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Colorectal cancer is a life-threatening disease. This study evaluates whether sour coconut (Butia capitata) prevents the appearance of aberrant crypt foci (ACF) in the colon of rats, induced with 1,2-dimethylhydrazine (DMH). The test subjects were divided into four treatment groups: I - Control; II - aqueous extract of sour coconut pulp; III - DMH and IV - Aqueous extract of sour coconut pulp + DMH. The colons of the subjects were submitted to ACF count, analysis of gene expression and histopathological. The count of ACF differed in the proximal portion of the colon between animals treated III and IV, with a lower count in Treatment IV (p ). The interleukin-1 (IL-1) gene (p ) was less expressed in Treatment IV. In the histopalogic analysis of the colons in Treatment IV, less dilation was observed at the base of the crypts and the lumen was moderately dilated. The sour coconut acted in preventing the appearance of ACF, probably due to its high composition in bioactive compounds, such as phenolic compounds, polyunsaturated fatty acids and vitamin E. The anti-inflammatory capacity reduces the expression of the IL-1 gene and preserves the histo-architecture of the colon.

The high body fat percentage incresed risk of cardiovascular and metabolic. To evaluate the influence of body fat on inflammatory markers and cardiometabolic risk factors in female adolescents. Cross-sectional study with 555 female adolescents, aged 10 to 19 years. The Body Mass Index (BMI) was calculated. Body fat percentage was obtained by dual-energy X-ray absorptiometry (DEXA) equipment. Were evaluated systolic and diastolic blood pressures, fasting glucose levels, insulin, lipid profile, uric acid, and inflammatory markers (Interleukin 6 - IL-6, Interleukin 10 - IL-10, high-sensitivity C Reactive Protein – hs-CRP, Tumor Necrosis Factor - TNF-α, Leptin, and Tumor Necrosis Factor - TNF-α). The Kolmogorov-Smirnov test was performed to verify the distribution of the variables, and the Pearson and Spearman correlation tests were used according to the characteristics of the variables. Linear regression analyses were performed. A statistical significance level of 5% was adopted. Increased body fat in adolescent girls relates to increased values of blood pressure, lipid profile, insulin, uric acid, leptin and IL-6. The increasing one percent body fat increases uric acid by 1.22 mg/dL and leptin by 0.0005 pg/mL, suggesting that for these two markers, eutrophic adolescents with high percent body fat show similar behavior as obese adolescents (with high BMI and body fat). The highlight the need to assess body composition in adolescents to identify those with higher fat percentage, since, even with normal weight, they may present increased risk of developing cardiovascular and metabolic complications at this stage of life, which may be maintained or worsened in adulthood.