12 results on '"Mariana, Haedo"'
Search Results
2. ENETS Newsletter Summer/Fall 2011
- Author
-
Yukinori Kato, Michela Tessari, Maria Florencia Gallelli, Elena Gonzalez-Rey, Eduardo Arzt, Yoshiko Kuroda, Sonoko Ogawa, Kazuyo Nagata, Maria Fernanda Cabrera-Blatter, Sergio Melotto, Tanja Wolloscheck, Mariko Nakata, Mariana Haedo, Emilio Merlo Pich, Debra K. Kelleher, Marta Soaje, Katsumi Toda, Marta Labeur, Johanna Stalla, Mumeko C. Tsuda, Marily Theodoropoulou, Isabella Spiwoks-Becker, Marta Caro, Mauro Corsi, Fiorella Campo Verde Arboccó, Vivian J A Costantini, Druck Reinhardt Druck Basel, Günter K. Stalla, Rainer Spessert, Herbert A. Schmid, Satz Mengensatzproduktion, Sandrine M. Dupre, Gisela E. Pennacchio, Matteo Sartori, Francesca Michielin, Enzo Valerio, Fabio Maria Sabbatini, Ryohei Kurihara, Melisa M. Bonafede, Luciana Souza-Moreira, Víctor Castillo, Veronika Weyer, Nils H. Rohleder, Shinji Tsukahara, Stefano Lepore, Elena Vicentini, Oliver Rickes, Kai Xiao, Graciela A. Jahn, Susana R. Valdez, and Jenny Campos-Salinas
- Subjects
Cellular and Molecular Neuroscience ,medicine.medical_specialty ,Endocrinology ,Endocrine and Autonomic Systems ,Endocrinology, Diabetes and Metabolism ,Internal medicine ,medicine ,Psychology - Published
- 2011
3. Intrapituitary Expression and Regulation of the gp130 Cytokine Interleukin-6 and Its Implication in Pituitary Physiology and Pathophysiology
- Author
-
Marcelo Paez Pereda, Eliane Correa De Santana, Günter K. Stalla, Mariana Haedo, Bianca Fröhlich, Juan Gerez, Eduardo Arzt, C. Onofri, and Ulrich Renner
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Biology ,General Biochemistry, Genetics and Molecular Biology ,History and Philosophy of Science ,Anterior pituitary ,Internal medicine ,Cytokine Receptor gp130 ,medicine ,Animals ,Humans ,Pituitary Neoplasms ,Interleukin 6 ,Innate immune system ,Interleukin-6 ,General Neuroscience ,Pituitary tumors ,Interleukin ,medicine.disease ,Glycoprotein 130 ,Cytokine ,Endocrinology ,medicine.anatomical_structure ,Pituitary Gland ,biology.protein ,Corticotropic cell - Abstract
Interleukin (IL)-6, a member of the gp130 cytokine family, is sometimes designated as an "endocrine" cytokine because of its strong regulatory influence on hormone production. Systemically acting IL-6 derived from immune cells is a potent stimulator of the hypothalamus-pituitary-adrenal axis and therefore plays an important role in modulating immune-neuroendocrine interactions during inflammatory or infectious processes. However, IL-6 is also produced within the anterior pituitary by so-called folliculostellate (FS) cells and is also synthesized in and released by tumor cells in pituitary adenomas. Growth factors (e.g., transforming growth factor-beta), neuropeptides (e.g., pituitary adenylate cyclase-activating polypeptide), or hormones (e.g., glucocorticoids) regulate IL-6 production both in FS and pituitary tumor cells. Interestingly, components of the innate immune system, such as toll-like receptor 4 and nucleotide-binding oligomerization domains (NODs), are expressed in FS and pituitary tumor cells. Therefore, cell-wall components of bacteria (lipopolysaccharide, muramyl dipeptide, diamino pimelic acid) stimulate IL-6 production in normal and tumoral pituitary. The intrinsic IL-6 production by FS cells in normal anterior pituitary may participate in immune-neuroendocrine interactions during inflammatory processes. In pituitary adenomas, IL-6 stimulates hormone secretion, tumor cell proliferation, and the production of angiogenic factors, such as vascular endothelial growth factor-A, suggesting an important role of IL-6 in the pathophysiology and progression of pituitary adenomas.
- Published
- 2009
4. Differential Gene Expression in Models of Pituitary Prolactin-Producing Tumoral Cells
- Author
-
Damiana Giacomini, Günter K. Stalla, Eduardo Arzt, Juan Gerez, Marcelo Paez-Pereda, Marta Labeur, Jimena Druker, and Mariana Haedo
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Bone Morphogenetic Protein 4 ,macromolecular substances ,Biology ,Models, Biological ,Mice ,Endocrinology ,Cell Line, Tumor ,Internal medicine ,TGF beta signaling pathway ,Gene expression ,medicine ,Animals ,Humans ,Prolactinoma ,Gene ,Pituitary tumours ,Mice, Knockout ,Receptors, Dopamine D2 ,Effector ,Gene Expression Profiling ,Cushing's disease ,medicine.disease ,Cell Hypoxia ,Prolactin ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,Cell Transformation, Neoplastic ,Pediatrics, Perinatology and Child Health ,Cancer research ,Signalling pathways ,Signal Transduction ,Transcription Factors - Abstract
Although several genes and signalling pathways have been identified as important effectors in the development of pituitary tumours, our understanding of pituitary tumorigenesis remains incomplete and is the focus of much current research. Use of the mRNA differential display technique in prolactinomas from D2-receptor knockout mice and in stable GH3 cell line clones with enhanced tumorigenicity in vivo has led to the identification of two genes that are involved in the pathogenic process – BMP-4 and RSUME. Bone morphogenetic protein-4 (BMP-4) has been found to have a crucial role in prolactinoma development and also in signalling crosstalk with oestrogens. In contrast, BMP-4 has an inhibitory role in corticotrophinomas. RSUME (RWD-containing sumoylation enhancer) was identified from a transformed lactosomatotrophic cell line that had increased tumorigenic and angiogenic potential. Expression of RSUME was induced under hypoxic conditions and it has a potential role during vascularization. The differential expression and action of BMP-4 in prolactinomas and corticotrophinomas highlights the importance of studying a gene with contrasting actions in two cell lineages of the same organ in order to understand the pituitary transformation process. Both BMP-4 and RSUME may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
- Published
- 2009
5. Regulation of Pituitary Function by Cytokines
- Author
-
Damiana Giacomini, Eduardo Arzt, Ulrich Renner, Mariana Fuertes, Mariana Haedo, Marta Labeur, Juan Gerez, Marcelo Paez-Pereda, and Günter K. Stalla
- Subjects
Adenoma ,medicine.medical_specialty ,Pituitary gland ,Somatotropic cell ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Pituitary neoplasm ,Biology ,Models, Biological ,Prolactin cell ,Endocrinology ,Internal medicine ,medicine ,Animals ,Humans ,Pituitary Neoplasms ,Cellular Senescence ,Interleukin-6 ,Pituitary tumors ,medicine.disease ,Cytokine ,medicine.anatomical_structure ,Pituitary Gland ,Pediatrics, Perinatology and Child Health ,Cytokines ,Cell aging - Abstract
Research performed on the pituitary has proven that cytokines play an important role in maintaining pituitary physiology, affecting not only cell proliferation but also hormone secretion. The effects of cytokines can be autocrine or paracrine. This review gives an overview on the effects of the most studied cytokines in the pituitary. Special interest is focused on interleukin-6 (IL-6) because it has the distinctive characteristic of stimulating pituitary tumor cell growth, but has the opposite effect on normal pituitary cells. On the other hand, IL-6 is a cytokine of interest in the pituitary because recent work has shown that it promotes and maintains senescence in certain types of tumors. Given that the majority of pituitary adenomas are microadenomas and the fact that clinically inapparent pituitary tumors are quite common, senescence, perhaps mediated by IL-6, is an attractive mechanism for explaining the benign nature of pituitary tumors.
- Published
- 2009
6. Cellular and molecular specificity of pituitary gland physiology
- Author
-
Ulrich Renner, Mariana Haedo, Eduardo Arzt, Günter K. Stalla, and Carolina Perez-Castro
- Subjects
medicine.medical_specialty ,Pituitary gland ,Physiology ,Otras Ciencias Biológicas ,Cell ,CELLULAR AND MOLECULAR SPECIFICITY ,PITUITARY GLAND PHYSIOLOGY ,Endocrine System ,Cell Communication ,Biology ,Ciencias Biológicas ,stomatognathic system ,Anterior pituitary ,Physiology (medical) ,Cell Plasticity ,Internal medicine ,medicine ,Animals ,Homeostasis ,Humans ,Hormone metabolism ,Secretion ,BODY HOMEOSTASIS ,PLASTICITY ,Molecular Biology ,General Medicine ,Neurosecretory Systems ,Hormones ,Cell biology ,medicine.anatomical_structure ,Endocrinology ,Pituitary Gland ,CIENCIAS NATURALES Y EXACTAS ,Hormone ,Signal Transduction - Abstract
The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of multiple signaling transduction pathways and transcriptional regulatory networks that cooperate for hormone secretion, cell plasticity, and ultimately specific pituitary responses that are essential for an appropriate physiological response. We discuss the physiopathological and molecular mechanisms related to this integrative regulatory system of the anterior pituitary gland and how it contributes to modulate the gland functions and impacts on body homeostasis. Fil: Perez Castro, Carolina Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina Fil: Renner, Ulrich. Max Planck Institut Für Psychiatrie; Alemania Fil: Haedo, Mariana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina Fil: Stalla, Gunter K.. Max Planck Institut Für Psychiatrie; Alemania Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
- Published
- 2012
7. RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells
- Author
-
Juan Gerez, Mariana Fuertes, Günter K. Stalla, Mariana Haedo, Marco Losa, Eduardo Arzt, Bing Shan, Ulrich Renner, Michael Buchfelder, Marily Theodoropoulou, Shan, B., Gerez, J., Haedo, M., Fuertes, M., Theodoropoulou, M., Buchfelder, M., Losa, M., Stalla, G. K., Arzt, E., and Renner, U.
- Subjects
Adenoma ,Vascular Endothelial Growth Factor A ,Cancer Research ,medicine.medical_specialty ,CIENCIAS MÉDICAS Y DE LA SALUD ,Transcription Factor ,Endocrinology, Diabetes and Metabolism ,Biology ,Pituitary neoplasm ,Mice ,Endocrinology ,Pituitary adenoma ,Cell Line, Tumor ,Internal medicine ,Tumor Cells, Cultured ,medicine ,Animals ,Humans ,Pituitary Neoplasms ,Secretion ,Pituitary Neoplasm ,RNA, Messenger ,Hypoxia ,Transcription factor ,Messenger RNA ,Neovascularization, Pathologic ,Animal ,Pituitary tumour ,Cobalt ,Hypoxia-Inducible Factor 1, alpha Subunit ,medicine.disease ,Otras Ciencias Médicas ,Vascular endothelial growth factor A ,Oncology ,Cell culture ,Cancer research ,RSUME ,Transcription Factors ,Human - Abstract
The recently cloned small RWD-domain containing protein RSUME was shown to increase protein levels of hypoxia-inducible factor-1a (HIF-1a). The latter is the oxygen-regulated subunit of HIF-1, the most important transcription factor of the cellular adaptive processes to hypoxic conditions. It is also a major regulator of vascular endothelial growth factor-A (VEGF-A), which is critically involved in the complex process of tumour neovascularisation. In this study, the expression and role of RSUME in pituitary tumours was studied. We found that RSUME mRNA was up-regulated in pituitary adenomas and significantly correlated with HIF-1a mRNA levels. Hypoxia (1% O2) or treatment with hypoxia-mimicking CoCl2 enhanced RSUME and HIF-1a expression, induced translocation of HIF-1a to the nuclei and stimulated VEGF-A production both in pituitary tumour cell lines and primary human pituitary adenoma cell cultures. When RSUME expression was specifically down-regulated by siRNA, the CoCl2-induced increase VEGF-A secretion was strongly reduced which was shown to be a consequence of the RSUME knockdown-associated reduction of HIF-1a synthesis. Thus, RSUME plays an important role in initiating pituitary tumour neovascularisation through regulating HIF-1a levels and subsequent VEGF-A production and may therefore be critically involved in pituitary adenoma progression. Fil: Shan, B.. Max-Planck-Institut für Psychiatrie; Alemania Fil: Gerez, Juan Atilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Pque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Haedo, Mariana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Pque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Fuertes, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Pque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Theodoropoulou, M.. Max-Planck-Institut für Psychiatrie; Alemania Fil: Buchfelder, M.. Universitat Erlangen-Nuremberg; Alemania Fil: Losa, M.. Istituto San Raffaele; Italia Fil: Stalla, G.. Max-Planck-Institut für Psychiatrie; Alemania Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Pque. Centenario. Instituto de Investigación En Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Renner, U.. Max-Planck-Institut für Psychiatrie; Alemania
- Published
- 2012
8. Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
- Author
-
Mariana, Fuertes, Juan, Gerez, Mariana, Haedo, Damiana, Giacomini, Marcelo, Páez-Pereda, Marta, Labeur, Günter K, Stalla, and Eduardo, Arzt
- Subjects
Interleukin-6 ,Gene Expression Profiling ,Cytokine Receptor gp130 ,Animals ,Humans ,Pituitary Neoplasms ,Transcription Factors - Abstract
Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion and growth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has been shown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process in adenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein, RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathways involved in angiogenic and tumorigenic processes (NF-kappaB/IkappaB and HIF-1alpha pathways). Thus, it could have an important role in the development of the pituitary tumors.
- Published
- 2010
9. Novel Medical Therapies for Pituitary Tumors
- Author
-
Mariana Haedo, G. K. Stalla, Marcelo J. Perone, Eduardo Arzt, M. Paez Pereda, Marta Labeur, Marily Theodoropoulou, and Ulrich Renner
- Subjects
endocrine system ,Pathology ,medicine.medical_specialty ,Medical treatment ,business.industry ,Pituitary tumors ,Medicine ,Corticotropic cell ,business ,medicine.disease ,Bioinformatics ,Hormone - Abstract
Despite considerable progress, there is still no medical treatment available for some kinds of pituitary tumors, in particular hormone inactive adenomas and corticotroph pituitary tumors. Surgical rem
- Published
- 2010
10. Cytokines and Genes in Pituitary Tumorigenesis: RSUME Role in Cell Biology
- Author
-
Mariana Haedo, Günter K. Stalla, Juan Gerez, Marcelo Paez-Pereda, Damiana Giacomini, Mariana Fuertes, Eduardo Arzt, and Marta Labeur
- Subjects
Gene expression profiling ,Biology ,Pituitary tumorigenesis ,Glycoprotein 130 ,Gene ,Function (biology) ,Cell biology - Abstract
Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal
- Published
- 2010
11. Pituitary tumors: cell type-specific roles for BMP-4
- Author
-
Eduardo Arzt, Mariana Haedo, Marcelo Paez-Pereda, Marta Labeur, and Günter K. Stalla
- Subjects
Adult ,endocrine system ,medicine.medical_specialty ,CIENCIAS MÉDICAS Y DE LA SALUD ,PROLACTIN ,Bone Morphogenetic Protein 4 ,Biology ,Biochemistry ,Prolactin cell ,Mice ,Endocrinology ,Anterior pituitary ,Adrenocorticotropic Hormone ,Internal medicine ,RETINOIC ACID ,BMP-4 ,medicine ,Animals ,Humans ,Pituitary Neoplasms ,Prolactinoma ,Pituitary ACTH Hypersecretion ,Molecular Biology ,Gonadotroph Cell ,Pituitary tumors ,Otras Medicina Básica ,PITUITARY TUMORS ,TGF-&Beta ,medicine.disease ,Growth hormone secretion ,Prolactin ,ACTH ,Rats ,Medicina Básica ,Somatostatin ,medicine.anatomical_structure ,Pituitary Gland ,embryonic structures ,Bone Morphogenetic Proteins ,Cancer research ,Corticotropic cell ,hormones, hormone substitutes, and hormone antagonists - Abstract
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania
- Published
- 2009
12. Subject Index Vol. 71, Suppl. 2, 2009
- Author
-
Eivind Carlsen, Michelle T. Fleming, Karen P. Steel, Lars Sävendahl, Damiana Giacomini, Gavin Kelsey, Joel N. Hirschhorn, David B. Dunger, Guillaume Lettre, Ivo J.P. Arnhold, Eduardo Arzt, James W. MacDonald, Thomas Eggermann, Amanda H. Mortensen, Shannon W. Davis, Günter K. Stalla, Noboru Egashira, Catherine Molinas, Piero Carninci, Yoshihide Hayashizaki, Sunita K. Agarwal, Márta Korbonits, Stephen J. Marx, Wietske A. Ester, Carmen M. Mateo, Atsushi Ozawa, Debashis Ghosh, Linda Fryklund, Albert Beckers, Anita Hokken Koelega, Juan Gerez, Marcelo Paez-Pereda, Sally A. Camper, Vera Popovic-Brkic, Robert H. Lyons, Mehul T. Dattani, Marta Labeur, Andrea Lania, Andrei S. Chagin, Ron G. Rosenfeld, Mariana Haedo, Shlomo Melmed, Michelle L. Brinkmeier, Jimena Druker, Anna Spada, Maithé Tauber, Janina Caliebe, Alexander A. L. Jorge, Adrian J. L. Clark, L.B. Johnston, Wolter J. Mooi, Vera Chesnokova, Mary Anne Potok, Robert Yoshiyuki Osamura, Adrian F. Daly, Vivian Hwa, Maria A. Tichomirowa, Michael B. Ranke, Martin O. Savage, Gerhard Binder, and Hartmut A. Wollmann
- Subjects
Endocrinology ,Index (economics) ,Endocrinology, Diabetes and Metabolism ,Pediatrics, Perinatology and Child Health ,Statistics ,Subject (documents) ,Psychology - Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.