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Introduction: Onychomycosis is a common superficial fungal infection of nail in both developed and developing countries. It may involve any component of the nail unit, including the nail matrix, the nail bed, or the nail plate. It represents up to 20.0% of all nail disorders. Its prevalence is estimated at 2 to 18 percentage worldwide and up to 48-percentage incidence by age 70. Onychomycosis can be caused by dermatophyte mold, yeasts and non dermatophyte mold. We planned this study to determine the frequency of onychomycosis in psoriatic nails to establish the local perspective as the international studies shows wide variation. Objective: To find the presence of fungal elements in nails of patients affected by psoriasis. Setting: Dermatology (OPD), Baqai Medical University. Duration: 06 months from 15th July 2022 - 15th Dec 2022. Design: Descriptive Cross-sectional study. Results: In this study, out of 96 cases, 32.29% (n=31) of patients were between 18-40 years and 67.71% (n=65) were between 41-70 years of age, mean+SD: 47.32+11.94 years.

Objective: Psoriasis is an immune mediated inflammatory skin disorder that potentially requires lifelong management. Different therapies treating psoriasis have been recognized wherein Secukinumab is a fully humanized, IL-17A monoclonal antibody that has been approved by US Food and Drug administration for the treatment of moderate to severe plaque psoriasis. Therefore, this study targeted to assess the efficacy of Secukinumab in patients with moderate to severe psoriasis. Methodology: This was a Prospective interventional multicenter study conducted by using consecutive sampling technique. The duration of study was about one year. The sample size was 138. Adult patients between 18-65 years of either gender with clinical diagnosis of psoriasis vulgaris involving scalp, face, hands, or genital areas, were include. Treatment initiated by the administration of a single dose of 300 mg Secukinumab subcutaneously for 4 weeks then monthly for 52 weeks. Paired t-test was applied to assess the difference in the PASI score at various follow ups. Results: The study results showed that out of 138 patients, 112(81.2%) were males and 26(18.8%) were females and their mean age was 40.47±9.55 years. As far as distribution of disease is concerned, 117(84.8%) patients reported Plaque Psoriasis, 57(41.3%) patients reported Scalp Psoriasis, 9(6.5%) patients reported nail Psoriasis, 11(8.0%) patients reported Palmoplantar Psoriasis, and 5(3.6%) patients reported Erythrodermic psoriasis. For the comparison of Secukinumab treatment under PASI scores, there was statistically significant reduction observed from mean of baseline PASI scores till 1 week (p

Objective: To evaluate the efficacy of intradermal tranexamic acid in melasma. Stduy Design: Cross-Sectional study. Setting: Out-patient Department of Dermatology at Dow University of Health Sciences. Period: January 2018 to June 2018. Material & Methods: Enrolling 73 patients the research was done on patients with resistant melasma. For this 0.2 ml tranexamic acid diluted in 0.8 ml normal saline was injected intradermally into the melasma lesion at 1 cm distance at every 2 weeks for 4 months and results were analysed by using the modified Melasma Area and Severity Index (MASI) at their first visit and then monthly with strict sun protection. A total of 73 patients were included in this study with age ranging from 22 years to 47 years. All of them had resistant melasma and had not taken any treatment for the last six months. Results: Out of 73 patient 10 (13.7%) patients had poor response, 48 (65.8%) patients had fair response, 14 (19.1%) patients had good responses and only 1 (1.4%) had excellent response. No significant side effects were observed. Out of 73 patients, 63 patients were satisfied with the treatment. Only 2 patients complained of redness over the affected area which subsided within a week without any intervention, no other side effects were noted. Conclusion: Intralesonal tranexamic acid is safe, effective and an affordable option in resistant melasma.

Objective To evaluate the outcomes of microneedling in patients with atrophic post-acne scars. Methodology A retrospective cross-sectional study was conducted at the Department of Dermatology, Patel Hospital for a duration of six months. Patients who were diagnosed with moderate to severe-grade atrophic acne scars were enrolled in the study. Patients with a history of photosensitivity, systemic lupus erythematosus, and xeroderma pigmentosum were excluded from the study. Goodman and Baron's acne scar-grading system was used to evaluate the degree of atrophic scarring. A total of three sessions divided into four weekly intervals were conducted. The scar-grading was done before the procedure and after three treatment sessions using Goodman and Baron's acne scar grading system. Results A total of 50 patients were included in this study; 36 (72%) were females and 14 (28%) were males, with a mean age of 30.92±6.19 years. A decrease in the acne scar-grade was noted from grade III to grade II after three sessions of treatment. A significantly higher number of patients were in grade II after three-month sessions compared with before treatment (p=0.009), and a significantly lesser number of patients were in grade III (p=0.045). A significantly higher proportion of patients with moderate acne scars, as compared to severe, were in grade II (77.3% vs. 22.7%; p

Introduction: Lichen amyloidosus (LA) is the major variant of the primarycutaneous amyloidoses which present with severe and therapy resistant itching. Varioustherapeutic modalities such as antihistamines, intralesional injection or topical applicationof corticosteroids, etretinate, UVB irradiation and dermoabrasion have been employed withvariable success. Some authors have observed encouraging beneficial clinical effects by usingtopical dimethyl sulphoxide (DMSO). Objectives: The objective of the study was to: evaluatethe efficacy of topical Dimethyl sulfoxide (D.M.S.O) 70% in Lichen Amyloidosis. Study Design:Case series. Settings: This study was conducted at dermatology department, Abbasi ShaheedHospital in outpatient department (OPD). Duration of Study: The data collection was done in06 months after approval of synopsis. From: 2nd June 2013 to 2nd December 2013. Results: Inthis study, out of 71 cases, 42.25%(n=30) were between 16-40 years while 57.75%(n=41) werebetween 41-80 years of age, mean+sd was calculated as 41.79+10.87 years, 26.76%(n=19)were male and 73.24%(n=52) were females, 36.62%(n=26) had

Striae gravidarum (SG) is a physiological skin change that many pregnant women experience during pregnancy. Striae gravidarum seems to be undesirable to many pregnant women but its impact on women’s life is unclear. It is a disfiguring change on the skin of pregnant women presenting atrophic linear scars. They may occur anywhere on the body, though the abdomen, breasts, hips and legs are common. This change has a deep impact on the psychology and quality of life (QoL) of women. The quality of life of pregnant women deteriorates with distressing body image, causing psychological problems.The aim of this study is to evaluate the impact of striae gravidarum on the dermatology-specific quality of life (QOL) of pregnant women. Objectives:To evaluate the impact of Stria gravidarum on the dermatology - specific qualoty of life (QOL) among pregnant women.Method:A multi-disciplinary cross-sectional study was conducted among the pregnant women attending the outpatient department at Dow university hospital for antenatal visits in third trimester. Striae gravidarum was assessed by using Dave’s score. After taking informed consent, Skindex 16 dermatology specific QOL questionnaire was used to evaluate the QOL. Data was analyzed by using SPSS version -16. Using Mann Whitney level of significance

Objectives: To determine the frequency of Pulmonary Tuberculosis inPemphigus Vulgaris patients on immunosuppressive therapy for more than one year. StudyDesign: Prospective Cross Sectional. Plan and Duration of Study: The study was conductedat Dermatology department Civil Hospital Karachi (a tertiary care hospital affiliated with DowUniversity of Health Sciences). It was conducted from January 2016 to June 2016. Materialand Methods: The study included 31 diagnosed cases of Pemphigus Vulgaris patients onimmunosuppressive drugs for more than one year. These patients were either admittedin dermatology ward CHK or presented in CHK OPD. A Pro-forma was used to record thehistory, physical examination and results of screening tests. Results: Out of 31 PemphigusVulgaris patients who were on immunosuppressive drugs for more 1 year, 3 patients (9.6%)developed Pulmonary Tuberculosis. Conclusion: Patients of Pemphigus Vulgaris on long termimmunosuppressant drugs can develop Pulmonary Tuberculosis.