ratings are indicative of COVID-19 status in a country, significantly correlating with national infection rates over time. More importantly, we observe indicative power at the individual level (79% sensitivity and 87% specificity). Critically, this olfactory screen remains effective in participants with COVID-19 but without symptoms, and in participants with symptoms but without COVID-19. Conclusions The current odorant-based olfactory screen adds a component to online symptom-checkers, to potentially provide an added first line of defense that can help fight disease progression at the population level. The data derived from this tool may allow better understanding of the link between COVID-19 and olfaction.
- Published
- 2022
7. Truths and fakes in the smell terminology during the COVID‐19 outbreak
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Arana‐Fernández, B., primary, Santamaría‐Gadea, A., additional, Mariño‐Sánchez, F., additional, and Mullol, J., additional
- Published
- 2021
- Full Text
- View/download PDF
8. Pediatric Barcelona Olfactory Test ̶ 6 (pBOT-6): Validation of a Combined Odor Identification and Threshold Screening Test in Healthy Spanish Children and Adolescents
- Author
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Mariño-Sánchez, F, primary, Valls-Mateus, M, additional, Fragola, C, additional, de los Santos, G, additional, Aguirre, A, additional, Alonso, J, additional, Valero, J, additional, Santamaría, A, additional, Rojas Lechuga, MJ, additional, Cobeta, I, additional, Alobid, I, additional, and Mullol, J, additional
- Published
- 2020
- Full Text
- View/download PDF
9. Is it possible to predict the development of diabetes insipidus after pituitary surgery? Study of 241 endoscopic transsphenoidal pituitary surgeries
- Author
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Araujo-Castro, M., primary, Mariño-Sánchez, F., additional, Acitores Cancela, A., additional, García Fernández, A., additional, García Duque, S., additional, and Rodríguez Berrocal, V., additional
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- 2020
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10. Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study
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Izquierdo-Domínguez, A, primary, Rojas-Lechuga, MJ, additional, Chiesa-Estomba, C, additional, Calvo-Henríquez, C, additional, Ninchritz-Becerra, E, additional, Soriano-Reixach, M, additional, Poletti-Serafini, D, additional, Villarreal, IM, additional, Maza-Solano, JM, additional, Moreno-Luna, R, additional, Villarroel, PP, additional, Mateos-Serrano, B, additional, Agudelo, D, additional, Valcarcel, F, additional, del Cuvillo, A, additional, Santamaría, A, additional, Mariño-Sánchez, F, additional, Aguilar, J, additional, Vergés, P, additional, Inciarte, A, additional, Soriano, A, additional, Mullol, J, additional, and Alobid, I, additional
- Published
- 2020
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11. Multimorbidities of Pediatric Allergic Rhinitis
- Author
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Mariño-Sánchez F, Valls-Mateus M, de Los Santos G, Plaza-Martín AM, Cobeta I, and Mullol J
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Septal deformity ,Adenoids ,Turbinate enlargement ,Asthma ,Atopic dermatitis ,Pediatric allergic rhinitis - Abstract
PURPOSE OF REVIEW: Most children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities. RECENT FINDINGS: The presence of AR and one or more accompanying multimorbidities is associated to a higher severity and duration of the disease, a negative impact on quality of life, with worse control and lack of improvement with medical treatment. Therefore, AR needs to be managed with a multidisciplinary collaborative approach. Pediatric AR needs to be considered in the context of a systemic disease, which requires a coordinated therapeutic strategy.
- Published
- 2019
12. Influence of nasal septum deformity on nasal obstruction, disease severity, and medical treatment response among children and adolescents with persistent allergic rhinitis
- Author
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Mariño-Sánchez F, Valls-Mateus M, María Paulina Cárdenas Escalante, Haag O, Ruiz-Echevarría K, Jiménez-Feijoo R, Lozano-Blasco J, Giner MT, Plaza-Martín AM, and Mullol J
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Nasal septum ,Septal deviation ,Classification ,Allergic rhinitis ,Nose deformities - Abstract
OBJECTIVE: To evaluate the impact of different types of nasal septum deformity (NSD) on nasal obstruction, rhinitis severity and response to medical treatment among pediatric persistent allergic rhinitis (PER) patients. METHODS: In a prospective, real-life study, 150 children and adolescents (mean age 13 ± 2.8 years, females 32.6%) diagnosed with PER according to ARIA guidelines were assessed by nasal endoscopy for NSD according to Mladina's classification, their response to medical treatment (intranasal steroids and antihistamines or antileucotriens), the presence of comorbidities, rhinitis severity (modified-ARIA criterion) and nasal obstruction visual analog scale score (VAS). RESULTS: Most patients (87%) had 1 of the 7 types of septal deformities. There was a high prevalence of bilateral (types 4 and 6; 46%) and anterior unilateral (types 1 and 2; 25%) NSD in patients not responding to medical treatment. Type 4 (OR = 6.4; p = 0.005) or type 6 (OR = 4.4; p = 0.03) NSD increased the risk of lack of improvement with medical treatment. Coexistence of anterior unilateral or bilateral NSD with severe turbinate enlargement increased >20-fold the risk of lack of improvement. Patients with bilateral NSD presented greater rhinitis severity. Non-responder adolescents displayed higher prevalence of bilateral NSD than children (53% vs. 23%; p = 0.02). Nasal obstruction VAS was higher for patients with anterior than posterior NSD, and greater for patients with bilateral NSD than any other type of septal morphology. CONCLUSION: Nasal endoscopy shows that bilateral and unilateral anterior nasal septum deformities are strongly associated with a poor response to medical treatment, greater rhinitis severity and higher nasal obstruction VAS. Consequently, nasal endoscopy is necessary in the PER patients to understand the disease severity as well as to plan a specific surgical treatment in order to improve nasal obstruction, disease severity, and patient's quality of life.
- Published
- 2017
13. Utilidad de los colgajos e injertos endonasales en cirugía endoscópica nasosinusal y de base de cráneo. Documento de consenso
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Moreno-Luna, R., Mariño Sánchez, F., Kaen, A., Gras Cabrerizo, J.R., Mata Castro, N., González García, J., Villacampa Auba, J.M., Cárdenas Ruiz-Valdepeñas, E., Monjas Cánovas, I., del Cuvillo Bernal, A., García Piñero, A., Maza Solano, J.M., Fernández de Liesa, R., Sánchez Gómez, S., and Alobid, I.
- Abstract
de la cirugía endoscópica endonasal expandida. Existen multitud de injertos y colgajos de origen endonasal que han demostrado su utilidad en el control de complicaciones como las fístulas de LCR, entre otras. Se hace necesaria la revisión y el análisis de los recursos endonasales y su uso en cirugía endoscópica endonasal expandida (CEEE).
- Published
- 2021
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14. Nonsurgical Rhinoplasty after Rhinoplasty: A Systematic Review of the Technique, Results, and Complications.
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Santamaría-Gadea A, Sevil-Serrano C, Buendía Pérez J, and Mariño-Sánchez F
- Abstract
Introduction: Surgical rhinoplasty is a complex procedure with a high revision rate. Nonsurgical rhinoplasty (NSR) could avoid secondary rhinoplasty allowing the correction of postsurgical defects. A systematic review has been performed among adult patients who had previously undergone surgical rhinoplasty and now presenting for NSR with filler, demonstrated most common indications, fillers, and complications in this technique. Materials and Methods: A systematic review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) system guidelines. Primary outcomes included indications for NSR in patients with prior rhinoplasty and complication rate. Secondary outcomes included filler material and degree of patient satisfaction. Results: Twenty articles met the inclusion criteria, obtaining 2,048 patients analyzed in the review. Hyaluronic acid was the most used filler, found in 67% of patients. Indications were highly variable, considering deformities of the middle third of the nose the most remarkable. A high degree of satisfaction was found in the analyzed studies and the rate of major complications was low. Discussion and Conclusions: NSR in patients with prior rhinoplasty is a useful option for correcting a range from subtle aesthetic defects to severe nasal deformities. However, this technique is not exempt from complications, since an increased risk of skin necrosis has been observed.
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- 2024
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15. Septal Perforation Quality of Life questionnaire (SEPEQOL): validation of a new instrument to assess patients undergoing endoscopic repair of a nasal septal perforation.
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Arana-Fernández B, Santamaría-Gadea A, Mariño-Sánchez F, Rojas-Lechuga MJ, and Alobid I
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- Humans, Male, Female, Prospective Studies, Reproducibility of Results, Middle Aged, Adult, Surveys and Questionnaires, Patient Reported Outcome Measures, Aged, Quality of Life, Nasal Septal Perforation surgery, Psychometrics, Endoscopy methods
- Abstract
Purpose: Nasoseptal perforations (NSP) are a clinically heterogeneous group of disorders with a wide range of available treatments. Patient-reported outcome measures (PROMs) can provide valuable insights for assessing clinical and surgical outcomes. This study aims to develop and validate a novel-specific questionnaire for patients with NSP., Methods: A multi-centre prospective observational study was conducted at two tertiary referral hospitals. "Septal Perforation Quality of Life" (SEPEQOL) was developed by a committee of experts. The psychometric properties, including reproducibility, reliability, validity, and responsiveness, were assessed., Results: The study included 96 symptomatic NSP patients and 30 healthy controls. SEPEQOL internal consistency was satisfactory [Cronbach´s α = 0.7843; 95% confidence interval (CI), 0.702-0.856]. Test-retest reliability was excellent, demonstrated by the absolute intraclass correlation (ICC = 0.974; 95% CI, 0.935-0.989, P-value < 0.001) and Bland-Altman plot (line bias = 1.6 ± 4.57; 95% CI -0.54-3.74, P-value < 0.001). The mean total SEPEQOL score was higher before surgery (25.16 ± 1.65) compared to 6-months after the procedure (13.72 ± 11.39), with a mean difference of 12.19 [standard deviation (SD) 10.76], P-value < 0.001., Conclusions: SEPEQOL is reliable, consistent, valid, and sensitive to change over time. SEPEQOL assesses the impact of health-related quality of life on NSP and its management in clinical practice. Moreover, it is easy to apply in clinical settings with minimal burden., (© 2024. The Author(s).)
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- 2024
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16. Endoscopic "Racket-on-Donut" Technique for Large Anterior Nasoseptal Perforations.
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Alobid I, Santamaría-Gadea A, and Mariño-Sánchez F
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- Humans, Arteries, Endoscopy methods, Head, Nasal Septum surgery, Surgical Flaps surgery, Nasal Septal Perforation surgery
- Abstract
Endoscopic Racket-on-Donut technique is a combination of a modified greater palatine artery and inverted edges flaps. Endoscopic Racket-on-Donut technique is very useful for anterior NSP repair. Laryngoscope, 134:143-147, 2024., (© 2023 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2024
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17. Oroantral Fistula Closure Using Double-Layered Flap: Greater Palatine Artery Flap and Buccal Fat Pad.
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Arana-Fernández B, Santamaría-Gadea A, Almeida-Parra F, and Mariño-Sánchez F
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- Humans, Cheek surgery, Adipose Tissue transplantation, Oroantral Fistula surgery, Surgical Flaps
- Abstract
A novel surgical technique based on a combined approach to oroantral fistula closure using a double-layered flap: greater palatine artery pedicled flap and buccal fat pad combination. Laryngoscope, 133:1824-1827, 2023., (© 2022 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2023
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18. Endoscopic endonasal approach to pituitary adenomas: Impact on adenohypophyseal function. Study of 231 cases.
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Araujo-Castro M, Mariño-Sánchez F, García Fernández A, Acitores Cancela A, and Rodríguez Berrocal V
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- Humans, Retrospective Studies, Vision Disorders etiology, Pituitary Neoplasms complications, Pituitary Neoplasms surgery, Pituitary Neoplasms pathology, Adenoma complications, Adenoma surgery, Adenoma pathology, Hypopituitarism etiology, Hypopituitarism complications
- Abstract
Purpose: To identify presurgical and surgical factors associated with the development of hypopituitarism and its recovery after endoscopic endonasal transsphenoidal (EET) resection of pituitary adenomas (PAs)., Methods: Retrospective study of patients with PAs operated by the same neurosurgeon through an EET approach in two Spanish tertiary hospitals in ten years., Results: 242 pituitary surgeries performed in 231 patients were analyzed. In the 154 surgeries performed in 146 patients with non-functioning PAs (NFPAs), 46.8% (n=72) presented presurgical hypopituitarism. After PAs resection, 41 of these (56.9%) normalized pituitary function and 11 of 82 patients with preoperative normal function (13.4%) developed new pituitary deficits. Patients with preoperative visual impairment (OR=3.9, p=0.046) and operated in the first four years of the neurosurgeon's learning curve (OR=5.7, p=0.016) presented a higher risk of developing postoperative hypopituitarism. Of the 88 surgeries in 85 patients with functioning PAs (FPAs), 23.9% presented presurgical hypopituitarism, and 47.6% of those recovered after surgery. 9% of the cases with preoperative normal function developed new pituitary deficit/s. Diabetic patients presented a higher risk of persistence of hypopituitarism (OR=10.5, p=0.024). Patients with presurgical visual impairment (OR=30.0, p=0.010) and PAs>3cm (OR=14.0, p=0.027) had higher risk of developing new pituitary deficits., Conclusion: Approximately 50% of patients with PAs and preoperative hypopituitarism recover pituitary function after EET surgery. 10% of patients with normal function develop new deficits. Patients with NFPAs with visual involvement and operated in the first four years of neurosurgeon's learning curve, and FPAs patients with presurgical visual impairment and tumor size>3cm have a higher risk of postoperative hypopituitarism., (Copyright © 2021 Sociedad Española de Neurocirugía. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2022
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19. Usefulness of endonasal flaps and grafts in skull base surgery. Consensus document.
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Moreno-Luna R, Mariño Sánchez F, Kaen A, Gras Cabrerizo JR, Mata Castro N, González García J, Villacampa Aubá JM, Cárdenas Ruiz-Valdepeñas E, Monjas Cánovas I, Del Cuvillo Bernal A, García Piñero A, Maza Solano JM, Fernández de Liesa R, Sánchez-Gómez S, and Alobid I
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- Consensus, Humans, Retrospective Studies, Skull Base surgery, Surgical Flaps surgery, Plastic Surgery Procedures methods
- Abstract
Introduction: Skull base reconstruction is one of the greatest challenges extended endonasal endoscopic surgery. Many grafts and flaps from the endonasal fossa have been demonstrated to be useful in the control of complications such a cerebrospinal fluid leaks. Review and analysis of these resources are necessary in skull base recontruction to improve outcomes., Objectives: The target is to create a consensus document on the use of different endonasal flaps and grafts in the skull base surgery., Material and Methods: Literature review of the most relevant free grafts and vascularized flaps from the endonasal fossa. Analysis using the Delphi method on the use of the different endonasal resources for endoscopic repair of skull base defects., Results: We obtained two results: 1) A selection of the most representative flaps and grafts from the endonasal fossa, describing origin, surface and indications, based on a literature review. 2) A consensus document, using Delphi methodology, with general considerations (2), recommendations (10) and limitations (6) of the different endonasal flaps and grafts., Conclusions: We present the first consensus document in the field of extended endonasal endoscopic surgery using the Delphi method as a working tool. We highlight the usefulness of the nasoseptal flap together with other endonasal flaps and grafts for skull base reconstruction., (Copyright © 2021 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
20. Radiofrequency ablation turbinoplasty improves the sense of smell in pediatric patients: A prospective study.
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Calvo-Henriquez C, Mariño-Sánchez F, Lechien JR, Maldonado-Alvarado B, Maniaci A, Maza-Solano J, Martínez-Capoccioni G, Neves JC, and Martin-Martin C
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Odorants, Prospective Studies, Smell, Turbinates surgery, Olfaction Disorders diagnosis, Olfaction Disorders etiology, Radiofrequency Ablation
- Abstract
Introduction: The olfactory sense is of paramount importance for the adequate development of a child. Olfactory loss in children might have different origins. One of the most common is conductive, when nasal obstruction prevents odorants from reaching the olfactory epithelium. Rhinitis and turbinate enlargement have been proven to diminish the sense of smell in pediatric patients. A common treatment for resistant rhinitis in these patients is turbinate radiofrequency ablation (TRA). However, despite an increasing research effort in this field, there are no studies instrumentally assessing olfaction in children undergoing turbinate surgery to date. This study was designed with the aim of assessing changes in olfaction through validated instrumental tools in pediatric patients undergoing TRA for the first time., Methods: A prospective uncontrolled intervention clinical trial design was conducted. Two cohorts of children ranging 4-15 years old were consecutively selected from a third level referral Hospital and subjected to the universal sniff test (U-Sniff), alcohol sniff test (AST), and sniffin sticks threshold test (SST) before and 1, 3 and 6 months after surgery. Cohort A consisted of children solely undergoing TRA. Cohort B consisted of children on whom adenoidectomy and TRA had been performed. Additionally, a cohort of Spanish healthy controls, paired by sex and age, were asked to perform the U-Sniff., Results: A total of 81 participants with a mean age of 10.31 ± 2.56 years were included. Fifty-three patients underwent TRA exclusively and 28 were subjected to associated adenoidectomy. Despite a tendency toward improvement in the U-sniff scores, there were no statistically significant differences after surgery. However, statistically significant differences were obtained for threshold tasks measured with SST and AST, revealing differences at 1, 3 and 6 months after surgery compared to preoperative scores., Conclusions: In summary, this research demonstrated adequate levels in the sense of smell regarding identification tasks, but decreased olfactory threshold scores in pediatric patients suffering from TE. TRA, alone or with adenoidectomy, improved smell threshold scores, but had no significant effect on identification tasks., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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21. Loss of smell in patients with traumatic brain injury is associated with neuropsychiatric behavioral alterations.
- Author
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Langdon C, Laxe S, Lehrer E, Berenguer J, Alobid I, Quintó L, Mariño-Sánchez F, Bernabeu M, Marin C, and Mullol J
- Subjects
- Adult, Female, Glasgow Coma Scale, Humans, Prospective Studies, Smell, Anosmia, Brain Injuries, Traumatic complications
- Abstract
Objective: We sought to identify and correlate the severity of traumatic brain injuries (TBIs) associated with olfactory dysfunction with cognitive and behavioral profiles., Participants and Setting: Patients with TBI undergoing treatment in a specialized neuro-rehabilitation hospital., Design: Prospective study., Main Measures: Glasgow Coma Scale (GCS) at the time of injury and during posttraumatic amnesia. Motor functions were assessed with the Functional Instrument Measure and Disability Rating Scales. The Wechsler Adult Intelligence test was used for neuropsychologic assessment and the Neuropsychiatric Inventory was used to assess behavioral changes. The Barcelona Smell Test-24 was used to study subjective smell loss., Results: A total of 111 patients with TBI were enrolled (33 females; mean age 32.86 years); 38.73% exhibited smell loss. Patients with no olfactory impairment (OI) had worse TBIs than those with OI (GCS scores 5.65 and 7.74, respectively); no significant differences in cognitive behaviors, such as attention memory, visuoperception, and visuoconstruction, were observed. However, patients with TBI and olfactory dysfunction showed statistically significant alterations in neuropsychiatric behavioral performances such as feeding when compared with patients with TBI without smell loss., Conclusion: Olfactory dysfunction in patients with a TBI correlates with altered neuropsychiatric behavioral performances such as feeding, sleeping, and motor behavior.
- Published
- 2021
- Full Text
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22. Usefulness of endonasal flaps and grafts in skull base surgery. Consensus document.
- Author
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Moreno-Luna R, Mariño Sánchez F, Kaen A, Gras Cabrerizo JR, Mata Castro N, González García J, Villacampa Aubá JM, Cárdenas Ruiz-Valdepeñas E, Monjas Cánovas I, Del Cuvillo Bernal A, García Piñero A, Maza Solano JM, Fernández de Liesa R, Sánchez-Gómez S, and Alobid I
- Abstract
Introduction: Skull base reconstruction is one of the greatest challenges extended endonasal endoscopic surgery. Many grafts and flaps from the endonasal fossa have been demonstrated to be useful in the control of complications such a cerebrospinal fluid leaks. Review and analysis of these resources are necessary in skull base recontruction to improve outcomes., Objectives: The target is to create a consensus document on the use of different endonasal flaps and grafts in the skull base surgery., Material and Methods: Literature review of the most relevant free grafts and vascularized flaps from the endonasal fossa. Analysis using the Delphi method on the use of the different endonasal resources for endoscopic repair of skull base defects., Results: We obtained two results: 1) A selection of the most representative flaps and grafts from the endonasal fossa, describing origin, surface and indications, based on a literature review. 2) A consensus document, using Delphi methodology, with general considerations (2), recommendations (10) and limitations (6) of the different endonasal flaps and grafts., Conclusions: We present the first consensus document in the field of extended endonasal endoscopic surgery using the Delphi method as a working tool. We highlight the usefulness of the nasoseptal flap together with other endonasal flaps and grafts for skull base reconstruction., (Copyright © 2021 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
23. Greater palatine artery pedicled flap for nasal septal perforation repair: radiological study and case series.
- Author
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Santamaría-Gadea A, Vaca M, de Los Santos G, Alobid I, and Mariño-Sánchez F
- Subjects
- Arteries, Endoscopy, Humans, Nasal Septum diagnostic imaging, Nasal Septum surgery, Surgical Flaps, Nasal Septal Perforation diagnostic imaging, Nasal Septal Perforation surgery
- Abstract
Purpose: The greater palatine artery (GPA) is one of the main vessels supplying the nasal septum. We recently described a novel technique to reconstruct a nasal septal perforation (NSP) using a GPA flap. This radiological study explores the feasibility and limits of using a GPA flap for an anterior NSP repair., Methods: We describe our technique for repairing anterior-most NSP. Radiological measurements of the GPA flap and their limits were analysed. Additionally, a cohort of four patients who underwent reconstruction of a NSP with a GPA flap was included., Results: The radiological study of 150 nasal cavities showed a 31.5 ± 2.7 cm
2 maximum flap area. Taking into account the retraction process (30%), the remaining area was 22.0 ± 1.9 cm2 . The septal area anterior to the GPA was 6.1 ± 2.1 cm2 . The septal portion of the flap was larger than the area anterior to the GPA pedicle in all cases. Complete NSP repair was achieved in four patients. All cases of NSP remained closed during the follow-up., Conclusion: The unilateral GPA pedicled flap is a useful technique suitable for the reconstruction of anterior-most perforations that are difficult to cover with other endonasal techniques.- Published
- 2021
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24. Innovative Surgical Techniques for Nasal Septal Perforations: Management and Treatment.
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Santamaría-Gadea A, Mariño-Sánchez F, Arana-Fernández B, Mullol J, and Alobid I
- Subjects
- Endoscopy, Humans, Nose, Surgical Flaps, Nasal Septal Perforation etiology, Nasal Septal Perforation surgery
- Abstract
Purpose of Review: The aim of this study was to review and describe the main innovative surgical techniques for nasal septal perforation (NSP) repair that have been published in recent years., Recent Findings: Several techniques for NSP repair have been developed recently. The anterior ethmoidal artery (AEA) flap is a versatile technique for middle-size perforations in different locations. The greater palatine artery (GPA) flap is an excellent option for anterior-most NSPs. The lateral nasal wall flap and the pericranial flap are the most appropriate techniques for large perforations. The advent of these techniques has changed the management and has expanded the therapeutic arsenal to treat all types of NSPs according to the size, location, and osteo-cartilaginous support. However, no technique has been accepted as the gold standard. Extensive knowledge of different techniques is important to individualize the treatment, selecting the most appropriate in each case.
- Published
- 2021
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25. Errors and Biases in Meta-analysis of the Prevalence of Olfactory Dysfunction in Patients With COVID-19.
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Santamaría-Gadea A, de Los Santos G, Alobid I, Mullol J, and Mariño-Sánchez F
- Subjects
- Bias, Humans, Prevalence, SARS-CoV-2, COVID-19, Olfaction Disorders epidemiology, Olfaction Disorders etiology
- Published
- 2021
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- View/download PDF
26. Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients.
- Author
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Calvo-Henriquez C, Maldonado-Alvarado B, Chiesa-Estomba C, Rivero-Fernández I, Sanz-Rodriguez M, Villarreal IM, Rodriguez-Iglesias M, Mariño-Sánchez F, Rivero-de-Aguilar A, Lechien JR, Martínez-Capoccioni G, Saussez S, Capasso R, Karkos PD, Schriever V, Martin-Martin C, Alobid I, Santamaría-Gadea A, Fragola C, Mayo-Yáñez M, Pérez-Freixo H, Ninchritz-Becerra E, Soriano-Reixach M, Mondragon-Rezola E, Ruiz-Coello MDMM, Navarro RA, García-Fernández A, and Marchan-López Á
- Subjects
- Adult, Aged, Aged, 80 and over, COVID-19, Case-Control Studies, Costs and Cost Analysis, Female, Humans, Male, Middle Aged, Olfaction Disorders etiology, Olfaction Disorders physiopathology, Pandemics, SARS-CoV-2, Smell, Young Adult, Betacoronavirus, Coronavirus Infections complications, Ethanol pharmacology, Olfaction Disorders diagnosis, Pneumonia, Viral complications
- Abstract
Objective: COVID-19 patients may present mild symptoms. The identification of paucisymptomatic patients is paramount in order to interrupt the transmission chain of the virus. Olfactory loss could be one of those early symptoms which might help in the diagnosis of COVID-19 patients. In this study, we aim to develop and validate a fast, inexpensive, reliable and easy-to-perform olfactory test for the screening of suspected COVID-19 patients., Study Design: Phase I was a case-control study and Phase II a transversal descriptive study., Subjects and Methods: Olfaction was assessed with the ethyl alcohol threshold test and symptoms with visual analogue scales. The study was designed in two phases: In Phase I, we compared confirmed COVID-19 patients and healthy controls. In Phase II, patients with suspected COVID-19 infection referred for testing were studied., Results: 275 participants were included in Phase I, 135 in Phase II. The ROC curve showed an AUC of 0.749 in Phase I, 0.737 in Phase II. The cutoff value which offered the highest amount of correctly classified patients was ≥ 2 (10% alcohol) for all age intervals. The odds ratio was 8.19 in Phase I, 6.56 in Phase II with a 75% sensitivity. When cases report normal sense of smell (VAS < 4), it misdiagnoses 57.89% of patients detected by the alcohol threshold test., Conclusion: The olfactory loss assessed with the alcohol threshold test has shown high sensitivity and odds ratio in both patients with confirmed COVID-19 illness and participants with suspected SARS-CoV-2 infection.
- Published
- 2020
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27. The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries.
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Mullol J, Alobid I, Mariño-Sánchez F, Izquierdo-Domínguez A, Marin C, Klimek L, Wang DY, and Liu Z
- Subjects
- Acute Disease, COVID-19, Humans, SARS-CoV-2, Sinusitis, Betacoronavirus, Coronavirus Infections complications, Coronavirus Infections diagnosis, Coronavirus Infections physiopathology, Coronavirus Infections prevention & control, Olfaction Disorders virology, Pandemics prevention & control, Pneumonia, Viral complications, Pneumonia, Viral diagnosis, Pneumonia, Viral physiopathology, Pneumonia, Viral prevention & control, Taste Disorders virology
- Abstract
Purpose of Review: Olfactory dysfunction in upper airway viral infections (common cold, acute rhinosinusitis) is common (> 60%). During the COVID-19 outbreak, frequency of sensory disorders (smell and/or taste) in affected patients has shown a high variability from 5 to 98%, depending on the methodology, country, and study., Recent Findings: A sudden, severe, isolated loss of smell and/or taste, in the absence of other upper airway inflammatory diseases (allergic rhinitis, chronic rhinosinusitis, nasal polyposis), should alert individuals and physicians on being potentially affected by COVID-19. The evaluation of smell/taste disorders with a visual analogue scale or an individual olfactory or gustatory test, at the hospital or by telemedicine, to prevent contamination might facilitate an early detection of infected patients and reduce the transmission of SARS-CoV-2. During the COVID-19 outbreak, patients with sudden loss of smell should initiate social distancing and home isolation measures and be tested for SARS-CoV-2 diagnostic test when available. Olfactory training is recommended when smell does not come back after 1 month but can be started earlier.
- Published
- 2020
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28. Psychophysical olfactory testing in COVID-19: is smell function really impaired in nearly all patients?
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Mariño-Sánchez F, Santamaría-Gadea A, de Los Santos G, Alobid I, and Mullol J
- Subjects
- Betacoronavirus, Biomarkers, COVID-19, Humans, SARS-CoV-2, Coronavirus Infections, Olfaction Disorders, Pandemics, Pneumonia, Viral, Smell
- Published
- 2020
- Full Text
- View/download PDF
29. Technique to Repair a Septal Perforation Endoscopically with a Greater Palatine Artery Pedicled Flap.
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Mariño-Sánchez F, Santamaría-Gadea A, and Vaca M
- Subjects
- Arteries, Humans, Endoscopy methods, Nasal Septal Perforation surgery, Rhinoplasty methods, Surgical Flaps blood supply
- Published
- 2020
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30. Relationship between odor intensity estimates and COVID-19 prevalence prediction in a Swedish population.
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Iravani B, Arshamian A, Ravia A, Mishor E, Snitz K, Shushan S, Roth Y, Perl O, Honigstein D, Weissgross R, Karagach S, Ernst G, Okamoto M, Mainen Z, Monteleone E, Dinnella C, Spinelli S, Mariño-Sánchez F, Ferdenzi C, Smeets M, Touhara K, Bensafi M, Hummel T, Sobel N, and Lundström JN
- Abstract
In response to the COVID-19 pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a step-wise manner, monitoring of COVID-19 prevalence is of importance to guide decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r=-0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before wide-spread testing can be facilitated., (© The Author(s) 2020. Published by Oxford University Press.)
- Published
- 2020
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31. The sense of smell in chronic rhinosinusitis.
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Mullol J, Mariño-Sánchez F, Valls M, Alobid I, and Marin C
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- Chronic Disease, Humans, Nasal Polyps complications, Olfaction Disorders epidemiology, Prevalence, Olfaction Disorders etiology, Rhinitis complications, Sinusitis complications
- Published
- 2020
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32. Incidental Histopathologic Finding of Sinonasal Inverted Papilloma Among Surgically Excised Polyps Increases the Risk of Tumor Recurrence.
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Mariño-Sánchez F, de Los Santos G, Giribet A, Aguirre A, Alonso J, Wansley DL, and Cobeta I
- Abstract
Inverted papilloma (IP) is a benign tumor remarkable for its tendency toward recurrence. Local relapse implicates incomplete resection concerning the bone adjacent to tumor base. The high false negative rates on biopsies, mainly when nasal polyps coexist, may affect the surgical management and outcomes. Our objective was to study the impact of preoperative histologic diagnosis in IP recurrence, particularly in patients with pre-surgical diagnosis of inflammatory polyps. A retrospective analysis of 62 patients treated for IP was conducted. Demographic data and information about smoking status, alcohol intake, tumor location, histology, presence of nasal polyps, staging, malignancy, previous biopsies and surgical approach were evaluated to identify factors associated with recurrence. Prevalence of nasal polyps was higher in patients with recurrence. Smoking history, alcohol abuse, staging, histologic type, malignancy and surgical approach were not associated with recurrence. The presence of nasal polyps at endoscopy was inversely associated with the diagnosis of IP at incisional biopsy. Incidental histologic diagnosis of IP after surgery increased the risk of recurrence more than tenfold. Biopsy reporting the diagnosis of IP previous to surgery was inversely associated to recurrence. In patients with IP, coexistence of nasal polyps at initial endoscopy and lack of pathological IP diagnosis prior to surgery are strongly associated with a higher risk of recurrence. When excisional biopsy reports IP incidentally, an early revision surgery should be considered in order to avoid future aggressive surgeries because of tumor recurrence., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© Association of Otolaryngologists of India 2018.)
- Published
- 2019
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33. Olfactory Training in Post-Traumatic Smell Impairment: Mild Improvement in Threshold Performances: Results from a Randomized Controlled Trial.
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Langdon C, Lehrer E, Berenguer J, Laxe S, Alobid I, Quintó L, Mariño-Sánchez F, Bernabeu M, Marin C, and Mullol J
- Subjects
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Quality of Life, Sensory Thresholds, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic pathology, Olfaction Disorders etiology, Olfaction Disorders pathology, Olfaction Disorders rehabilitation
- Abstract
Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, randomized, and controlled study was developed. Patients with TBI-induced olfactory dysfunction (n = 42) were randomized into an experimental group with OT and a control group without (nOT). OT was performed twice daily with a six odor training set during 12 weeks. Olfactory loss was assessed using subjective olfactometry (Barcelona Smell Test [BAST] 24), a visual analogue scale (VAS), and n-butanol threshold (n-BTt) at baseline at 4, 12, and 24 weeks. Additionally, patients underwent MRI of the olfactory brain and olfactory bulbs (OB). Based on the MRI results, an overall score (0-16) was developed to associate the structural neurological damage with olfactory outcomes. The primary outcome was the change in olfactory measurements (VAS and BAST-24) between baseline and 12 weeks. The secondary outcome was the association of the MRI score with olfactory outcomes at baseline, and the impact on quality of life (QoL). After 12 weeks of training, OT patients showed a significant improvement in n-BTt (0.6 ± 1.7 OT vs. -0.6 ± 1.8 nOT, p < 0.05), but not in the smell VAS and BAST-24 scores. Olfactory outcomes (VAS, BAST-24, and n-BTt) were significantly associated with MRI structural findings (p < 0.001), but not with the OB volume or olfactory sulcus length. The present study suggests that 12 weeks of OT mildly improves the olfactory threshold in TBI, whereas the overall MRI score may be used as an imaging marker of olfactory dysfunction and disease severity in TBI patients.
- Published
- 2018
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34. Narrow band imaging endoscopy improves visualization of vessels of the perforated tympanic membrane.
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Cordero Devesa A, Vaca González M, Mariño-Sánchez F, Pérez Martínez C, Polo López R, Medina González MDM, and Cobeta Marco I
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- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Myringosclerosis diagnostic imaging, Prospective Studies, Tympanic Membrane blood supply, Video Recording, Young Adult, Endoscopy, Narrow Band Imaging, Tympanic Membrane diagnostic imaging, Tympanic Membrane Perforation diagnostic imaging
- Abstract
Purpose: Because successful healing of a tympanic membrane perforation (TMP) depends upon the maintenance of blood supply to the injured area, we assessed the usefulness of narrow band imaging (NBI) video endoscopy to evaluate its vascularization. To our knowledge, the use of NBI to assess tympanic membrane (TM) vascular patterns has never been attempted., Methods: Prospective observational study. NBI and cold white light (CWL) flexible videoendoscopy was used to explore perforated TMs of 100 patients. Main outcome measures were visualization of vessels among abnormal TM findings: monomeric areas (MA) (n = 6), myringosclerosis plaques (MP) (n = 65) and perforation edges (n = 100). They were graded by a vascular otoendoscopic score (VOS) comparing both types of lights (Wilcoxon test). Location and vascularization patterns were analyzed (Fisher's test)., Results: NBI was better to observe vascularization of 32% of perforation edges and 75.4% of MP (p < 0.001). NBI displayed higher (better) VOS when evaluating TMP edges (1.05 vs. 0.73) and MP (1.56 vs. 0.81, p < 0.001). The majority of TMP edges showed a ring pattern (66%), followed by irregular (19%), avascular (12%) and radial patterns (3%). The avascular pattern was more frequent in posterior perforations (p = 0.003). The radial pattern was most frequently found in MP, especially at posterior quadrants (p = 0.048). MA presented an irregular pattern in 83.3% of TMs., Conclusions: NBI videoendoscopy is a promising non-invasive technique, superior to CWL for visualizing vessels among TMP edges and MP, based on further study, could become a supplementary diagnostic tool in the workup of TMP and the decision-making surgical field.
- Published
- 2018
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35. Development of an International Odor Identification Test for Children: The Universal Sniff Test.
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Schriever VA, Agosin E, Altundag A, Avni H, Cao Van H, Cornejo C, de Los Santos G, Fishman G, Fragola C, Guarneros M, Gupta N, Hudson R, Kamel R, Knaapila A, Konstantinidis I, Landis BN, Larsson M, Lundström JN, Macchi A, Mariño-Sánchez F, Martinec Nováková L, Mori E, Mullol J, Nord M, Parma V, Philpott C, Propst EJ, Rawan A, Sandell M, Sorokowska A, Sorokowski P, Sparing-Paschke LM, Stetzler C, Valder C, Vodicka J, and Hummel T
- Subjects
- Child, Child, Preschool, Female, Humans, Internationality, Male, Reproducibility of Results, Sensitivity and Specificity, Odorants, Olfaction Disorders congenital, Olfaction Disorders diagnosis, Smell physiology
- Abstract
Objective: To assess olfactory function in children and to create and validate an odor identification test to diagnose olfactory dysfunction in children, which we called the Universal Sniff (U-Sniff) test., Study Design: This is a multicenter study involving 19 countries. The U-Sniff test was developed in 3 phases including 1760 children age 5-7 years. Phase 1: identification of potentially recognizable odors; phase 2: selection of odorants for the odor identification test; and phase 3: evaluation of the test and acquisition of normative data. Test-retest reliability was evaluated in a subgroup of children (n = 27), and the test was validated using children with congenital anosmia (n = 14)., Results: Twelve odors were familiar to children and, therefore, included in the U-Sniff test. Children scored a mean ± SD of 9.88 ± 1.80 points out of 12. Normative data was obtained and reported for each country. The U-Sniff test demonstrated a high test-retest reliability (r
27 = 0.83, P < .001) and enabled discrimination between normosmia and children with congenital anosmia with a sensitivity of 100% and specificity of 86%., Conclusions: The U-Sniff is a valid and reliable method of testing olfaction in children and can be used internationally., (Copyright © 2018 Elsevier Inc. All rights reserved.)- Published
- 2018
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36. Olfactory function in an excitotoxic model for secondary neuronal degeneration: Role of dopaminergic interneurons.
- Author
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Marin C, Laxe S, Langdon C, Berenguer J, Lehrer E, Mariño-Sánchez F, Alobid I, Bernabeu M, and Mullol J
- Subjects
- Animals, Disease Models, Animal, Magnetic Resonance Imaging, Male, N-Methylaspartate administration & dosage, Neurotoxins administration & dosage, Rats, Rats, Sprague-Dawley, Brain Injuries, Traumatic complications, Dopaminergic Neurons physiology, Interneurons physiology, Lateral Ventricles drug effects, Lateral Ventricles pathology, Lateral Ventricles physiopathology, N-Methylaspartate pharmacology, Neurodegenerative Diseases chemically induced, Neurodegenerative Diseases pathology, Neurodegenerative Diseases physiopathology, Neurogenesis physiology, Neurotoxins pharmacology, Olfaction Disorders chemically induced, Olfaction Disorders pathology, Olfaction Disorders physiopathology, Olfactory Bulb drug effects, Olfactory Bulb pathology, Olfactory Bulb physiopathology
- Abstract
Secondary neuronal degeneration (SND) occurring in Traumatic brain injury (TBI) consists in downstream destructive events affecting cells that were not or only marginally affected by the initial wound, further increasing the effects of the primary injury. Glutamate excitotoxicity is hypothesized to play an important role in SND. TBI is a common cause of olfactory dysfunction that may be spontaneous and partially recovered. The role of the glutamate excitotoxicity in the TBI-induced olfactory dysfunction is still unknown. We investigated the effects of excitotoxicity induced by bilateral N-Methyl-D-Aspartate (NMDA) OB administration in the olfactory function, OB volumes, and subventricular zone (SVZ) and OB neurogenesis in rats. NMDA OB administration induced a decrease in the number of correct choices in the olfactory discrimination tests one week after lesions (p<0.01), and a spontaneous recovery of the olfactory deficit two weeks after lesions (p<0.05). A lack of correlation between OB volumes and olfactory function was observed. An increase in SVZ neurogenesis (Ki67+ cells, PSANCAM+ cells (p<0.01) associated with an increase in OB glomerular dopaminergic immunostaining (p<0.05) were related to olfactory function recovery. The present results show that changes in OB volumes cannot explain the recovery of the olfactory function and suggest a relevant role for dopaminergic OB interneurons in the pathophysiology of recovery of loss of smell in TBI., (Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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37. Pediatric intranasal lobular capillary hemangioma: Report of two new cases and review of the literature.
- Author
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Mariño-Sánchez F, Lopez-Chacon M, Jou C, and Haag O
- Abstract
Background: Lobular capillary hemangioma (LCH) is an acquired benign vascular tumor of unknown origin. It usually affects skin and mucous membranes of the oropharynx. It rarely involves the nasal cavity which most commonly manifests as epistaxis. To our knowledge, only fifteen pediatric intranasal LCH cases have been reported in the literature. None of these occurred in the inferior turbinate. We report two new pediatric cases of LCH, one of them on the inferior turbinate and the other one on the anterior nasal septum. Our principal aim was to highlight the importance of considering this lesion as a differential diagnosis for pediatric unilateral nasal obstruction and epistaxis., Methods: Retrospective case series and review of current literature regarding the possible causes, diagnosis, and treatment of nasal LCH., Description of Cases: Two adolescents presented with symptoms of unilateral nasal obstruction and epistaxis. Plain and contrast enhanced computed tomography revealed a well-defined intensely enhancing lesion in both cases. Patients underwent transnasal endoscopic excision and bipolar electrocautery at the base of the tumor for hemostasis. Histopathological examination confirmed the diagnosis of LCH., Discussion: Current epidemiological and pathophysiological data suggests that the development of LCH may be associated to previous nasal trauma or endocrine disorders. LCH should be considered in the differential diagnosis of all pediatric endonasal masses associated with unilateral epistaxis and nasal obstruction. Endoscopic total excision with bipolar electrocautery for hemostasis is an appropriate treatment.
- Published
- 2016
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38. Expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors has a negative impact on sinonasal symptoms and quality of life.
- Author
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Alobid I, Enseñat J, Mariño-Sánchez F, Rioja E, de Notaris M, Mullol J, and Bernal-Sprekelsen M
- Subjects
- Adenoma physiopathology, Adult, Endoscopy, Female, Humans, Male, Middle Aged, Nasal Mucosa surgery, Pituitary Neoplasms physiopathology, Quality of Life, Treatment Outcome, Adenoma surgery, Nasal Mucosa pathology, Nasal Septum surgery, Paranasal Sinuses surgery, Pituitary Neoplasms surgery, Plastic Surgery Procedures, Surgical Flaps statistics & numerical data
- Abstract
Background: Endoscopic transsphenoidal surgery is currently the optimal treatment for skull base tumors. This study was designed to assess patient's sinonasal symptoms and quality of life (QoL) after resection of pituitary adenoma or skull base tumors using vascularized septal flap (VSF) reconstruction., Methods: Patients with pituitary adenoma underwent the transnasal transsphenoidal endoscopic approach (TTEA; n = 38), and patients with other benign parasellar tumors underwent the expanded endonasal approach (EEA; n = 17) with VSF. Assessment of sinonasal symptoms and QoL by the 36-item Short-Form (SF-36) and the 31-item Rhinosinusitis Outcome Measure (RSOM-31) were performed before and 3 months after surgery., Results: At baseline, the total seven-sinonasal symptom score (T7SSS) was similar between both groups. After surgery, T7SSS significantly increased in EEA but not in TTEA patients. EEA patients reported more smell loss (40.1 ± 26.2; p < 0.05) and posterior nasal discharge (49.3 ± 30.1; p < 0.05) than TTEA patients (21.6 ± 30.9 and 22.5 ± 27.5, respectively). At baseline, both groups had poorer SF-36 compared with the general population. TTEA patients had poorer QoL (on general health, vitality, and mental health) than EEA patients. After surgery, TTEA patients showed impaired physical role and bodily pain compared with baseline, and EEA patients showed impaired physical role and mental health. At baseline, RSOM scores were similar in TTEA and EEA groups. After surgery, EEA but not TTEA patients reported poorer nasal and general symptoms., Conclusion: The EEA with VSF produces more sinonasal symptoms than pituitary surgery, surgery for skull base and pituitary tumors has negative impact on QoL, and functioning tumors have no further negative effect on sinonasal symptoms and QoL.
- Published
- 2013
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39. Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors.
- Author
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Alobid I, Enseñat J, Mariño-Sánchez F, de Notaris M, Centellas S, Mullol J, and Bernal-Sprekelsen M
- Subjects
- Adenoma diagnosis, Adenoma epidemiology, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Nasal Cavity surgery, Pituitary Neoplasms diagnosis, Pituitary Neoplasms epidemiology, Postoperative Complications epidemiology, Prospective Studies, Plastic Surgery Procedures adverse effects, Skull Base Neoplasms diagnosis, Skull Base Neoplasms epidemiology, Skull Base Neoplasms surgery, Young Adult, Adenoma surgery, Mucociliary Clearance physiology, Neuroendoscopy adverse effects, Pituitary Neoplasms surgery, Postoperative Complications diagnosis, Smell physiology, Surgical Flaps adverse effects
- Abstract
Background: Endoscopic skull base surgery is now the preferred treatment option to remove skull base tumors., Objective: To evaluate the patient's sense of smell and mucociliary clearance time (MCT) after skull base surgery., Methods: Patients with pituitary adenoma underwent a transnasal transsphenoidal endoscopic approach (TTEA group, n = 36), whereas patients with other benign parasellar tumors underwent an expanded endonasal approach (EEA group, n = 14) with a vascularized septal flap. Assessment of symptoms (Visual Analogue Scale), olfactometry (Barcelona Smell Test, BAST-24), and MCT (saccharin test) were performed before and 3 months after surgery., Results: Before surgery, patients reported poorer BAST-24 scores on detection, identification, and forced choice than the healthy population, but both study groups had similar sinonasal symptoms, BAST-24, and MCT scores. After surgery, no changes in symptom scores (Visual Analogue Scale) were observed except for the loss of smell (26.7 ± 30.5 mm, P < .05) and posterior nasal discharge (29.7 ± 30.3 mm, P < .05) compared with baseline (5.2 ± 11.3, 19.1 ± 25.3, respectively). EEA patients reported higher loss of smell and posterior nasal discharge compared with TTEA. TTEA and EEA groups had similar scores on postoperative BAST-24. After surgery, however, patients showed prolonged saccharin test (15.6 ± 10.8 min, P < .05) compared with baseline (8.4 ± 4.4 min). In addition, EEA patients reported longer MCT than TTEA patients., Conclusion: EEA but not TTEA has a short-term (3 months) negative impact on patient's olfaction and mucociliary clearance. Patients should be informed about smell loss as a consequence of skull base surgery to prevent legal claims. Likewise, further research and some modifications on reconstruction flaps are encouraged to avoid damaging the olfactory neuroepithelium.
- Published
- 2013
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40. Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study).
- Author
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Mullol J, Alobid I, Mariño-Sánchez F, Quintó L, de Haro J, Bernal-Sprekelsen M, Valero A, Picado C, and Marin C
- Abstract
Objectives: To investigate olfaction in general population, prevalence of olfactory dysfunction and related risk factors., Design: Cross-sectional population-based survey, distributing four microencapsulated odorants (rose, banana, musk and gas) and two self-administered questionnaires (odour description; epidemiology/health status)., Setting: The survey was distributed to general population through a bilingual (Catalan, Spanish) newspaper in Catalonia (Spain), on December 2003., Participants: Newspaper readers of all ages and gender; 9348 surveys were analysed from the 10 783 returned., Main Outcome Measures: Characteristics of surveyed population, olfaction by age and gender, smell self-perception and smell impairment risk factors. Terms normosmia, hyposmia and anosmia were used when participants detected, recognised or identified all four, one to three or none of the odours, respectively., Results: Survey profile was a 43-year-old woman with medium-high educational level, living in a city. Olfaction was considered normal in 80.6% (detection), 56% (recognition/memory) and 50.7% (identification). Prevalence of smell dysfunction was 19.4% for detection (0.3% anosmia, 19.1% hyposmia), 43.5% for recognition (0.2% anosmia, 43.3% hyposmia) and 48.8% for identification (0.8% anosmia, 48% hyposmia). Olfaction was worse (p<0.0001) in men than in women through all ages. There was a significant age-related smell detection decline however smell recognition and identification increased up to fourth decade and declined after the sixth decade of life. Risk factors for anosmia were: male gender, loss of smell history and poor olfactory self-perception for detection; low educational level, poor self-perception and pregnancy for recognition; and older age, poor self-perception and history of head trauma and loss of smell for identification. Smoking and exposure to noxious substances were mild protective factors for smell recognition., Conclusions: Sense of smell in women is better than in men suggesting a learning process during life with deterioration in older ages. Poor self-perception, history of smell loss, head trauma and pregnancy are potential risk factors for olfactory disorders.
- Published
- 2012
- Full Text
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41. [Cervical vertebral tuberculosis simulating a peritonsillar abscess].
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Mariño-Sánchez F, Rioja E, Rusiecka M, and Alobid I
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Cervical Vertebrae, Peritonsillar Abscess diagnosis, Tuberculosis, Spinal diagnosis
- Abstract
We report the case of a 28-year-old woman initially diagnosed with a left peritonsillar abscess, which was drained, resulting in clinical relief. Twelve days later, a bulge was observed in the posterior pharyngeal wall. CT and MRI showed a tumour with destruction of atlas lateral mass, with a soft tissue component in prevertebral, retropharyngeal, left carotid and paraspinal spaces. Biopsy and microbiological study confirmed the presence of Mycobacterium tuberculosis. Therapy was initiated with isoniazid, pyrazinamide, rifampicin and ethambutol, an occipitocervical-C1-C2 arthrodesis was performed, and the patient improved successfully., (Copyright © 2010 Elsevier España, S.L. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
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