1. Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses
- Author
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Lusania Maria Greggi Antunes, Martin Kussmann, Rosana Queiroz da Silva, Jim Kaput, Mariana Moraes de Oliveira, Jacqueline Pontes Monteiro, Tamiris Trevisan de Barros, Esther Campos Giménez, Elaine Hillesheim, Joyce Moraes Camarneiro, Sara Colombo Mottaz, Maria Olímpia Ribeiro do Vale Almada, Roberta Garcia Salomão, Giovanna Zambianchi Corsini, Antoine Lévèques, Marina Takemoto Matsumoto, Patrick Descombes, Melissa J. Morine, Raquel Ricci, Stephanie Kazu Brandão Myoshi, Vinícius de Paula Venâncio, Corrado Priami, Isabela Ribeiro Rossi, Gabriela Cristina Arces de Souza, Catherine Gimenez, Karine Redeuil, Letícia Lima Falquetti, Mayara Leite Fagá, Jéssica Ré Jorge, Marie-Pier Scott-Boyer, Mariana Chinarelli Reche, Alexandre Goyon, Carolina de Almeida Coelho-Landell, Vicky Nogueira-Pileggi, José Simon Camelo-Junior, Lívia Cristina Hernandes, Jean-Marie Oberson, Thaís Helena Alves da Cunha, Emmanuelle Bertschy, Paula Vitória Sozza Silva, Driele Cristina Gomes Quinhoneiro, Colleen Draper, Taís Fontellas Laurito, Mariana Mendes Muniz, Roseli Borges Donegá Toffano, Nelly Conus, Sébastien Lacroix, Slyviane Métairon, Tâmara Hambúrguer Tambellini, Jérôme Carayol, Thalia Manfrin Martins Deminice, and Mariana Giaretta Mathias
- Subjects
0301 basic medicine ,Vitamin ,Male ,Response to intervention ,Adolescent ,Individuality ,Disease ,03 medical and health sciences ,chemistry.chemical_compound ,Intervention (counseling) ,Environmental health ,computational systems biology ,Medicine ,Humans ,Baseline (configuration management) ,Child ,Research Articles ,targeted and systems nutrition ,Dyslipidemias ,metabolic health ,030109 nutrition & dietetics ,business.industry ,VITAMINAS ,bioinformatics ,Feeding Behavior ,Vitamins ,Anthropometry ,Micronutrient ,community based participatory research ,chemistry ,community‐based participatory research ,micronutrients ,computational systems biology, bioinformatics, community based participatory research ,Female ,business ,Multivitamin ,Food Science ,Biotechnology ,Research Article - Abstract
Scope Micronutrients are in small amounts in foods, act in concert, and require variable amounts of time to see changes in health and risk for disease. These first principles are incorporated into an intervention study designed to develop new experimental strategies for setting target recommendations for food bioactives for populations and individuals. Methods and results A 6-week multivitamin/mineral intervention is conducted in 9-13 year olds. Participants (136) are (i) their own control (n-of-1); (ii) monitored for compliance; (iii) measured for 36 circulating vitamin forms, 30 clinical, anthropometric, and food intake parameters at baseline, post intervention, and following a 6-week washout; and (iv) had their ancestry accounted for as modifier of vitamin baseline or response. The same intervention is repeated the following year (135 participants). Most vitamins respond positively and many clinical parameters change in directions consistent with improved metabolic health to the intervention. Baseline levels of any metabolite predict its own response to the intervention. Elastic net penalized regression models are identified, and significantly predict response to intervention on the basis of multiple vitamin/clinical baseline measures. Conclusions The study design, computational methods, and results are a step toward developing recommendations for optimizing vitamin levels and health parameters for individuals.
- Published
- 2018