1. Sex hormone-binding globulin in gestational diabetes
- Author
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Rafael Comino-Delgado, Maria Del Carmen Gomez-Jaen, Jose L. Bartha, and Raquel Romero-Carmona
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,chemistry.chemical_compound ,Insulin resistance ,Sex hormone-binding globulin ,Diabetes mellitus ,Internal medicine ,polycyclic compounds ,medicine ,Hyperinsulinemia ,reproductive and urinary physiology ,Glucose tolerance test ,medicine.diagnostic_test ,biology ,business.industry ,Insulin ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Gestational diabetes ,Fructosamine ,Endocrinology ,chemistry ,biology.protein ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Background. Insulin is an important regulator of serum sex hormone-binding globulin (SHBG) concentration which works by inhibiting its production in hepatocytes. Low SHBG level is associated with increased insulin resistance and hyperinsulinemia. Our purpose was to compare maternal serum SHBG level between normal and gestational diabetic pregnant women and to study the relationships between SHBG, SHBG/insulin and SHBG/glucose ratio and several endocrine, metabolic and clinical parameters.Methods. Serum SHBG concentrations were measured in 34 women with gestational diabetes and in 32 matched controls. Glucose, insulin, C-peptide, fructosamine, s-HCG, cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoprotein A, apolipoprotein B, total and free T4, total and free estriol, T3 and IGF-1 were measured. Insulin sensitivity was estimated using the short insulin tolerance test.Results. SHBG, SHBG/insulinemia ratio and SHBG/glucose ratio were significantly lower in the diabetic group (309.54± 112...
- Published
- 2000
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